{ "date": "Wed May 17 00:41:28 UTC 2023", "pathways": [ { "glytoucan_ac": "G00017IP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56271TF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G56271TF", "dp": 8 }, { "id": "G00017IP", "dp": 8 } ], "links": [ { "target": "G00017IP", "source": "G56271TF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56271TF", "source": "G59741XZ", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00026MO", "error": "Starting point for pathway to G00026MO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00028MO", "error": "Starting point for pathway to G00028MO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00113FP", "error": "Missing intermediate; no pathways to [G00113FP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00176HZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00201AB", "error": "Missing intermediate; no pathways to [G00201AB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00212RH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G55479DB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G11929SN", "dp": 14 }, { "id": "G55479DB", "dp": 15 }, { "id": "G00212RH", "dp": 15 } ], "links": [ { "target": "G00212RH", "source": "G55479DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G55479DB", "source": "G11929SN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929SN", "source": "G80294GH", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00231WL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19469VZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G19469VZ", "dp": 18 }, { "id": "G00231WL", "dp": 18 } ], "links": [ { "target": "G00231WL", "source": "G19469VZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19469VZ", "source": "G92574YO", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00247PL", "error": "Missing intermediate; no pathways to [G00247PL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42477ZH]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G00279YF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29434RB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G00279YF", "dp": 9 } ], "links": [ { "target": "G00279YF", "source": "G29434RB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00320ZP", "error": "Missing intermediate; no pathways to [G00320ZP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00335DM", "error": "Starting point for pathway to G00335DM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00349CA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59942FB]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 }, { "id": "G59942FB", "dp": 11 }, { "id": "G00349CA", "dp": 11 } ], "links": [ { "target": "G00349CA", "source": "G59942FB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59942FB", "source": "G56748EO", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00361YF", "error": "Starting point for pathway to G00361YF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00368HM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 } ], "links": [ { "target": "G00368HM", "source": "G86357DX", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00369RM", "error": "Missing intermediate; no pathways to [G00369RM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00383KP", "error": "Starting point for pathway to G00383KP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00383YF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74574VX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G74574VX", "dp": 11 }, { "id": "G00383YF", "dp": 11 } ], "links": [ { "target": "G00383YF", "source": "G74574VX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00413UF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 } ], "links": [ { "target": "G00413UF", "source": "G84376FR", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00420CS", "error": "Missing intermediate; no pathways to [G00420CS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52483OL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00432WV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36523TZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G36523TZ", "dp": 12 }, { "id": "G00432WV", "dp": 12 } ], "links": [ { "target": "G00432WV", "source": "G36523TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36523TZ", "source": "G29857RC", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00433KW", "error": "Starting point for pathway to G00433KW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00463XD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G59277TZ", "dp": 10 } ], "links": [ { "target": "G00463XD", "source": "G59277TZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59277TZ", "source": "G30159WR", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00470UO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G12061IK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G00470UO", "dp": 11 } ], "links": [ { "target": "G00470UO", "source": "G12061IK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00471UP", "error": "Missing intermediate; no pathways to [G00471UP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G00480IB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G90223GH", "dp": 9 } ], "links": [ { "target": "G00480IB", "source": "G90223GH", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G90223GH", "source": "G29011JC", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00480KJ", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G26795PW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G11929CD", "dp": 10 }, { "id": "G26795PW", "dp": 11 }, { "id": "G00480KJ", "dp": 11 } ], "links": [ { "target": "G00480KJ", "source": "G26795PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26795PW", "source": "G11929CD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929CD", "source": "G09782JM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00480NH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46503KK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G46503KK", "dp": 12 }, { "id": "G00480NH", "dp": 12 } ], "links": [ { "target": "G00480NH", "source": "G46503KK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46503KK", "source": "G18219CJ", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00492CQ", "error": "Starting point for pathway to G00492CQ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00503EE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00536FZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G00536FZ", "dp": 12 }, { "id": "G00503EE", "dp": 12 } ], "links": [ { "target": "G00503EE", "source": "G00536FZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00536FZ", "source": "G71679MX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00504PZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G72718TT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G00504PZ", "dp": 9 } ], "links": [ { "target": "G00504PZ", "source": "G72718TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00514XC", "error": "Missing intermediate; no pathways to [G00514XC] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00519UD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26795PW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G11929CD", "dp": 10 }, { "id": "G26795PW", "dp": 11 }, { "id": "G00519UD", "dp": 11 } ], "links": [ { "target": "G00519UD", "source": "G26795PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26795PW", "source": "G11929CD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929CD", "source": "G09782JM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00531ZU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23340ZN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G71835BN", "dp": 10 }, { "id": "G01378OV", "dp": 11 }, { "id": "G23340ZN", "dp": 12 }, { "id": "G00531ZU", "dp": 12 } ], "links": [ { "target": "G00531ZU", "source": "G23340ZN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23340ZN", "source": "G01378OV", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01378OV", "source": "G71835BN", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00536FZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 } ], "links": [ { "target": "G00536FZ", "source": "G71679MX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00582VL", "error": "Missing intermediate; no pathways to [G00582VL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G00584LL", "error": "Missing intermediate; no pathways to [G00584LL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00591PZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 } ], "links": [ { "target": "G00591PZ", "source": "G82779CI", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00606LX", "error": "Missing intermediate; no pathways to [G00606LX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G70830AN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00618HB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69600TI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G69600TI", "dp": 9 }, { "id": "G00618HB", "dp": 9 } ], "links": [ { "target": "G00618HB", "source": "G69600TI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69600TI", "source": "G64669AQ", "residue_affected": { "residue_id": "N477", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylf", "full_name": "β-D-Xylf" }, "effect": "Add β-D-Xylf", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G00636QL", "error": "Missing intermediate; no pathways to [G00636QL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00646SN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G02934UB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G02934UB", "dp": 14 }, { "id": "G00646SN", "dp": 14 } ], "links": [ { "target": "G00646SN", "source": "G02934UB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02934UB", "source": "G99074EO", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00662IB", "error": "Missing intermediate; no pathways to [G00662IB] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00666EC", "error": "Missing intermediate; no pathways to [G00666EC] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00695JO", "error": "Missing intermediate; no pathways to [G00695JO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00706AL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53396PX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G53396PX", "dp": 14 }, { "id": "G00706AL", "dp": 14 } ], "links": [ { "target": "G00706AL", "source": "G53396PX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53396PX", "source": "G82050MN", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00706QN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G27188NC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G27188NC", "dp": 8 }, { "id": "G00706QN", "dp": 8 } ], "links": [ { "target": "G00706QN", "source": "G27188NC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27188NC", "source": "G02427KF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00706YM", "error": "Missing intermediate; no pathways to [G00706YM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00738BQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G00738BQ", "source": "G11041DA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00740UU", "error": "Missing intermediate; no pathways to [G00740UU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85891FA]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G00741NZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46213JU]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G46213JU", "dp": 10 }, { "id": "G00741NZ", "dp": 10 } ], "links": [ { "target": "G00741NZ", "source": "G46213JU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46213JU", "source": "G16828VN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00743WU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 } ], "links": [ { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00797ZX", "error": "Missing intermediate; no pathways to [G00797ZX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00805TZ", "error": "Missing intermediate; no pathways to [G00805TZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75671DO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00810PC", "error": "Missing intermediate; no pathways to [G00810PC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23546LY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00826SV", "error": "Starting point for pathway to G00826SV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00835TJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63787RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G63787RZ", "dp": 10 }, { "id": "G00835TJ", "dp": 10 } ], "links": [ { "target": "G00835TJ", "source": "G63787RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63787RZ", "source": "G27919IH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00850LT", "error": "Starting point for pathway to G00850LT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00876GU", "error": "Starting point for pathway to G00876GU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00883DO", "error": "Starting point for pathway to G00883DO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00883ZT", "error": "Starting point for pathway to G00883ZT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00886GB", "error": "Missing intermediate; no pathways to [G00886GB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00888JR", "error": "Starting point for pathway to G00888JR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00900AZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64669AQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G00900AZ", "dp": 8 } ], "links": [ { "target": "G00900AZ", "source": "G64669AQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G00909GK", "error": "Starting point for pathway to G00909GK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00909PI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 } ], "links": [ { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00910WD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G99533GU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 }, { "id": "G99533GU", "dp": 18 }, { "id": "G00910WD", "dp": 18 } ], "links": [ { "target": "G00910WD", "source": "G99533GU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99533GU", "source": "G28106CM", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00915XC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19019TY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 }, { "id": "G19019TY", "dp": 11 }, { "id": "G00915XC", "dp": 11 } ], "links": [ { "target": "G00915XC", "source": "G19019TY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19019TY", "source": "G09670SR", "residue_affected": { "residue_id": "N72", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00923KH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70511VE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G70511VE", "dp": 12 }, { "id": "G00923KH", "dp": 12 } ], "links": [ { "target": "G00923KH", "source": "G70511VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70511VE", "source": "G53752TA", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00948WV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 }, { "id": "G23151RC", "dp": 13 } ], "links": [ { "target": "G00948WV", "source": "G23151RC", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G23151RC", "source": "G17689DH", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00951UF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G79198BK", "dp": 9 } ], "links": [ { "target": "G00951UF", "source": "G79198BK", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79198BK", "source": "G10219AA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00966RI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21679ID]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G21679ID", "dp": 11 }, { "id": "G00966RI", "dp": 11 } ], "links": [ { "target": "G00966RI", "source": "G21679ID", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21679ID", "source": "G52934AK", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00978TF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69411IG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G00978TF", "dp": 7 } ], "links": [ { "target": "G00978TF", "source": "G69411IG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00979HB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25350TT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G59361OW", "dp": 11 }, { "id": "G25350TT", "dp": 12 }, { "id": "G00979HB", "dp": 12 } ], "links": [ { "target": "G00979HB", "source": "G25350TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25350TT", "source": "G59361OW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59361OW", "source": "G44946WH", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G00982QD", "error": "Starting point for pathway to G00982QD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00986YT", "error": "Starting point for pathway to G00986YT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G00995HW", "error": "Missing intermediate; no pathways to [G00995HW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30483FB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G00998NI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78059CC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G00998NI", "dp": 10 } ], "links": [ { "target": "G00998NI", "source": "G78059CC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01001RL", "error": "Missing intermediate; no pathways to [G01001RL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01010HW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 } ], "links": [ { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01023RC", "error": "Starting point for pathway to G01023RC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01028FJ", "error": "Starting point for pathway to G01028FJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01034MJ", "error": "Missing intermediate; no pathways to [G01034MJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40064GR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01050GH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33241WC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G33241WC", "dp": 15 }, { "id": "G01050GH", "dp": 15 } ], "links": [ { "target": "G01050GH", "source": "G33241WC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33241WC", "source": "G45720CA", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01063DC", "error": "Starting point for pathway to G01063DC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01069AK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G01069AK", "source": "G91365ZQ", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01079TS", "error": "Missing intermediate; no pathways to [G01079TS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G01123UL", "error": "Missing intermediate; no pathways to [G01123UL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01169EW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65597BI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G01169EW", "dp": 10 } ], "links": [ { "target": "G01169EW", "source": "G65597BI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01218JA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G83992YN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 }, { "id": "G66961CH", "dp": 15 }, { "id": "G83992YN", "dp": 16 }, { "id": "G01218JA", "dp": 16 } ], "links": [ { "target": "G01218JA", "source": "G83992YN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G83992YN", "source": "G66961CH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01220PX", "error": "Starting point for pathway to G01220PX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01223IC", "error": "Missing intermediate; no pathways to [G01223IC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01244DB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 } ], "links": [ { "target": "G01244DB", "source": "G77252PU", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01260KO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86270DU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G86270DU", "dp": 12 }, { "id": "G01260KO", "dp": 12 } ], "links": [ { "target": "G01260KO", "source": "G86270DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86270DU", "source": "G11041DA", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01260RY", "error": "Starting point for pathway to G01260RY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01265XZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01295AX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29449JO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G01295AX", "dp": 13 } ], "links": [ { "target": "G01295AX", "source": "G29449JO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01300OI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76345AA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G76345AA", "dp": 9 }, { "id": "G01300OI", "dp": 9 } ], "links": [ { "target": "G01300OI", "source": "G76345AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76345AA", "source": "G12398HZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01308XT", "error": "Starting point for pathway to G01308XT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01310VF", "error": "Missing intermediate; no pathways to [G01310VF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95542JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01323LL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77384FE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G91337ZP", "dp": 10 }, { "id": "G77384FE", "dp": 11 }, { "id": "G01323LL", "dp": 11 } ], "links": [ { "target": "G01323LL", "source": "G77384FE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77384FE", "source": "G91337ZP", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91337ZP", "source": "G58667NI", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01342FO", "error": "Missing intermediate; no pathways to [G01342FO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01354KL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 } ], "links": [ { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01361CV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11041DA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G01361CV", "dp": 11 } ], "links": [ { "target": "G01361CV", "source": "G11041DA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01375NQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37022BP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G37022BP", "dp": 12 }, { "id": "G01375NQ", "dp": 12 } ], "links": [ { "target": "G01375NQ", "source": "G37022BP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37022BP", "source": "G30460NZ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01378OV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G71835BN", "dp": 10 } ], "links": [ { "target": "G01378OV", "source": "G71835BN", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01406RR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36701GV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G36701GV", "dp": 12 }, { "id": "G01406RR", "dp": 12 } ], "links": [ { "target": "G01406RR", "source": "G36701GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36701GV", "source": "G53752TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01414CL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G34838RM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G01414CL", "dp": 10 } ], "links": [ { "target": "G01414CL", "source": "G34838RM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01424EN", "error": "Starting point for pathway to G01424EN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01450VD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G33001NX", "dp": 8 } ], "links": [ { "target": "G01450VD", "source": "G33001NX", "residue_affected": { "residue_id": "N267", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G33001NX", "source": "G39089YD", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G01476WA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82955EQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G82955EQ", "dp": 11 }, { "id": "G01476WA", "dp": 11 } ], "links": [ { "target": "G01476WA", "source": "G82955EQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82955EQ", "source": "G87073UP", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01489UZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G18219CJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G01489UZ", "dp": 11 } ], "links": [ { "target": "G01489UZ", "source": "G18219CJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01521YU", "error": "Missing intermediate; no pathways to [G01521YU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01522FD", "error": "Missing intermediate; no pathways to [G01522FD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01590HD", "error": "Starting point for pathway to G01590HD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01613KN", "error": "Missing intermediate; no pathways to [G01613KN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G31991IV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01631SU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68937TM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G01631SU", "dp": 10 } ], "links": [ { "target": "G01631SU", "source": "G68937TM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01668VR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11929SN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G11929SN", "dp": 14 }, { "id": "G01668VR", "dp": 14 } ], "links": [ { "target": "G01668VR", "source": "G11929SN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11929SN", "source": "G80294GH", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01669LU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01670UQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91365ZQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G01670UQ", "dp": 10 } ], "links": [ { "target": "G01670UQ", "source": "G91365ZQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01685IB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52187WF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G02290KA", "dp": 10 }, { "id": "G52187WF", "dp": 11 }, { "id": "G01685IB", "dp": 11 } ], "links": [ { "target": "G01685IB", "source": "G52187WF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52187WF", "source": "G02290KA", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01701XV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 } ], "links": [ { "target": "G01701XV", "source": "G71013KY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01727PW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 } ], "links": [ { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01734XU", "error": "Missing intermediate; no pathways to [G01734XU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34508UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01752VH", "error": "Starting point for pathway to G01752VH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01772HV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93075HW]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G40289RO", "dp": 10 }, { "id": "G71102UV", "dp": 11 }, { "id": "G93075HW", "dp": 12 }, { "id": "G01772HV", "dp": 12 } ], "links": [ { "target": "G01772HV", "source": "G93075HW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93075HW", "source": "G71102UV", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71102UV", "source": "G40289RO", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40289RO", "source": "G20966TZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01789AQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G72662IG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G80537QW", "dp": 14 }, { "id": "G72662IG", "dp": 15 }, { "id": "G01789AQ", "dp": 15 } ], "links": [ { "target": "G01789AQ", "source": "G72662IG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72662IG", "source": "G80537QW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80537QW", "source": "G93582HM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01827FA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03075ZE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G03075ZE", "dp": 14 }, { "id": "G01827FA", "dp": 14 } ], "links": [ { "target": "G01827FA", "source": "G03075ZE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03075ZE", "source": "G04989WY", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01851EU", "error": "Missing intermediate; no pathways to [G01851EU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60227QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01856RL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 } ], "links": [ { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01891JS", "error": "Missing intermediate; no pathways to [G01891JS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01917CF", "error": "Missing intermediate; no pathways to [G01917CF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84390MS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01919UV", "error": "Starting point for pathway to G01919UV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G01923XE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 } ], "links": [ { "target": "G01923XE", "source": "G95898GD", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01935FK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G01935FK", "source": "G36191CD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01959AV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03727RK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G03727RK", "dp": 14 }, { "id": "G01959AV", "dp": 14 } ], "links": [ { "target": "G01959AV", "source": "G03727RK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03727RK", "source": "G66282NU", "residue_affected": { "residue_id": "N251", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01978EJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94045IP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G94045IP", "dp": 13 }, { "id": "G01978EJ", "dp": 13 } ], "links": [ { "target": "G01978EJ", "source": "G94045IP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94045IP", "source": "G91023GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G01996OW", "error": "Missing intermediate; no pathways to [G01996OW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G01999JH", "error": "Missing intermediate; no pathways to [G01999JH] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G08520NM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G02018EI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19843TY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G19843TY", "dp": 10 }, { "id": "G02018EI", "dp": 10 } ], "links": [ { "target": "G02018EI", "source": "G19843TY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19843TY", "source": "G27919IH", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02021XC", "error": "Starting point for pathway to G02021XC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G02025MF", "error": "Missing intermediate; no pathways to [G02025MF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02041MX", "error": "Missing intermediate; no pathways to [G02041MX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02076VP", "error": "Missing intermediate; no pathways to [G02076VP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43873MM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02081QK", "error": "Missing intermediate; no pathways to [G02081QK] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G71972AT]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G02081VW", "error": "Missing intermediate; no pathways to [G02081VW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50278HE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02122FK", "error": "Missing intermediate; no pathways to [G02122FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40428GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02132BT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98366ZJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G98366ZJ", "dp": 14 }, { "id": "G02132BT", "dp": 14 } ], "links": [ { "target": "G02132BT", "source": "G98366ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98366ZJ", "source": "G99074EO", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02133IK", "error": "Missing intermediate; no pathways to [G02133IK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61751GZ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02152MS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36519NW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G36519NW", "dp": 13 }, { "id": "G02152MS", "dp": 13 } ], "links": [ { "target": "G02152MS", "source": "G36519NW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36519NW", "source": "G01669LU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02156UW", "error": "Starting point for pathway to G02156UW could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G02174FQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G94531EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 }, { "id": "G02174FQ", "dp": 18 } ], "links": [ { "target": "G02174FQ", "source": "G94531EZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02183OE", "error": "Missing intermediate; no pathways to [G02183OE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02188RD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18219CJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G02188RD", "dp": 11 } ], "links": [ { "target": "G02188RD", "source": "G18219CJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02193CV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40194MN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G40194MN", "dp": 16 }, { "id": "G02193CV", "dp": 16 } ], "links": [ { "target": "G02193CV", "source": "G40194MN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40194MN", "source": "G76842ZR", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02207TG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G33241WC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G33241WC", "dp": 15 }, { "id": "G02207TG", "dp": 15 } ], "links": [ { "target": "G02207TG", "source": "G33241WC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33241WC", "source": "G45720CA", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02243JW", "error": "Missing intermediate; no pathways to [G02243JW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44223QP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G02284UY", "error": "Missing intermediate; no pathways to [G02284UY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02290KA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02296PF", "error": "Starting point for pathway to G02296PF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G02302MM", "error": "Missing intermediate; no pathways to [G02302MM] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G75972ZC]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02310VX", "error": "Starting point for pathway to G02310VX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G02311IE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 } ], "links": [ { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02322JK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07947TY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G21828OD", "dp": 13 }, { "id": "G07947TY", "dp": 14 }, { "id": "G02322JK", "dp": 14 } ], "links": [ { "target": "G02322JK", "source": "G07947TY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07947TY", "source": "G21828OD", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21828OD", "source": "G45359RY", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02410EE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06209KS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G06209KS", "dp": 8 }, { "id": "G02410EE", "dp": 8 } ], "links": [ { "target": "G02410EE", "source": "G06209KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06209KS", "source": "G69411IG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02422RD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G02422RD", "source": "G10219AA", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02427KF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02429WR", "error": "Missing intermediate; no pathways to [G02429WR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02441OB", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G03272YQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G21788RU", "dp": 12 }, { "id": "G03272YQ", "dp": 13 }, { "id": "G02441OB", "dp": 13 } ], "links": [ { "target": "G02441OB", "source": "G03272YQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03272YQ", "source": "G21788RU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21788RU", "source": "G25520XG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02442YU", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G91303GW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G91303GW", "dp": 11 }, { "id": "G02442YU", "dp": 11 } ], "links": [ { "target": "G02442YU", "source": "G91303GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91303GW", "source": "G45560HM", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02470AU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16155TD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G16155TD", "dp": 13 }, { "id": "G02470AU", "dp": 13 } ], "links": [ { "target": "G02470AU", "source": "G16155TD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16155TD", "source": "G01669LU", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02470WS", "error": "Missing intermediate; no pathways to [G02470WS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02471GW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 } ], "links": [ { "target": "G02471GW", "source": "G32305RZ", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02473HY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G73418FX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 }, { "id": "G73418FX", "dp": 12 }, { "id": "G02473HY", "dp": 12 } ], "links": [ { "target": "G02473HY", "source": "G73418FX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73418FX", "source": "G00743WU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02474FD", "error": "Missing intermediate; no pathways to [G02474FD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02483WT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10292TC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G02483WT", "dp": 15 } ], "links": [ { "target": "G02483WT", "source": "G10292TC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02513HF", "error": "Starting point for pathway to G02513HF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G02536WY", "error": "Missing intermediate; no pathways to [G02536WY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02582JY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G30901GC", "dp": 9 } ], "links": [ { "target": "G02582JY", "source": "G30901GC", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02646YL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G07392QY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G07392QY", "dp": 11 }, { "id": "G02646YL", "dp": 11 } ], "links": [ { "target": "G02646YL", "source": "G07392QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07392QY", "source": "G78059CC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02654EL", "error": "Starting point for pathway to G02654EL could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G02660WC", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G29492IF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G02660WC", "dp": 8 } ], "links": [ { "target": "G02660WC", "source": "G29492IF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02670IJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 } ], "links": [ { "target": "G02670IJ", "source": "G09482NW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02679YX", "error": "Missing intermediate; no pathways to [G02679YX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02760XH", "error": "Missing intermediate; no pathways to [G02760XH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43351VW]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02786XX", "error": "Missing intermediate; no pathways to [G02786XX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81096RM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02797YE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30302VM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G02797YE", "dp": 11 } ], "links": [ { "target": "G02797YE", "source": "G30302VM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02824PK", "error": "Missing intermediate; no pathways to [G02824PK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90130AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G02841EM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75143LK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G75143LK", "dp": 11 }, { "id": "G02841EM", "dp": 11 } ], "links": [ { "target": "G02841EM", "source": "G75143LK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75143LK", "source": "G71013KY", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02872OI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91337ZP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G91337ZP", "dp": 10 }, { "id": "G02872OI", "dp": 10 } ], "links": [ { "target": "G02872OI", "source": "G91337ZP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91337ZP", "source": "G58667NI", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02915XR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89941FZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 }, { "id": "G89941FZ", "dp": 12 }, { "id": "G02915XR", "dp": 12 } ], "links": [ { "target": "G02915XR", "source": "G89941FZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89941FZ", "source": "G00743WU", "residue_affected": { "residue_id": "N70", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02934UB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 } ], "links": [ { "target": "G02934UB", "source": "G99074EO", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02945KQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71470CO]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G71470CO", "dp": 9 }, { "id": "G02945KQ", "dp": 9 } ], "links": [ { "target": "G02945KQ", "source": "G71470CO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71470CO", "source": "G08520NM", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02987EY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43664YB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G43664YB", "dp": 9 }, { "id": "G02987EY", "dp": 9 } ], "links": [ { "target": "G02987EY", "source": "G43664YB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43664YB", "source": "G24420RT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G02995BO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56749GV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G02995BO", "dp": 12 } ], "links": [ { "target": "G02995BO", "source": "G56749GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03004PD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G13267ZY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G13267ZY", "dp": 10 }, { "id": "G03004PD", "dp": 10 } ], "links": [ { "target": "G03004PD", "source": "G13267ZY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G13267ZY", "source": "G46638GC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03005MJ", "error": "Starting point for pathway to G03005MJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G03021WA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G80393PG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G03021WA", "dp": 9 } ], "links": [ { "target": "G03021WA", "source": "G80393PG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03048ZV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07337US]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G13156PQ", "dp": 12 }, { "id": "G07337US", "dp": 13 }, { "id": "G03048ZV", "dp": 13 } ], "links": [ { "target": "G03048ZV", "source": "G07337US", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07337US", "source": "G13156PQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13156PQ", "source": "G53752TA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03075ZE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 } ], "links": [ { "target": "G03075ZE", "source": "G04989WY", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03096WL", "error": "Missing intermediate; no pathways to [G03096WL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03136UJ", "error": "Missing intermediate; no pathways to [G03136UJ] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G70583LH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03142ET", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G22728HO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G54584ER", "dp": 14 }, { "id": "G22728HO", "dp": 15 }, { "id": "G03142ET", "dp": 15 } ], "links": [ { "target": "G03142ET", "source": "G22728HO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G22728HO", "source": "G54584ER", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G54584ER", "source": "G18938DW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03164NE", "error": "Missing intermediate; no pathways to [G03164NE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29857PJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03165SD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29377XJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G29377XJ", "dp": 12 }, { "id": "G03165SD", "dp": 12 } ], "links": [ { "target": "G03165SD", "source": "G29377XJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29377XJ", "source": "G63585HN", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03177HU", "error": "Missing intermediate; no pathways to [G03177HU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03203II", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G92024SL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G03203II", "dp": 7 } ], "links": [ { "target": "G03203II", "source": "G92024SL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03207XQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11929SN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G11929SN", "dp": 14 }, { "id": "G03207XQ", "dp": 14 } ], "links": [ { "target": "G03207XQ", "source": "G11929SN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11929SN", "source": "G80294GH", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03216SJ", "error": "Starting point for pathway to G03216SJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G03228NK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86083QZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G04185VX", "dp": 10 }, { "id": "G30569KZ", "dp": 11 }, { "id": "G86083QZ", "dp": 12 }, { "id": "G03228NK", "dp": 12 } ], "links": [ { "target": "G03228NK", "source": "G86083QZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86083QZ", "source": "G30569KZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30569KZ", "source": "G04185VX", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03229IR", "error": "Missing intermediate; no pathways to [G03229IR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38637SA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03230AX", "error": "Missing intermediate; no pathways to [G03230AX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G20711NK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03250UN", "error": "Missing intermediate; no pathways to [G03250UN] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53504BR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03260OU", "error": "Missing intermediate; no pathways to [G03260OU] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03272YQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G21788RU", "dp": 12 } ], "links": [ { "target": "G03272YQ", "source": "G21788RU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21788RU", "source": "G25520XG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03275SD", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03296OS", "error": "Missing intermediate; no pathways to [G03296OS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03319HQ", "error": "Missing intermediate; no pathways to [G03319HQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03321AC", "error": "Starting point for pathway to G03321AC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G03345AP", "error": "Missing intermediate; no pathways to [G03345AP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G96235XM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03346FO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25505UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 }, { "id": "G03346FO", "dp": 14 } ], "links": [ { "target": "G03346FO", "source": "G25505UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03347EL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G78503JC", "dp": 12 }, { "id": "G52886RR", "dp": 13 } ], "links": [ { "target": "G03347EL", "source": "G52886RR", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G52886RR", "source": "G78503JC", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78503JC", "source": "G31010RQ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03385XG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 } ], "links": [ { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03393PF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39377DE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G39377DE", "dp": 11 }, { "id": "G03393PF", "dp": 11 } ], "links": [ { "target": "G03393PF", "source": "G39377DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39377DE", "source": "G09921WG", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03404VQ", "error": "Missing intermediate; no pathways to [G03404VQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03414KZ", "error": "Missing intermediate; no pathways to [G03414KZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40707SF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03431NA", "error": "Missing intermediate; no pathways to [G03431NA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03445UI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 } ], "links": [ { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03459AF", "error": "Starting point for pathway to G03459AF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G03473UD", "error": "Missing intermediate; no pathways to [G03473UD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03529DJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82033VN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G82033VN", "dp": 14 }, { "id": "G03529DJ", "dp": 14 } ], "links": [ { "target": "G03529DJ", "source": "G82033VN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82033VN", "source": "G20926BB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03542LT", "error": "Missing intermediate; no pathways to [G03542LT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03554XO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76478FT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G76478FT", "dp": 11 }, { "id": "G03554XO", "dp": 11 } ], "links": [ { "target": "G03554XO", "source": "G76478FT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76478FT", "source": "G78059CC", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03583SA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99954ZJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G99954ZJ", "dp": 13 }, { "id": "G03583SA", "dp": 13 } ], "links": [ { "target": "G03583SA", "source": "G99954ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99954ZJ", "source": "G10733HY", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03595ET", "error": "Starting point for pathway to G03595ET could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G03600YM", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G45560HM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G03600YM", "dp": 10 } ], "links": [ { "target": "G03600YM", "source": "G45560HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03605AV", "error": "Missing intermediate; no pathways to [G03605AV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10425AY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03605BS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82942ZJ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G82942ZJ", "dp": 9 }, { "id": "G03605BS", "dp": 9 } ], "links": [ { "target": "G03605BS", "source": "G82942ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82942ZJ", "source": "G08520NM", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03606VC", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G17213JF", "dp": 11 }, { "id": "G56376TA", "dp": 12 } ], "links": [ { "target": "G03606VC", "source": "G56376TA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56376TA", "source": "G17213JF", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03652TR", "error": "Starting point for pathway to G03652TR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G03654ML", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41278YY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G82540VC", "dp": 8 }, { "id": "G41278YY", "dp": 9 }, { "id": "G03654ML", "dp": 9 } ], "links": [ { "target": "G03654ML", "source": "G41278YY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41278YY", "source": "G82540VC", "residue_affected": { "residue_id": "N238", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G82540VC", "source": "G39213VZ", "residue_affected": { "residue_id": "N250", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03664PT", "error": "Missing intermediate; no pathways to [G03664PT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30293NE]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03668AQ", "error": "Missing intermediate; no pathways to [G03668AQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43088GK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03681UF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39298RF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 }, { "id": "G39298RF", "dp": 11 }, { "id": "G03681UF", "dp": 11 } ], "links": [ { "target": "G03681UF", "source": "G39298RF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39298RF", "source": "G71690HK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03727RK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 } ], "links": [ { "target": "G03727RK", "source": "G66282NU", "residue_affected": { "residue_id": "N251", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03740OH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52428MJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G52428MJ", "dp": 10 }, { "id": "G03740OH", "dp": 10 } ], "links": [ { "target": "G03740OH", "source": "G52428MJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52428MJ", "source": "G42672MA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03750RD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65603XA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G80352NL", "dp": 14 }, { "id": "G65603XA", "dp": 15 }, { "id": "G03750RD", "dp": 15 } ], "links": [ { "target": "G03750RD", "source": "G65603XA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65603XA", "source": "G80352NL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80352NL", "source": "G66282NU", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03754YM", "error": "Missing intermediate; no pathways to [G03754YM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03764XL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G22795QB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G03764XL", "dp": 10 } ], "links": [ { "target": "G03764XL", "source": "G22795QB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03783BX", "error": "Starting point for pathway to G03783BX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G03818JD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G43677TG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G03818JD", "dp": 8 } ], "links": [ { "target": "G03818JD", "source": "G43677TG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03820FM", "error": "Starting point for pathway to G03820FM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G03834RX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53933HU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G53933HU", "dp": 8 }, { "id": "G03834RX", "dp": 8 } ], "links": [ { "target": "G03834RX", "source": "G53933HU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53933HU", "source": "G59741XZ", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03864MI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G03864MI", "source": "G78059CC", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03895SR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 } ], "links": [ { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03912QC", "error": "Missing intermediate; no pathways to [G03912QC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G87457SB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03921DY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72221XM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 }, { "id": "G72221XM", "dp": 12 }, { "id": "G03921DY", "dp": 12 } ], "links": [ { "target": "G03921DY", "source": "G72221XM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72221XM", "source": "G45187EI", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03948VT", "error": "Missing intermediate; no pathways to [G03948VT] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G03951JJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 } ], "links": [ { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03962UN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 } ], "links": [ { "target": "G03962UN", "source": "G43677TG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G03974HM", "error": "Starting point for pathway to G03974HM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04023GJ", "error": "Missing intermediate; no pathways to [G04023GJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54018RP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04048YA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59741XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G04048YA", "dp": 7 } ], "links": [ { "target": "G04048YA", "source": "G59741XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04065SU", "error": "Missing intermediate; no pathways to [G04065SU] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04078TP", "error": "Missing intermediate; no pathways to [G04078TP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04105TN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53000RQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G53000RQ", "dp": 11 }, { "id": "G04105TN", "dp": 11 } ], "links": [ { "target": "G04105TN", "source": "G53000RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04109RU", "error": "Missing intermediate; no pathways to [G04109RU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G62389NM]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G04152JO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80962OX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G80962OX", "dp": 9 }, { "id": "G04152JO", "dp": 9 } ], "links": [ { "target": "G04152JO", "source": "G80962OX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80962OX", "source": "G66937TJ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04163JP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G99954ZJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G99954ZJ", "dp": 13 }, { "id": "G04163JP", "dp": 13 } ], "links": [ { "target": "G04163JP", "source": "G99954ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99954ZJ", "source": "G10733HY", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04185VX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04213EK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 } ], "links": [ { "target": "G04213EK", "source": "G79609RF", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04214MY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 } ], "links": [ { "target": "G04214MY", "source": "G28826SH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04216GB", "error": "Starting point for pathway to G04216GB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04220HB", "error": "Starting point for pathway to G04220HB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04241HQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79394LC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 }, { "id": "G79394LC", "dp": 13 }, { "id": "G04241HQ", "dp": 13 } ], "links": [ { "target": "G04241HQ", "source": "G79394LC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79394LC", "source": "G97765TT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04246XX", "error": "Starting point for pathway to G04246XX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04261UG", "error": "Missing intermediate; no pathways to [G04261UG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G04269TC", "error": "Starting point for pathway to G04269TC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04273XP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G03385XG", "dp": 13 } ], "links": [ { "target": "G04273XP", "source": "G03385XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04275BW", "error": "Starting point for pathway to G04275BW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04291CA", "error": "Missing intermediate; no pathways to [G04291CA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14615WQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04348PK", "error": "Missing intermediate; no pathways to [G04348PK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04414GO", "error": "Starting point for pathway to G04414GO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04423CA", "error": "Missing intermediate; no pathways to [G04423CA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61203OK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04445KN", "error": "Missing intermediate; no pathways to [G04445KN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53168IY]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G04448SF", "error": "Starting point for pathway to G04448SF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04453SY", "error": "Missing intermediate; no pathways to [G04453SY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04467BX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G06283RQ", "dp": 12 } ], "links": [ { "target": "G04467BX", "source": "G06283RQ", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06283RQ", "source": "G31010RQ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04471LY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 } ], "links": [ { "target": "G04471LY", "source": "G79609RF", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04483SK", "error": "Starting point for pathway to G04483SK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04508HC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00176HZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G04508HC", "dp": 10 } ], "links": [ { "target": "G04508HC", "source": "G00176HZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04544OS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 } ], "links": [ { "target": "G04544OS", "source": "G12740VA", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04554UL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G04554UL", "source": "G91365ZQ", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04562GJ", "error": "Starting point for pathway to G04562GJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04576KS", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G04576KS", "source": "G16828VN", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04598XU", "error": "Missing intermediate; no pathways to [G04598XU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G19687OL]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04622LK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38115KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G71857KQ", "dp": 10 }, { "id": "G38115KZ", "dp": 11 }, { "id": "G04622LK", "dp": 11 } ], "links": [ { "target": "G04622LK", "source": "G38115KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38115KZ", "source": "G71857KQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71857KQ", "source": "G29434RB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04681PT", "error": "Starting point for pathway to G04681PT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04708ME", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G72536JI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 }, { "id": "G72536JI", "dp": 13 }, { "id": "G04708ME", "dp": 13 } ], "links": [ { "target": "G04708ME", "source": "G72536JI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72536JI", "source": "G81432SH", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04717US", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02290KA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G02290KA", "dp": 10 }, { "id": "G04717US", "dp": 10 } ], "links": [ { "target": "G04717US", "source": "G02290KA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04719BG", "error": "Missing intermediate; no pathways to [G04719BG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81326IN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04743RS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 } ], "links": [ { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04744XB", "error": "Starting point for pathway to G04744XB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04745QB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65603XA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G80352NL", "dp": 14 }, { "id": "G65603XA", "dp": 15 }, { "id": "G04745QB", "dp": 15 } ], "links": [ { "target": "G04745QB", "source": "G65603XA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65603XA", "source": "G80352NL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80352NL", "source": "G66282NU", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04751OE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81085EP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G81085EP", "dp": 11 }, { "id": "G04751OE", "dp": 11 } ], "links": [ { "target": "G04751OE", "source": "G81085EP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81085EP", "source": "G87073UP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04751SB", "error": "Missing intermediate; no pathways to [G04751SB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04764ON", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 } ], "links": [ { "target": "G04764ON", "source": "G30302VM", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04767HS", "error": "Starting point for pathway to G04767HS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04767QO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07947TY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G21828OD", "dp": 13 }, { "id": "G07947TY", "dp": 14 }, { "id": "G04767QO", "dp": 14 } ], "links": [ { "target": "G04767QO", "source": "G07947TY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07947TY", "source": "G21828OD", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21828OD", "source": "G45359RY", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04775TV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G15828WB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G88382QE", "dp": 14 }, { "id": "G15828WB", "dp": 15 }, { "id": "G04775TV", "dp": 15 } ], "links": [ { "target": "G04775TV", "source": "G15828WB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G15828WB", "source": "G88382QE", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88382QE", "source": "G18938DW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04783EJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G05600OX", "dp": 14 } ], "links": [ { "target": "G04783EJ", "source": "G05600OX", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05600OX", "source": "G01727PW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04791QM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04791YX", "error": "Missing intermediate; no pathways to [G04791YX] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G04792UK", "error": "Starting point for pathway to G04792UK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04816EV", "error": "Starting point for pathway to G04816EV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04820ZT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32305RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G04820ZT", "dp": 10 } ], "links": [ { "target": "G04820ZT", "source": "G32305RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04829RO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 }, { "id": "G01010HW", "dp": 9 } ], "links": [ { "target": "G04829RO", "source": "G01010HW", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04844PH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28747XN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G96921ZU", "dp": 12 }, { "id": "G28747XN", "dp": 13 }, { "id": "G04844PH", "dp": 13 } ], "links": [ { "target": "G04844PH", "source": "G28747XN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28747XN", "source": "G96921ZU", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04851FX", "error": "Missing intermediate; no pathways to [G04851FX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51367TM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G04855ZO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37597FW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 }, { "id": "G04855ZO", "dp": 13 } ], "links": [ { "target": "G04855ZO", "source": "G37597FW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04903PZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G71704AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 }, { "id": "G71704AG", "dp": 15 }, { "id": "G04903PZ", "dp": 15 } ], "links": [ { "target": "G04903PZ", "source": "G71704AG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71704AG", "source": "G42686NQ", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04931SY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17413FR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G17413FR", "dp": 13 }, { "id": "G04931SY", "dp": 13 } ], "links": [ { "target": "G04931SY", "source": "G17413FR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17413FR", "source": "G56749GV", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04964UA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60667OL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 }, { "id": "G60667OL", "dp": 10 }, { "id": "G04964UA", "dp": 10 } ], "links": [ { "target": "G04964UA", "source": "G60667OL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60667OL", "source": "G11535IB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G04987NY", "error": "Starting point for pathway to G04987NY could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G04989WY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 } ], "links": [ { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05011OT", "error": "Starting point for pathway to G05011OT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G05024RF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52880ZN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G52880ZN", "dp": 12 }, { "id": "G05024RF", "dp": 12 } ], "links": [ { "target": "G05024RF", "source": "G52880ZN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52880ZN", "source": "G82252QI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05028UJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G12699VT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G12699VT", "dp": 11 }, { "id": "G05028UJ", "dp": 11 } ], "links": [ { "target": "G05028UJ", "source": "G12699VT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12699VT", "source": "G78059CC", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05050BW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17740GV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G17740GV", "dp": 15 }, { "id": "G05050BW", "dp": 15 } ], "links": [ { "target": "G05050BW", "source": "G17740GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17740GV", "source": "G89877QI", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05060ST", "error": "Missing intermediate; no pathways to [G05060ST] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05081RC", "error": "Missing intermediate; no pathways to [G05081RC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05096LE", "error": "Missing intermediate; no pathways to [G05096LE] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G59989VG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05107UT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68946DB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G76528ZS", "dp": 11 }, { "id": "G68946DB", "dp": 12 }, { "id": "G05107UT", "dp": 12 } ], "links": [ { "target": "G05107UT", "source": "G68946DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G68946DB", "source": "G76528ZS", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05120VZ", "error": "Starting point for pathway to G05120VZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G05143WC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 }, { "id": "G97958KV", "dp": 11 } ], "links": [ { "target": "G05143WC", "source": "G97958KV", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97958KV", "source": "G45365RV", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05151WT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 } ], "links": [ { "target": "G05151WT", "source": "G59877NF", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05188BU", "error": "Missing intermediate; no pathways to [G05188BU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G58547FH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05227QG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G87535DG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G87535DG", "dp": 12 }, { "id": "G05227QG", "dp": 12 } ], "links": [ { "target": "G05227QG", "source": "G87535DG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G87535DG", "source": "G74675FC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05250QH", "error": "Missing intermediate; no pathways to [G05250QH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05253EZ", "error": "Missing intermediate; no pathways to [G05253EZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05260RH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 } ], "links": [ { "target": "G05260RH", "source": "G56591LC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05293CX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07699XI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 }, { "id": "G07699XI", "dp": 11 }, { "id": "G05293CX", "dp": 11 } ], "links": [ { "target": "G05293CX", "source": "G07699XI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07699XI", "source": "G78155FK", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05303BZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 } ], "links": [ { "target": "G05303BZ", "source": "G28826SH", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05307LM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 } ], "links": [ { "target": "G05307LM", "source": "G91023GB", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05319BS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G48954CA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G48954CA", "dp": 9 }, { "id": "G05319BS", "dp": 9 } ], "links": [ { "target": "G05319BS", "source": "G48954CA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48954CA", "source": "G12398HZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05339VD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39439UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G39439UR", "dp": 9 }, { "id": "G05339VD", "dp": 9 } ], "links": [ { "target": "G05339VD", "source": "G39439UR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39439UR", "source": "G10209QU", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05360PA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40554DX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G40554DX", "dp": 14 }, { "id": "G05360PA", "dp": 14 } ], "links": [ { "target": "G05360PA", "source": "G40554DX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40554DX", "source": "G75120WS", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05368PM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G64830WP", "dp": 8 } ], "links": [ { "target": "G05368PM", "source": "G64830WP", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64830WP", "source": "G39213VZ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05377HJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72082VM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G05377HJ", "dp": 10 } ], "links": [ { "target": "G05377HJ", "source": "G72082VM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05382JE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61207RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G05382JE", "dp": 9 } ], "links": [ { "target": "G05382JE", "source": "G61207RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05395ZW", "error": "Missing intermediate; no pathways to [G05395ZW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05421OW", "error": "Starting point for pathway to G05421OW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G05441GN", "error": "Missing intermediate; no pathways to [G05441GN] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G93698KA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05478GN", "error": "Missing intermediate; no pathways to [G05478GN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82320NZ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05546WG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 } ], "links": [ { "target": "G05546WG", "source": "G69812OF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05552HC", "error": "Starting point for pathway to G05552HC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G05561HT", "error": "Missing intermediate; no pathways to [G05561HT] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G79099UV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05562XX", "error": "Missing intermediate; no pathways to [G05562XX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05600OX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 } ], "links": [ { "target": "G05600OX", "source": "G01727PW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05611SB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59877NF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G05611SB", "dp": 11 } ], "links": [ { "target": "G05611SB", "source": "G59877NF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05619KO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84852GW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G84852GW", "dp": 9 }, { "id": "G05619KO", "dp": 9 } ], "links": [ { "target": "G05619KO", "source": "G84852GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84852GW", "source": "G12398HZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05654CV", "error": "Missing intermediate; no pathways to [G05654CV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G73977KO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05660XJ", "error": "Missing intermediate; no pathways to [G05660XJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05698FC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G80661IW", "dp": 10 }, { "id": "G85319UV", "dp": 11 } ], "links": [ { "target": "G05698FC", "source": "G85319UV", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85319UV", "source": "G80661IW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80661IW", "source": "G46638GC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05763EW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13151XE]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G05763EW", "dp": 9 } ], "links": [ { "target": "G05763EW", "source": "G13151XE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05786ES", "error": "Missing intermediate; no pathways to [G05786ES] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82639GQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05794RZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 } ], "links": [ { "target": "G05794RZ", "source": "G40806JH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05801RW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 } ], "links": [ { "target": "G05801RW", "source": "G99645NK", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05808PZ", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 } ], "links": [ { "target": "G05808PZ", "source": "G03275SD", "residue_affected": { "residue_id": "N476", "pubchem_name": "phosphate", "anomer": "n", "absolute": "n", "form_name": "phosphate", "full_name": "-n-phosphate" }, "effect": "Add -n-phosphate", "enzymes": [] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05834TJ", "error": "Starting point for pathway to G05834TJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G05840XL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G72821WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G72821WX", "dp": 9 }, { "id": "G05840XL", "dp": 9 } ], "links": [ { "target": "G05840XL", "source": "G72821WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05845GC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53322JT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G53322JT", "dp": 11 }, { "id": "G05845GC", "dp": 11 } ], "links": [ { "target": "G05845GC", "source": "G53322JT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53322JT", "source": "G00176HZ", "residue_affected": { "residue_id": "N502", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G05862XJ", "error": "Missing intermediate; no pathways to [G05862XJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05892GB", "error": "Starting point for pathway to G05892GB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G05945XE", "error": "Starting point for pathway to G05945XE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G05946VK", "error": "Missing intermediate; no pathways to [G05946VK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36223VW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G05948HK", "error": "Starting point for pathway to G05948HK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G05979RR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60103QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 }, { "id": "G60103QI", "dp": 12 }, { "id": "G05979RR", "dp": 12 } ], "links": [ { "target": "G05979RR", "source": "G60103QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60103QI", "source": "G54611ZT", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06015QH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88928GI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G88928GI", "dp": 12 }, { "id": "G06015QH", "dp": 12 } ], "links": [ { "target": "G06015QH", "source": "G88928GI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88928GI", "source": "G11041DA", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06017WG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59128IS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G56147VV", "dp": 15 }, { "id": "G59128IS", "dp": 16 }, { "id": "G06017WG", "dp": 16 } ], "links": [ { "target": "G06017WG", "source": "G59128IS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59128IS", "source": "G56147VV", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56147VV", "source": "G17168RO", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06022SA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G05600OX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G05600OX", "dp": 14 }, { "id": "G06022SA", "dp": 14 } ], "links": [ { "target": "G06022SA", "source": "G05600OX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05600OX", "source": "G01727PW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06024BE", "error": "Starting point for pathway to G06024BE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06032HI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G29112GC", "dp": 10 }, { "id": "G72060AW", "dp": 11 } ], "links": [ { "target": "G06032HI", "source": "G72060AW", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72060AW", "source": "G29112GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29112GC", "source": "G20030CU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06040PA", "error": "Missing intermediate; no pathways to [G06040PA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90987JA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06042VA", "error": "Starting point for pathway to G06042VA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06054EC", "error": "Starting point for pathway to G06054EC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06059DJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G16774YZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G16774YZ", "dp": 18 }, { "id": "G06059DJ", "dp": 18 } ], "links": [ { "target": "G06059DJ", "source": "G16774YZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16774YZ", "source": "G86696LV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06067KZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G64633BH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G64633BH", "dp": 9 }, { "id": "G06067KZ", "dp": 9 } ], "links": [ { "target": "G06067KZ", "source": "G64633BH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G64633BH", "source": "G79348ZY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06070KG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20956ZK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G06070KG", "dp": 8 } ], "links": [ { "target": "G06070KG", "source": "G20956ZK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06131VP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 } ], "links": [ { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06134ZW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06290ZS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G06134ZW", "dp": 9 } ], "links": [ { "target": "G06134ZW", "source": "G06290ZS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06142UM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93193OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G17473NR", "dp": 13 }, { "id": "G93193OD", "dp": 14 }, { "id": "G06142UM", "dp": 14 } ], "links": [ { "target": "G06142UM", "source": "G93193OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93193OD", "source": "G17473NR", "residue_affected": { "residue_id": "N267", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G17473NR", "source": "G10733HY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06152YZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 } ], "links": [ { "target": "G06152YZ", "source": "G89993FE", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06162IF", "error": "Missing intermediate; no pathways to [G06162IF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06191GU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 } ], "links": [ { "target": "G06191GU", "source": "G79809MM", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06195HM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G04214MY", "dp": 11 } ], "links": [ { "target": "G06195HM", "source": "G04214MY", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04214MY", "source": "G28826SH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06209KS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G06209KS", "source": "G69411IG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06215DG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46712PI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G46712PI", "dp": 11 }, { "id": "G06215DG", "dp": 11 } ], "links": [ { "target": "G06215DG", "source": "G46712PI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46712PI", "source": "G00176HZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06216UH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 } ], "links": [ { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06279KD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10691MJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G06279KD", "dp": 11 } ], "links": [ { "target": "G06279KD", "source": "G10691MJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06283RQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 } ], "links": [ { "target": "G06283RQ", "source": "G31010RQ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06290ZS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 } ], "links": [ { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06295ZP", "error": "Missing intermediate; no pathways to [G06295ZP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06301TU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G52428MJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G52428MJ", "dp": 10 }, { "id": "G06301TU", "dp": 10 } ], "links": [ { "target": "G06301TU", "source": "G52428MJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52428MJ", "source": "G42672MA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06327TZ", "error": "Missing intermediate; no pathways to [G06327TZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03754YM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06343EK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28231AL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 }, { "id": "G31004HS", "dp": 18 }, { "id": "G28231AL", "dp": 19 }, { "id": "G06343EK", "dp": 19 } ], "links": [ { "target": "G06343EK", "source": "G28231AL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28231AL", "source": "G31004HS", "residue_affected": { "residue_id": "N362", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06371NP", "error": "Starting point for pathway to G06371NP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06374YY", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G06374YY", "source": "G16828VN", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06400QJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G39377DE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G39377DE", "dp": 11 }, { "id": "G06400QJ", "dp": 11 } ], "links": [ { "target": "G06400QJ", "source": "G39377DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39377DE", "source": "G09921WG", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06404ZJ", "error": "Starting point for pathway to G06404ZJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06432WK", "error": "Missing intermediate; no pathways to [G06432WK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06437BU", "error": "Missing intermediate; no pathways to [G06437BU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21050RT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06444RU", "error": "Missing intermediate; no pathways to [G06444RU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66847YI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06550JR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G89993FE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G06550JR", "dp": 8 } ], "links": [ { "target": "G06550JR", "source": "G89993FE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06578MY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20170YB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G20170YB", "dp": 12 }, { "id": "G06578MY", "dp": 12 } ], "links": [ { "target": "G06578MY", "source": "G20170YB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20170YB", "source": "G63585HN", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06581HO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 } ], "links": [ { "target": "G06581HO", "source": "G71679MX", "residue_affected": { "residue_id": "N59", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06582LH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G87073UP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G06582LH", "dp": 10 } ], "links": [ { "target": "G06582LH", "source": "G87073UP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06586DL", "error": "Starting point for pathway to G06586DL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06594DV", "error": "Missing intermediate; no pathways to [G06594DV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06607JJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16155TD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G16155TD", "dp": 13 }, { "id": "G06607JJ", "dp": 13 } ], "links": [ { "target": "G06607JJ", "source": "G16155TD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16155TD", "source": "G01669LU", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06635WE", "error": "Missing intermediate; no pathways to [G06635WE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06648CG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 } ], "links": [ { "target": "G06648CG", "source": "G06969ZX", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06675AE", "error": "Starting point for pathway to G06675AE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06675DM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46213JU]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G46213JU", "dp": 10 }, { "id": "G06675DM", "dp": 10 } ], "links": [ { "target": "G06675DM", "source": "G46213JU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46213JU", "source": "G16828VN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06721LM", "error": "Starting point for pathway to G06721LM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06729UK", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 } ], "links": [ { "target": "G06729UK", "source": "G13151XE", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06730AH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82779CI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G06730AH", "dp": 11 } ], "links": [ { "target": "G06730AH", "source": "G82779CI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06731AE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54505OS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G54505OS", "dp": 11 }, { "id": "G06731AE", "dp": 11 } ], "links": [ { "target": "G06731AE", "source": "G54505OS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54505OS", "source": "G65597BI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06768XI", "error": "Starting point for pathway to G06768XI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06772YH", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 } ], "links": [ { "target": "G06772YH", "source": "G20966TZ", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06795XH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 } ], "links": [ { "target": "G06795XH", "source": "G03445UI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06804FL", "error": "Missing intermediate; no pathways to [G06804FL] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25406HP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06820QR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 } ], "links": [ { "target": "G06820QR", "source": "G53485VW", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06821PR", "error": "Missing intermediate; no pathways to [G06821PR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19687OL]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06830II", "error": "Starting point for pathway to G06830II could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06833NJ", "error": "Starting point for pathway to G06833NJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06857RO", "error": "Missing intermediate; no pathways to [G06857RO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03473UD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06885ZB", "error": "Starting point for pathway to G06885ZB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06889HK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49305IN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G49305IN", "dp": 18 }, { "id": "G06889HK", "dp": 18 } ], "links": [ { "target": "G06889HK", "source": "G49305IN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49305IN", "source": "G86696LV", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06906MP", "error": "Missing intermediate; no pathways to [G06906MP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G06920GM", "error": "Starting point for pathway to G06920GM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G06968OS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G20018DL", "dp": 14 } ], "links": [ { "target": "G06968OS", "source": "G20018DL", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20018DL", "source": "G18938DW", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G06969ZX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07014AW", "error": "Starting point for pathway to G07014AW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07015TW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G10664FL", "dp": 10 } ], "links": [ { "target": "G07015TW", "source": "G10664FL", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10664FL", "source": "G45262QY", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07041CT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 } ], "links": [ { "target": "G07041CT", "source": "G97765TT", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07098TP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43507KQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G09826WW", "dp": 11 }, { "id": "G43507KQ", "dp": 12 }, { "id": "G07098TP", "dp": 12 } ], "links": [ { "target": "G07098TP", "source": "G43507KQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43507KQ", "source": "G09826WW", "residue_affected": { "residue_id": "N272", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G09826WW", "source": "G85542KD", "residue_affected": { "residue_id": "N271", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07123BN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59877NF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G07123BN", "dp": 11 } ], "links": [ { "target": "G07123BN", "source": "G59877NF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07141SK", "error": "Starting point for pathway to G07141SK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07147QM", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G30901GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G30901GC", "dp": 9 }, { "id": "G07147QM", "dp": 9 } ], "links": [ { "target": "G07147QM", "source": "G30901GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07151TJ", "error": "Missing intermediate; no pathways to [G07151TJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34483UH]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G07162IJ", "error": "Missing intermediate; no pathways to [G07162IJ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07169PS", "error": "Starting point for pathway to G07169PS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07209HW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92024SL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G07209HW", "dp": 7 } ], "links": [ { "target": "G07209HW", "source": "G92024SL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07218NO", "error": "Starting point for pathway to G07218NO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07224ZK", "error": "Starting point for pathway to G07224ZK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07228BR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 } ], "links": [ { "target": "G07228BR", "source": "G93500PH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07233JN", "error": "Missing intermediate; no pathways to [G07233JN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07248LS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G36268TW", "dp": 12 } ], "links": [ { "target": "G07248LS", "source": "G36268TW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36268TW", "source": "G77252PU", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07262RR", "error": "Missing intermediate; no pathways to [G07262RR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07292LK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60963AS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G65796FM", "dp": 13 }, { "id": "G60963AS", "dp": 14 }, { "id": "G07292LK", "dp": 14 } ], "links": [ { "target": "G07292LK", "source": "G60963AS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60963AS", "source": "G65796FM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65796FM", "source": "G79344MI", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07309UL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81473LO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G81473LO", "dp": 11 }, { "id": "G07309UL", "dp": 11 } ], "links": [ { "target": "G07309UL", "source": "G81473LO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81473LO", "source": "G01856RL", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07322RE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60926LS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 }, { "id": "G39298RF", "dp": 11 }, { "id": "G60926LS", "dp": 12 }, { "id": "G07322RE", "dp": 12 } ], "links": [ { "target": "G07322RE", "source": "G60926LS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60926LS", "source": "G39298RF", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39298RF", "source": "G71690HK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07328EF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74120DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G07328EF", "dp": 12 } ], "links": [ { "target": "G07328EF", "source": "G74120DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07337US", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G13156PQ", "dp": 12 } ], "links": [ { "target": "G07337US", "source": "G13156PQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13156PQ", "source": "G53752TA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07352BK", "error": "Missing intermediate; no pathways to [G07352BK] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G83402YY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07368IA", "error": "Missing intermediate; no pathways to [G07368IA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G33802UM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07376BS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G75120WS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G07376BS", "dp": 13 } ], "links": [ { "target": "G07376BS", "source": "G75120WS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07380TS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99270AV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G07380TS", "dp": 10 } ], "links": [ { "target": "G07380TS", "source": "G99270AV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07392QY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G07392QY", "source": "G78059CC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07410AW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 } ], "links": [ { "target": "G07410AW", "source": "G37597FW", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07414JA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07228BR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G07228BR", "dp": 10 }, { "id": "G07414JA", "dp": 10 } ], "links": [ { "target": "G07414JA", "source": "G07228BR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07228BR", "source": "G93500PH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07415VH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30159WR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G07415VH", "dp": 9 } ], "links": [ { "target": "G07415VH", "source": "G30159WR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07417LG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G47031UJ", "dp": 12 } ], "links": [ { "target": "G07417LG", "source": "G47031UJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47031UJ", "source": "G71679MX", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07466MF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84467IZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 }, { "id": "G07466MF", "dp": 11 } ], "links": [ { "target": "G07466MF", "source": "G84467IZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07473GL", "error": "Starting point for pathway to G07473GL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07483YN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07505DF", "error": "Starting point for pathway to G07505DF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07505KH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G00368HM", "dp": 13 } ], "links": [ { "target": "G07505KH", "source": "G00368HM", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00368HM", "source": "G86357DX", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07528DS", "error": "Missing intermediate; no pathways to [G07528DS] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G55314RK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07568IR", "error": "Starting point for pathway to G07568IR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07589QZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G18026EK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G18026EK", "dp": 12 }, { "id": "G07589QZ", "dp": 12 } ], "links": [ { "target": "G07589QZ", "source": "G18026EK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18026EK", "source": "G37046CZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07617FP", "error": "Starting point for pathway to G07617FP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07626WD", "error": "Starting point for pathway to G07626WD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07640EG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 }, { "id": "G01010HW", "dp": 9 }, { "id": "G11588II", "dp": 10 }, { "id": "G61312PU", "dp": 11 } ], "links": [ { "target": "G07640EG", "source": "G61312PU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61312PU", "source": "G11588II", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11588II", "source": "G01010HW", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07666IB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82861UH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G82861UH", "dp": 9 }, { "id": "G07666IB", "dp": 9 } ], "links": [ { "target": "G07666IB", "source": "G82861UH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82861UH", "source": "G59471TH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07669FN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G06131VP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G07669FN", "dp": 11 } ], "links": [ { "target": "G07669FN", "source": "G06131VP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07674LF", "error": "Starting point for pathway to G07674LF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07695ZT", "error": "Starting point for pathway to G07695ZT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07699XI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 } ], "links": [ { "target": "G07699XI", "source": "G78155FK", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07703ST", "error": "Missing intermediate; no pathways to [G07703ST] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G34819LS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07707SU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 } ], "links": [ { "target": "G07707SU", "source": "G62504BU", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07732UP", "error": "Missing intermediate; no pathways to [G07732UP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30880RA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07757CG", "error": "Starting point for pathway to G07757CG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07800ED", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G40358EZ", "dp": 11 } ], "links": [ { "target": "G07800ED", "source": "G40358EZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40358EZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07802IC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 } ], "links": [ { "target": "G07802IC", "source": "G56749GV", "residue_affected": { "residue_id": "N483", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07810DU", "error": "Missing intermediate; no pathways to [G07810DU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G07815PK", "error": "Missing intermediate; no pathways to [G07815PK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07817HH", "error": "Missing intermediate; no pathways to [G07817HH] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10425AY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07829JQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88468EP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G29706UC", "dp": 10 }, { "id": "G88468EP", "dp": 11 }, { "id": "G07829JQ", "dp": 11 } ], "links": [ { "target": "G07829JQ", "source": "G88468EP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88468EP", "source": "G29706UC", "residue_affected": { "residue_id": "N484", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G29706UC", "source": "G58667NI", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07842DQ", "error": "Missing intermediate; no pathways to [G07842DQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14393TF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07865ET", "error": "Missing intermediate; no pathways to [G07865ET] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G07870PN", "error": "Starting point for pathway to G07870PN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07887XY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17213JF]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G17213JF", "dp": 11 }, { "id": "G07887XY", "dp": 11 } ], "links": [ { "target": "G07887XY", "source": "G17213JF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07920ZX", "error": "Starting point for pathway to G07920ZX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G07947TY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G21828OD", "dp": 13 } ], "links": [ { "target": "G07947TY", "source": "G21828OD", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21828OD", "source": "G45359RY", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07982BU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34838RM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G07982BU", "dp": 10 } ], "links": [ { "target": "G07982BU", "source": "G34838RM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07990UY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G75850OP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G75850OP", "dp": 10 }, { "id": "G07990UY", "dp": 10 } ], "links": [ { "target": "G07990UY", "source": "G75850OP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75850OP", "source": "G36191CD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G07995VK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08005PG", "error": "Missing intermediate; no pathways to [G08005PG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G84536BM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08036QU", "error": "Missing intermediate; no pathways to [G08036QU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88582ZD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08060JF", "error": "Starting point for pathway to G08060JF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08062CY", "error": "Missing intermediate; no pathways to [G08062CY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08076GP", "error": "Missing intermediate; no pathways to [G08076GP] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G08078RH", "error": "Missing intermediate; no pathways to [G08078RH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77485UZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08096ND", "error": "Starting point for pathway to G08096ND could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08111FJ", "error": "Missing intermediate; no pathways to [G08111FJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G22558JP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08113XU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23824AT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G23824AT", "dp": 11 }, { "id": "G08113XU", "dp": 11 } ], "links": [ { "target": "G08113XU", "source": "G23824AT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23824AT", "source": "G56591LC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08161JQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08577ZR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G08161JQ", "dp": 10 } ], "links": [ { "target": "G08161JQ", "source": "G08577ZR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08187GM", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08191RW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99954ZJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G99954ZJ", "dp": 13 }, { "id": "G08191RW", "dp": 13 } ], "links": [ { "target": "G08191RW", "source": "G99954ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99954ZJ", "source": "G10733HY", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08194HH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08197NF", "error": "Starting point for pathway to G08197NF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08205LJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 } ], "links": [ { "target": "G08205LJ", "source": "G48658PB", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08242BT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 } ], "links": [ { "target": "G08242BT", "source": "G26949IX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08256MX", "error": "Starting point for pathway to G08256MX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08262EP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14428PM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G89143RS", "dp": 13 }, { "id": "G14428PM", "dp": 14 }, { "id": "G08262EP", "dp": 14 } ], "links": [ { "target": "G08262EP", "source": "G14428PM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14428PM", "source": "G89143RS", "residue_affected": { "residue_id": "N46", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89143RS", "source": "G32065BG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08302GT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59300GC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G59300GC", "dp": 14 }, { "id": "G08302GT", "dp": 14 } ], "links": [ { "target": "G08302GT", "source": "G59300GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59300GC", "source": "G73492AT", "residue_affected": { "residue_id": "N78", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08340FW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 } ], "links": [ { "target": "G08340FW", "source": "G39089YD", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G08356XY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31004HS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 }, { "id": "G31004HS", "dp": 18 }, { "id": "G08356XY", "dp": 18 } ], "links": [ { "target": "G08356XY", "source": "G31004HS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08364MT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25505UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 }, { "id": "G08364MT", "dp": 14 } ], "links": [ { "target": "G08364MT", "source": "G25505UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08371QU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G47031UJ", "dp": 12 }, { "id": "G07417LG", "dp": 13 } ], "links": [ { "target": "G08371QU", "source": "G07417LG", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07417LG", "source": "G47031UJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47031UJ", "source": "G71679MX", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08405VU", "error": "Missing intermediate; no pathways to [G08405VU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25406HP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08418PB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08863NS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G08418PB", "dp": 10 } ], "links": [ { "target": "G08418PB", "source": "G08863NS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08450OR", "error": "Starting point for pathway to G08450OR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08456TO", "error": "Starting point for pathway to G08456TO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08474XG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G87073UP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G08474XG", "dp": 10 } ], "links": [ { "target": "G08474XG", "source": "G87073UP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08486RO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31532GK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G03895SR", "dp": 15 }, { "id": "G09118YK", "dp": 16 }, { "id": "G31532GK", "dp": 17 }, { "id": "G08486RO", "dp": 17 } ], "links": [ { "target": "G08486RO", "source": "G31532GK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31532GK", "source": "G09118YK", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G09118YK", "source": "G03895SR", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08492JZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65796FM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G65796FM", "dp": 13 }, { "id": "G08492JZ", "dp": 13 } ], "links": [ { "target": "G08492JZ", "source": "G65796FM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65796FM", "source": "G79344MI", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08493GY", "error": "Missing intermediate; no pathways to [G08493GY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08502EX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85116XO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G36701GV", "dp": 12 }, { "id": "G85116XO", "dp": 13 }, { "id": "G08502EX", "dp": 13 } ], "links": [ { "target": "G08502EX", "source": "G85116XO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85116XO", "source": "G36701GV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36701GV", "source": "G53752TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08520NM", "error": "Missing intermediate; no pathways to [G08520NM] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G08550XN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98140IX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G98140IX", "dp": 7 }, { "id": "G08550XN", "dp": 7 } ], "links": [ { "target": "G08550XN", "source": "G98140IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98140IX", "source": "G61751GZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08551YA", "error": "Starting point for pathway to G08551YA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08561XZ", "error": "Missing intermediate; no pathways to [G08561XZ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G13585JF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08577RF", "error": "Missing intermediate; no pathways to [G08577RF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08577ZR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 } ], "links": [ { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08589UC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69411IG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G08589UC", "dp": 7 } ], "links": [ { "target": "G08589UC", "source": "G69411IG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08597BP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86005HP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 }, { "id": "G86005HP", "dp": 16 }, { "id": "G08597BP", "dp": 16 } ], "links": [ { "target": "G08597BP", "source": "G86005HP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86005HP", "source": "G25097RR", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08646IB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53728DU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G53728DU", "dp": 11 }, { "id": "G08646IB", "dp": 11 } ], "links": [ { "target": "G08646IB", "source": "G53728DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53728DU", "source": "G91365ZQ", "residue_affected": { "residue_id": "N276", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08646YJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75850OP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G75850OP", "dp": 10 }, { "id": "G08646YJ", "dp": 10 } ], "links": [ { "target": "G08646YJ", "source": "G75850OP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75850OP", "source": "G36191CD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08675PK", "error": "Missing intermediate; no pathways to [G08675PK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53288JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08679EM", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G81432SH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 }, { "id": "G08679EM", "dp": 12 } ], "links": [ { "target": "G08679EM", "source": "G81432SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08679LR", "error": "Missing intermediate; no pathways to [G08679LR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94394GK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08709JB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 } ], "links": [ { "target": "G08709JB", "source": "G45359RY", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08742GK", "error": "Missing intermediate; no pathways to [G08742GK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82847HG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08755WX", "error": "Starting point for pathway to G08755WX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08774YL", "error": "Starting point for pathway to G08774YL could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08820NR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44946WH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G08820NR", "dp": 10 } ], "links": [ { "target": "G08820NR", "source": "G44946WH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08826KQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11012KS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G11012KS", "dp": 12 }, { "id": "G08826KQ", "dp": 12 } ], "links": [ { "target": "G08826KQ", "source": "G11012KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11012KS", "source": "G37046CZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08830EU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04576KS]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G04576KS", "dp": 10 }, { "id": "G08830EU", "dp": 10 } ], "links": [ { "target": "G08830EU", "source": "G04576KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04576KS", "source": "G16828VN", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08841QE", "error": "Missing intermediate; no pathways to [G08841QE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53854XZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08863NS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08866CW", "error": "Starting point for pathway to G08866CW could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08882LF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39018CC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 }, { "id": "G39018CC", "dp": 15 }, { "id": "G08882LF", "dp": 15 } ], "links": [ { "target": "G08882LF", "source": "G39018CC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39018CC", "source": "G25505UF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08883FC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77974XY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77974XY", "dp": 10 }, { "id": "G08883FC", "dp": 10 } ], "links": [ { "target": "G08883FC", "source": "G77974XY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77974XY", "source": "G20030CU", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08894MB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45262QY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G08894MB", "dp": 9 } ], "links": [ { "target": "G08894MB", "source": "G45262QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08896RO", "error": "Missing intermediate; no pathways to [G08896RO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08907YK", "error": "Starting point for pathway to G08907YK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08922VD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75720YC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G75720YC", "dp": 11 }, { "id": "G08922VD", "dp": 11 } ], "links": [ { "target": "G08922VD", "source": "G75720YC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75720YC", "source": "G01856RL", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08936DJ", "error": "Starting point for pathway to G08936DJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G08949VK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G90564EX", "dp": 11 } ], "links": [ { "target": "G08949VK", "source": "G90564EX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90564EX", "source": "G28826SH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08950XV", "error": "Missing intermediate; no pathways to [G08950XV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14393TF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G08979EC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 } ], "links": [ { "target": "G08979EC", "source": "G88417ED", "residue_affected": { "residue_id": "N438", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G08997GC", "error": "Missing intermediate; no pathways to [G08997GC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09015XG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91208VE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 }, { "id": "G09015XG", "dp": 9 } ], "links": [ { "target": "G09015XG", "source": "G91208VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09019KT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G60941RE", "dp": 13 } ], "links": [ { "target": "G09019KT", "source": "G60941RE", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60941RE", "source": "G75185NU", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09020HN", "error": "Missing intermediate; no pathways to [G09020HN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75398ZA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09022KY", "error": "Missing intermediate; no pathways to [G09022KY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09025ID", "error": "Missing intermediate; no pathways to [G09025ID] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G69960SA]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G09057LN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66665YI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G66665YI", "dp": 14 }, { "id": "G09057LN", "dp": 14 } ], "links": [ { "target": "G09057LN", "source": "G66665YI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66665YI", "source": "G66282NU", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09064IP", "error": "Starting point for pathway to G09064IP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09066KJ", "error": "Missing intermediate; no pathways to [G09066KJ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09089WF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11012KS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G11012KS", "dp": 12 }, { "id": "G09089WF", "dp": 12 } ], "links": [ { "target": "G09089WF", "source": "G11012KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11012KS", "source": "G37046CZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09101YR", "error": "Missing intermediate; no pathways to [G09101YR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09115OQ", "error": "Missing intermediate; no pathways to [G09115OQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82234NO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09118YK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G03895SR", "dp": 15 } ], "links": [ { "target": "G09118YK", "source": "G03895SR", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09125WG", "error": "Missing intermediate; no pathways to [G09125WG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07262RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09128UQ", "error": "Missing intermediate; no pathways to [G09128UQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74264KM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09130LO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07228BR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G07228BR", "dp": 10 }, { "id": "G09130LO", "dp": 10 } ], "links": [ { "target": "G09130LO", "source": "G07228BR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07228BR", "source": "G93500PH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09150LP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 } ], "links": [ { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09169SF", "error": "Missing intermediate; no pathways to [G09169SF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09179AZ", "error": "Missing intermediate; no pathways to [G09179AZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71906BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09194PV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88380UG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G88380UG", "dp": 8 }, { "id": "G09194PV", "dp": 8 } ], "links": [ { "target": "G09194PV", "source": "G88380UG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88380UG", "source": "G39213VZ", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09255AF", "error": "Missing intermediate; no pathways to [G09255AF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09260EL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59579TL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G86753CK", "dp": 17 }, { "id": "G59579TL", "dp": 18 }, { "id": "G09260EL", "dp": 18 } ], "links": [ { "target": "G09260EL", "source": "G59579TL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59579TL", "source": "G86753CK", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09276TA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11034PZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G09276TA", "dp": 12 } ], "links": [ { "target": "G09276TA", "source": "G11034PZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09322OS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84376FR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G09322OS", "dp": 12 } ], "links": [ { "target": "G09322OS", "source": "G84376FR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09330TE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11953VE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G09330TE", "dp": 14 } ], "links": [ { "target": "G09330TE", "source": "G11953VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09349XQ", "error": "Missing intermediate; no pathways to [G09349XQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79099UV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09351VH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G71679MX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G09351VH", "dp": 11 } ], "links": [ { "target": "G09351VH", "source": "G71679MX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09362PR", "error": "Missing intermediate; no pathways to [G09362PR] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G61751GZ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09362VG", "error": "Missing intermediate; no pathways to [G09362VG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G87457SB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09389FE", "error": "Starting point for pathway to G09389FE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09393NL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G15828WB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G88382QE", "dp": 14 }, { "id": "G15828WB", "dp": 15 }, { "id": "G09393NL", "dp": 15 } ], "links": [ { "target": "G09393NL", "source": "G15828WB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G15828WB", "source": "G88382QE", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88382QE", "source": "G18938DW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09416DG", "error": "Starting point for pathway to G09416DG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09420NN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52770HR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G52770HR", "dp": 10 }, { "id": "G09420NN", "dp": 10 } ], "links": [ { "target": "G09420NN", "source": "G52770HR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52770HR", "source": "G36191CD", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09446VC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 } ], "links": [ { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09452ED", "error": "Starting point for pathway to G09452ED could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09482NW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 } ], "links": [ { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09513RD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74438AB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G74438AB", "dp": 12 }, { "id": "G09513RD", "dp": 12 } ], "links": [ { "target": "G09513RD", "source": "G74438AB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74438AB", "source": "G34905OT", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09538AR", "error": "Missing intermediate; no pathways to [G09538AR] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09556KR", "error": "Missing intermediate; no pathways to [G09556KR] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09568JT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G18938DW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G09568JT", "dp": 13 } ], "links": [ { "target": "G09568JT", "source": "G18938DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09576QH", "error": "Missing intermediate; no pathways to [G09576QH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09578TK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61088TM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G61088TM", "dp": 12 }, { "id": "G09578TK", "dp": 12 } ], "links": [ { "target": "G09578TK", "source": "G61088TM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61088TM", "source": "G90870DG", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09579UY", "error": "Starting point for pathway to G09579UY could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09599ZO", "error": "Starting point for pathway to G09599ZO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09605DV", "error": "Missing intermediate; no pathways to [G09605DV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09629PQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G04544OS", "dp": 11 }, { "id": "G95201NS", "dp": 12 } ], "links": [ { "target": "G09629PQ", "source": "G95201NS", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95201NS", "source": "G04544OS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04544OS", "source": "G12740VA", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09646ZI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61088TM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G61088TM", "dp": 12 }, { "id": "G09646ZI", "dp": 12 } ], "links": [ { "target": "G09646ZI", "source": "G61088TM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61088TM", "source": "G90870DG", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09650BK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38753OV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G38753OV", "dp": 11 }, { "id": "G09650BK", "dp": 11 } ], "links": [ { "target": "G09650BK", "source": "G38753OV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38753OV", "source": "G52934AK", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09666WO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G09446VC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G09666WO", "dp": 10 } ], "links": [ { "target": "G09666WO", "source": "G09446VC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09670SR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 } ], "links": [ { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09675DY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G84467IZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 }, { "id": "G09675DY", "dp": 11 } ], "links": [ { "target": "G09675DY", "source": "G84467IZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09696LZ", "error": "Starting point for pathway to G09696LZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09724ZC", "error": "Starting point for pathway to G09724ZC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09727XA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G28723UT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G28723UT", "dp": 11 }, { "id": "G09727XA", "dp": 11 } ], "links": [ { "target": "G09727XA", "source": "G28723UT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28723UT", "source": "G87073UP", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09730EH", "error": "Missing intermediate; no pathways to [G09730EH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09782JM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 } ], "links": [ { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09826WW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 } ], "links": [ { "target": "G09826WW", "source": "G85542KD", "residue_affected": { "residue_id": "N271", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09840DL", "error": "Starting point for pathway to G09840DL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09857WN", "error": "Missing intermediate; no pathways to [G09857WN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G70684QL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09902CG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75308SV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G88966ZO", "dp": 15 }, { "id": "G75308SV", "dp": 16 }, { "id": "G09902CG", "dp": 16 } ], "links": [ { "target": "G09902CG", "source": "G75308SV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75308SV", "source": "G88966ZO", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88966ZO", "source": "G63889NK", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09909FT", "error": "Missing intermediate; no pathways to [G09909FT] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G80085KS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G09921WG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 } ], "links": [ { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G09947VE", "error": "Starting point for pathway to G09947VE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09952UD", "error": "Starting point for pathway to G09952UD could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G09976WS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 } ], "links": [ { "target": "G09976WS", "source": "G92024SL", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10024QA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30651IU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G10024QA", "dp": 13 } ], "links": [ { "target": "G10024QA", "source": "G30651IU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10026RE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47011KD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G47011KD", "dp": 9 }, { "id": "G10026RE", "dp": 9 } ], "links": [ { "target": "G10026RE", "source": "G47011KD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47011KD", "source": "G34527RW", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10034LM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 } ], "links": [ { "target": "G10034LM", "source": "G90284FM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10039YD", "error": "Starting point for pathway to G10039YD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10040DS", "error": "Starting point for pathway to G10040DS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10042AD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79565XA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G19469VZ", "dp": 18 }, { "id": "G79565XA", "dp": 19 }, { "id": "G10042AD", "dp": 19 } ], "links": [ { "target": "G10042AD", "source": "G79565XA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79565XA", "source": "G19469VZ", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G19469VZ", "source": "G92574YO", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10106TL", "error": "Starting point for pathway to G10106TL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10108GZ", "error": "Missing intermediate; no pathways to [G10108GZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G44005DK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10152AF", "error": "Missing intermediate; no pathways to [G10152AF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72112RK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10154BC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37140SO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G37140SO", "dp": 10 }, { "id": "G10154BC", "dp": 10 } ], "links": [ { "target": "G10154BC", "source": "G37140SO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37140SO", "source": "G93500PH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10160CQ", "error": "Starting point for pathway to G10160CQ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10179FS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G36191CD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G10179FS", "dp": 9 } ], "links": [ { "target": "G10179FS", "source": "G36191CD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10182XZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10189EJ", "error": "Missing intermediate; no pathways to [G10189EJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82036CW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10197JO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79348ZY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G10197JO", "dp": 8 } ], "links": [ { "target": "G10197JO", "source": "G79348ZY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10209QU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10219AA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10223RO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90175OT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G90175OT", "dp": 9 }, { "id": "G10223RO", "dp": 9 } ], "links": [ { "target": "G10223RO", "source": "G90175OT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90175OT", "source": "G37476QB", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10224GU", "error": "Missing intermediate; no pathways to [G10224GU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10228AY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G35565NM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 }, { "id": "G35565NM", "dp": 15 }, { "id": "G10228AY", "dp": 15 } ], "links": [ { "target": "G10228AY", "source": "G35565NM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G35565NM", "source": "G53485VW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10228OD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 } ], "links": [ { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10236SD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G97674NY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G97674NY", "dp": 15 }, { "id": "G10236SD", "dp": 15 } ], "links": [ { "target": "G10236SD", "source": "G97674NY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97674NY", "source": "G89877QI", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10240SH", "error": "Missing intermediate; no pathways to [G10240SH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10255XW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G16759KR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G10255XW", "dp": 9 } ], "links": [ { "target": "G10255XW", "source": "G16759KR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10258MC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 } ], "links": [ { "target": "G10258MC", "source": "G25835MT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10270EI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G73057DA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G73057DA", "dp": 9 }, { "id": "G10270EI", "dp": 9 } ], "links": [ { "target": "G10270EI", "source": "G73057DA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73057DA", "source": "G34527RW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10292TC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 } ], "links": [ { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10295MW", "error": "Missing intermediate; no pathways to [G10295MW] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10300DY", "error": "Missing intermediate; no pathways to [G10300DY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G10317HK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16341ZC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G57943ZV", "dp": 11 }, { "id": "G16341ZC", "dp": 12 }, { "id": "G10317HK", "dp": 12 } ], "links": [ { "target": "G10317HK", "source": "G16341ZC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16341ZC", "source": "G57943ZV", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10382VG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49515VE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G10382VG", "dp": 12 } ], "links": [ { "target": "G10382VG", "source": "G49515VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10385EY", "error": "Missing intermediate; no pathways to [G10385EY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10417XF", "error": "Missing intermediate; no pathways to [G10417XF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G13585JF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10425AY", "error": "Missing intermediate; no pathways to [G10425AY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10425SO", "error": "Starting point for pathway to G10425SO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10435LQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59741XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G10435LQ", "dp": 7 } ], "links": [ { "target": "G10435LQ", "source": "G59741XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10440YK", "error": "Starting point for pathway to G10440YK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10444WX", "error": "Missing intermediate; no pathways to [G10444WX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98453VS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10448ZR", "error": "Starting point for pathway to G10448ZR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10467OR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43694RQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G10467OR", "dp": 10 } ], "links": [ { "target": "G10467OR", "source": "G43694RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10470SE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50489VC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G10470SE", "dp": 17 } ], "links": [ { "target": "G10470SE", "source": "G50489VC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10474JO", "error": "Starting point for pathway to G10474JO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10482KN", "error": "Missing intermediate; no pathways to [G10482KN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G10483PN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10733HY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G10483PN", "dp": 12 } ], "links": [ { "target": "G10483PN", "source": "G10733HY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10529ZR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96113SZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G82420SH", "dp": 10 }, { "id": "G96113SZ", "dp": 11 }, { "id": "G10529ZR", "dp": 11 } ], "links": [ { "target": "G10529ZR", "source": "G96113SZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96113SZ", "source": "G82420SH", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10540LB", "error": "Missing intermediate; no pathways to [G10540LB] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10563SE", "error": "Missing intermediate; no pathways to [G10563SE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10578GY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17155VX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G10578GY", "dp": 16 } ], "links": [ { "target": "G10578GY", "source": "G17155VX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10614GM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 } ], "links": [ { "target": "G10614GM", "source": "G10209QU", "residue_affected": { "residue_id": "N275", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10614XK", "error": "Missing intermediate; no pathways to [G10614XK] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G38637SA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10627KR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47175EF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G10627KR", "dp": 11 } ], "links": [ { "target": "G10627KR", "source": "G47175EF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10627MD", "error": "Missing intermediate; no pathways to [G10627MD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10637WE", "error": "Missing intermediate; no pathways to [G10637WE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50278HE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10640ZR", "error": "Starting point for pathway to G10640ZR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10650OV", "error": "Missing intermediate; no pathways to [G10650OV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10663SB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G11012KS", "dp": 12 } ], "links": [ { "target": "G10663SB", "source": "G11012KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11012KS", "source": "G37046CZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10664FL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 } ], "links": [ { "target": "G10664FL", "source": "G45262QY", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10666VQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30569KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G04185VX", "dp": 10 }, { "id": "G30569KZ", "dp": 11 }, { "id": "G10666VQ", "dp": 11 } ], "links": [ { "target": "G10666VQ", "source": "G30569KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30569KZ", "source": "G04185VX", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10673SQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39018CC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 }, { "id": "G39018CC", "dp": 15 }, { "id": "G10673SQ", "dp": 15 } ], "links": [ { "target": "G10673SQ", "source": "G39018CC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39018CC", "source": "G25505UF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10684FE", "error": "Missing intermediate; no pathways to [G10684FE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10691MJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 } ], "links": [ { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10694XU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G74120DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G10694XU", "dp": 12 } ], "links": [ { "target": "G10694XU", "source": "G74120DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10700RM", "error": "Starting point for pathway to G10700RM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10714WB", "error": "Starting point for pathway to G10714WB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10716SX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 } ], "links": [ { "target": "G10716SX", "source": "G37385TT", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10725II", "error": "Missing intermediate; no pathways to [G10725II] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10733HY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10741VJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74107UT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74107UT", "dp": 11 }, { "id": "G10741VJ", "dp": 11 } ], "links": [ { "target": "G10741VJ", "source": "G74107UT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74107UT", "source": "G78059CC", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10750YS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71812IK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G71812IK", "dp": 9 }, { "id": "G10750YS", "dp": 9 } ], "links": [ { "target": "G10750YS", "source": "G71812IK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71812IK", "source": "G80858MF", "residue_affected": { "residue_id": "N322", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10770RR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G82033VN", "dp": 14 } ], "links": [ { "target": "G10770RR", "source": "G82033VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82033VN", "source": "G20926BB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10774UR", "error": "Missing intermediate; no pathways to [G10774UR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18594ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10800FG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82420SH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G82420SH", "dp": 10 }, { "id": "G10800FG", "dp": 10 } ], "links": [ { "target": "G10800FG", "source": "G82420SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10805TH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G39213VZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10805TH", "dp": 7 } ], "links": [ { "target": "G10805TH", "source": "G39213VZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10819DS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82861UH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G82861UH", "dp": 9 }, { "id": "G10819DS", "dp": 9 } ], "links": [ { "target": "G10819DS", "source": "G82861UH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82861UH", "source": "G59471TH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10835DD", "error": "Missing intermediate; no pathways to [G10835DD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59752BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10843FG", "error": "Starting point for pathway to G10843FG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10843VM", "error": "Missing intermediate; no pathways to [G10843VM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10844WB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56591LC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G10844WB", "dp": 10 } ], "links": [ { "target": "G10844WB", "source": "G56591LC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10845BX", "error": "Missing intermediate; no pathways to [G10845BX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74238CC]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10874QT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 } ], "links": [ { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10881VB", "error": "Starting point for pathway to G10881VB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G10897DJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G14512NS", "dp": 9 }, { "id": "G72893LL", "dp": 10 } ], "links": [ { "target": "G10897DJ", "source": "G72893LL", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72893LL", "source": "G14512NS", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14512NS", "source": "G24420RT", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G10920IN", "error": "Missing intermediate; no pathways to [G10920IN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10946GI", "error": "Missing intermediate; no pathways to [G10946GI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77475MM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10965EB", "error": "Missing intermediate; no pathways to [G10965EB] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G10965ZT", "error": "Missing intermediate; no pathways to [G10965ZT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10986OF", "error": "Missing intermediate; no pathways to [G10986OF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G10989IB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 }, { "id": "G31004HS", "dp": 18 } ], "links": [ { "target": "G10989IB", "source": "G31004HS", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11010AN", "error": "Missing intermediate; no pathways to [G11010AN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11012KS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 } ], "links": [ { "target": "G11012KS", "source": "G37046CZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11034PZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 } ], "links": [ { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11041DA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 } ], "links": [ { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11052OE", "error": "Starting point for pathway to G11052OE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11058EJ", "error": "Starting point for pathway to G11058EJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11075DR", "error": "Missing intermediate; no pathways to [G11075DR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14938IR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11096GJ", "error": "Starting point for pathway to G11096GJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11128BY", "error": "Missing intermediate; no pathways to [G11128BY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11165BC", "error": "Missing intermediate; no pathways to [G11165BC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11179AM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14127XU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G14127XU", "dp": 13 }, { "id": "G11179AM", "dp": 13 } ], "links": [ { "target": "G11179AM", "source": "G14127XU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14127XU", "source": "G91023GB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11180GU", "error": "Missing intermediate; no pathways to [G11180GU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11189WY", "error": "Starting point for pathway to G11189WY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11200NG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40358EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G40358EZ", "dp": 11 }, { "id": "G11200NG", "dp": 11 } ], "links": [ { "target": "G11200NG", "source": "G40358EZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40358EZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11213NA", "error": "Missing intermediate; no pathways to [G11213NA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81738MQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11249YX", "error": "Missing intermediate; no pathways to [G11249YX] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G87192TH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11256DQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G70945OS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G70945OS", "dp": 13 }, { "id": "G11256DQ", "dp": 13 } ], "links": [ { "target": "G11256DQ", "source": "G70945OS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70945OS", "source": "G41331JX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11264VO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77363ER]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G77363ER", "dp": 11 }, { "id": "G11264VO", "dp": 11 } ], "links": [ { "target": "G11264VO", "source": "G77363ER", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77363ER", "source": "G91365ZQ", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11278YL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 } ], "links": [ { "target": "G11278YL", "source": "G42672MA", "residue_affected": { "residue_id": "N72", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11282GU", "error": "Starting point for pathway to G11282GU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11286QT", "error": "Missing intermediate; no pathways to [G11286QT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16753NR]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G11287YT", "error": "Missing intermediate; no pathways to [G11287YT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11323LX", "error": "Missing intermediate; no pathways to [G11323LX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11350UX", "error": "Missing intermediate; no pathways to [G11350UX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17134VG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11359ZJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39298RF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 }, { "id": "G39298RF", "dp": 11 }, { "id": "G11359ZJ", "dp": 11 } ], "links": [ { "target": "G11359ZJ", "source": "G39298RF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39298RF", "source": "G71690HK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11365AH", "error": "Starting point for pathway to G11365AH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11376KE", "error": "Starting point for pathway to G11376KE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11389PE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45777DE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G26939ZY", "dp": 8 }, { "id": "G45777DE", "dp": 9 }, { "id": "G11389PE", "dp": 9 } ], "links": [ { "target": "G11389PE", "source": "G45777DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45777DE", "source": "G26939ZY", "residue_affected": { "residue_id": "N305", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G26939ZY", "source": "G39213VZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11394DU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36523TZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G36523TZ", "dp": 12 }, { "id": "G11394DU", "dp": 12 } ], "links": [ { "target": "G11394DU", "source": "G36523TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36523TZ", "source": "G29857RC", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11402KL", "error": "Missing intermediate; no pathways to [G11402KL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08062CY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11414XN", "error": "Starting point for pathway to G11414XN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11450BY", "error": "Missing intermediate; no pathways to [G11450BY] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G57345HS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11460AB", "error": "Starting point for pathway to G11460AB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11479AN", "error": "Missing intermediate; no pathways to [G11479AN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85106DS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11508EH", "error": "Missing intermediate; no pathways to [G11508EH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11509RN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 } ], "links": [ { "target": "G11509RN", "source": "G30302VM", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11530HI", "error": "Missing intermediate; no pathways to [G11530HI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84777MO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11535IB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 } ], "links": [ { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11540FP", "error": "Missing intermediate; no pathways to [G11540FP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11542JY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61718TK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G61718TK", "dp": 11 }, { "id": "G11542JY", "dp": 11 } ], "links": [ { "target": "G11542JY", "source": "G61718TK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61718TK", "source": "G43694RQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11551UU", "error": "Missing intermediate; no pathways to [G11551UU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11574TM", "error": "Starting point for pathway to G11574TM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11588II", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 }, { "id": "G01010HW", "dp": 9 } ], "links": [ { "target": "G11588II", "source": "G01010HW", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11615SW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G73817GH", "dp": 10 }, { "id": "G57601AP", "dp": 11 } ], "links": [ { "target": "G11615SW", "source": "G57601AP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57601AP", "source": "G73817GH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11635LG", "error": "Missing intermediate; no pathways to [G11635LG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11636UX", "error": "Missing intermediate; no pathways to [G11636UX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86377SM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11637WL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11641YE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G04185VX", "dp": 10 }, { "id": "G30569KZ", "dp": 11 } ], "links": [ { "target": "G11641YE", "source": "G30569KZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30569KZ", "source": "G04185VX", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11671GQ", "error": "Missing intermediate; no pathways to [G11671GQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11679NT", "error": "Starting point for pathway to G11679NT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11683GE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G66313YW", "dp": 13 } ], "links": [ { "target": "G11683GE", "source": "G66313YW", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66313YW", "source": "G74645FT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11696PX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G73211XU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G95919TI", "dp": 14 }, { "id": "G73211XU", "dp": 15 }, { "id": "G11696PX", "dp": 15 } ], "links": [ { "target": "G11696PX", "source": "G73211XU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73211XU", "source": "G95919TI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95919TI", "source": "G30651IU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11700UP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98559XP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G98559XP", "dp": 14 }, { "id": "G11700UP", "dp": 14 } ], "links": [ { "target": "G11700UP", "source": "G98559XP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98559XP", "source": "G18938DW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11712ZQ", "error": "Starting point for pathway to G11712ZQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11721NX", "error": "Missing intermediate; no pathways to [G11721NX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G42909GK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11734TD", "error": "Missing intermediate; no pathways to [G11734TD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11740AG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93075HW]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G40289RO", "dp": 10 }, { "id": "G71102UV", "dp": 11 }, { "id": "G93075HW", "dp": 12 }, { "id": "G11740AG", "dp": 12 } ], "links": [ { "target": "G11740AG", "source": "G93075HW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93075HW", "source": "G71102UV", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71102UV", "source": "G40289RO", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40289RO", "source": "G20966TZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11745DB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G73817GH", "dp": 10 }, { "id": "G57601AP", "dp": 11 }, { "id": "G11615SW", "dp": 12 } ], "links": [ { "target": "G11745DB", "source": "G11615SW", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G11615SW", "source": "G57601AP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57601AP", "source": "G73817GH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11745XZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 } ], "links": [ { "target": "G11745XZ", "source": "G84467IZ", "residue_affected": { "residue_id": "N299", "pubchem_name": "Fuc", "anomer": "b", "absolute": "L", "form_name": "Fucp", "full_name": "β-L-Fucp" }, "effect": "Add β-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11762BM", "error": "Missing intermediate; no pathways to [G11762BM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11805NJ", "error": "Starting point for pathway to G11805NJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11818HY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G00536FZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G00536FZ", "dp": 12 }, { "id": "G11818HY", "dp": 12 } ], "links": [ { "target": "G11818HY", "source": "G00536FZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00536FZ", "source": "G71679MX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11823ZO", "error": "Starting point for pathway to G11823ZO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11885NX", "error": "Starting point for pathway to G11885NX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11908SZ", "error": "Starting point for pathway to G11908SZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G11910RR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 } ], "links": [ { "target": "G11910RR", "source": "G89877QI", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11929CD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 } ], "links": [ { "target": "G11929CD", "source": "G09782JM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11929SN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 } ], "links": [ { "target": "G11929SN", "source": "G80294GH", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11953VE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 } ], "links": [ { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11960UF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G09482NW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G11960UF", "dp": 9 } ], "links": [ { "target": "G11960UF", "source": "G09482NW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G11986EX", "error": "Missing intermediate; no pathways to [G11986EX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G11994QC", "error": "Starting point for pathway to G11994QC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12034WA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34838RM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G12034WA", "dp": 10 } ], "links": [ { "target": "G12034WA", "source": "G34838RM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12061IK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12086GM", "error": "Starting point for pathway to G12086GM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12089IA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06195HM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G04214MY", "dp": 11 }, { "id": "G06195HM", "dp": 12 }, { "id": "G12089IA", "dp": 12 } ], "links": [ { "target": "G12089IA", "source": "G06195HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06195HM", "source": "G04214MY", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04214MY", "source": "G28826SH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12110NN", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 } ], "links": [ { "target": "G12110NN", "source": "G13151XE", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12133DL", "error": "Missing intermediate; no pathways to [G12133DL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68758PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12174PW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G12174PW", "source": "G39213VZ", "residue_affected": { "residue_id": "N488", "pubchem_name": "Man", "anomer": "b", "absolute": "D", "form_name": "Manp", "full_name": "β-D-Manp" }, "effect": "Add β-D-Manp", "enzymes": [] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12174RN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47606XQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G26320VO", "dp": 10 }, { "id": "G47606XQ", "dp": 11 }, { "id": "G12174RN", "dp": 11 } ], "links": [ { "target": "G12174RN", "source": "G47606XQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47606XQ", "source": "G26320VO", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26320VO", "source": "G58667NI", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12187FG", "error": "Missing intermediate; no pathways to [G12187FG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10650OV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12203WB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G46021KV", "dp": 12 } ], "links": [ { "target": "G12203WB", "source": "G46021KV", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46021KV", "source": "G29857RC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12222NC", "error": "Missing intermediate; no pathways to [G12222NC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12241WD", "error": "Missing intermediate; no pathways to [G12241WD] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12243WN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29026MS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G29026MS", "dp": 12 }, { "id": "G12243WN", "dp": 12 } ], "links": [ { "target": "G12243WN", "source": "G29026MS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29026MS", "source": "G59877NF", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12252DD", "error": "Starting point for pathway to G12252DD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12254MW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G38407OC", "dp": 12 }, { "id": "G95233RZ", "dp": 13 } ], "links": [ { "target": "G12254MW", "source": "G95233RZ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95233RZ", "source": "G38407OC", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38407OC", "source": "G20815TK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12266SO", "error": "Missing intermediate; no pathways to [G12266SO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12274AS", "error": "Starting point for pathway to G12274AS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12305BJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97267JL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G97267JL", "dp": 8 }, { "id": "G12305BJ", "dp": 8 } ], "links": [ { "target": "G12305BJ", "source": "G97267JL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97267JL", "source": "G69411IG", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12318EJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G66313YW", "dp": 13 } ], "links": [ { "target": "G12318EJ", "source": "G66313YW", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66313YW", "source": "G74645FT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12352RJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G04783EJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G05600OX", "dp": 14 }, { "id": "G04783EJ", "dp": 15 }, { "id": "G12352RJ", "dp": 15 } ], "links": [ { "target": "G12352RJ", "source": "G04783EJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04783EJ", "source": "G05600OX", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05600OX", "source": "G01727PW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12378KS", "error": "Starting point for pathway to G12378KS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12398HZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12406MX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G59915YZ", "dp": 11 }, { "id": "G98380JU", "dp": 12 } ], "links": [ { "target": "G12406MX", "source": "G98380JU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98380JU", "source": "G59915YZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59915YZ", "source": "G79609RF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12422FH", "error": "Starting point for pathway to G12422FH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12438DW", "error": "Missing intermediate; no pathways to [G12438DW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G67410LQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12438YM", "error": "Starting point for pathway to G12438YM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12448WG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38395YJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G38395YJ", "dp": 14 }, { "id": "G12448WG", "dp": 14 } ], "links": [ { "target": "G12448WG", "source": "G38395YJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12450CJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G90564EX", "dp": 11 }, { "id": "G08949VK", "dp": 12 } ], "links": [ { "target": "G12450CJ", "source": "G08949VK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08949VK", "source": "G90564EX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90564EX", "source": "G28826SH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12472CC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 } ], "links": [ { "target": "G12472CC", "source": "G43299SD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12474XI", "error": "Missing intermediate; no pathways to [G12474XI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74286KY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12504XV", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G12504XV", "source": "G08520NM", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G12524BD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86102AA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G86102AA", "dp": 11 }, { "id": "G12524BD", "dp": 11 } ], "links": [ { "target": "G12524BD", "source": "G86102AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86102AA", "source": "G85542KD", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12531EE", "error": "Starting point for pathway to G12531EE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12561VS", "error": "Missing intermediate; no pathways to [G12561VS] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12572NU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79348ZY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G12572NU", "dp": 8 } ], "links": [ { "target": "G12572NU", "source": "G79348ZY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12593TX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07483YN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12593TX", "dp": 7 } ], "links": [ { "target": "G12593TX", "source": "G07483YN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12594VB", "error": "Missing intermediate; no pathways to [G12594VB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12631FF", "error": "Missing intermediate; no pathways to [G12631FF] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G74074HU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12643EB", "error": "Starting point for pathway to G12643EB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12643KN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G34175ZP", "dp": 10 } ], "links": [ { "target": "G12643KN", "source": "G34175ZP", "residue_affected": { "residue_id": "N302", "pubchem_name": "GlcNAc", "anomer": "a", "absolute": "D", "form_name": "GlcpNAc", "full_name": "α-D-GlcpNAc" }, "effect": "Add α-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G34175ZP", "source": "G01265XZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12671JE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83594ZB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G11929CD", "dp": 10 }, { "id": "G26795PW", "dp": 11 }, { "id": "G83594ZB", "dp": 12 }, { "id": "G12671JE", "dp": 12 } ], "links": [ { "target": "G12671JE", "source": "G83594ZB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G83594ZB", "source": "G26795PW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26795PW", "source": "G11929CD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929CD", "source": "G09782JM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12679LF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38291RB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G38291RB", "dp": 13 }, { "id": "G12679LF", "dp": 13 } ], "links": [ { "target": "G12679LF", "source": "G38291RB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38291RB", "source": "G45359RY", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12699VT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G12699VT", "source": "G78059CC", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12704ID", "error": "Starting point for pathway to G12704ID could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12715AH", "error": "Starting point for pathway to G12715AH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12715RL", "error": "Missing intermediate; no pathways to [G12715RL] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G41596PV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12727SF", "error": "Missing intermediate; no pathways to [G12727SF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G12740VA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 } ], "links": [ { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12749IL", "error": "Starting point for pathway to G12749IL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12757LB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89143RS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G89143RS", "dp": 13 }, { "id": "G12757LB", "dp": 13 } ], "links": [ { "target": "G12757LB", "source": "G89143RS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89143RS", "source": "G32065BG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12762FV", "error": "Starting point for pathway to G12762FV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12764SQ", "error": "Missing intermediate; no pathways to [G12764SQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72411HX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12775AE", "error": "Missing intermediate; no pathways to [G12775AE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57835AK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12788PX", "error": "Missing intermediate; no pathways to [G12788PX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12798XW", "error": "Starting point for pathway to G12798XW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12801FH", "error": "Starting point for pathway to G12801FH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12802HY", "error": "Starting point for pathway to G12802HY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12852SA", "error": "Missing intermediate; no pathways to [G12852SA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83845ZV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12861CT", "error": "Starting point for pathway to G12861CT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G12878NK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81923ER]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G12878NK", "dp": 10 } ], "links": [ { "target": "G12878NK", "source": "G81923ER", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G12951NT", "error": "Missing intermediate; no pathways to [G12951NT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G12991XQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G35096EN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G35096EN", "dp": 10 }, { "id": "G12991XQ", "dp": 10 } ], "links": [ { "target": "G12991XQ", "source": "G35096EN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G35096EN", "source": "G20030CU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13006TG", "error": "Starting point for pathway to G13006TG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13049QY", "error": "Starting point for pathway to G13049QY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13055JW", "error": "Missing intermediate; no pathways to [G13055JW] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G14938IR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13074BX", "error": "Starting point for pathway to G13074BX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13091NP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19726AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G13091NP", "dp": 13 } ], "links": [ { "target": "G13091NP", "source": "G19726AG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13095WF", "error": "Missing intermediate; no pathways to [G13095WF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08076GP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G13113SB", "error": "Starting point for pathway to G13113SB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13151XE", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13156PQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 } ], "links": [ { "target": "G13156PQ", "source": "G53752TA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13181ZZ", "error": "Starting point for pathway to G13181ZZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13196IZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59277TZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G59277TZ", "dp": 10 }, { "id": "G13196IZ", "dp": 10 } ], "links": [ { "target": "G13196IZ", "source": "G59277TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59277TZ", "source": "G30159WR", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13210XL", "error": "Missing intermediate; no pathways to [G13210XL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13213HD", "error": "Missing intermediate; no pathways to [G13213HD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G18803PL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13235YD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45720CA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G13235YD", "dp": 14 } ], "links": [ { "target": "G13235YD", "source": "G45720CA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13267ZY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G13267ZY", "source": "G46638GC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13282WA", "error": "Missing intermediate; no pathways to [G13282WA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13291XJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G02934UB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G02934UB", "dp": 14 }, { "id": "G13291XJ", "dp": 14 } ], "links": [ { "target": "G13291XJ", "source": "G02934UB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02934UB", "source": "G99074EO", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13305QJ", "error": "Starting point for pathway to G13305QJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13315PT", "error": "Missing intermediate; no pathways to [G13315PT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13322RS", "error": "Missing intermediate; no pathways to [G13322RS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13335AQ", "error": "Starting point for pathway to G13335AQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13345HJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30569KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G04185VX", "dp": 10 }, { "id": "G30569KZ", "dp": 11 }, { "id": "G13345HJ", "dp": 11 } ], "links": [ { "target": "G13345HJ", "source": "G30569KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30569KZ", "source": "G04185VX", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13366PY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61684ET]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G61684ET", "dp": 12 }, { "id": "G13366PY", "dp": 12 } ], "links": [ { "target": "G13366PY", "source": "G61684ET", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61684ET", "source": "G25520XG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13382WY", "error": "Starting point for pathway to G13382WY could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13441KG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08709JB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G08709JB", "dp": 13 }, { "id": "G13441KG", "dp": 13 } ], "links": [ { "target": "G13441KG", "source": "G08709JB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08709JB", "source": "G45359RY", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13444XN", "error": "Starting point for pathway to G13444XN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13477HM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82357WL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G82357WL", "dp": 11 }, { "id": "G13477HM", "dp": 11 } ], "links": [ { "target": "G13477HM", "source": "G82357WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82357WL", "source": "G28826SH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13495RN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72974NP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 }, { "id": "G01354KL", "dp": 14 }, { "id": "G72974NP", "dp": 15 }, { "id": "G13495RN", "dp": 15 } ], "links": [ { "target": "G13495RN", "source": "G72974NP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72974NP", "source": "G01354KL", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13498IL", "error": "Missing intermediate; no pathways to [G13498IL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13515ZY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79344MI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G13515ZY", "dp": 12 } ], "links": [ { "target": "G13515ZY", "source": "G79344MI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13519KZ", "error": "Missing intermediate; no pathways to [G13519KZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42130KX]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13535FD", "error": "Missing intermediate; no pathways to [G13535FD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13537KO", "error": "Missing intermediate; no pathways to [G13537KO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13542HW", "error": "Starting point for pathway to G13542HW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13545DP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72221XM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 }, { "id": "G72221XM", "dp": 12 }, { "id": "G13545DP", "dp": 12 } ], "links": [ { "target": "G13545DP", "source": "G72221XM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72221XM", "source": "G45187EI", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13583BZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36108GD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G36108GD", "dp": 11 }, { "id": "G13583BZ", "dp": 11 } ], "links": [ { "target": "G13583BZ", "source": "G36108GD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36108GD", "source": "G32305RZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13585JF", "error": "Missing intermediate; no pathways to [G13585JF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13592VY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G13592VY", "source": "G69411IG", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13594XM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36176RV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G36176RV", "dp": 12 }, { "id": "G13594XM", "dp": 12 } ], "links": [ { "target": "G13594XM", "source": "G36176RV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36176RV", "source": "G30302VM", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13614FV", "error": "Starting point for pathway to G13614FV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13628SS", "error": "Missing intermediate; no pathways to [G13628SS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27783SY]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G13646GG", "error": "Missing intermediate; no pathways to [G13646GG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13657KC", "error": "Missing intermediate; no pathways to [G13657KC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54953LX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13659RH", "error": "Missing intermediate; no pathways to [G13659RH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13663YA", "error": "Missing intermediate; no pathways to [G13663YA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13671HC", "error": "Starting point for pathway to G13671HC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13672YG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41331JX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G13672YG", "dp": 12 } ], "links": [ { "target": "G13672YG", "source": "G41331JX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13687TQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82861UH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G82861UH", "dp": 9 }, { "id": "G13687TQ", "dp": 9 } ], "links": [ { "target": "G13687TQ", "source": "G82861UH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82861UH", "source": "G59471TH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13688QP", "error": "Missing intermediate; no pathways to [G13688QP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G36316RB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13696DW", "error": "Missing intermediate; no pathways to [G13696DW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91550OH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13720TX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G24402OX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G66098KC", "dp": 14 }, { "id": "G24402OX", "dp": 15 }, { "id": "G13720TX", "dp": 15 } ], "links": [ { "target": "G13720TX", "source": "G24402OX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G24402OX", "source": "G66098KC", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66098KC", "source": "G18938DW", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13725EV", "error": "Starting point for pathway to G13725EV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13744OG", "error": "Missing intermediate; no pathways to [G13744OG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13746SQ", "error": "Starting point for pathway to G13746SQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13781GJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09670SR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 }, { "id": "G13781GJ", "dp": 10 } ], "links": [ { "target": "G13781GJ", "source": "G09670SR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13836YR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G33909XJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G33909XJ", "dp": 11 }, { "id": "G13836YR", "dp": 11 } ], "links": [ { "target": "G13836YR", "source": "G33909XJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33909XJ", "source": "G81923ER", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13843CF", "error": "Missing intermediate; no pathways to [G13843CF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G13856VP", "error": "Missing intermediate; no pathways to [G13856VP] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13859RU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03445UI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G13859RU", "dp": 10 } ], "links": [ { "target": "G13859RU", "source": "G03445UI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13865MD", "error": "Missing intermediate; no pathways to [G13865MD] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13869TL", "error": "Starting point for pathway to G13869TL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13909GK", "error": "Missing intermediate; no pathways to [G13909GK] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53288JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13921YF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16828VN]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G13921YF", "dp": 9 } ], "links": [ { "target": "G13921YF", "source": "G16828VN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13939BK", "error": "Missing intermediate; no pathways to [G13939BK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01342FO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G13964RX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70374KJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G70374KJ", "dp": 11 }, { "id": "G13964RX", "dp": 11 } ], "links": [ { "target": "G13964RX", "source": "G70374KJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70374KJ", "source": "G88417ED", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G13974DV", "error": "Starting point for pathway to G13974DV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G13976WV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G73492AT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G13976WV", "dp": 13 } ], "links": [ { "target": "G13976WV", "source": "G73492AT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14015IL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75308SV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G88966ZO", "dp": 15 }, { "id": "G75308SV", "dp": 16 }, { "id": "G14015IL", "dp": 16 } ], "links": [ { "target": "G14015IL", "source": "G75308SV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75308SV", "source": "G88966ZO", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88966ZO", "source": "G63889NK", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14020CV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30569KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G04185VX", "dp": 10 }, { "id": "G30569KZ", "dp": 11 }, { "id": "G14020CV", "dp": 11 } ], "links": [ { "target": "G14020CV", "source": "G30569KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30569KZ", "source": "G04185VX", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14047PA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G14047PA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14054GG", "error": "Missing intermediate; no pathways to [G14054GG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14068WV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 } ], "links": [ { "target": "G14068WV", "source": "G04743RS", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14070IQ", "error": "Missing intermediate; no pathways to [G14070IQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14077SN", "error": "Missing intermediate; no pathways to [G14077SN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14095XN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G20018DL", "dp": 14 } ], "links": [ { "target": "G14095XN", "source": "G20018DL", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G20018DL", "source": "G18938DW", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14127XU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 } ], "links": [ { "target": "G14127XU", "source": "G91023GB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14131GE", "error": "Missing intermediate; no pathways to [G14131GE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14190WK", "error": "Starting point for pathway to G14190WK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14201CU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G73492AT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G14201CU", "dp": 13 } ], "links": [ { "target": "G14201CU", "source": "G73492AT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14233VW", "error": "Missing intermediate; no pathways to [G14233VW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27844UM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14307KB", "error": "Starting point for pathway to G14307KB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14311HQ", "error": "Starting point for pathway to G14311HQ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14319DS", "error": "Missing intermediate; no pathways to [G14319DS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G87377KZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14328ZY", "error": "Starting point for pathway to G14328ZY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14354BD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G47606XQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G26320VO", "dp": 10 }, { "id": "G47606XQ", "dp": 11 }, { "id": "G14354BD", "dp": 11 } ], "links": [ { "target": "G14354BD", "source": "G47606XQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47606XQ", "source": "G26320VO", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26320VO", "source": "G58667NI", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14356TR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G42240DE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G42240DE", "dp": 12 }, { "id": "G14356TR", "dp": 12 } ], "links": [ { "target": "G14356TR", "source": "G42240DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42240DE", "source": "G20815TK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14371YU", "error": "Missing intermediate; no pathways to [G14371YU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14373ZY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G73211XU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G95919TI", "dp": 14 }, { "id": "G73211XU", "dp": 15 }, { "id": "G14373ZY", "dp": 15 } ], "links": [ { "target": "G14373ZY", "source": "G73211XU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73211XU", "source": "G95919TI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95919TI", "source": "G30651IU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14393TF", "error": "Missing intermediate; no pathways to [G14393TF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14422DQ", "error": "Starting point for pathway to G14422DQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14428PM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G89143RS", "dp": 13 } ], "links": [ { "target": "G14428PM", "source": "G89143RS", "residue_affected": { "residue_id": "N46", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89143RS", "source": "G32065BG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14431ZQ", "error": "Missing intermediate; no pathways to [G14431ZQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98906WL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14438ZT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17168RO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G14438ZT", "dp": 14 } ], "links": [ { "target": "G14438ZT", "source": "G17168RO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14488UY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G60564DP", "dp": 14 } ], "links": [ { "target": "G14488UY", "source": "G60564DP", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14491HM", "error": "Missing intermediate; no pathways to [G14491HM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64761FU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14492PU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G27946NT", "dp": 9 } ], "links": [ { "target": "G14492PU", "source": "G27946NT", "residue_affected": { "residue_id": "N72", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27946NT", "source": "G24420RT", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14510SZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G63074CQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G14510SZ", "dp": 9 } ], "links": [ { "target": "G14510SZ", "source": "G63074CQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14512NS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 } ], "links": [ { "target": "G14512NS", "source": "G24420RT", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14520ZO", "error": "Missing intermediate; no pathways to [G14520ZO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14549GA", "error": "Starting point for pathway to G14549GA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14576KZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07483YN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G14576KZ", "dp": 7 } ], "links": [ { "target": "G14576KZ", "source": "G07483YN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14615WQ", "error": "Missing intermediate; no pathways to [G14615WQ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14617QG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G26756VT", "dp": 11 } ], "links": [ { "target": "G14617QG", "source": "G26756VT", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26756VT", "source": "G08863NS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14631XO", "error": "Starting point for pathway to G14631XO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14675SI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G90703DJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G90703DJ", "dp": 13 }, { "id": "G14675SI", "dp": 13 } ], "links": [ { "target": "G14675SI", "source": "G90703DJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90703DJ", "source": "G74120DW", "residue_affected": { "residue_id": "N295", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14690RN", "error": "Missing intermediate; no pathways to [G14690RN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90542MP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14695KF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30553WH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G30553WH", "dp": 9 }, { "id": "G14695KF", "dp": 9 } ], "links": [ { "target": "G14695KF", "source": "G30553WH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30553WH", "source": "G20956ZK", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14761OA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G78503JC", "dp": 12 } ], "links": [ { "target": "G14761OA", "source": "G78503JC", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G78503JC", "source": "G31010RQ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14767DF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G14767DF", "source": "G69411IG", "residue_affected": { "residue_id": "N205", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14782PJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 } ], "links": [ { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14801HT", "error": "Missing intermediate; no pathways to [G14801HT] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14809NR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G51490BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G14809NR", "dp": 8 } ], "links": [ { "target": "G14809NR", "source": "G51490BW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14838TI", "error": "Missing intermediate; no pathways to [G14838TI] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14840SZ", "error": "Missing intermediate; no pathways to [G14840SZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14854WL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50779LX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G50779LX", "dp": 12 }, { "id": "G14854WL", "dp": 12 } ], "links": [ { "target": "G14854WL", "source": "G50779LX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50779LX", "source": "G25140TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14888AE", "error": "Missing intermediate; no pathways to [G14888AE] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14899VS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26264SQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 }, { "id": "G26264SQ", "dp": 12 }, { "id": "G14899VS", "dp": 12 } ], "links": [ { "target": "G14899VS", "source": "G26264SQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26264SQ", "source": "G42028DN", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14905AZ", "error": "Starting point for pathway to G14905AZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14905MK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 } ], "links": [ { "target": "G14905MK", "source": "G61207RZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14927KP", "error": "Starting point for pathway to G14927KP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G14938IR", "error": "Missing intermediate; no pathways to [G14938IR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14939LO", "error": "Missing intermediate; no pathways to [G14939LO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14942ZU", "error": "Missing intermediate; no pathways to [G14942ZU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75853FN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G14954HI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37022BP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G37022BP", "dp": 12 }, { "id": "G14954HI", "dp": 12 } ], "links": [ { "target": "G14954HI", "source": "G37022BP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37022BP", "source": "G30460NZ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14959WS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 } ], "links": [ { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14996IQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G14996IQ", "source": "G69411IG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G14998UC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 } ], "links": [ { "target": "G14998UC", "source": "G25140TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15001YX", "error": "Starting point for pathway to G15001YX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15006PM", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G96674LJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G96674LJ", "dp": 18 }, { "id": "G15006PM", "dp": 18 } ], "links": [ { "target": "G15006PM", "source": "G96674LJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96674LJ", "source": "G50489VC", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15025FT", "error": "Missing intermediate; no pathways to [G15025FT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15103WJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G15103WJ", "source": "G25520XG", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15112UU", "error": "Missing intermediate; no pathways to [G15112UU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86321OX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15114JI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70708LW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G70708LW", "dp": 12 }, { "id": "G15114JI", "dp": 12 } ], "links": [ { "target": "G15114JI", "source": "G70708LW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70708LW", "source": "G74675FC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15158LV", "error": "Starting point for pathway to G15158LV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15164ZG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53000RQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G53000RQ", "dp": 11 }, { "id": "G15164ZG", "dp": 11 } ], "links": [ { "target": "G15164ZG", "source": "G53000RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15192BD", "error": "Missing intermediate; no pathways to [G15192BD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15204IM", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G94297FY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G94297FY", "dp": 9 }, { "id": "G15204IM", "dp": 9 } ], "links": [ { "target": "G15204IM", "source": "G94297FY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94297FY", "source": "G29492IF", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15216UP", "error": "Missing intermediate; no pathways to [G15216UP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G55314RK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15222RS", "error": "Starting point for pathway to G15222RS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15268QU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26529EC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 }, { "id": "G16451PE", "dp": 11 }, { "id": "G26529EC", "dp": 12 }, { "id": "G15268QU", "dp": 12 } ], "links": [ { "target": "G15268QU", "source": "G26529EC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26529EC", "source": "G16451PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16451PE", "source": "G45365RV", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15269NF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17413FR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G17413FR", "dp": 13 }, { "id": "G15269NF", "dp": 13 } ], "links": [ { "target": "G15269NF", "source": "G17413FR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17413FR", "source": "G56749GV", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15303EK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04273XP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G03385XG", "dp": 13 }, { "id": "G04273XP", "dp": 14 }, { "id": "G15303EK", "dp": 14 } ], "links": [ { "target": "G15303EK", "source": "G04273XP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04273XP", "source": "G03385XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15306QC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99866WK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G38395YJ", "dp": 14 }, { "id": "G99866WK", "dp": 15 }, { "id": "G15306QC", "dp": 15 } ], "links": [ { "target": "G15306QC", "source": "G99866WK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99866WK", "source": "G38395YJ", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15310YY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23060KN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G23060KN", "dp": 11 }, { "id": "G15310YY", "dp": 11 } ], "links": [ { "target": "G15310YY", "source": "G23060KN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23060KN", "source": "G09446VC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15317IZ", "error": "Starting point for pathway to G15317IZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15318TJ", "error": "Missing intermediate; no pathways to [G15318TJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93698KA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15329MZ", "error": "Starting point for pathway to G15329MZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15348EA", "error": "Missing intermediate; no pathways to [G15348EA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31991IV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15355KC", "error": "Missing intermediate; no pathways to [G15355KC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41087ZA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15355XO", "error": "Starting point for pathway to G15355XO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15369UO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74675FC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G15369UO", "dp": 11 } ], "links": [ { "target": "G15369UO", "source": "G74675FC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15403PA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G55479DB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G11929SN", "dp": 14 }, { "id": "G55479DB", "dp": 15 }, { "id": "G15403PA", "dp": 15 } ], "links": [ { "target": "G15403PA", "source": "G55479DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G55479DB", "source": "G11929SN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929SN", "source": "G80294GH", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15467DQ", "error": "Starting point for pathway to G15467DQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15496AG", "error": "Starting point for pathway to G15496AG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15503SL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G42548XF", "dp": 7 }, { "id": "G95956WE", "dp": 8 } ], "links": [ { "target": "G15503SL", "source": "G95956WE", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95956WE", "source": "G42548XF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42548XF", "source": "G61751GZ", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] } ] } , { "glytoucan_ac": "G15522RV", "error": "Missing intermediate; no pathways to [G15522RV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15527QL", "error": "Missing intermediate; no pathways to [G15527QL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32173NW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15571KX", "error": "Missing intermediate; no pathways to [G15571KX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15591FI", "error": "Missing intermediate; no pathways to [G15591FI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75107JX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15605OU", "error": "Missing intermediate; no pathways to [G15605OU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57675TR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15638PX", "error": "Starting point for pathway to G15638PX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15655AE", "error": "Missing intermediate; no pathways to [G15655AE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15681WF", "error": "Missing intermediate; no pathways to [G15681WF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15696PP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G01727PW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G15696PP", "dp": 13 } ], "links": [ { "target": "G15696PP", "source": "G01727PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15696VL", "error": "Missing intermediate; no pathways to [G15696VL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00320ZP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15719NX", "error": "Missing intermediate; no pathways to [G15719NX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G15727JK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G15727JK", "source": "G69411IG", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15730FJ", "error": "Missing intermediate; no pathways to [G15730FJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15732HH", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G15732HH", "source": "G08520NM", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G15751RX", "error": "Starting point for pathway to G15751RX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15757QE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10614GM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G10614GM", "dp": 9 }, { "id": "G15757QE", "dp": 9 } ], "links": [ { "target": "G15757QE", "source": "G10614GM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10614GM", "source": "G10209QU", "residue_affected": { "residue_id": "N275", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15794TC", "error": "Missing intermediate; no pathways to [G15794TC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77812KJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15807GH", "error": "Missing intermediate; no pathways to [G15807GH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57671LP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G15821ZM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32592IB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G32592IB", "dp": 15 }, { "id": "G15821ZM", "dp": 15 } ], "links": [ { "target": "G15821ZM", "source": "G32592IB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32592IB", "source": "G10228OD", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15825OT", "error": "Starting point for pathway to G15825OT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15828AN", "error": "Starting point for pathway to G15828AN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G15828WB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G88382QE", "dp": 14 } ], "links": [ { "target": "G15828WB", "source": "G88382QE", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88382QE", "source": "G18938DW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15859AU", "error": "Missing intermediate; no pathways to [G15859AU] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15890XK", "error": "Missing intermediate; no pathways to [G15890XK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G15972DM", "error": "Missing intermediate; no pathways to [G15972DM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39601JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G15987FM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95998QK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G49827WK", "dp": 11 }, { "id": "G95998QK", "dp": 12 }, { "id": "G15987FM", "dp": 12 } ], "links": [ { "target": "G15987FM", "source": "G95998QK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95998QK", "source": "G49827WK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49827WK", "source": "G09446VC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G15998WM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 } ], "links": [ { "target": "G15998WM", "source": "G79950YS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16028RM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40194MN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G40194MN", "dp": 16 }, { "id": "G16028RM", "dp": 16 } ], "links": [ { "target": "G16028RM", "source": "G40194MN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40194MN", "source": "G76842ZR", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16038YA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G33742YO", "dp": 9 } ], "links": [ { "target": "G16038YA", "source": "G33742YO", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16042LM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37476QB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G16042LM", "dp": 8 } ], "links": [ { "target": "G16042LM", "source": "G37476QB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16057DE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 } ], "links": [ { "target": "G16057DE", "source": "G67289UM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16058FI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99897FQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G99897FQ", "dp": 9 }, { "id": "G16058FI", "dp": 9 } ], "links": [ { "target": "G16058FI", "source": "G99897FQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99897FQ", "source": "G67045LB", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16119YF", "error": "Starting point for pathway to G16119YF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16150CJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 } ], "links": [ { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16155TD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 } ], "links": [ { "target": "G16155TD", "source": "G01669LU", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16201LW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14996IQ", "dp": 8 } ], "links": [ { "target": "G16201LW", "source": "G14996IQ", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G14996IQ", "source": "G69411IG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16206CD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62826CL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G62826CL", "dp": 9 }, { "id": "G16206CD", "dp": 9 } ], "links": [ { "target": "G16206CD", "source": "G62826CL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62826CL", "source": "G80858MF", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16230QU", "error": "Missing intermediate; no pathways to [G16230QU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94490EL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G16271QB", "error": "Starting point for pathway to G16271QB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16276IK", "error": "Starting point for pathway to G16276IK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16293AI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G74645FT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G16293AI", "dp": 12 } ], "links": [ { "target": "G16293AI", "source": "G74645FT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16294GR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94297FY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G94297FY", "dp": 9 }, { "id": "G16294GR", "dp": 9 } ], "links": [ { "target": "G16294GR", "source": "G94297FY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94297FY", "source": "G29492IF", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16325IK", "error": "Missing intermediate; no pathways to [G16325IK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11635LG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16328IY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04791QM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G16328IY", "dp": 9 } ], "links": [ { "target": "G16328IY", "source": "G04791QM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16340ZJ", "error": "Missing intermediate; no pathways to [G16340ZJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16341ZC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G57943ZV", "dp": 11 } ], "links": [ { "target": "G16341ZC", "source": "G57943ZV", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16344ZG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47975JA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G47975JA", "dp": 12 }, { "id": "G16344ZG", "dp": 12 } ], "links": [ { "target": "G16344ZG", "source": "G47975JA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47975JA", "source": "G11041DA", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16393FR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04989WY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16393FR", "dp": 13 } ], "links": [ { "target": "G16393FR", "source": "G04989WY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16397GM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94045IP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G94045IP", "dp": 13 }, { "id": "G16397GM", "dp": 13 } ], "links": [ { "target": "G16397GM", "source": "G94045IP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94045IP", "source": "G91023GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16403CC", "error": "Missing intermediate; no pathways to [G16403CC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96719MC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16404YH", "error": "Starting point for pathway to G16404YH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16417CU", "error": "Starting point for pathway to G16417CU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16437LH", "error": "Missing intermediate; no pathways to [G16437LH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16441MS", "error": "Missing intermediate; no pathways to [G16441MS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16451PE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 } ], "links": [ { "target": "G16451PE", "source": "G45365RV", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16464LC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 } ], "links": [ { "target": "G16464LC", "source": "G43694RQ", "residue_affected": { "residue_id": "N322", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16476DW", "error": "Missing intermediate; no pathways to [G16476DW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16481GK", "error": "Missing intermediate; no pathways to [G16481GK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51562OR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16516HD", "error": "Missing intermediate; no pathways to [G16516HD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16520OZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G56591LC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G16520OZ", "dp": 10 } ], "links": [ { "target": "G16520OZ", "source": "G56591LC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16523AO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16529MG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 } ], "links": [ { "target": "G16529MG", "source": "G56549DH", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16546ZZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 } ], "links": [ { "target": "G16546ZZ", "source": "G41331JX", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16552HD", "error": "Missing intermediate; no pathways to [G16552HD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16578NV", "error": "Missing intermediate; no pathways to [G16578NV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G16588UI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G16588UI", "source": "G78059CC", "residue_affected": { "residue_id": "N483", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16600BL", "error": "Missing intermediate; no pathways to [G16600BL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16604UX", "error": "Starting point for pathway to G16604UX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16614GV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06374YY]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G06374YY", "dp": 10 }, { "id": "G16614GV", "dp": 10 } ], "links": [ { "target": "G16614GV", "source": "G06374YY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06374YY", "source": "G16828VN", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16679DU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G69086TY", "dp": 12 }, { "id": "G42400JK", "dp": 13 } ], "links": [ { "target": "G16679DU", "source": "G42400JK", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42400JK", "source": "G69086TY", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16702HQ", "error": "Missing intermediate; no pathways to [G16702HQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16705KA", "error": "Missing intermediate; no pathways to [G16705KA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G16717IV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G29011JC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G16717IV", "dp": 8 } ], "links": [ { "target": "G16717IV", "source": "G29011JC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16733YD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09670SR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 }, { "id": "G16733YD", "dp": 10 } ], "links": [ { "target": "G16733YD", "source": "G09670SR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16743OM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20983SP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 }, { "id": "G20983SP", "dp": 19 }, { "id": "G16743OM", "dp": 19 } ], "links": [ { "target": "G16743OM", "source": "G20983SP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20983SP", "source": "G94531EZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16743PO", "error": "Starting point for pathway to G16743PO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16753NR", "error": "Missing intermediate; no pathways to [G16753NR] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G16759KR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16768LX", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G78059CC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G16768LX", "dp": 10 } ], "links": [ { "target": "G16768LX", "source": "G78059CC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16774YZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 } ], "links": [ { "target": "G16774YZ", "source": "G86696LV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16776JC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89036WC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G89036WC", "dp": 8 }, { "id": "G16776JC", "dp": 8 } ], "links": [ { "target": "G16776JC", "source": "G89036WC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89036WC", "source": "G02427KF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16778ZK", "error": "Missing intermediate; no pathways to [G16778ZK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95298UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16782SL", "error": "Missing intermediate; no pathways to [G16782SL] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G55645TD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16809IL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71812IK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G71812IK", "dp": 9 }, { "id": "G16809IL", "dp": 9 } ], "links": [ { "target": "G16809IL", "source": "G71812IK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71812IK", "source": "G80858MF", "residue_affected": { "residue_id": "N322", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16827VK", "error": "Missing intermediate; no pathways to [G16827VK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16828VN", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G16873YG", "error": "Missing intermediate; no pathways to [G16873YG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16879YK", "error": "Starting point for pathway to G16879YK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16921OK", "error": "Missing intermediate; no pathways to [G16921OK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06594DV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16932ML", "error": "Starting point for pathway to G16932ML could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G16938IW", "error": "Missing intermediate; no pathways to [G16938IW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83635VI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16956YO", "error": "Missing intermediate; no pathways to [G16956YO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16967GJ", "error": "Missing intermediate; no pathways to [G16967GJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16976BN", "error": "Missing intermediate; no pathways to [G16976BN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08076GP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G16986CA", "error": "Missing intermediate; no pathways to [G16986CA] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82847HG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G16999DQ", "error": "Starting point for pathway to G16999DQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17029BL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G59579TL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G86753CK", "dp": 17 }, { "id": "G59579TL", "dp": 18 }, { "id": "G17029BL", "dp": 18 } ], "links": [ { "target": "G17029BL", "source": "G59579TL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59579TL", "source": "G86753CK", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17029IU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46638GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G17029IU", "dp": 9 } ], "links": [ { "target": "G17029IU", "source": "G46638GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17041TR", "error": "Missing intermediate; no pathways to [G17041TR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17044PM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G46470AD", "dp": 11 } ], "links": [ { "target": "G17044PM", "source": "G46470AD", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46470AD", "source": "G01856RL", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17089XZ", "error": "Missing intermediate; no pathways to [G17089XZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G48753IC]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G17101AZ", "error": "Missing intermediate; no pathways to [G17101AZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17107VB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99935CU]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G99969SS", "dp": 10 }, { "id": "G99935CU", "dp": 11 }, { "id": "G17107VB", "dp": 11 } ], "links": [ { "target": "G17107VB", "source": "G99935CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99935CU", "source": "G99969SS", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G99969SS", "source": "G13151XE", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17115PO", "error": "Starting point for pathway to G17115PO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17118PL", "error": "Missing intermediate; no pathways to [G17118PL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74497TS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17120XF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G06969ZX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 }, { "id": "G17120XF", "dp": 10 } ], "links": [ { "target": "G17120XF", "source": "G06969ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17134VG", "error": "Missing intermediate; no pathways to [G17134VG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17140UR", "error": "Missing intermediate; no pathways to [G17140UR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G17153CQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84964KJ", "dp": 12 } ], "links": [ { "target": "G17153CQ", "source": "G84964KJ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84964KJ", "source": "G29857RC", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17153FQ", "error": "Starting point for pathway to G17153FQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17155VX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 } ], "links": [ { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17157SF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G63838JW]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G30588SI", "dp": 9 }, { "id": "G63838JW", "dp": 10 }, { "id": "G17157SF", "dp": 10 } ], "links": [ { "target": "G17157SF", "source": "G63838JW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63838JW", "source": "G30588SI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30588SI", "source": "G08520NM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17160IJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G27776PG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G27776PG", "dp": 9 }, { "id": "G17160IJ", "dp": 9 } ], "links": [ { "target": "G17160IJ", "source": "G27776PG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27776PG", "source": "G20956ZK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17164DX", "error": "Missing intermediate; no pathways to [G17164DX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17168RO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 } ], "links": [ { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17172ZR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39540XG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G10258MC", "dp": 11 }, { "id": "G39540XG", "dp": 12 }, { "id": "G17172ZR", "dp": 12 } ], "links": [ { "target": "G17172ZR", "source": "G39540XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39540XG", "source": "G10258MC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10258MC", "source": "G25835MT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17207FU", "error": "Starting point for pathway to G17207FU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17213JF", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 } ], "links": [ { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17226QK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95956WE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G42548XF", "dp": 7 }, { "id": "G95956WE", "dp": 8 }, { "id": "G17226QK", "dp": 8 } ], "links": [ { "target": "G17226QK", "source": "G95956WE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95956WE", "source": "G42548XF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42548XF", "source": "G61751GZ", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] } ] } , { "glytoucan_ac": "G17228YV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G40542QP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G40542QP", "dp": 15 }, { "id": "G17228YV", "dp": 15 } ], "links": [ { "target": "G17228YV", "source": "G40542QP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40542QP", "source": "G10228OD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17236US", "error": "Missing intermediate; no pathways to [G17236US] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17238GT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90703DJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G90703DJ", "dp": 13 }, { "id": "G17238GT", "dp": 13 } ], "links": [ { "target": "G17238GT", "source": "G90703DJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90703DJ", "source": "G74120DW", "residue_affected": { "residue_id": "N295", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17253JN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65449BO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G36519NW", "dp": 13 }, { "id": "G65449BO", "dp": 14 }, { "id": "G17253JN", "dp": 14 } ], "links": [ { "target": "G17253JN", "source": "G65449BO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65449BO", "source": "G36519NW", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G36519NW", "source": "G01669LU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17264LS", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G17264LS", "source": "G16828VN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17266HP", "error": "Missing intermediate; no pathways to [G17266HP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17274VA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65981EG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 }, { "id": "G65981EG", "dp": 12 }, { "id": "G17274VA", "dp": 12 } ], "links": [ { "target": "G17274VA", "source": "G65981EG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65981EG", "source": "G37385TT", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17286ZM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G78503JC", "dp": 12 }, { "id": "G86202BL", "dp": 13 } ], "links": [ { "target": "G17286ZM", "source": "G86202BL", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86202BL", "source": "G78503JC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78503JC", "source": "G31010RQ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17297XR", "error": "Missing intermediate; no pathways to [G17297XR] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G03296OS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17315BS", "error": "Missing intermediate; no pathways to [G17315BS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56516KW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17336FF", "error": "Missing intermediate; no pathways to [G17336FF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75896PD]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G17336UY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70520DS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G24083XE", "dp": 12 }, { "id": "G70520DS", "dp": 13 }, { "id": "G17336UY", "dp": 13 } ], "links": [ { "target": "G17336UY", "source": "G70520DS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70520DS", "source": "G24083XE", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24083XE", "source": "G82252QI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17339LD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G52770HR", "dp": 10 } ], "links": [ { "target": "G17339LD", "source": "G52770HR", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G52770HR", "source": "G36191CD", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17344FG", "error": "Missing intermediate; no pathways to [G17344FG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G94490EL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G17348SA", "error": "Missing intermediate; no pathways to [G17348SA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72112RK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17389EH", "error": "Missing intermediate; no pathways to [G17389EH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03948VT]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17413FR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 } ], "links": [ { "target": "G17413FR", "source": "G56749GV", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17429BS", "error": "Starting point for pathway to G17429BS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17437BX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 } ], "links": [ { "target": "G17437BX", "source": "G92359VA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17441MI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98366ZJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G98366ZJ", "dp": 14 }, { "id": "G17441MI", "dp": 14 } ], "links": [ { "target": "G17441MI", "source": "G98366ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98366ZJ", "source": "G99074EO", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17465IO", "error": "Missing intermediate; no pathways to [G17465IO] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17473NR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 } ], "links": [ { "target": "G17473NR", "source": "G10733HY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17490CY", "error": "Starting point for pathway to G17490CY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17539BJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17168RO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G17539BJ", "dp": 14 } ], "links": [ { "target": "G17539BJ", "source": "G17168RO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17540HT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 } ], "links": [ { "target": "G17540HT", "source": "G30460NZ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17540MV", "error": "Missing intermediate; no pathways to [G17540MV] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G02679YX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17595XL", "error": "Starting point for pathway to G17595XL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17597KD", "error": "Missing intermediate; no pathways to [G17597KD] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G41953RN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17639DA", "error": "Starting point for pathway to G17639DA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17650QU", "error": "Missing intermediate; no pathways to [G17650QU] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17652NI", "error": "Missing intermediate; no pathways to [G17652NI] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G01342FO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17689DH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 } ], "links": [ { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17691MO", "error": "Missing intermediate; no pathways to [G17691MO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36787EI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17695MH", "error": "Missing intermediate; no pathways to [G17695MH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17698NO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39089YD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G17698NO", "dp": 7 } ], "links": [ { "target": "G17698NO", "source": "G39089YD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G17740GV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 } ], "links": [ { "target": "G17740GV", "source": "G89877QI", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17751FJ", "error": "Starting point for pathway to G17751FJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17761IT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91511MZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G91511MZ", "dp": 12 }, { "id": "G17761IT", "dp": 12 } ], "links": [ { "target": "G17761IT", "source": "G91511MZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91511MZ", "source": "G11041DA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17769YX", "error": "Missing intermediate; no pathways to [G17769YX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17779DH", "error": "Missing intermediate; no pathways to [G17779DH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17800QD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G12398HZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G17800QD", "dp": 8 } ], "links": [ { "target": "G17800QD", "source": "G12398HZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17801HD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81392TU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G81392TU", "dp": 14 }, { "id": "G17801HD", "dp": 14 } ], "links": [ { "target": "G17801HD", "source": "G81392TU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81392TU", "source": "G85085MS", "residue_affected": { "residue_id": "N246", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17807LO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50078RT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G50078RT", "dp": 12 }, { "id": "G17807LO", "dp": 12 } ], "links": [ { "target": "G17807LO", "source": "G50078RT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50078RT", "source": "G79809MM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17820VB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99270AV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G17820VB", "dp": 10 } ], "links": [ { "target": "G17820VB", "source": "G99270AV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17848HM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 } ], "links": [ { "target": "G17848HM", "source": "G85767HW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17851MM", "error": "Missing intermediate; no pathways to [G17851MM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25471TG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17857ZF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G57970NA", "dp": 13 } ], "links": [ { "target": "G17857ZF", "source": "G57970NA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57970NA", "source": "G49515VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17863YV", "error": "Starting point for pathway to G17863YV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17875TE", "error": "Starting point for pathway to G17875TE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17909DH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17964DY", "error": "Missing intermediate; no pathways to [G17964DY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17964XN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43346PX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G43346PX", "dp": 12 }, { "id": "G17964XN", "dp": 12 } ], "links": [ { "target": "G17964XN", "source": "G43346PX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43346PX", "source": "G04743RS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17968CJ", "error": "Missing intermediate; no pathways to [G17968CJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G63065KG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17969PJ", "error": "Missing intermediate; no pathways to [G17969PJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79099UV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17970KD", "error": "Missing intermediate; no pathways to [G17970KD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11635LG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G17977UE", "error": "Starting point for pathway to G17977UE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17987CU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53098FA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 }, { "id": "G53098FA", "dp": 14 }, { "id": "G17987CU", "dp": 14 } ], "links": [ { "target": "G17987CU", "source": "G53098FA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53098FA", "source": "G95898GD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G17988XO", "error": "Starting point for pathway to G17988XO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G17996ZO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76136FD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G86102AA", "dp": 11 }, { "id": "G76136FD", "dp": 12 }, { "id": "G17996ZO", "dp": 12 } ], "links": [ { "target": "G17996ZO", "source": "G76136FD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76136FD", "source": "G86102AA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86102AA", "source": "G85542KD", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18026EK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 } ], "links": [ { "target": "G18026EK", "source": "G37046CZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18082CO", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10691MJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G18082CO", "dp": 11 } ], "links": [ { "target": "G18082CO", "source": "G10691MJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18109IM", "error": "Starting point for pathway to G18109IM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18125MC", "error": "Missing intermediate; no pathways to [G18125MC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18133RH", "error": "Missing intermediate; no pathways to [G18133RH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94163JZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18144ZF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86928UZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 }, { "id": "G86928UZ", "dp": 11 }, { "id": "G18144ZF", "dp": 11 } ], "links": [ { "target": "G18144ZF", "source": "G86928UZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86928UZ", "source": "G85767HW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18157KC", "error": "Missing intermediate; no pathways to [G18157KC] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18160VJ", "error": "Starting point for pathway to G18160VJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18165XJ", "error": "Starting point for pathway to G18165XJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18196JE", "error": "Missing intermediate; no pathways to [G18196JE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14520ZO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18219CJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18223CA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33241WC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G33241WC", "dp": 15 }, { "id": "G18223CA", "dp": 15 } ], "links": [ { "target": "G18223CA", "source": "G33241WC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33241WC", "source": "G45720CA", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18247HD", "error": "Missing intermediate; no pathways to [G18247HD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18264WJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30901GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G30901GC", "dp": 9 }, { "id": "G18264WJ", "dp": 9 } ], "links": [ { "target": "G18264WJ", "source": "G30901GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18286BM", "error": "Missing intermediate; no pathways to [G18286BM] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G68283NG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18306LO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59575FI]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G66129DI", "dp": 11 }, { "id": "G59575FI", "dp": 12 }, { "id": "G18306LO", "dp": 12 } ], "links": [ { "target": "G18306LO", "source": "G59575FI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59575FI", "source": "G66129DI", "residue_affected": { "residue_id": "N476", "pubchem_name": "phosphate", "anomer": "n", "absolute": "n", "form_name": "phosphate", "full_name": "-n-phosphate" }, "effect": "Add -n-phosphate", "enzymes": [] }, { "target": "G66129DI", "source": "G03275SD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18340ZI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G27223CU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G27223CU", "dp": 12 }, { "id": "G18340ZI", "dp": 12 } ], "links": [ { "target": "G18340ZI", "source": "G27223CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27223CU", "source": "G82252QI", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18386MU", "error": "Missing intermediate; no pathways to [G18386MU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65832JS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18410AS", "error": "Starting point for pathway to G18410AS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18469SX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25505UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 }, { "id": "G18469SX", "dp": 14 } ], "links": [ { "target": "G18469SX", "source": "G25505UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18506AD", "error": "Missing intermediate; no pathways to [G18506AD] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G51367TM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G18510PG", "error": "Missing intermediate; no pathways to [G18510PG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18512IC", "error": "Missing intermediate; no pathways to [G18512IC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18516QW", "error": "Starting point for pathway to G18516QW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18581LO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 } ], "links": [ { "target": "G18581LO", "source": "G19726AG", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18584GW", "error": "Missing intermediate; no pathways to [G18584GW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21756MV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18594ZT", "error": "Missing intermediate; no pathways to [G18594ZT] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18609UY", "error": "Starting point for pathway to G18609UY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18614BQ", "error": "Starting point for pathway to G18614BQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18641AT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97947UQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G14047PA", "dp": 11 }, { "id": "G97947UQ", "dp": 12 }, { "id": "G18641AT", "dp": 12 } ], "links": [ { "target": "G18641AT", "source": "G97947UQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97947UQ", "source": "G14047PA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14047PA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18641OW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 } ], "links": [ { "target": "G18641OW", "source": "G88417ED", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18676RO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14068WV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G14068WV", "dp": 12 }, { "id": "G18676RO", "dp": 12 } ], "links": [ { "target": "G18676RO", "source": "G14068WV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14068WV", "source": "G04743RS", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18687CN", "error": "Starting point for pathway to G18687CN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18694JB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99356PZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G99356PZ", "dp": 9 }, { "id": "G18694JB", "dp": 9 } ], "links": [ { "target": "G18694JB", "source": "G99356PZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99356PZ", "source": "G12398HZ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18724OW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03075ZE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G03075ZE", "dp": 14 }, { "id": "G18724OW", "dp": 14 } ], "links": [ { "target": "G18724OW", "source": "G03075ZE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03075ZE", "source": "G04989WY", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18731YM", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G49515VE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G18731YM", "dp": 12 } ], "links": [ { "target": "G18731YM", "source": "G49515VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18738PX", "error": "Missing intermediate; no pathways to [G18738PX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G64761FU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18738RV", "error": "Missing intermediate; no pathways to [G18738RV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18756YE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96091LW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G07228BR", "dp": 10 }, { "id": "G96091LW", "dp": 11 }, { "id": "G18756YE", "dp": 11 } ], "links": [ { "target": "G18756YE", "source": "G96091LW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96091LW", "source": "G07228BR", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07228BR", "source": "G93500PH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18768EK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 } ], "links": [ { "target": "G18768EK", "source": "G78803YD", "residue_affected": { "residue_id": "N78", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18784ZP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 } ], "links": [ { "target": "G18784ZP", "source": "G78155FK", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18803CK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00951UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G79198BK", "dp": 9 }, { "id": "G00951UF", "dp": 10 }, { "id": "G18803CK", "dp": 10 } ], "links": [ { "target": "G18803CK", "source": "G00951UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00951UF", "source": "G79198BK", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79198BK", "source": "G10219AA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18803PL", "error": "Missing intermediate; no pathways to [G18803PL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18814PP", "error": "Missing intermediate; no pathways to [G18814PP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18818DM", "error": "Missing intermediate; no pathways to [G18818DM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19104OH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18854ET", "error": "Missing intermediate; no pathways to [G18854ET] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77562VR]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G18859UG", "error": "Starting point for pathway to G18859UG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18869TR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G18869TR", "source": "G46638GC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18871XZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63074CQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G18871XZ", "dp": 9 } ], "links": [ { "target": "G18871XZ", "source": "G63074CQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18875WG", "error": "Missing intermediate; no pathways to [G18875WG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18877VR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79457WN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G79457WN", "dp": 11 }, { "id": "G18877VR", "dp": 11 } ], "links": [ { "target": "G18877VR", "source": "G79457WN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79457WN", "source": "G00176HZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18880MW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86083QZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G04185VX", "dp": 10 }, { "id": "G30569KZ", "dp": 11 }, { "id": "G86083QZ", "dp": 12 }, { "id": "G18880MW", "dp": 12 } ], "links": [ { "target": "G18880MW", "source": "G86083QZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86083QZ", "source": "G30569KZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30569KZ", "source": "G04185VX", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18887FK", "error": "Starting point for pathway to G18887FK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18897BX", "error": "Missing intermediate; no pathways to [G18897BX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61203OK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G18905AN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21319HP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G40906DZ", "dp": 14 }, { "id": "G21319HP", "dp": 15 }, { "id": "G18905AN", "dp": 15 } ], "links": [ { "target": "G18905AN", "source": "G21319HP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21319HP", "source": "G40906DZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40906DZ", "source": "G18938DW", "residue_affected": { "residue_id": "N43", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18913QB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94363RH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G94363RH", "dp": 17 }, { "id": "G18913QB", "dp": 17 } ], "links": [ { "target": "G18913QB", "source": "G94363RH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94363RH", "source": "G79950YS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18938DW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 } ], "links": [ { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G18948TG", "error": "Starting point for pathway to G18948TG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G18956GV", "error": "Missing intermediate; no pathways to [G18956GV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19019TY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 } ], "links": [ { "target": "G19019TY", "source": "G09670SR", "residue_affected": { "residue_id": "N72", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19026NP", "error": "Missing intermediate; no pathways to [G19026NP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19053XS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19726AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G19053XS", "dp": 13 } ], "links": [ { "target": "G19053XS", "source": "G19726AG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19083SI", "error": "Starting point for pathway to G19083SI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19103IX", "error": "Missing intermediate; no pathways to [G19103IX] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19104OH", "error": "Missing intermediate; no pathways to [G19104OH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19106CR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56271TF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G56271TF", "dp": 8 }, { "id": "G19106CR", "dp": 8 } ], "links": [ { "target": "G19106CR", "source": "G56271TF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56271TF", "source": "G59741XZ", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19124KK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 } ], "links": [ { "target": "G19124KK", "source": "G84467IZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19126UP", "error": "Starting point for pathway to G19126UP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19140RD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28747XN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G96921ZU", "dp": 12 }, { "id": "G28747XN", "dp": 13 }, { "id": "G19140RD", "dp": 13 } ], "links": [ { "target": "G19140RD", "source": "G28747XN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28747XN", "source": "G96921ZU", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19146BQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57504TA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G28723UT", "dp": 11 }, { "id": "G57504TA", "dp": 12 }, { "id": "G19146BQ", "dp": 12 } ], "links": [ { "target": "G19146BQ", "source": "G57504TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57504TA", "source": "G28723UT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28723UT", "source": "G87073UP", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19155BS", "error": "Starting point for pathway to G19155BS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19173US", "error": "Starting point for pathway to G19173US could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19197RD", "error": "Missing intermediate; no pathways to [G19197RD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97865QM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19209QL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02934UB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G02934UB", "dp": 14 }, { "id": "G19209QL", "dp": 14 } ], "links": [ { "target": "G19209QL", "source": "G02934UB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02934UB", "source": "G99074EO", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19226BI", "error": "Starting point for pathway to G19226BI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19242QH", "error": "Missing intermediate; no pathways to [G19242QH] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G19243TV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G72580QS", "dp": 14 } ], "links": [ { "target": "G19243TV", "source": "G72580QS", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G72580QS", "source": "G66282NU", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19267AT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G07228BR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G07228BR", "dp": 10 }, { "id": "G19267AT", "dp": 10 } ], "links": [ { "target": "G19267AT", "source": "G07228BR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07228BR", "source": "G93500PH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19271GD", "error": "Missing intermediate; no pathways to [G19271GD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19281RB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95490LA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95490LA", "dp": 14 }, { "id": "G19281RB", "dp": 14 } ], "links": [ { "target": "G19281RB", "source": "G95490LA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95490LA", "source": "G18938DW", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19287UY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46503KK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G46503KK", "dp": 12 }, { "id": "G19287UY", "dp": 12 } ], "links": [ { "target": "G19287UY", "source": "G46503KK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46503KK", "source": "G18219CJ", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19289JN", "error": "Missing intermediate; no pathways to [G19289JN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19294RF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G31037WG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G31037WG", "dp": 18 }, { "id": "G19294RF", "dp": 18 } ], "links": [ { "target": "G19294RF", "source": "G31037WG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31037WG", "source": "G92574YO", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19310VN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32201IL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G19310VN", "dp": 10 } ], "links": [ { "target": "G19310VN", "source": "G32201IL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19315TM", "error": "Missing intermediate; no pathways to [G19315TM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19317GV", "error": "Missing intermediate; no pathways to [G19317GV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19353CF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26949IX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G19353CF", "dp": 11 } ], "links": [ { "target": "G19353CF", "source": "G26949IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19378QH", "error": "Starting point for pathway to G19378QH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19378ZS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92617LF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G92617LF", "dp": 10 }, { "id": "G19378ZS", "dp": 10 } ], "links": [ { "target": "G19378ZS", "source": "G92617LF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92617LF", "source": "G27919IH", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19429IT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03385XG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G03385XG", "dp": 13 }, { "id": "G19429IT", "dp": 13 } ], "links": [ { "target": "G19429IT", "source": "G03385XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19430NR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76422GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G76422GC", "dp": 12 }, { "id": "G19430NR", "dp": 12 } ], "links": [ { "target": "G19430NR", "source": "G76422GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76422GC", "source": "G25140TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19444JC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 } ], "links": [ { "target": "G19444JC", "source": "G45720CA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19444YR", "error": "Missing intermediate; no pathways to [G19444YR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19447ZX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23295TF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G23295TF", "dp": 10 }, { "id": "G19447ZX", "dp": 10 } ], "links": [ { "target": "G19447ZX", "source": "G23295TF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23295TF", "source": "G27919IH", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19469VZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 } ], "links": [ { "target": "G19469VZ", "source": "G92574YO", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19483RZ", "error": "Missing intermediate; no pathways to [G19483RZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19520XO", "error": "Missing intermediate; no pathways to [G19520XO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42438ZG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19526IZ", "error": "Missing intermediate; no pathways to [G19526IZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G22558JP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19532EC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95081VM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G19532EC", "dp": 9 } ], "links": [ { "target": "G19532EC", "source": "G95081VM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19537TS", "error": "Missing intermediate; no pathways to [G19537TS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G87807PF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19541IU", "error": "Missing intermediate; no pathways to [G19541IU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74859XI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19553VJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G26182BM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G19553VJ", "dp": 8 } ], "links": [ { "target": "G19553VJ", "source": "G26182BM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19565UD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75720YC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G75720YC", "dp": 11 }, { "id": "G19565UD", "dp": 11 } ], "links": [ { "target": "G19565UD", "source": "G75720YC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75720YC", "source": "G01856RL", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19592AH", "error": "Starting point for pathway to G19592AH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19607EP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60439QY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 }, { "id": "G99891PR", "dp": 16 }, { "id": "G60439QY", "dp": 17 }, { "id": "G19607EP", "dp": 17 } ], "links": [ { "target": "G19607EP", "source": "G60439QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60439QY", "source": "G99891PR", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19615BB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G08242BT", "dp": 12 } ], "links": [ { "target": "G19615BB", "source": "G08242BT", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08242BT", "source": "G26949IX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19636RY", "error": "Missing intermediate; no pathways to [G19636RY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19668FQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99645NK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G19668FQ", "dp": 11 } ], "links": [ { "target": "G19668FQ", "source": "G99645NK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19677EK", "error": "Starting point for pathway to G19677EK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19687OL", "error": "Missing intermediate; no pathways to [G19687OL] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19697JA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G33742YO", "dp": 9 }, { "id": "G47859DD", "dp": 10 } ], "links": [ { "target": "G19697JA", "source": "G47859DD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47859DD", "source": "G33742YO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19726AG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 } ], "links": [ { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19739KB", "error": "Missing intermediate; no pathways to [G19739KB] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19740UO", "error": "Missing intermediate; no pathways to [G19740UO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75896PD]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G19747OA", "error": "Starting point for pathway to G19747OA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19763QB", "error": "Starting point for pathway to G19763QB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19778AE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07041CT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 }, { "id": "G07041CT", "dp": 13 }, { "id": "G19778AE", "dp": 13 } ], "links": [ { "target": "G19778AE", "source": "G07041CT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07041CT", "source": "G97765TT", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19782JM", "error": "Missing intermediate; no pathways to [G19782JM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97309BN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19790PJ", "error": "Starting point for pathway to G19790PJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19839OY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62504BU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G19839OY", "dp": 10 } ], "links": [ { "target": "G19839OY", "source": "G62504BU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19841IT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82942ZJ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G82942ZJ", "dp": 9 }, { "id": "G19841IT", "dp": 9 } ], "links": [ { "target": "G19841IT", "source": "G82942ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82942ZJ", "source": "G08520NM", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19843TY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 } ], "links": [ { "target": "G19843TY", "source": "G27919IH", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19854OL", "error": "Missing intermediate; no pathways to [G19854OL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19854PG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 } ], "links": [ { "target": "G19854PG", "source": "G56549DH", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19868AX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G19868AX", "source": "G39213VZ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19885CO", "error": "Missing intermediate; no pathways to [G19885CO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19886LH", "error": "Starting point for pathway to G19886LH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19894RH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G93500PH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G19894RH", "dp": 9 } ], "links": [ { "target": "G19894RH", "source": "G93500PH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19906BM", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G20096RP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G20096RP", "dp": 12 }, { "id": "G19906BM", "dp": 12 } ], "links": [ { "target": "G19906BM", "source": "G20096RP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20096RP", "source": "G25520XG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19911YR", "error": "Missing intermediate; no pathways to [G19911YR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31637BB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G19938TJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75049FP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G19938TJ", "dp": 12 } ], "links": [ { "target": "G19938TJ", "source": "G75049FP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19943KG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G74090KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G74090KZ", "dp": 7 }, { "id": "G19943KG", "dp": 7 } ], "links": [ { "target": "G19943KG", "source": "G74090KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74090KZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G19949UL", "error": "Starting point for pathway to G19949UL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19958IL", "error": "Starting point for pathway to G19958IL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G19971JJ", "error": "Missing intermediate; no pathways to [G19971JJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20018DL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G20018DL", "source": "G18938DW", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20021PB", "error": "Starting point for pathway to G20021PB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20030CU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20034RK", "error": "Starting point for pathway to G20034RK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20064NM", "error": "Starting point for pathway to G20064NM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20079RG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71013KY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G20079RG", "dp": 10 } ], "links": [ { "target": "G20079RG", "source": "G71013KY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20096RP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G20096RP", "source": "G25520XG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20140JS", "error": "Starting point for pathway to G20140JS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20160SB", "error": "Missing intermediate; no pathways to [G20160SB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20167OW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 } ], "links": [ { "target": "G20167OW", "source": "G25140TA", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20168MP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G02290KA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G02290KA", "dp": 10 }, { "id": "G20168MP", "dp": 10 } ], "links": [ { "target": "G20168MP", "source": "G02290KA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20170YB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 } ], "links": [ { "target": "G20170YB", "source": "G63585HN", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20172ET", "error": "Missing intermediate; no pathways to [G20172ET] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G43351VW]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20173ZW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G13151XE]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G20173ZW", "dp": 9 } ], "links": [ { "target": "G20173ZW", "source": "G13151XE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20174ZL", "error": "Starting point for pathway to G20174ZL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20197BG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78956IC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 }, { "id": "G78956IC", "dp": 16 }, { "id": "G20197BG", "dp": 16 } ], "links": [ { "target": "G20197BG", "source": "G78956IC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78956IC", "source": "G91413ZX", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20212GT", "error": "Starting point for pathway to G20212GT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20248TO", "error": "Starting point for pathway to G20248TO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20266PH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 } ], "links": [ { "target": "G20266PH", "source": "G84467IZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20268UK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51793MY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G51793MY", "dp": 11 }, { "id": "G20268UK", "dp": 11 } ], "links": [ { "target": "G20268UK", "source": "G51793MY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51793MY", "source": "G45560HM", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20284VH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G13156PQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G13156PQ", "dp": 12 }, { "id": "G20284VH", "dp": 12 } ], "links": [ { "target": "G20284VH", "source": "G13156PQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G13156PQ", "source": "G53752TA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20296ED", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23782KP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G23782KP", "dp": 14 }, { "id": "G20296ED", "dp": 14 } ], "links": [ { "target": "G20296ED", "source": "G23782KP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23782KP", "source": "G01727PW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20326YW", "error": "Missing intermediate; no pathways to [G20326YW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20394QS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69170UT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G69170UT", "dp": 14 }, { "id": "G20394QS", "dp": 14 } ], "links": [ { "target": "G20394QS", "source": "G69170UT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69170UT", "source": "G82050MN", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20410RW", "error": "Missing intermediate; no pathways to [G20410RW] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20426LM", "error": "Missing intermediate; no pathways to [G20426LM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10563SE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20449BJ", "error": "Starting point for pathway to G20449BJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20455AW", "error": "Missing intermediate; no pathways to [G20455AW] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G42130KX]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20463HA", "error": "Starting point for pathway to G20463HA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20512LK", "error": "Starting point for pathway to G20512LK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20532UQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27281KS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G18641OW", "dp": 11 }, { "id": "G27281KS", "dp": 12 }, { "id": "G20532UQ", "dp": 12 } ], "links": [ { "target": "G20532UQ", "source": "G27281KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27281KS", "source": "G18641OW", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18641OW", "source": "G88417ED", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20542OL", "error": "Missing intermediate; no pathways to [G20542OL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76190UX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20544CY", "error": "Missing intermediate; no pathways to [G20544CY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08493GY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20546OR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 } ], "links": [ { "target": "G20546OR", "source": "G63889NK", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20551LK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 } ], "links": [ { "target": "G20551LK", "source": "G62504BU", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20621ZX", "error": "Starting point for pathway to G20621ZX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20624LQ", "error": "Starting point for pathway to G20624LQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20636FS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25731WL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 }, { "id": "G66961CH", "dp": 15 }, { "id": "G83992YN", "dp": 16 }, { "id": "G25731WL", "dp": 17 }, { "id": "G20636FS", "dp": 17 } ], "links": [ { "target": "G20636FS", "source": "G25731WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25731WL", "source": "G83992YN", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83992YN", "source": "G66961CH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20643DZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03275SD]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G20643DZ", "dp": 10 } ], "links": [ { "target": "G20643DZ", "source": "G03275SD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20650NV", "error": "Missing intermediate; no pathways to [G20650NV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84330VA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20652MD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71704AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 }, { "id": "G71704AG", "dp": 15 }, { "id": "G20652MD", "dp": 15 } ], "links": [ { "target": "G20652MD", "source": "G71704AG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71704AG", "source": "G42686NQ", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20662UG", "error": "Missing intermediate; no pathways to [G20662UG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80943NY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20692QU", "error": "Missing intermediate; no pathways to [G20692QU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77475MM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20711NK", "error": "Missing intermediate; no pathways to [G20711NK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20720CG", "error": "Missing intermediate; no pathways to [G20720CG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20758LC", "error": "Missing intermediate; no pathways to [G20758LC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G62619LG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20794PH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14996IQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14996IQ", "dp": 8 }, { "id": "G20794PH", "dp": 8 } ], "links": [ { "target": "G20794PH", "source": "G14996IQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14996IQ", "source": "G69411IG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20815TK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 } ], "links": [ { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20847FN", "error": "Starting point for pathway to G20847FN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20873FQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G33742YO", "dp": 9 }, { "id": "G47859DD", "dp": 10 }, { "id": "G19697JA", "dp": 11 } ], "links": [ { "target": "G20873FQ", "source": "G19697JA", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19697JA", "source": "G47859DD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47859DD", "source": "G33742YO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20877ZV", "error": "Missing intermediate; no pathways to [G20877ZV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G13210XL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20885BK", "error": "Missing intermediate; no pathways to [G20885BK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20894MY", "error": "Starting point for pathway to G20894MY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20909AP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40542QP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G40542QP", "dp": 15 }, { "id": "G20909AP", "dp": 15 } ], "links": [ { "target": "G20909AP", "source": "G40542QP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40542QP", "source": "G10228OD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20924UR", "error": "Missing intermediate; no pathways to [G20924UR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G20926BB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 } ], "links": [ { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20946SK", "error": "Starting point for pathway to G20946SK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G20953SW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G19444JC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G19444JC", "dp": 15 }, { "id": "G20953SW", "dp": 15 } ], "links": [ { "target": "G20953SW", "source": "G19444JC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19444JC", "source": "G45720CA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20956ZK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20966TZ", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G20983SP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 } ], "links": [ { "target": "G20983SP", "source": "G94531EZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21005TQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14996IQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14996IQ", "dp": 8 }, { "id": "G21005TQ", "dp": 8 } ], "links": [ { "target": "G21005TQ", "source": "G14996IQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14996IQ", "source": "G69411IG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21009VI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26320VO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G26320VO", "dp": 10 }, { "id": "G21009VI", "dp": 10 } ], "links": [ { "target": "G21009VI", "source": "G26320VO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26320VO", "source": "G58667NI", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21021HG", "error": "Missing intermediate; no pathways to [G21021HG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30085SO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21050RT", "error": "Missing intermediate; no pathways to [G21050RT] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21072IJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59746QC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G59746QC", "dp": 14 }, { "id": "G21072IJ", "dp": 14 } ], "links": [ { "target": "G21072IJ", "source": "G59746QC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59746QC", "source": "G00909PI", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21100JS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G78503JC", "dp": 12 }, { "id": "G86202BL", "dp": 13 }, { "id": "G17286ZM", "dp": 14 } ], "links": [ { "target": "G21100JS", "source": "G17286ZM", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G17286ZM", "source": "G86202BL", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86202BL", "source": "G78503JC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78503JC", "source": "G31010RQ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21109OS", "error": "Missing intermediate; no pathways to [G21109OS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G21130MT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G58403SV", "dp": 11 } ], "links": [ { "target": "G21130MT", "source": "G58403SV", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G58403SV", "source": "G99270AV", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21167TN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61707PW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G74928QN", "dp": 14 }, { "id": "G61707PW", "dp": 15 }, { "id": "G21167TN", "dp": 15 } ], "links": [ { "target": "G21167TN", "source": "G61707PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61707PW", "source": "G74928QN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74928QN", "source": "G29449JO", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21203TW", "error": "Missing intermediate; no pathways to [G21203TW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21219OJ", "error": "Missing intermediate; no pathways to [G21219OJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94163JZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21246OH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G21246OH", "source": "G00176HZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21251LN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G59471TH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G21251LN", "dp": 8 } ], "links": [ { "target": "G21251LN", "source": "G59471TH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21266OX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81923ER]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G21266OX", "dp": 10 } ], "links": [ { "target": "G21266OX", "source": "G81923ER", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21270CB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46406BL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G46406BL", "dp": 12 }, { "id": "G21270CB", "dp": 12 } ], "links": [ { "target": "G21270CB", "source": "G46406BL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46406BL", "source": "G11041DA", "residue_affected": { "residue_id": "N276", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21311PN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79348ZY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G21311PN", "dp": 8 } ], "links": [ { "target": "G21311PN", "source": "G79348ZY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21311YA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G21311YA", "source": "G11041DA", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21319HP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G40906DZ", "dp": 14 } ], "links": [ { "target": "G21319HP", "source": "G40906DZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40906DZ", "source": "G18938DW", "residue_affected": { "residue_id": "N43", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21327MO", "error": "Missing intermediate; no pathways to [G21327MO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82036CW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21342EB", "error": "Starting point for pathway to G21342EB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G21343HW", "error": "Missing intermediate; no pathways to [G21343HW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40707SF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21359LU", "error": "Starting point for pathway to G21359LU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G21359NQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 } ], "links": [ { "target": "G21359NQ", "source": "G32305RZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21380FF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G68946DB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G76528ZS", "dp": 11 }, { "id": "G68946DB", "dp": 12 }, { "id": "G21380FF", "dp": 12 } ], "links": [ { "target": "G21380FF", "source": "G68946DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G68946DB", "source": "G76528ZS", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21411AR", "error": "Starting point for pathway to G21411AR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G21421NG", "error": "Missing intermediate; no pathways to [G21421NG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G43040IL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21437MZ", "error": "Missing intermediate; no pathways to [G21437MZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94679TQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21438LK", "error": "Starting point for pathway to G21438LK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G21454AE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38022PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G21454AE", "dp": 14 } ], "links": [ { "target": "G21454AE", "source": "G38022PE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21456NQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63585HN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G21456NQ", "dp": 11 } ], "links": [ { "target": "G21456NQ", "source": "G63585HN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21459ST", "error": "Missing intermediate; no pathways to [G21459ST] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21470TX", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10770RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G82033VN", "dp": 14 }, { "id": "G10770RR", "dp": 15 }, { "id": "G21470TX", "dp": 15 } ], "links": [ { "target": "G21470TX", "source": "G10770RR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10770RR", "source": "G82033VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82033VN", "source": "G20926BB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21473QQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36268TW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G36268TW", "dp": 12 }, { "id": "G21473QQ", "dp": 12 } ], "links": [ { "target": "G21473QQ", "source": "G36268TW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36268TW", "source": "G77252PU", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21498SM", "error": "Missing intermediate; no pathways to [G21498SM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21513QX", "error": "Starting point for pathway to G21513QX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G21609FV", "error": "Missing intermediate; no pathways to [G21609FV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21627CA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G09826WW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G09826WW", "dp": 11 }, { "id": "G21627CA", "dp": 11 } ], "links": [ { "target": "G21627CA", "source": "G09826WW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09826WW", "source": "G85542KD", "residue_affected": { "residue_id": "N271", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21679ID", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 } ], "links": [ { "target": "G21679ID", "source": "G52934AK", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21729HC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G18026EK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G18026EK", "dp": 12 }, { "id": "G21729HC", "dp": 12 } ], "links": [ { "target": "G21729HC", "source": "G18026EK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18026EK", "source": "G37046CZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21733DU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62880PC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G62880PC", "dp": 9 }, { "id": "G21733DU", "dp": 9 } ], "links": [ { "target": "G21733DU", "source": "G62880PC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62880PC", "source": "G59471TH", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21737WY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 } ], "links": [ { "target": "G21737WY", "source": "G94531EZ", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21755KD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 } ], "links": [ { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21756MV", "error": "Missing intermediate; no pathways to [G21756MV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21767ND", "error": "Missing intermediate; no pathways to [G21767ND] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91550OH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21788RU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G21788RU", "source": "G25520XG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21825UH", "error": "Starting point for pathway to G21825UH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G21828OD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 } ], "links": [ { "target": "G21828OD", "source": "G45359RY", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21898KP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 } ], "links": [ { "target": "G21898KP", "source": "G90870DG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21916IS", "error": "Starting point for pathway to G21916IS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G21925JZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G21925JZ", "source": "G36191CD", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21927IY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72260GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G72260GO", "dp": 12 }, { "id": "G21927IY", "dp": 12 } ], "links": [ { "target": "G21927IY", "source": "G72260GO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72260GO", "source": "G04743RS", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21928XN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69912LP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G41720HN", "dp": 8 }, { "id": "G69912LP", "dp": 9 }, { "id": "G21928XN", "dp": 9 } ], "links": [ { "target": "G21928XN", "source": "G69912LP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69912LP", "source": "G41720HN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41720HN", "source": "G07483YN", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21929YV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcNAc]", "homologous pathway end-point [G43299SD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G21929YV", "dp": 9 } ], "links": [ { "target": "G21929YV", "source": "G43299SD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21933XG", "error": "Missing intermediate; no pathways to [G21933XG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41797PU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G21969LH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G39029JR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G39029JR", "dp": 10 }, { "id": "G21969LH", "dp": 10 } ], "links": [ { "target": "G21969LH", "source": "G39029JR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39029JR", "source": "G93500PH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G21969UD", "error": "Missing intermediate; no pathways to [G21969UD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43040IL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22006DT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04829RO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 }, { "id": "G01010HW", "dp": 9 }, { "id": "G04829RO", "dp": 10 }, { "id": "G22006DT", "dp": 10 } ], "links": [ { "target": "G22006DT", "source": "G04829RO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04829RO", "source": "G01010HW", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22009DO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G68845SP", "dp": 14 } ], "links": [ { "target": "G22009DO", "source": "G68845SP", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68845SP", "source": "G18938DW", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22011DS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39408YK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G39408YK", "dp": 12 }, { "id": "G22011DS", "dp": 12 } ], "links": [ { "target": "G22011DS", "source": "G39408YK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39408YK", "source": "G25520XG", "residue_affected": { "residue_id": "N368", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22014NH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86696LV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G22014NH", "dp": 17 } ], "links": [ { "target": "G22014NH", "source": "G86696LV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22018VM", "error": "Starting point for pathway to G22018VM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22032KD", "error": "Starting point for pathway to G22032KD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22043HZ", "error": "Missing intermediate; no pathways to [G22043HZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22078MT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59471TH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G22078MT", "dp": 8 } ], "links": [ { "target": "G22078MT", "source": "G59471TH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22079SE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G68845SP", "dp": 14 } ], "links": [ { "target": "G22079SE", "source": "G68845SP", "residue_affected": { "residue_id": "N48", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68845SP", "source": "G18938DW", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22098NU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 } ], "links": [ { "target": "G22098NU", "source": "G71013KY", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22107KA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 } ], "links": [ { "target": "G22107KA", "source": "G08863NS", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22117HL", "error": "Missing intermediate; no pathways to [G22117HL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22117NA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45777DE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G26939ZY", "dp": 8 }, { "id": "G45777DE", "dp": 9 }, { "id": "G22117NA", "dp": 9 } ], "links": [ { "target": "G22117NA", "source": "G45777DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45777DE", "source": "G26939ZY", "residue_affected": { "residue_id": "N305", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G26939ZY", "source": "G39213VZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22120QI", "error": "Missing intermediate; no pathways to [G22120QI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22122FL", "error": "Starting point for pathway to G22122FL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22137KZ", "error": "Missing intermediate; no pathways to [G22137KZ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G42022OY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22146HW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78555BT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G82540VC", "dp": 8 }, { "id": "G41278YY", "dp": 9 }, { "id": "G78555BT", "dp": 10 }, { "id": "G22146HW", "dp": 10 } ], "links": [ { "target": "G22146HW", "source": "G78555BT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78555BT", "source": "G41278YY", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41278YY", "source": "G82540VC", "residue_affected": { "residue_id": "N238", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G82540VC", "source": "G39213VZ", "residue_affected": { "residue_id": "N250", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22170TU", "error": "Starting point for pathway to G22170TU could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22188XM", "error": "Missing intermediate; no pathways to [G22188XM] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G44005DK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22230QR", "error": "Missing intermediate; no pathways to [G22230QR] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G77485UZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22237ZE", "error": "Missing intermediate; no pathways to [G22237ZE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99943EE]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22246QW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65796FM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G65796FM", "dp": 13 }, { "id": "G22246QW", "dp": 13 } ], "links": [ { "target": "G22246QW", "source": "G65796FM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65796FM", "source": "G79344MI", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22254MF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 }, { "id": "G05546WG", "dp": 9 } ], "links": [ { "target": "G22254MF", "source": "G05546WG", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05546WG", "source": "G69812OF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22330AF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51490BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G22330AF", "dp": 8 } ], "links": [ { "target": "G22330AF", "source": "G51490BW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22351RY", "error": "Starting point for pathway to G22351RY could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22354SF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G00368HM", "dp": 13 }, { "id": "G07505KH", "dp": 14 } ], "links": [ { "target": "G22354SF", "source": "G07505KH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07505KH", "source": "G00368HM", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00368HM", "source": "G86357DX", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22361XJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 } ], "links": [ { "target": "G22361XJ", "source": "G04791QM", "residue_affected": { "residue_id": "N267", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22375QZ", "error": "Missing intermediate; no pathways to [G22375QZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80717KS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22387ST", "error": "Starting point for pathway to G22387ST could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22388FD", "error": "Missing intermediate; no pathways to [G22388FD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22432GF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88461FF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G22432GF", "dp": 9 } ], "links": [ { "target": "G22432GF", "source": "G88461FF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22437MC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77537OB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G77537OB", "dp": 11 }, { "id": "G22437MC", "dp": 11 } ], "links": [ { "target": "G22437MC", "source": "G77537OB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77537OB", "source": "G03445UI", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22444UV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74120DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G22444UV", "dp": 12 } ], "links": [ { "target": "G22444UV", "source": "G74120DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22457TG", "error": "Missing intermediate; no pathways to [G22457TG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43040IL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22467XI", "error": "Starting point for pathway to G22467XI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22477EB", "error": "Starting point for pathway to G22477EB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22486LT", "error": "Missing intermediate; no pathways to [G22486LT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84879CH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22487WN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G12061IK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G22487WN", "dp": 11 } ], "links": [ { "target": "G22487WN", "source": "G12061IK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22511JU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23824AT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G23824AT", "dp": 11 }, { "id": "G22511JU", "dp": 11 } ], "links": [ { "target": "G22511JU", "source": "G23824AT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23824AT", "source": "G56591LC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22550VJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 } ], "links": [ { "target": "G22550VJ", "source": "G45262QY", "residue_affected": { "residue_id": "N135", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22558JP", "error": "Missing intermediate; no pathways to [G22558JP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22571UF", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G83594ZB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G11929CD", "dp": 10 }, { "id": "G26795PW", "dp": 11 }, { "id": "G83594ZB", "dp": 12 }, { "id": "G22571UF", "dp": 12 } ], "links": [ { "target": "G22571UF", "source": "G83594ZB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G83594ZB", "source": "G26795PW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26795PW", "source": "G11929CD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929CD", "source": "G09782JM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22576RV", "error": "Missing intermediate; no pathways to [G22576RV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22587DK", "error": "Starting point for pathway to G22587DK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22599MH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52663AD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G22599MH", "dp": 9 } ], "links": [ { "target": "G22599MH", "source": "G52663AD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22678XU", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G17264LS", "dp": 10 } ], "links": [ { "target": "G22678XU", "source": "G17264LS", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17264LS", "source": "G16828VN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22686TA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98366ZJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G98366ZJ", "dp": 14 }, { "id": "G22686TA", "dp": 14 } ], "links": [ { "target": "G22686TA", "source": "G98366ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98366ZJ", "source": "G99074EO", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22728HO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G54584ER", "dp": 14 } ], "links": [ { "target": "G22728HO", "source": "G54584ER", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G54584ER", "source": "G18938DW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22731HP", "error": "Missing intermediate; no pathways to [G22731HP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22732WO", "error": "Missing intermediate; no pathways to [G22732WO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22754FQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G56749GV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G22754FQ", "dp": 12 } ], "links": [ { "target": "G22754FQ", "source": "G56749GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22768VO", "error": "Starting point for pathway to G22768VO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22795QB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 } ], "links": [ { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22836DF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59655SA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G59655SA", "dp": 12 }, { "id": "G22836DF", "dp": 12 } ], "links": [ { "target": "G22836DF", "source": "G59655SA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59655SA", "source": "G53752TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22864HF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88468EP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G29706UC", "dp": 10 }, { "id": "G88468EP", "dp": 11 }, { "id": "G22864HF", "dp": 11 } ], "links": [ { "target": "G22864HF", "source": "G88468EP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88468EP", "source": "G29706UC", "residue_affected": { "residue_id": "N484", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G29706UC", "source": "G58667NI", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22864KB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80294GH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G22864KB", "dp": 13 } ], "links": [ { "target": "G22864KB", "source": "G80294GH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22865RK", "error": "Missing intermediate; no pathways to [G22865RK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22893QE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25140TA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G22893QE", "dp": 11 } ], "links": [ { "target": "G22893QE", "source": "G25140TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22898PA", "error": "Starting point for pathway to G22898PA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22912TT", "error": "Missing intermediate; no pathways to [G22912TT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39601JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22914HB", "error": "Starting point for pathway to G22914HB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22920IO", "error": "Missing intermediate; no pathways to [G22920IO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G67173FM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22927MQ", "error": "Missing intermediate; no pathways to [G22927MQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58768FH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22928ZH", "error": "Missing intermediate; no pathways to [G22928ZH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22945AJ", "error": "Starting point for pathway to G22945AJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G22946YB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93107BF]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G93107BF", "dp": 11 }, { "id": "G22946YB", "dp": 11 } ], "links": [ { "target": "G22946YB", "source": "G93107BF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93107BF", "source": "G11637WL", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G22949KX", "error": "Missing intermediate; no pathways to [G22949KX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20711NK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G22979QH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28948UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G28948UC", "dp": 12 }, { "id": "G22979QH", "dp": 12 } ], "links": [ { "target": "G22979QH", "source": "G28948UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28948UC", "source": "G10691MJ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23002WE", "error": "Missing intermediate; no pathways to [G23002WE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23013VP", "error": "Missing intermediate; no pathways to [G23013VP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G55314RK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23023HU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30370YC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G23023HU", "dp": 9 } ], "links": [ { "target": "G23023HU", "source": "G30370YC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23026QZ", "error": "Missing intermediate; no pathways to [G23026QZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23036BB", "error": "Starting point for pathway to G23036BB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23060KN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 } ], "links": [ { "target": "G23060KN", "source": "G09446VC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23117SI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G69812OF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 }, { "id": "G23117SI", "dp": 8 } ], "links": [ { "target": "G23117SI", "source": "G69812OF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23134YS", "error": "Starting point for pathway to G23134YS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23134ZR", "error": "Missing intermediate; no pathways to [G23134ZR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30627OI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23142YD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G84852GW", "dp": 9 } ], "links": [ { "target": "G23142YD", "source": "G84852GW", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G84852GW", "source": "G12398HZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23151RC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 } ], "links": [ { "target": "G23151RC", "source": "G17689DH", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23166NU", "error": "Missing intermediate; no pathways to [G23166NU] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23176IZ", "error": "Starting point for pathway to G23176IZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23210FC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G18026EK", "dp": 12 }, { "id": "G43073RP", "dp": 13 } ], "links": [ { "target": "G23210FC", "source": "G43073RP", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43073RP", "source": "G18026EK", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18026EK", "source": "G37046CZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23290TL", "error": "Missing intermediate; no pathways to [G23290TL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23295TF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 } ], "links": [ { "target": "G23295TF", "source": "G27919IH", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23296IL", "error": "Missing intermediate; no pathways to [G23296IL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00662IB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23340ZN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G71835BN", "dp": 10 }, { "id": "G01378OV", "dp": 11 } ], "links": [ { "target": "G23340ZN", "source": "G01378OV", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01378OV", "source": "G71835BN", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23342BO", "error": "Starting point for pathway to G23342BO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23345GE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 } ], "links": [ { "target": "G23345GE", "source": "G42686NQ", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23377WN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G03864MI", "dp": 11 } ], "links": [ { "target": "G23377WN", "source": "G03864MI", "residue_affected": { "residue_id": "N483", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G03864MI", "source": "G78059CC", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23416CI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G04743RS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G23416CI", "dp": 11 } ], "links": [ { "target": "G23416CI", "source": "G04743RS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23416IW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G67782JV", "dp": 12 } ], "links": [ { "target": "G23416IW", "source": "G67782JV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67782JV", "source": "G35310KA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23416VJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19019TY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 }, { "id": "G19019TY", "dp": 11 }, { "id": "G23416VJ", "dp": 11 } ], "links": [ { "target": "G23416VJ", "source": "G19019TY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19019TY", "source": "G09670SR", "residue_affected": { "residue_id": "N72", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23419AQ", "error": "Missing intermediate; no pathways to [G23419AQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23436FC", "error": "Missing intermediate; no pathways to [G23436FC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23456BB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38022PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G23456BB", "dp": 14 } ], "links": [ { "target": "G23456BB", "source": "G38022PE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23458QH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G66572SF", "dp": 13 } ], "links": [ { "target": "G23458QH", "source": "G66572SF", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G66572SF", "source": "G48658PB", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23484GM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G69086TY", "dp": 12 }, { "id": "G42400JK", "dp": 13 } ], "links": [ { "target": "G23484GM", "source": "G42400JK", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42400JK", "source": "G69086TY", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23511JD", "error": "Missing intermediate; no pathways to [G23511JD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23520SQ", "error": "Starting point for pathway to G23520SQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23529DA", "error": "Missing intermediate; no pathways to [G23529DA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42175IR]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G23546LY", "error": "Missing intermediate; no pathways to [G23546LY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23572BH", "error": "Starting point for pathway to G23572BH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23577TY", "error": "Missing intermediate; no pathways to [G23577TY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23581SB", "error": "Missing intermediate; no pathways to [G23581SB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23598DU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G70511VE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G70511VE", "dp": 12 }, { "id": "G23598DU", "dp": 12 } ], "links": [ { "target": "G23598DU", "source": "G70511VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70511VE", "source": "G53752TA", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23601EL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G33742YO", "dp": 9 } ], "links": [ { "target": "G23601EL", "source": "G33742YO", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23616ZX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 } ], "links": [ { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23626NI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 } ], "links": [ { "target": "G23626NI", "source": "G85542KD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23647WB", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G30553WH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G30553WH", "dp": 9 }, { "id": "G23647WB", "dp": 9 } ], "links": [ { "target": "G23647WB", "source": "G30553WH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30553WH", "source": "G20956ZK", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23667XV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82779CI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G23667XV", "dp": 11 } ], "links": [ { "target": "G23667XV", "source": "G82779CI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23709VK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G82357WL", "dp": 11 } ], "links": [ { "target": "G23709VK", "source": "G82357WL", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82357WL", "source": "G28826SH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23711JB", "error": "Starting point for pathway to G23711JB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23718VU", "error": "Missing intermediate; no pathways to [G23718VU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23722TU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G83926PC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 }, { "id": "G01354KL", "dp": 14 }, { "id": "G83926PC", "dp": 15 }, { "id": "G23722TU", "dp": 15 } ], "links": [ { "target": "G23722TU", "source": "G83926PC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G83926PC", "source": "G01354KL", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23726CO", "error": "Missing intermediate; no pathways to [G23726CO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59159PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23765TI", "error": "Starting point for pathway to G23765TI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23768VY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76075NA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G76075NA", "dp": 12 }, { "id": "G23768VY", "dp": 12 } ], "links": [ { "target": "G23768VY", "source": "G76075NA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76075NA", "source": "G90870DG", "residue_affected": { "residue_id": "N62", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23770JR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G23770JR", "source": "G36191CD", "residue_affected": { "residue_id": "N299", "pubchem_name": "Fuc", "anomer": "b", "absolute": "L", "form_name": "Fucp", "full_name": "β-L-Fucp" }, "effect": "Add β-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23782KP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 } ], "links": [ { "target": "G23782KP", "source": "G01727PW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23795SX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G69600TI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G69600TI", "dp": 9 }, { "id": "G23795SX", "dp": 9 } ], "links": [ { "target": "G23795SX", "source": "G69600TI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69600TI", "source": "G64669AQ", "residue_affected": { "residue_id": "N477", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylf", "full_name": "β-D-Xylf" }, "effect": "Add β-D-Xylf", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G23799GS", "error": "Starting point for pathway to G23799GS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23805AC", "error": "Starting point for pathway to G23805AC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23817OE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25326BM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G25326BM", "dp": 9 }, { "id": "G23817OE", "dp": 9 } ], "links": [ { "target": "G23817OE", "source": "G25326BM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25326BM", "source": "G89993FE", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23819TW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93582HM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G23819TW", "dp": 13 } ], "links": [ { "target": "G23819TW", "source": "G93582HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23824AT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 } ], "links": [ { "target": "G23824AT", "source": "G56591LC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23824XF", "error": "Starting point for pathway to G23824XF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23897ET", "error": "Missing intermediate; no pathways to [G23897ET] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78980OK]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G23901NY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 } ], "links": [ { "target": "G23901NY", "source": "G52934AK", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23914JN", "error": "Missing intermediate; no pathways to [G23914JN] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G23934WD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G52770HR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G52770HR", "dp": 10 }, { "id": "G23934WD", "dp": 10 } ], "links": [ { "target": "G23934WD", "source": "G52770HR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52770HR", "source": "G36191CD", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23936EH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 } ], "links": [ { "target": "G23936EH", "source": "G32065BG", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G23946TS", "error": "Starting point for pathway to G23946TS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23949TZ", "error": "Starting point for pathway to G23949TZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G23980PE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72718TT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G23980PE", "dp": 9 } ], "links": [ { "target": "G23980PE", "source": "G72718TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24046UO", "error": "Missing intermediate; no pathways to [G24046UO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40341NV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24074HE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10989IB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 }, { "id": "G31004HS", "dp": 18 }, { "id": "G10989IB", "dp": 19 }, { "id": "G24074HE", "dp": 19 } ], "links": [ { "target": "G24074HE", "source": "G10989IB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10989IB", "source": "G31004HS", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24083XE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 } ], "links": [ { "target": "G24083XE", "source": "G82252QI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24084TY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17540HT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G17540HT", "dp": 12 }, { "id": "G24084TY", "dp": 12 } ], "links": [ { "target": "G24084TY", "source": "G17540HT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17540HT", "source": "G30460NZ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24092TN", "error": "Missing intermediate; no pathways to [G24092TN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24094XC", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G93265QH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G57117TO", "dp": 8 }, { "id": "G93265QH", "dp": 9 }, { "id": "G24094XC", "dp": 9 } ], "links": [ { "target": "G24094XC", "source": "G93265QH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93265QH", "source": "G57117TO", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G57117TO", "source": "G69411IG", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24095BS", "error": "Missing intermediate; no pathways to [G24095BS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24121ID", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32305RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G24121ID", "dp": 10 } ], "links": [ { "target": "G24121ID", "source": "G32305RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24122ZI", "error": "Missing intermediate; no pathways to [G24122ZI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60227QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24125FE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21737WY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 }, { "id": "G21737WY", "dp": 19 }, { "id": "G24125FE", "dp": 19 } ], "links": [ { "target": "G24125FE", "source": "G21737WY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21737WY", "source": "G94531EZ", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24155DW", "error": "Missing intermediate; no pathways to [G24155DW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24163SS", "error": "Missing intermediate; no pathways to [G24163SS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24172SG", "error": "Starting point for pathway to G24172SG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24203FO", "error": "Missing intermediate; no pathways to [G24203FO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74074HU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24226KZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G15828WB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G88382QE", "dp": 14 }, { "id": "G15828WB", "dp": 15 }, { "id": "G24226KZ", "dp": 15 } ], "links": [ { "target": "G24226KZ", "source": "G15828WB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G15828WB", "source": "G88382QE", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88382QE", "source": "G18938DW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24229GD", "error": "Missing intermediate; no pathways to [G24229GD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47384NK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24275AM", "error": "Starting point for pathway to G24275AM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24284HU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88928GI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G88928GI", "dp": 12 }, { "id": "G24284HU", "dp": 12 } ], "links": [ { "target": "G24284HU", "source": "G88928GI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88928GI", "source": "G11041DA", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24284KU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G15998WM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G15998WM", "dp": 17 }, { "id": "G24284KU", "dp": 17 } ], "links": [ { "target": "G24284KU", "source": "G15998WM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G15998WM", "source": "G79950YS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24292VT", "error": "Missing intermediate; no pathways to [G24292VT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93464IM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G24305IZ", "error": "Starting point for pathway to G24305IZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24327OK", "error": "Missing intermediate; no pathways to [G24327OK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24329OK", "error": "Starting point for pathway to G24329OK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24336IA", "error": "Missing intermediate; no pathways to [G24336IA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65867II]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24338MH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79344MI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G24338MH", "dp": 12 } ], "links": [ { "target": "G24338MH", "source": "G79344MI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24346JZ", "error": "Missing intermediate; no pathways to [G24346JZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57675TR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24355OK", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G15828WB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G88382QE", "dp": 14 }, { "id": "G15828WB", "dp": 15 }, { "id": "G24355OK", "dp": 15 } ], "links": [ { "target": "G24355OK", "source": "G15828WB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G15828WB", "source": "G88382QE", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88382QE", "source": "G18938DW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24364HL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23060KN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G23060KN", "dp": 11 }, { "id": "G24364HL", "dp": 11 } ], "links": [ { "target": "G24364HL", "source": "G23060KN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23060KN", "source": "G09446VC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24366XJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88948CY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G24366XJ", "dp": 11 } ], "links": [ { "target": "G24366XJ", "source": "G88948CY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24402OX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G66098KC", "dp": 14 } ], "links": [ { "target": "G24402OX", "source": "G66098KC", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66098KC", "source": "G18938DW", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24413UY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 } ], "links": [ { "target": "G24413UY", "source": "G78890OB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24420RT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24465EF", "error": "Missing intermediate; no pathways to [G24465EF] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24517QL", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G16201LW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14996IQ", "dp": 8 }, { "id": "G16201LW", "dp": 9 }, { "id": "G24517QL", "dp": 9 } ], "links": [ { "target": "G24517QL", "source": "G16201LW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16201LW", "source": "G14996IQ", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G14996IQ", "source": "G69411IG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24529UD", "error": "Starting point for pathway to G24529UD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24546DC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91905FJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G24546DC", "dp": 14 } ], "links": [ { "target": "G24546DC", "source": "G91905FJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24552KE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G01727PW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G24552KE", "dp": 13 } ], "links": [ { "target": "G24552KE", "source": "G01727PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24585JV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G04791QM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G24585JV", "dp": 9 } ], "links": [ { "target": "G24585JV", "source": "G04791QM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24596WC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19868AX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G19868AX", "dp": 8 }, { "id": "G24596WC", "dp": 8 } ], "links": [ { "target": "G24596WC", "source": "G19868AX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19868AX", "source": "G39213VZ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24599MW", "error": "Starting point for pathway to G24599MW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24604HV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29857RC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G24604HV", "dp": 11 } ], "links": [ { "target": "G24604HV", "source": "G29857RC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24620AI", "error": "Starting point for pathway to G24620AI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24622ZA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33862NZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G90703DJ", "dp": 13 }, { "id": "G33862NZ", "dp": 14 }, { "id": "G24622ZA", "dp": 14 } ], "links": [ { "target": "G24622ZA", "source": "G33862NZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33862NZ", "source": "G90703DJ", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G90703DJ", "source": "G74120DW", "residue_affected": { "residue_id": "N295", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24630CF", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G45664QZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 }, { "id": "G45664QZ", "dp": 13 }, { "id": "G24630CF", "dp": 13 } ], "links": [ { "target": "G24630CF", "source": "G45664QZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45664QZ", "source": "G81432SH", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24635ZS", "error": "Missing intermediate; no pathways to [G24635ZS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24657IT", "error": "Starting point for pathway to G24657IT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24668UI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G28550OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G24668UI", "dp": 9 } ], "links": [ { "target": "G24668UI", "source": "G28550OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24674CB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93060PS]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G93060PS", "dp": 9 }, { "id": "G24674CB", "dp": 9 } ], "links": [ { "target": "G24674CB", "source": "G93060PS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93060PS", "source": "G08520NM", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24687JM", "error": "Missing intermediate; no pathways to [G24687JM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11010AN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24700EX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G27802LV", "dp": 10 } ], "links": [ { "target": "G24700EX", "source": "G27802LV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27802LV", "source": "G36191CD", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24705DL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G73759SD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G73759SD", "dp": 13 }, { "id": "G24705DL", "dp": 13 } ], "links": [ { "target": "G24705DL", "source": "G73759SD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73759SD", "source": "G96963QG", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24739VM", "error": "Starting point for pathway to G24739VM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24748QU", "error": "Missing intermediate; no pathways to [G24748QU] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24752UA", "error": "Starting point for pathway to G24752UA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24754HF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G04576KS", "dp": 10 } ], "links": [ { "target": "G24754HF", "source": "G04576KS", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G04576KS", "source": "G16828VN", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24758NZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G31220IW]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G30588SI", "dp": 9 }, { "id": "G32319IP", "dp": 10 }, { "id": "G31220IW", "dp": 11 }, { "id": "G24758NZ", "dp": 11 } ], "links": [ { "target": "G24758NZ", "source": "G31220IW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31220IW", "source": "G32319IP", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32319IP", "source": "G30588SI", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30588SI", "source": "G08520NM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24766QM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79578JB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G24766QM", "dp": 12 } ], "links": [ { "target": "G24766QM", "source": "G79578JB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24767EG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G78661LW", "dp": 11 } ], "links": [ { "target": "G24767EG", "source": "G78661LW", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78661LW", "source": "G32201IL", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24769QK", "error": "Starting point for pathway to G24769QK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24791UN", "error": "Starting point for pathway to G24791UN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24796HF", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G12504XV", "dp": 9 } ], "links": [ { "target": "G24796HF", "source": "G12504XV", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12504XV", "source": "G08520NM", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G24797UH", "error": "Starting point for pathway to G24797UH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24811FP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80147LG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G80147LG", "dp": 10 }, { "id": "G24811FP", "dp": 10 } ], "links": [ { "target": "G24811FP", "source": "G80147LG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80147LG", "source": "G27919IH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24812WY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G05151WT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G05151WT", "dp": 12 }, { "id": "G24812WY", "dp": 12 } ], "links": [ { "target": "G24812WY", "source": "G05151WT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05151WT", "source": "G59877NF", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24816DA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G49305IN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G49305IN", "dp": 18 }, { "id": "G24816DA", "dp": 18 } ], "links": [ { "target": "G24816DA", "source": "G49305IN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49305IN", "source": "G86696LV", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24857FO", "error": "Missing intermediate; no pathways to [G24857FO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79010UT]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24867FR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37385TT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 }, { "id": "G24867FR", "dp": 11 } ], "links": [ { "target": "G24867FR", "source": "G37385TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24870CO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79344MI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G24870CO", "dp": 12 } ], "links": [ { "target": "G24870CO", "source": "G79344MI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24875YE", "error": "Missing intermediate; no pathways to [G24875YE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24888ZY", "error": "Missing intermediate; no pathways to [G24888ZY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G24920KE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G00368HM", "dp": 13 } ], "links": [ { "target": "G24920KE", "source": "G00368HM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00368HM", "source": "G86357DX", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24921TW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G24921TW", "source": "G29011JC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24936MG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G97895RK", "dp": 13 } ], "links": [ { "target": "G24936MG", "source": "G97895RK", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97895RK", "source": "G79578JB", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24984RR", "error": "Missing intermediate; no pathways to [G24984RR] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G24987DS", "error": "Starting point for pathway to G24987DS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G24990UB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93107BF]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G93107BF", "dp": 11 }, { "id": "G24990UB", "dp": 11 } ], "links": [ { "target": "G24990UB", "source": "G93107BF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93107BF", "source": "G11637WL", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G24994OK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G24994OK", "source": "G07483YN", "residue_affected": { "residue_id": "N275", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25000QN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30404XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G53000RQ", "dp": 11 }, { "id": "G38951VC", "dp": 12 }, { "id": "G30404XZ", "dp": 13 }, { "id": "G25000QN", "dp": 13 } ], "links": [ { "target": "G25000QN", "source": "G30404XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30404XZ", "source": "G38951VC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38951VC", "source": "G53000RQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25023DC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66937TJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G25023DC", "dp": 8 } ], "links": [ { "target": "G25023DC", "source": "G66937TJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25027GY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92024SL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G25027GY", "dp": 7 } ], "links": [ { "target": "G25027GY", "source": "G92024SL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25095HH", "error": "Starting point for pathway to G25095HH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25096GQ", "error": "Missing intermediate; no pathways to [G25096GQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26080SE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25097RR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 } ], "links": [ { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25132GJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G36523TZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G36523TZ", "dp": 12 }, { "id": "G25132GJ", "dp": 12 } ], "links": [ { "target": "G25132GJ", "source": "G36523TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36523TZ", "source": "G29857RC", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25140TA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 } ], "links": [ { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25142NH", "error": "Missing intermediate; no pathways to [G25142NH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25162JS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G69411IG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G25162JS", "dp": 7 } ], "links": [ { "target": "G25162JS", "source": "G69411IG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25164XM", "error": "Starting point for pathway to G25164XM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25173WC", "error": "Missing intermediate; no pathways to [G25173WC] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25200CR", "error": "Missing intermediate; no pathways to [G25200CR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25224QY", "error": "Missing intermediate; no pathways to [G25224QY] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G21756MV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25228LR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00413UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G00413UF", "dp": 13 }, { "id": "G25228LR", "dp": 13 } ], "links": [ { "target": "G25228LR", "source": "G00413UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00413UF", "source": "G84376FR", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25280VW", "error": "Starting point for pathway to G25280VW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25290DT", "error": "Missing intermediate; no pathways to [G25290DT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25317UI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20096RP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G20096RP", "dp": 12 }, { "id": "G25317UI", "dp": 12 } ], "links": [ { "target": "G25317UI", "source": "G20096RP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20096RP", "source": "G25520XG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25322UQ", "error": "Missing intermediate; no pathways to [G25322UQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G48109OV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25325YE", "error": "Starting point for pathway to G25325YE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25326BM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 } ], "links": [ { "target": "G25326BM", "source": "G89993FE", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25328BM", "error": "Starting point for pathway to G25328BM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25350TT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G59361OW", "dp": 11 } ], "links": [ { "target": "G25350TT", "source": "G59361OW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59361OW", "source": "G44946WH", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25391SS", "error": "Starting point for pathway to G25391SS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25392ZR", "error": "Missing intermediate; no pathways to [G25392ZR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25406HP", "error": "Missing intermediate; no pathways to [G25406HP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25407RZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 } ], "links": [ { "target": "G25407RZ", "source": "G65597BI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25423CA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32659RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G32659RY", "dp": 12 }, { "id": "G25423CA", "dp": 12 } ], "links": [ { "target": "G25423CA", "source": "G32659RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32659RY", "source": "G59877NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25426CZ", "error": "Starting point for pathway to G25426CZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25426UG", "error": "Missing intermediate; no pathways to [G25426UG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25429RR", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G32611KT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G25429RR", "dp": 8 } ], "links": [ { "target": "G25429RR", "source": "G32611KT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25457IZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G01935FK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G01935FK", "dp": 10 }, { "id": "G25457IZ", "dp": 10 } ], "links": [ { "target": "G25457IZ", "source": "G01935FK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01935FK", "source": "G36191CD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25460BQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42686NQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 }, { "id": "G25460BQ", "dp": 14 } ], "links": [ { "target": "G25460BQ", "source": "G42686NQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25461TF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74438AB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G74438AB", "dp": 12 }, { "id": "G25461TF", "dp": 12 } ], "links": [ { "target": "G25461TF", "source": "G74438AB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74438AB", "source": "G34905OT", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25463XU", "error": "Starting point for pathway to G25463XU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25471TG", "error": "Missing intermediate; no pathways to [G25471TG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25471TR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G25471TR", "source": "G91365ZQ", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25473LQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G19868AX", "dp": 8 } ], "links": [ { "target": "G25473LQ", "source": "G19868AX", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19868AX", "source": "G39213VZ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25495SR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G70374KJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G70374KJ", "dp": 11 }, { "id": "G25495SR", "dp": 11 } ], "links": [ { "target": "G25495SR", "source": "G70374KJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70374KJ", "source": "G88417ED", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25497SH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 } ], "links": [ { "target": "G25497SH", "source": "G43299SD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25505NO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 }, { "id": "G80986RU", "dp": 13 } ], "links": [ { "target": "G25505NO", "source": "G80986RU", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80986RU", "source": "G81432SH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25505UF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 } ], "links": [ { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25520XG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 } ], "links": [ { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25574DU", "error": "Starting point for pathway to G25574DU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25596NP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 }, { "id": "G01010HW", "dp": 9 } ], "links": [ { "target": "G25596NP", "source": "G01010HW", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25612NR", "error": "Starting point for pathway to G25612NR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25632TA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G97947UQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G14047PA", "dp": 11 }, { "id": "G97947UQ", "dp": 12 }, { "id": "G25632TA", "dp": 12 } ], "links": [ { "target": "G25632TA", "source": "G97947UQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97947UQ", "source": "G14047PA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14047PA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25640AW", "error": "Starting point for pathway to G25640AW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25666BX", "error": "Starting point for pathway to G25666BX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25700EP", "error": "Missing intermediate; no pathways to [G25700EP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25708TD", "error": "Starting point for pathway to G25708TD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25731WL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 }, { "id": "G66961CH", "dp": 15 }, { "id": "G83992YN", "dp": 16 } ], "links": [ { "target": "G25731WL", "source": "G83992YN", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83992YN", "source": "G66961CH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25744PP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10209QU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G25744PP", "dp": 8 } ], "links": [ { "target": "G25744PP", "source": "G10209QU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25757VW", "error": "Starting point for pathway to G25757VW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25787HL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G02290KA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G02290KA", "dp": 10 }, { "id": "G25787HL", "dp": 10 } ], "links": [ { "target": "G25787HL", "source": "G02290KA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25804NU", "error": "Missing intermediate; no pathways to [G25804NU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40909AN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25827FI", "error": "Starting point for pathway to G25827FI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25830EV", "error": "Missing intermediate; no pathways to [G25830EV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13585JF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25835MT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 } ], "links": [ { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25853OY", "error": "Missing intermediate; no pathways to [G25853OY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76190UX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25886YT", "error": "Missing intermediate; no pathways to [G25886YT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25890BU", "error": "Missing intermediate; no pathways to [G25890BU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G02025MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25902AL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45209NR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G45209NR", "dp": 15 }, { "id": "G25902AL", "dp": 15 } ], "links": [ { "target": "G25902AL", "source": "G45209NR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45209NR", "source": "G91905FJ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G25902PW", "error": "Starting point for pathway to G25902PW could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G25926OL", "error": "Missing intermediate; no pathways to [G25926OL] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G25984CA", "error": "Starting point for pathway to G25984CA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26016BX", "error": "Starting point for pathway to G26016BX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26018HD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 } ], "links": [ { "target": "G26018HD", "source": "G90870DG", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26027SF", "error": "Missing intermediate; no pathways to [G26027SF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26068PU", "error": "Missing intermediate; no pathways to [G26068PU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71906BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26069FK", "error": "Missing intermediate; no pathways to [G26069FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G26072HQ", "error": "Missing intermediate; no pathways to [G26072HQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G18157KC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26080SE", "error": "Missing intermediate; no pathways to [G26080SE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26081RR", "error": "Starting point for pathway to G26081RR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26106YB", "error": "Missing intermediate; no pathways to [G26106YB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71972AT]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G26137IM", "error": "Missing intermediate; no pathways to [G26137IM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26150FI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G37046CZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G26150FI", "dp": 11 } ], "links": [ { "target": "G26150FI", "source": "G37046CZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26153IK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36519NW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G36519NW", "dp": 13 }, { "id": "G26153IK", "dp": 13 } ], "links": [ { "target": "G26153IK", "source": "G36519NW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36519NW", "source": "G01669LU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26160AS", "error": "Missing intermediate; no pathways to [G26160AS] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G85768QF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26179TW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39377DE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G39377DE", "dp": 11 }, { "id": "G26179TW", "dp": 11 } ], "links": [ { "target": "G26179TW", "source": "G39377DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39377DE", "source": "G09921WG", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26182BM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26206DX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52336LJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G52336LJ", "dp": 12 }, { "id": "G26206DX", "dp": 12 } ], "links": [ { "target": "G26206DX", "source": "G52336LJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52336LJ", "source": "G30302VM", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26215AL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G49827WK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G49827WK", "dp": 11 }, { "id": "G26215AL", "dp": 11 } ], "links": [ { "target": "G26215AL", "source": "G49827WK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49827WK", "source": "G09446VC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26255AN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G26274XD", "dp": 11 } ], "links": [ { "target": "G26255AN", "source": "G26274XD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26274XD", "source": "G08187GM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26264SQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 } ], "links": [ { "target": "G26264SQ", "source": "G42028DN", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26274XD", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 } ], "links": [ { "target": "G26274XD", "source": "G08187GM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26275JI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09446VC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G26275JI", "dp": 10 } ], "links": [ { "target": "G26275JI", "source": "G09446VC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26295XE", "error": "Starting point for pathway to G26295XE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26298FT", "error": "Missing intermediate; no pathways to [G26298FT] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26299SM", "error": "Starting point for pathway to G26299SM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26320VO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 } ], "links": [ { "target": "G26320VO", "source": "G58667NI", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26347KH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88127MB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G88127MB", "dp": 13 }, { "id": "G26347KH", "dp": 13 } ], "links": [ { "target": "G26347KH", "source": "G88127MB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88127MB", "source": "G74120DW", "residue_affected": { "residue_id": "N46", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26357WC", "error": "Missing intermediate; no pathways to [G26357WC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26391HA", "error": "Starting point for pathway to G26391HA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26394UA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08242BT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G08242BT", "dp": 12 }, { "id": "G26394UA", "dp": 12 } ], "links": [ { "target": "G26394UA", "source": "G08242BT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08242BT", "source": "G26949IX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26397JS", "error": "Starting point for pathway to G26397JS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26458UO", "error": "Starting point for pathway to G26458UO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26474XX", "error": "Starting point for pathway to G26474XX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26501HM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82050MN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G26501HM", "dp": 13 } ], "links": [ { "target": "G26501HM", "source": "G82050MN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26508HK", "error": "Starting point for pathway to G26508HK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26520QU", "error": "Missing intermediate; no pathways to [G26520QU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11671GQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26529EC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 }, { "id": "G16451PE", "dp": 11 } ], "links": [ { "target": "G26529EC", "source": "G16451PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16451PE", "source": "G45365RV", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26534TO", "error": "Starting point for pathway to G26534TO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26537DD", "error": "Missing intermediate; no pathways to [G26537DD] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G85106DS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26566WH", "error": "Missing intermediate; no pathways to [G26566WH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G26580QL", "error": "Missing intermediate; no pathways to [G26580QL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26600PV", "error": "Missing intermediate; no pathways to [G26600PV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26629TM", "error": "Starting point for pathway to G26629TM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26640MK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85180ML]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G85180ML", "dp": 10 }, { "id": "G26640MK", "dp": 10 } ], "links": [ { "target": "G26640MK", "source": "G85180ML", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85180ML", "source": "G96063MG", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26664GH", "error": "Starting point for pathway to G26664GH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26681GV", "error": "Starting point for pathway to G26681GV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26703BH", "error": "Missing intermediate; no pathways to [G26703BH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26709HU", "error": "Missing intermediate; no pathways to [G26709HU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26713RV", "error": "Missing intermediate; no pathways to [G26713RV] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G16600BL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26714JN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80537QW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G80537QW", "dp": 14 }, { "id": "G26714JN", "dp": 14 } ], "links": [ { "target": "G26714JN", "source": "G80537QW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80537QW", "source": "G93582HM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26730QM", "error": "Missing intermediate; no pathways to [G26730QM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86377SM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26739XH", "error": "Missing intermediate; no pathways to [G26739XH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99943EE]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26756UI", "error": "Starting point for pathway to G26756UI could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26756VT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 } ], "links": [ { "target": "G26756VT", "source": "G08863NS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26762AY", "error": "Starting point for pathway to G26762AY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26795PW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G11929CD", "dp": 10 } ], "links": [ { "target": "G26795PW", "source": "G11929CD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929CD", "source": "G09782JM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26800YB", "error": "Starting point for pathway to G26800YB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26802BO", "error": "Missing intermediate; no pathways to [G26802BO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81096RM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26814OZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88948CY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G26814OZ", "dp": 11 } ], "links": [ { "target": "G26814OZ", "source": "G88948CY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26844MI", "error": "Missing intermediate; no pathways to [G26844MI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26877LE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G66572SF", "dp": 13 } ], "links": [ { "target": "G26877LE", "source": "G66572SF", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66572SF", "source": "G48658PB", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26877ST", "error": "Starting point for pathway to G26877ST could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26881SV", "error": "Missing intermediate; no pathways to [G26881SV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26892SG", "error": "Missing intermediate; no pathways to [G26892SG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26897XI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 } ], "links": [ { "target": "G26897XI", "source": "G06969ZX", "residue_affected": { "residue_id": "N299", "pubchem_name": "Fuc", "anomer": "b", "absolute": "L", "form_name": "Fucp", "full_name": "β-L-Fucp" }, "effect": "Add β-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26935KA", "error": "Missing intermediate; no pathways to [G26935KA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G26939ZY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G26939ZY", "source": "G39213VZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26949BV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01378OV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G71835BN", "dp": 10 }, { "id": "G01378OV", "dp": 11 }, { "id": "G26949BV", "dp": 11 } ], "links": [ { "target": "G26949BV", "source": "G01378OV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01378OV", "source": "G71835BN", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26949IX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G26983WI", "error": "Starting point for pathway to G26983WI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G26985TZ", "error": "Starting point for pathway to G26985TZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27025JP", "error": "Starting point for pathway to G27025JP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27040MJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G97765TT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 }, { "id": "G27040MJ", "dp": 12 } ], "links": [ { "target": "G27040MJ", "source": "G97765TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27048LG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G33742YO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G33742YO", "dp": 9 }, { "id": "G27048LG", "dp": 9 } ], "links": [ { "target": "G27048LG", "source": "G33742YO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27067YD", "error": "Missing intermediate; no pathways to [G27067YD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76294TY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27092SD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90870DG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G27092SD", "dp": 11 } ], "links": [ { "target": "G27092SD", "source": "G90870DG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27116XZ", "error": "Starting point for pathway to G27116XZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27119UQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G22728HO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G54584ER", "dp": 14 }, { "id": "G22728HO", "dp": 15 }, { "id": "G27119UQ", "dp": 15 } ], "links": [ { "target": "G27119UQ", "source": "G22728HO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G22728HO", "source": "G54584ER", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G54584ER", "source": "G18938DW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27123NH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27129QJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90175OT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G90175OT", "dp": 9 }, { "id": "G27129QJ", "dp": 9 } ], "links": [ { "target": "G27129QJ", "source": "G90175OT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90175OT", "source": "G37476QB", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27148YF", "error": "Starting point for pathway to G27148YF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27149SR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G45209NR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G45209NR", "dp": 15 }, { "id": "G27149SR", "dp": 15 } ], "links": [ { "target": "G27149SR", "source": "G45209NR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45209NR", "source": "G91905FJ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27168SG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89099NM]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G89099NM", "dp": 10 }, { "id": "G27168SG", "dp": 10 } ], "links": [ { "target": "G27168SG", "source": "G89099NM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89099NM", "source": "G20966TZ", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27169KC", "error": "Missing intermediate; no pathways to [G27169KC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27170BX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07995VK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G27170BX", "dp": 10 } ], "links": [ { "target": "G27170BX", "source": "G07995VK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27170NH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G04791QM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G27170NH", "dp": 9 } ], "links": [ { "target": "G27170NH", "source": "G04791QM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27171ZS", "error": "Starting point for pathway to G27171ZS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27188NC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 } ], "links": [ { "target": "G27188NC", "source": "G02427KF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27223CU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 } ], "links": [ { "target": "G27223CU", "source": "G82252QI", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27225SN", "error": "Missing intermediate; no pathways to [G27225SN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27259XX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74807KC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 }, { "id": "G78097CL", "dp": 13 }, { "id": "G74807KC", "dp": 14 }, { "id": "G27259XX", "dp": 14 } ], "links": [ { "target": "G27259XX", "source": "G74807KC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74807KC", "source": "G78097CL", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78097CL", "source": "G09150LP", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27262AE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32659RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G32659RY", "dp": 12 }, { "id": "G27262AE", "dp": 12 } ], "links": [ { "target": "G27262AE", "source": "G32659RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32659RY", "source": "G59877NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27263RW", "error": "Missing intermediate; no pathways to [G27263RW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G27273FD", "error": "Missing intermediate; no pathways to [G27273FD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27281KS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G18641OW", "dp": 11 } ], "links": [ { "target": "G27281KS", "source": "G18641OW", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18641OW", "source": "G88417ED", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27293OK", "error": "Starting point for pathway to G27293OK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27314YB", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G07483YN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G27314YB", "dp": 7 } ], "links": [ { "target": "G27314YB", "source": "G07483YN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27316ME", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17437BX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G17437BX", "dp": 14 }, { "id": "G27316ME", "dp": 14 } ], "links": [ { "target": "G27316ME", "source": "G17437BX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17437BX", "source": "G92359VA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27355OK", "error": "Starting point for pathway to G27355OK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27385LP", "error": "Missing intermediate; no pathways to [G27385LP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G33608TH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27389SR", "error": "Starting point for pathway to G27389SR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27419MQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99356PZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G99356PZ", "dp": 9 }, { "id": "G27419MQ", "dp": 9 } ], "links": [ { "target": "G27419MQ", "source": "G99356PZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99356PZ", "source": "G12398HZ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27421EI", "error": "Starting point for pathway to G27421EI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27427OE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72662IG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G80537QW", "dp": 14 }, { "id": "G72662IG", "dp": 15 }, { "id": "G27427OE", "dp": 15 } ], "links": [ { "target": "G27427OE", "source": "G72662IG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72662IG", "source": "G80537QW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80537QW", "source": "G93582HM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27432KC", "error": "Missing intermediate; no pathways to [G27432KC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27445YH", "error": "Missing intermediate; no pathways to [G27445YH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27456PF", "error": "Starting point for pathway to G27456PF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27461ST", "error": "Starting point for pathway to G27461ST could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27495UM", "error": "Starting point for pathway to G27495UM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27516AE", "error": "Missing intermediate; no pathways to [G27516AE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27534XE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82811EP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82811EP", "dp": 13 }, { "id": "G27534XE", "dp": 13 } ], "links": [ { "target": "G27534XE", "source": "G82811EP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82811EP", "source": "G84376FR", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27546OZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 } ], "links": [ { "target": "G27546OZ", "source": "G75049FP", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27571QK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38955TH]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 }, { "id": "G38955TH", "dp": 12 }, { "id": "G27571QK", "dp": 12 } ], "links": [ { "target": "G27571QK", "source": "G38955TH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38955TH", "source": "G40806JH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27576NC", "error": "Missing intermediate; no pathways to [G27576NC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27587OB", "error": "Missing intermediate; no pathways to [G27587OB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G51050LD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27629LY", "error": "Missing intermediate; no pathways to [G27629LY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50135PA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27641PQ", "error": "Starting point for pathway to G27641PQ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27658GQ", "error": "Starting point for pathway to G27658GQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27669RW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59361OW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G59361OW", "dp": 11 }, { "id": "G27669RW", "dp": 11 } ], "links": [ { "target": "G27669RW", "source": "G59361OW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59361OW", "source": "G44946WH", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27692UI", "error": "Starting point for pathway to G27692UI could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27776PG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 } ], "links": [ { "target": "G27776PG", "source": "G20956ZK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27783DL", "error": "Starting point for pathway to G27783DL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27783SY", "error": "Missing intermediate; no pathways to [G27783SY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G27799KH", "error": "Missing intermediate; no pathways to [G27799KH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70583LH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27802LV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G27802LV", "source": "G36191CD", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27814XA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86298IX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G60215UL", "dp": 12 }, { "id": "G86298IX", "dp": 13 }, { "id": "G27814XA", "dp": 13 } ], "links": [ { "target": "G27814XA", "source": "G86298IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86298IX", "source": "G60215UL", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60215UL", "source": "G47175EF", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27844UM", "error": "Missing intermediate; no pathways to [G27844UM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27855VW", "error": "Starting point for pathway to G27855VW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27865GU", "error": "Missing intermediate; no pathways to [G27865GU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27874QL", "error": "Starting point for pathway to G27874QL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27898DU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G22795QB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G27898DU", "dp": 10 } ], "links": [ { "target": "G27898DU", "source": "G22795QB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27919IH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 } ], "links": [ { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27929ZE", "error": "Starting point for pathway to G27929ZE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27939KO", "error": "Starting point for pathway to G27939KO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27946NT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 } ], "links": [ { "target": "G27946NT", "source": "G24420RT", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27957OQ", "error": "Starting point for pathway to G27957OQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G27992WA", "error": "Missing intermediate; no pathways to [G27992WA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66016NA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G27994UV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47175EF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G27994UV", "dp": 11 } ], "links": [ { "target": "G27994UV", "source": "G47175EF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G27995KI", "error": "Starting point for pathway to G27995KI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28060PF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95919TI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G95919TI", "dp": 14 }, { "id": "G28060PF", "dp": 14 } ], "links": [ { "target": "G28060PF", "source": "G95919TI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95919TI", "source": "G30651IU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28096QY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G35565NM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 }, { "id": "G35565NM", "dp": 15 }, { "id": "G28096QY", "dp": 15 } ], "links": [ { "target": "G28096QY", "source": "G35565NM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G35565NM", "source": "G53485VW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28106CM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 } ], "links": [ { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28110RC", "error": "Missing intermediate; no pathways to [G28110RC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28127QJ", "error": "Starting point for pathway to G28127QJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28128KH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60103QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 }, { "id": "G60103QI", "dp": 12 }, { "id": "G28128KH", "dp": 12 } ], "links": [ { "target": "G28128KH", "source": "G60103QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60103QI", "source": "G54611ZT", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28136CO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71013KY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G28136CO", "dp": 10 } ], "links": [ { "target": "G28136CO", "source": "G71013KY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28144EE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74928QN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G74928QN", "dp": 14 }, { "id": "G28144EE", "dp": 14 } ], "links": [ { "target": "G28144EE", "source": "G74928QN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74928QN", "source": "G29449JO", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28149BN", "error": "Missing intermediate; no pathways to [G28149BN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68313WI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28157XS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30460NZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G28157XS", "dp": 11 } ], "links": [ { "target": "G28157XS", "source": "G30460NZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28214FL", "error": "Missing intermediate; no pathways to [G28214FL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14938IR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28218GE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 } ], "links": [ { "target": "G28218GE", "source": "G17689DH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28222JZ", "error": "Missing intermediate; no pathways to [G28222JZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28231AL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 }, { "id": "G31004HS", "dp": 18 } ], "links": [ { "target": "G28231AL", "source": "G31004HS", "residue_affected": { "residue_id": "N362", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28274SP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G16155TD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G16155TD", "dp": 13 }, { "id": "G28274SP", "dp": 13 } ], "links": [ { "target": "G28274SP", "source": "G16155TD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16155TD", "source": "G01669LU", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28281DE", "error": "Starting point for pathway to G28281DE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28298VW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 } ], "links": [ { "target": "G28298VW", "source": "G48658PB", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28312JO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53752TA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G28312JO", "dp": 11 } ], "links": [ { "target": "G28312JO", "source": "G53752TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28327SH", "error": "Missing intermediate; no pathways to [G28327SH] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28330DZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23616ZX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G28330DZ", "dp": 14 } ], "links": [ { "target": "G28330DZ", "source": "G23616ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28355VE", "error": "Starting point for pathway to G28355VE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28355WG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84064AY]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G84064AY", "dp": 9 }, { "id": "G28355WG", "dp": 9 } ], "links": [ { "target": "G28355WG", "source": "G84064AY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84064AY", "source": "G08520NM", "residue_affected": { "residue_id": "N365", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G28368FX", "error": "Missing intermediate; no pathways to [G28368FX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82853YO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28371QL", "error": "Starting point for pathway to G28371QL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28411LB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19124KK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 }, { "id": "G19124KK", "dp": 12 }, { "id": "G28411LB", "dp": 12 } ], "links": [ { "target": "G28411LB", "source": "G19124KK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19124KK", "source": "G84467IZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28436VD", "error": "Missing intermediate; no pathways to [G28436VD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28449NP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92940AF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 }, { "id": "G92940AF", "dp": 14 }, { "id": "G28449NP", "dp": 14 } ], "links": [ { "target": "G28449NP", "source": "G92940AF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92940AF", "source": "G67289UM", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28459KM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25505UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 }, { "id": "G28459KM", "dp": 14 } ], "links": [ { "target": "G28459KM", "source": "G25505UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28478RU", "error": "Starting point for pathway to G28478RU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28502IW", "error": "Missing intermediate; no pathways to [G28502IW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28550OD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28558PZ", "error": "Starting point for pathway to G28558PZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28562FF", "error": "Missing intermediate; no pathways to [G28562FF] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G42731RJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28571LM", "error": "Missing intermediate; no pathways to [G28571LM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70410NP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G28593TO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G04829RO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 }, { "id": "G01010HW", "dp": 9 }, { "id": "G04829RO", "dp": 10 }, { "id": "G28593TO", "dp": 10 } ], "links": [ { "target": "G28593TO", "source": "G04829RO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04829RO", "source": "G01010HW", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28615QI", "error": "Starting point for pathway to G28615QI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28654UV", "error": "Starting point for pathway to G28654UV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28659UB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74645FT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G28659UB", "dp": 12 } ], "links": [ { "target": "G28659UB", "source": "G74645FT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28663KH", "error": "Starting point for pathway to G28663KH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28678TH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39408YK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G39408YK", "dp": 12 }, { "id": "G28678TH", "dp": 12 } ], "links": [ { "target": "G28678TH", "source": "G39408YK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39408YK", "source": "G25520XG", "residue_affected": { "residue_id": "N368", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28695FK", "error": "Missing intermediate; no pathways to [G28695FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94610SC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28707FT", "error": "Missing intermediate; no pathways to [G28707FT] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G03948VT]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28720MP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32611KT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G28720MP", "dp": 8 } ], "links": [ { "target": "G28720MP", "source": "G32611KT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28723UT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 } ], "links": [ { "target": "G28723UT", "source": "G87073UP", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28747XN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G96921ZU", "dp": 12 } ], "links": [ { "target": "G28747XN", "source": "G96921ZU", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28761GM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79809MM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G28761GM", "dp": 11 } ], "links": [ { "target": "G28761GM", "source": "G79809MM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28826SH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 } ], "links": [ { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28846QB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G42097JO", "dp": 14 } ], "links": [ { "target": "G28846QB", "source": "G42097JO", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42097JO", "source": "G85085MS", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28870UM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95898GD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 }, { "id": "G28870UM", "dp": 13 } ], "links": [ { "target": "G28870UM", "source": "G95898GD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28882QV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07015TW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G10664FL", "dp": 10 }, { "id": "G07015TW", "dp": 11 }, { "id": "G28882QV", "dp": 11 } ], "links": [ { "target": "G28882QV", "source": "G07015TW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07015TW", "source": "G10664FL", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10664FL", "source": "G45262QY", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28896CL", "error": "Starting point for pathway to G28896CL could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G28943FW", "error": "Missing intermediate; no pathways to [G28943FW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68283NG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G28948UC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 } ], "links": [ { "target": "G28948UC", "source": "G10691MJ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28957FB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 } ], "links": [ { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28959FS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43694RQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G28959FS", "dp": 10 } ], "links": [ { "target": "G28959FS", "source": "G43694RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G28962GO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G63166WT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G63166WT", "dp": 12 }, { "id": "G28962GO", "dp": 12 } ], "links": [ { "target": "G28962GO", "source": "G63166WT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63166WT", "source": "G30302VM", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29005BV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47566FL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G47566FL", "dp": 8 }, { "id": "G29005BV", "dp": 8 } ], "links": [ { "target": "G29005BV", "source": "G47566FL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47566FL", "source": "G07483YN", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29011JC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29021SQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90825UM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G90825UM", "dp": 11 }, { "id": "G29021SQ", "dp": 11 } ], "links": [ { "target": "G29021SQ", "source": "G90825UM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90825UM", "source": "G01856RL", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29024OJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G27919IH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G29024OJ", "dp": 9 } ], "links": [ { "target": "G29024OJ", "source": "G27919IH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29025AG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25520XG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G29025AG", "dp": 11 } ], "links": [ { "target": "G29025AG", "source": "G25520XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29026MS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 } ], "links": [ { "target": "G29026MS", "source": "G59877NF", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29032AL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23709VK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G82357WL", "dp": 11 }, { "id": "G23709VK", "dp": 12 }, { "id": "G29032AL", "dp": 12 } ], "links": [ { "target": "G29032AL", "source": "G23709VK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23709VK", "source": "G82357WL", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82357WL", "source": "G28826SH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29056SI", "error": "Starting point for pathway to G29056SI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29078QN", "error": "Starting point for pathway to G29078QN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29080AE", "error": "Starting point for pathway to G29080AE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29101XT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75850OP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G75850OP", "dp": 10 }, { "id": "G29101XT", "dp": 10 } ], "links": [ { "target": "G29101XT", "source": "G75850OP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75850OP", "source": "G36191CD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29109PM", "error": "Missing intermediate; no pathways to [G29109PM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82320NZ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29112GC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G29112GC", "source": "G20030CU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29130SY", "error": "Missing intermediate; no pathways to [G29130SY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29140EJ", "error": "Missing intermediate; no pathways to [G29140EJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29147GG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91208VE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 }, { "id": "G29147GG", "dp": 9 } ], "links": [ { "target": "G29147GG", "source": "G91208VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29159AI", "error": "Missing intermediate; no pathways to [G29159AI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75671DO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29159BL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G29159BL", "source": "G12398HZ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29184OZ", "error": "Missing intermediate; no pathways to [G29184OZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29197GH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G29197GH", "source": "G10219AA", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29218GG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81473LO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G81473LO", "dp": 11 }, { "id": "G29218GG", "dp": 11 } ], "links": [ { "target": "G29218GG", "source": "G81473LO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81473LO", "source": "G01856RL", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29248WR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46470AD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G46470AD", "dp": 11 }, { "id": "G29248WR", "dp": 11 } ], "links": [ { "target": "G29248WR", "source": "G46470AD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46470AD", "source": "G01856RL", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29277BJ", "error": "Missing intermediate; no pathways to [G29277BJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70684QL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29288DT", "error": "Starting point for pathway to G29288DT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29290EB", "error": "Starting point for pathway to G29290EB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29377XJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 } ], "links": [ { "target": "G29377XJ", "source": "G63585HN", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29396PC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78155FK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 }, { "id": "G29396PC", "dp": 10 } ], "links": [ { "target": "G29396PC", "source": "G78155FK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29434RB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29441UP", "error": "Starting point for pathway to G29441UP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29443MC", "error": "Missing intermediate; no pathways to [G29443MC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29445ZK", "error": "Missing intermediate; no pathways to [G29445ZK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29449JO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 } ], "links": [ { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29459CO", "error": "Missing intermediate; no pathways to [G29459CO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66016NA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29461HI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30302VM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G29461HI", "dp": 11 } ], "links": [ { "target": "G29461HI", "source": "G30302VM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29467ZM", "error": "Starting point for pathway to G29467ZM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29488SE", "error": "Missing intermediate; no pathways to [G29488SE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29492IF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29519AS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G32065BG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G29519AS", "dp": 12 } ], "links": [ { "target": "G29519AS", "source": "G32065BG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29527KD", "error": "Missing intermediate; no pathways to [G29527KD] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29574TI", "error": "Missing intermediate; no pathways to [G29574TI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26881SV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29617QF", "error": "Starting point for pathway to G29617QF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29628IK", "error": "Starting point for pathway to G29628IK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29633ZY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16341ZC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G57943ZV", "dp": 11 }, { "id": "G16341ZC", "dp": 12 }, { "id": "G29633ZY", "dp": 12 } ], "links": [ { "target": "G29633ZY", "source": "G16341ZC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16341ZC", "source": "G57943ZV", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29676WX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G49743VF", "dp": 11 } ], "links": [ { "target": "G29676WX", "source": "G49743VF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49743VF", "source": "G06216UH", "residue_affected": { "residue_id": "N470", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29680KY", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G17213JF", "dp": 11 } ], "links": [ { "target": "G29680KY", "source": "G17213JF", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29695SR", "error": "Missing intermediate; no pathways to [G29695SR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G68283NG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29706UC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 } ], "links": [ { "target": "G29706UC", "source": "G58667NI", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29713JZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40358EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G40358EZ", "dp": 11 }, { "id": "G29713JZ", "dp": 11 } ], "links": [ { "target": "G29713JZ", "source": "G40358EZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40358EZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29733CJ", "error": "Missing intermediate; no pathways to [G29733CJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29748HZ", "error": "Starting point for pathway to G29748HZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29764SO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14428PM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G89143RS", "dp": 13 }, { "id": "G14428PM", "dp": 14 }, { "id": "G29764SO", "dp": 14 } ], "links": [ { "target": "G29764SO", "source": "G14428PM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14428PM", "source": "G89143RS", "residue_affected": { "residue_id": "N46", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89143RS", "source": "G32065BG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29797YX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G89181JW", "dp": 11 } ], "links": [ { "target": "G29797YX", "source": "G89181JW", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89181JW", "source": "G03445UI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29799SM", "error": "Starting point for pathway to G29799SM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29803MG", "error": "Starting point for pathway to G29803MG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29818DV", "error": "Missing intermediate; no pathways to [G29818DV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29821KJ", "error": "Starting point for pathway to G29821KJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29839FP", "error": "Starting point for pathway to G29839FP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29849KU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G23782KP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G23782KP", "dp": 14 }, { "id": "G29849KU", "dp": 14 } ], "links": [ { "target": "G29849KU", "source": "G23782KP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23782KP", "source": "G01727PW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29850BY", "error": "Missing intermediate; no pathways to [G29850BY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14520ZO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29855QR", "error": "Starting point for pathway to G29855QR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29857PJ", "error": "Missing intermediate; no pathways to [G29857PJ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29857RC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 } ], "links": [ { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29870RM", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G66866LE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G29870RM", "dp": 10 } ], "links": [ { "target": "G29870RM", "source": "G66866LE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29881WK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75185NU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G29881WK", "dp": 12 } ], "links": [ { "target": "G29881WK", "source": "G75185NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29884LW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20096RP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G20096RP", "dp": 12 }, { "id": "G29884LW", "dp": 12 } ], "links": [ { "target": "G29884LW", "source": "G20096RP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20096RP", "source": "G25520XG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29887ZU", "error": "Starting point for pathway to G29887ZU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29897FU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G47963XB", "dp": 14 } ], "links": [ { "target": "G29897FU", "source": "G47963XB", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G47963XB", "source": "G66282NU", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29905OR", "error": "Starting point for pathway to G29905OR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G29931YE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G60941RE", "dp": 13 } ], "links": [ { "target": "G29931YE", "source": "G60941RE", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60941RE", "source": "G75185NU", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29948BS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69912LP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G41720HN", "dp": 8 }, { "id": "G69912LP", "dp": 9 }, { "id": "G29948BS", "dp": 9 } ], "links": [ { "target": "G29948BS", "source": "G69912LP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69912LP", "source": "G41720HN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41720HN", "source": "G07483YN", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G29955AF", "error": "Missing intermediate; no pathways to [G29955AF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G29972ZX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G88380UG", "dp": 8 } ], "links": [ { "target": "G29972ZX", "source": "G88380UG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88380UG", "source": "G39213VZ", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30007CD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G25407RZ", "dp": 11 } ], "links": [ { "target": "G30007CD", "source": "G25407RZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G25407RZ", "source": "G65597BI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30015VH", "error": "Missing intermediate; no pathways to [G30015VH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72411HX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30024DK", "error": "Starting point for pathway to G30024DK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30035MO", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G77252PU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G30035MO", "dp": 11 } ], "links": [ { "target": "G30035MO", "source": "G77252PU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30048YR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 }, { "id": "G66190PM", "dp": 11 } ], "links": [ { "target": "G30048YR", "source": "G66190PM", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66190PM", "source": "G78155FK", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30055DT", "error": "Missing intermediate; no pathways to [G30055DT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30060ZO", "error": "Missing intermediate; no pathways to [G30060ZO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30062BR", "error": "Missing intermediate; no pathways to [G30062BR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41797PU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30067CL", "error": "Missing intermediate; no pathways to [G30067CL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26935KA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30085SO", "error": "Missing intermediate; no pathways to [G30085SO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30109UP", "error": "Starting point for pathway to G30109UP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30115SP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10691MJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G30115SP", "dp": 11 } ], "links": [ { "target": "G30115SP", "source": "G10691MJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30120OH", "error": "Missing intermediate; no pathways to [G30120OH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88094DN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30140II", "error": "Starting point for pathway to G30140II could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30149NP", "error": "Missing intermediate; no pathways to [G30149NP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G30159WR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 } ], "links": [ { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30229IT", "error": "Missing intermediate; no pathways to [G30229IT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16873YG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30242JS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42097JO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G42097JO", "dp": 14 }, { "id": "G30242JS", "dp": 14 } ], "links": [ { "target": "G30242JS", "source": "G42097JO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42097JO", "source": "G85085MS", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30249GY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11637WL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G30249GY", "dp": 10 } ], "links": [ { "target": "G30249GY", "source": "G11637WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30293NE", "error": "Missing intermediate; no pathways to [G30293NE] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30302VM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 } ], "links": [ { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30309QX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71013KY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G30309QX", "dp": 10 } ], "links": [ { "target": "G30309QX", "source": "G71013KY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30314VR", "error": "Starting point for pathway to G30314VR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30319FW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G46712PI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G46712PI", "dp": 11 }, { "id": "G30319FW", "dp": 11 } ], "links": [ { "target": "G30319FW", "source": "G46712PI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46712PI", "source": "G00176HZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30330EB", "error": "Missing intermediate; no pathways to [G30330EB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49933AX]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G30331AP", "error": "Missing intermediate; no pathways to [G30331AP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30347FC", "error": "Starting point for pathway to G30347FC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30370YC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30371AX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96963QG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G30371AX", "dp": 12 } ], "links": [ { "target": "G30371AX", "source": "G96963QG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30372WK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86566MF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G32699RJ", "dp": 10 }, { "id": "G86566MF", "dp": 11 }, { "id": "G30372WK", "dp": 11 } ], "links": [ { "target": "G30372WK", "source": "G86566MF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86566MF", "source": "G32699RJ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32699RJ", "source": "G63074CQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30404XZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G53000RQ", "dp": 11 }, { "id": "G38951VC", "dp": 12 } ], "links": [ { "target": "G30404XZ", "source": "G38951VC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38951VC", "source": "G53000RQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30416OM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47566FL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G47566FL", "dp": 8 }, { "id": "G30416OM", "dp": 8 } ], "links": [ { "target": "G30416OM", "source": "G47566FL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47566FL", "source": "G07483YN", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30437YI", "error": "Missing intermediate; no pathways to [G30437YI] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30447NS", "error": "Missing intermediate; no pathways to [G30447NS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43088GK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30460NZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30469GJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10691MJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G30469GJ", "dp": 11 } ], "links": [ { "target": "G30469GJ", "source": "G10691MJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30476LD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46661UU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G73817GH", "dp": 10 }, { "id": "G57601AP", "dp": 11 }, { "id": "G11615SW", "dp": 12 }, { "id": "G46661UU", "dp": 13 }, { "id": "G30476LD", "dp": 13 } ], "links": [ { "target": "G30476LD", "source": "G46661UU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46661UU", "source": "G11615SW", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11615SW", "source": "G57601AP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57601AP", "source": "G73817GH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30483FB", "error": "Missing intermediate; no pathways to [G30483FB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30505TQ", "error": "Starting point for pathway to G30505TQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30514JJ", "error": "Missing intermediate; no pathways to [G30514JJ] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G30517YN", "error": "Starting point for pathway to G30517YN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30519RC", "error": "Starting point for pathway to G30519RC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30526TI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77384FE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G91337ZP", "dp": 10 }, { "id": "G77384FE", "dp": 11 }, { "id": "G30526TI", "dp": 11 } ], "links": [ { "target": "G30526TI", "source": "G77384FE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77384FE", "source": "G91337ZP", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91337ZP", "source": "G58667NI", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30529FG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82779CI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G30529FG", "dp": 11 } ], "links": [ { "target": "G30529FG", "source": "G82779CI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30542PN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G73418FX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 }, { "id": "G73418FX", "dp": 12 }, { "id": "G30542PN", "dp": 12 } ], "links": [ { "target": "G30542PN", "source": "G73418FX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73418FX", "source": "G00743WU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30547LG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G61553DD", "dp": 9 } ], "links": [ { "target": "G30547LG", "source": "G61553DD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61553DD", "source": "G29011JC", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30553WH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 } ], "links": [ { "target": "G30553WH", "source": "G20956ZK", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30560ZC", "error": "Starting point for pathway to G30560ZC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30569KZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G04185VX", "dp": 10 } ], "links": [ { "target": "G30569KZ", "source": "G04185VX", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30585MP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10209QU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G30585MP", "dp": 8 } ], "links": [ { "target": "G30585MP", "source": "G10209QU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30588SI", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G30588SI", "source": "G08520NM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30600KL", "error": "Missing intermediate; no pathways to [G30600KL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06594DV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30618VC", "error": "Starting point for pathway to G30618VC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30627OI", "error": "Missing intermediate; no pathways to [G30627OI] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30651IU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 } ], "links": [ { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30673AC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42548XF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G42548XF", "dp": 7 }, { "id": "G30673AC", "dp": 7 } ], "links": [ { "target": "G30673AC", "source": "G42548XF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42548XF", "source": "G61751GZ", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] } ] } , { "glytoucan_ac": "G30687DL", "error": "Starting point for pathway to G30687DL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30690LP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G30690LP", "source": "G18938DW", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30694RX", "error": "Missing intermediate; no pathways to [G30694RX] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30723RE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 } ], "links": [ { "target": "G30723RE", "source": "G68937TM", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30762QR", "error": "Starting point for pathway to G30762QR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30804NF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90670ZD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G97093EP", "dp": 12 }, { "id": "G90670ZD", "dp": 13 }, { "id": "G30804NF", "dp": 13 } ], "links": [ { "target": "G30804NF", "source": "G90670ZD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90670ZD", "source": "G97093EP", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97093EP", "source": "G43433FA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30844CL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 } ], "links": [ { "target": "G30844CL", "source": "G24420RT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30857WQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25350TT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G59361OW", "dp": 11 }, { "id": "G25350TT", "dp": 12 }, { "id": "G30857WQ", "dp": 12 } ], "links": [ { "target": "G30857WQ", "source": "G25350TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25350TT", "source": "G59361OW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59361OW", "source": "G44946WH", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30878SA", "error": "Missing intermediate; no pathways to [G30878SA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30880RA", "error": "Missing intermediate; no pathways to [G30880RA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G30901GC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 } ], "links": [ { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30915AU", "error": "Starting point for pathway to G30915AU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30917DM", "error": "Starting point for pathway to G30917DM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30925FN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 } ], "links": [ { "target": "G30925FN", "source": "G45720CA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G30969JI", "error": "Starting point for pathway to G30969JI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G30996QM", "error": "Starting point for pathway to G30996QM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31004HS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 } ], "links": [ { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31010RQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 } ], "links": [ { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31013GB", "error": "Missing intermediate; no pathways to [G31013GB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31018GZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60926LS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 }, { "id": "G39298RF", "dp": 11 }, { "id": "G60926LS", "dp": 12 }, { "id": "G31018GZ", "dp": 12 } ], "links": [ { "target": "G31018GZ", "source": "G60926LS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60926LS", "source": "G39298RF", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39298RF", "source": "G71690HK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31019WF", "error": "Missing intermediate; no pathways to [G31019WF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31032XG", "error": "Missing intermediate; no pathways to [G31032XG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53504BR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31037WG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 } ], "links": [ { "target": "G31037WG", "source": "G92574YO", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31040SL", "error": "Missing intermediate; no pathways to [G31040SL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31145ZM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32156DB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G80661IW", "dp": 10 }, { "id": "G32156DB", "dp": 11 }, { "id": "G31145ZM", "dp": 11 } ], "links": [ { "target": "G31145ZM", "source": "G32156DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32156DB", "source": "G80661IW", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G80661IW", "source": "G46638GC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31146VU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09446VC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G31146VU", "dp": 10 } ], "links": [ { "target": "G31146VU", "source": "G09446VC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31156QG", "error": "Missing intermediate; no pathways to [G31156QG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G75398ZA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31186LT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79803HS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G74438AB", "dp": 12 }, { "id": "G79803HS", "dp": 13 }, { "id": "G31186LT", "dp": 13 } ], "links": [ { "target": "G31186LT", "source": "G79803HS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79803HS", "source": "G74438AB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74438AB", "source": "G34905OT", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31187IJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20030CU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G31187IJ", "dp": 9 } ], "links": [ { "target": "G31187IJ", "source": "G20030CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31196DF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G09921WG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G31196DF", "dp": 10 } ], "links": [ { "target": "G31196DF", "source": "G09921WG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31198XA", "error": "Missing intermediate; no pathways to [G31198XA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31213GU", "error": "Missing intermediate; no pathways to [G31213GU] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G70410NP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G31220IW", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G30588SI", "dp": 9 }, { "id": "G32319IP", "dp": 10 } ], "links": [ { "target": "G31220IW", "source": "G32319IP", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32319IP", "source": "G30588SI", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30588SI", "source": "G08520NM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31242TK", "error": "Starting point for pathway to G31242TK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31246GN", "error": "Missing intermediate; no pathways to [G31246GN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24155DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31252KI", "error": "Missing intermediate; no pathways to [G31252KI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31276WM", "error": "Starting point for pathway to G31276WM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31294RU", "error": "Starting point for pathway to G31294RU could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31297VK", "error": "Starting point for pathway to G31297VK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31337GK", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G71407IE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G71407IE", "dp": 8 }, { "id": "G31337GK", "dp": 8 } ], "links": [ { "target": "G31337GK", "source": "G71407IE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71407IE", "source": "G69411IG", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31341PC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38022PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G31341PC", "dp": 14 } ], "links": [ { "target": "G31341PC", "source": "G38022PE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31365TH", "error": "Missing intermediate; no pathways to [G31365TH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31373ZL", "error": "Starting point for pathway to G31373ZL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31384GR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98565KP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 }, { "id": "G98565KP", "dp": 15 }, { "id": "G31384GR", "dp": 15 } ], "links": [ { "target": "G31384GR", "source": "G98565KP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98565KP", "source": "G53485VW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31387PS", "error": "Starting point for pathway to G31387PS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31390DC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29676WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G49743VF", "dp": 11 }, { "id": "G29676WX", "dp": 12 }, { "id": "G31390DC", "dp": 12 } ], "links": [ { "target": "G31390DC", "source": "G29676WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29676WX", "source": "G49743VF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49743VF", "source": "G06216UH", "residue_affected": { "residue_id": "N470", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31411GR", "error": "Starting point for pathway to G31411GR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31416KB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41720HN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G41720HN", "dp": 8 }, { "id": "G31416KB", "dp": 8 } ], "links": [ { "target": "G31416KB", "source": "G41720HN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41720HN", "source": "G07483YN", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31421EZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G28948UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G28948UC", "dp": 12 }, { "id": "G31421EZ", "dp": 12 } ], "links": [ { "target": "G31421EZ", "source": "G28948UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28948UC", "source": "G10691MJ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31429YW", "error": "Starting point for pathway to G31429YW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31494OZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G60564DP", "dp": 14 } ], "links": [ { "target": "G31494OZ", "source": "G60564DP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31515BE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65239SF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G65239SF", "dp": 11 }, { "id": "G31515BE", "dp": 11 } ], "links": [ { "target": "G31515BE", "source": "G65239SF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65239SF", "source": "G81923ER", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31520YP", "error": "Starting point for pathway to G31520YP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31531YC", "error": "Starting point for pathway to G31531YC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31532GK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G03895SR", "dp": 15 }, { "id": "G09118YK", "dp": 16 } ], "links": [ { "target": "G31532GK", "source": "G09118YK", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G09118YK", "source": "G03895SR", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31540AF", "error": "Missing intermediate; no pathways to [G31540AF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56516KW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31555TF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 } ], "links": [ { "target": "G31555TF", "source": "G65597BI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31559RO", "error": "Missing intermediate; no pathways to [G31559RO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G68892PJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31579YP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23142YD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G84852GW", "dp": 9 }, { "id": "G23142YD", "dp": 10 }, { "id": "G31579YP", "dp": 10 } ], "links": [ { "target": "G31579YP", "source": "G23142YD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23142YD", "source": "G84852GW", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G84852GW", "source": "G12398HZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31587OK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G44623TX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G44623TX", "dp": 12 }, { "id": "G31587OK", "dp": 12 } ], "links": [ { "target": "G31587OK", "source": "G44623TX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44623TX", "source": "G79809MM", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31604HF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G31604HF", "source": "G07483YN", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31606TH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G31037WG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G31037WG", "dp": 18 }, { "id": "G31606TH", "dp": 18 } ], "links": [ { "target": "G31606TH", "source": "G31037WG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31037WG", "source": "G92574YO", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31616YD", "error": "Starting point for pathway to G31616YD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31627MW", "error": "Missing intermediate; no pathways to [G31627MW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G49915LA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31632NL", "error": "Starting point for pathway to G31632NL could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31637BB", "error": "Missing intermediate; no pathways to [G31637BB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31639EU", "error": "Starting point for pathway to G31639EU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31642UV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G43664YB", "dp": 9 } ], "links": [ { "target": "G31642UV", "source": "G43664YB", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43664YB", "source": "G24420RT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31662BR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 } ], "links": [ { "target": "G31662BR", "source": "G50584UT", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31668AP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G14047PA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G14047PA", "dp": 11 }, { "id": "G31668AP", "dp": 11 } ], "links": [ { "target": "G31668AP", "source": "G14047PA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14047PA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31670BC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G97093EP", "dp": 12 } ], "links": [ { "target": "G31670BC", "source": "G97093EP", "residue_affected": { "residue_id": "N246", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G97093EP", "source": "G43433FA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31679YU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G50078RT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G50078RT", "dp": 12 }, { "id": "G31679YU", "dp": 12 } ], "links": [ { "target": "G31679YU", "source": "G50078RT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50078RT", "source": "G79809MM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31680LJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88321DT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 }, { "id": "G88321DT", "dp": 15 }, { "id": "G31680LJ", "dp": 15 } ], "links": [ { "target": "G31680LJ", "source": "G88321DT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88321DT", "source": "G53485VW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31692TJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G07995VK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G31692TJ", "dp": 10 } ], "links": [ { "target": "G31692TJ", "source": "G07995VK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31720WP", "error": "Missing intermediate; no pathways to [G31720WP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31735XJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77639OD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G31735XJ", "dp": 10 } ], "links": [ { "target": "G31735XJ", "source": "G77639OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31773TP", "error": "Starting point for pathway to G31773TP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31814JO", "error": "Starting point for pathway to G31814JO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31822CM", "error": "Missing intermediate; no pathways to [G31822CM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57166CI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31828QS", "error": "Missing intermediate; no pathways to [G31828QS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29130SY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31833FK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25097RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 }, { "id": "G31833FK", "dp": 15 } ], "links": [ { "target": "G31833FK", "source": "G25097RR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31834GI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56591LC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G31834GI", "dp": 10 } ], "links": [ { "target": "G31834GI", "source": "G56591LC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31859DB", "error": "Missing intermediate; no pathways to [G31859DB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31865AG", "error": "Starting point for pathway to G31865AG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31898CI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44623TX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G44623TX", "dp": 12 }, { "id": "G31898CI", "dp": 12 } ], "links": [ { "target": "G31898CI", "source": "G44623TX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44623TX", "source": "G79809MM", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31922FD", "error": "Starting point for pathway to G31922FD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G31943KG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G61207RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G31943KG", "dp": 9 } ], "links": [ { "target": "G31943KG", "source": "G61207RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G31979RM", "error": "Missing intermediate; no pathways to [G31979RM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31991IV", "error": "Missing intermediate; no pathways to [G31991IV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G31993QW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11637WL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G31993QW", "dp": 10 } ], "links": [ { "target": "G31993QW", "source": "G11637WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32065BG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 } ], "links": [ { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32079YD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G14428PM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G89143RS", "dp": 13 }, { "id": "G14428PM", "dp": 14 }, { "id": "G32079YD", "dp": 14 } ], "links": [ { "target": "G32079YD", "source": "G14428PM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14428PM", "source": "G89143RS", "residue_affected": { "residue_id": "N46", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89143RS", "source": "G32065BG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32082KI", "error": "Missing intermediate; no pathways to [G32082KI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32114CQ", "error": "Missing intermediate; no pathways to [G32114CQ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32116UD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G42097JO", "dp": 14 }, { "id": "G28846QB", "dp": 15 } ], "links": [ { "target": "G32116UD", "source": "G28846QB", "residue_affected": { "residue_id": "N246", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G28846QB", "source": "G42097JO", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42097JO", "source": "G85085MS", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32149KV", "error": "Starting point for pathway to G32149KV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32156DB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G80661IW", "dp": 10 } ], "links": [ { "target": "G32156DB", "source": "G80661IW", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G80661IW", "source": "G46638GC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32156ZV", "error": "Starting point for pathway to G32156ZV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32173NW", "error": "Missing intermediate; no pathways to [G32173NW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32190EA", "error": "Starting point for pathway to G32190EA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32201IL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32216CL", "error": "Missing intermediate; no pathways to [G32216CL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32216KM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77252PU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G32216KM", "dp": 11 } ], "links": [ { "target": "G32216KM", "source": "G77252PU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32241HI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43299SD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G32241HI", "dp": 9 } ], "links": [ { "target": "G32241HI", "source": "G43299SD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32247GO", "error": "Missing intermediate; no pathways to [G32247GO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17650QU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32250LZ", "error": "Missing intermediate; no pathways to [G32250LZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58969RU]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G32283ZK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 } ], "links": [ { "target": "G32283ZK", "source": "G20956ZK", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32287FD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 } ], "links": [ { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32303JY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 } ], "links": [ { "target": "G32303JY", "source": "G81432SH", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32305RZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 } ], "links": [ { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32319IP", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G30588SI", "dp": 9 } ], "links": [ { "target": "G32319IP", "source": "G30588SI", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30588SI", "source": "G08520NM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32324QA", "error": "Missing intermediate; no pathways to [G32324QA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32340YV", "error": "Missing intermediate; no pathways to [G32340YV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32342EK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26018HD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G26018HD", "dp": 12 }, { "id": "G32342EK", "dp": 12 } ], "links": [ { "target": "G32342EK", "source": "G26018HD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26018HD", "source": "G90870DG", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32358YV", "error": "Missing intermediate; no pathways to [G32358YV] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G71957GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32364DF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17857ZF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G57970NA", "dp": 13 }, { "id": "G17857ZF", "dp": 14 }, { "id": "G32364DF", "dp": 14 } ], "links": [ { "target": "G32364DF", "source": "G17857ZF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17857ZF", "source": "G57970NA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57970NA", "source": "G49515VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32371XG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G36108GD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G36108GD", "dp": 11 }, { "id": "G32371XG", "dp": 11 } ], "links": [ { "target": "G32371XG", "source": "G36108GD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36108GD", "source": "G32305RZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32377GZ", "error": "Missing intermediate; no pathways to [G32377GZ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82234NO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32386AG", "error": "Missing intermediate; no pathways to [G32386AG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G22558JP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32418LI", "error": "Missing intermediate; no pathways to [G32418LI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32429DG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21679ID]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G21679ID", "dp": 11 }, { "id": "G32429DG", "dp": 11 } ], "links": [ { "target": "G32429DG", "source": "G21679ID", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21679ID", "source": "G52934AK", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32442UP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07802IC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G07802IC", "dp": 13 }, { "id": "G32442UP", "dp": 13 } ], "links": [ { "target": "G32442UP", "source": "G07802IC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07802IC", "source": "G56749GV", "residue_affected": { "residue_id": "N483", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32461GF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 } ], "links": [ { "target": "G32461GF", "source": "G86696LV", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32483HZ", "error": "Missing intermediate; no pathways to [G32483HZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32484KU", "error": "Starting point for pathway to G32484KU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32505QR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66282NU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G32505QR", "dp": 13 } ], "links": [ { "target": "G32505QR", "source": "G66282NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32510IZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G62765SF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G62765SF", "dp": 14 }, { "id": "G32510IZ", "dp": 14 } ], "links": [ { "target": "G32510IZ", "source": "G62765SF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62765SF", "source": "G04989WY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32514NN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38951VC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G53000RQ", "dp": 11 }, { "id": "G38951VC", "dp": 12 }, { "id": "G32514NN", "dp": 12 } ], "links": [ { "target": "G32514NN", "source": "G38951VC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38951VC", "source": "G53000RQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32518YQ", "error": "Missing intermediate; no pathways to [G32518YQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32591MS", "error": "Missing intermediate; no pathways to [G32591MS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83845ZV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32592IB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 } ], "links": [ { "target": "G32592IB", "source": "G10228OD", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32611KT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32646BW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G35655SC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G74574VX", "dp": 11 }, { "id": "G83499UD", "dp": 12 }, { "id": "G35655SC", "dp": 13 }, { "id": "G32646BW", "dp": 13 } ], "links": [ { "target": "G32646BW", "source": "G35655SC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G35655SC", "source": "G83499UD", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83499UD", "source": "G74574VX", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32659RY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 } ], "links": [ { "target": "G32659RY", "source": "G59877NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32660GU", "error": "Starting point for pathway to G32660GU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32684AI", "error": "Starting point for pathway to G32684AI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32699RJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 } ], "links": [ { "target": "G32699RJ", "source": "G63074CQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32704TW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G32704TW", "source": "G12398HZ", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32744YO", "error": "Starting point for pathway to G32744YO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32746QI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98559XP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G98559XP", "dp": 14 }, { "id": "G32746QI", "dp": 14 } ], "links": [ { "target": "G32746QI", "source": "G98559XP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98559XP", "source": "G18938DW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32747GU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52956BX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G52956BX", "dp": 9 }, { "id": "G32747GU", "dp": 9 } ], "links": [ { "target": "G32747GU", "source": "G52956BX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52956BX", "source": "G12398HZ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32758HZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G96921ZU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G96921ZU", "dp": 12 }, { "id": "G32758HZ", "dp": 12 } ], "links": [ { "target": "G32758HZ", "source": "G96921ZU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32761XQ", "error": "Missing intermediate; no pathways to [G32761XQ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G88864RV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G32779JS", "error": "Starting point for pathway to G32779JS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32783AY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86753CK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G86753CK", "dp": 17 }, { "id": "G32783AY", "dp": 17 } ], "links": [ { "target": "G32783AY", "source": "G86753CK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32808NL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 }, { "id": "G01923XE", "dp": 14 } ], "links": [ { "target": "G32808NL", "source": "G01923XE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01923XE", "source": "G95898GD", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32829EU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92681HQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G98852TR", "dp": 16 }, { "id": "G92681HQ", "dp": 17 }, { "id": "G32829EU", "dp": 17 } ], "links": [ { "target": "G32829EU", "source": "G92681HQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92681HQ", "source": "G98852TR", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G98852TR", "source": "G28957FB", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32860NT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78155FK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 }, { "id": "G32860NT", "dp": 10 } ], "links": [ { "target": "G32860NT", "source": "G78155FK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32871YT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31220IW]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G30588SI", "dp": 9 }, { "id": "G32319IP", "dp": 10 }, { "id": "G31220IW", "dp": 11 }, { "id": "G32871YT", "dp": 11 } ], "links": [ { "target": "G32871YT", "source": "G31220IW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31220IW", "source": "G32319IP", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32319IP", "source": "G30588SI", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30588SI", "source": "G08520NM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32883QH", "error": "Starting point for pathway to G32883QH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G32915BP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G58667NI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G32915BP", "dp": 9 } ], "links": [ { "target": "G32915BP", "source": "G58667NI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G32977ZV", "error": "Missing intermediate; no pathways to [G32977ZV] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G32995JP", "error": "Starting point for pathway to G32995JP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33001NX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 } ], "links": [ { "target": "G33001NX", "source": "G39089YD", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G33019PZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31037WG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G31037WG", "dp": 18 }, { "id": "G33019PZ", "dp": 18 } ], "links": [ { "target": "G33019PZ", "source": "G31037WG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31037WG", "source": "G92574YO", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33030OB", "error": "Starting point for pathway to G33030OB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33052SB", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98862GW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G98862GW", "dp": 13 }, { "id": "G33052SB", "dp": 13 } ], "links": [ { "target": "G33052SB", "source": "G98862GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98862GW", "source": "G75049FP", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33066WV", "error": "Starting point for pathway to G33066WV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33070IY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G09921WG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G33070IY", "dp": 10 } ], "links": [ { "target": "G33070IY", "source": "G09921WG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33070ZL", "error": "Missing intermediate; no pathways to [G33070ZL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G33082JZ", "error": "Missing intermediate; no pathways to [G33082JZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33089BG", "error": "Missing intermediate; no pathways to [G33089BG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33095QA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28826SH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G33095QA", "dp": 10 } ], "links": [ { "target": "G33095QA", "source": "G28826SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33135KB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31037WG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G31037WG", "dp": 18 }, { "id": "G33135KB", "dp": 18 } ], "links": [ { "target": "G33135KB", "source": "G31037WG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31037WG", "source": "G92574YO", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33150PJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78956IC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 }, { "id": "G78956IC", "dp": 16 }, { "id": "G33150PJ", "dp": 16 } ], "links": [ { "target": "G33150PJ", "source": "G78956IC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78956IC", "source": "G91413ZX", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33172SI", "error": "Starting point for pathway to G33172SI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33187XF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89143RS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G89143RS", "dp": 13 }, { "id": "G33187XF", "dp": 13 } ], "links": [ { "target": "G33187XF", "source": "G89143RS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89143RS", "source": "G32065BG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33192XL", "error": "Starting point for pathway to G33192XL could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33195LE", "error": "Starting point for pathway to G33195LE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33202XC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 } ], "links": [ { "target": "G33202XC", "source": "G75185NU", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33241WC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 } ], "links": [ { "target": "G33241WC", "source": "G45720CA", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33244HE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59451NL", "dp": 8 } ], "links": [ { "target": "G33244HE", "source": "G59451NL", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59451NL", "source": "G39213VZ", "residue_affected": { "residue_id": "N299", "pubchem_name": "Fuc", "anomer": "b", "absolute": "L", "form_name": "Fucp", "full_name": "β-L-Fucp" }, "effect": "Add β-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33249PE", "error": "Starting point for pathway to G33249PE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33262KR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 } ], "links": [ { "target": "G33262KR", "source": "G40806JH", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33262YZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 } ], "links": [ { "target": "G33262YZ", "source": "G52934AK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33264BF", "error": "Starting point for pathway to G33264BF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33271XM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59451NL", "dp": 8 } ], "links": [ { "target": "G33271XM", "source": "G59451NL", "residue_affected": { "residue_id": "N322", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59451NL", "source": "G39213VZ", "residue_affected": { "residue_id": "N299", "pubchem_name": "Fuc", "anomer": "b", "absolute": "L", "form_name": "Fucp", "full_name": "β-L-Fucp" }, "effect": "Add β-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33275DG", "error": "Starting point for pathway to G33275DG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33303XH", "error": "Starting point for pathway to G33303XH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33305GI", "error": "Missing intermediate; no pathways to [G33305GI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88094DN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33309GL", "error": "Missing intermediate; no pathways to [G33309GL] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G13210XL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33370EK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25097RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 }, { "id": "G33370EK", "dp": 15 } ], "links": [ { "target": "G33370EK", "source": "G25097RR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33415VV", "error": "Missing intermediate; no pathways to [G33415VV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G67549HD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33427JX", "error": "Missing intermediate; no pathways to [G33427JX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84778XH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33433QA", "error": "Missing intermediate; no pathways to [G33433QA] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G54953LX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33451YI", "error": "Starting point for pathway to G33451YI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33473DN", "error": "Starting point for pathway to G33473DN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33490PH", "error": "Starting point for pathway to G33490PH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33522ME", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G12061IK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G33522ME", "dp": 11 } ], "links": [ { "target": "G33522ME", "source": "G12061IK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33608TH", "error": "Missing intermediate; no pathways to [G33608TH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33612TW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24413UY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G24413UY", "dp": 11 }, { "id": "G33612TW", "dp": 11 } ], "links": [ { "target": "G33612TW", "source": "G24413UY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G24413UY", "source": "G78890OB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33620BP", "error": "Missing intermediate; no pathways to [G33620BP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G27273FD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33685ZQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53752TA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G33685ZQ", "dp": 11 } ], "links": [ { "target": "G33685ZQ", "source": "G53752TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33704YC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G38407OC", "dp": 12 } ], "links": [ { "target": "G33704YC", "source": "G38407OC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38407OC", "source": "G20815TK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33734YD", "error": "Starting point for pathway to G33734YD could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33742YO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33748AU", "error": "Missing intermediate; no pathways to [G33748AU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30085SO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33755SK", "error": "Missing intermediate; no pathways to [G33755SK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33765AL", "error": "Starting point for pathway to G33765AL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33769VO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05368PM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G64830WP", "dp": 8 }, { "id": "G05368PM", "dp": 9 }, { "id": "G33769VO", "dp": 9 } ], "links": [ { "target": "G33769VO", "source": "G05368PM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05368PM", "source": "G64830WP", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64830WP", "source": "G39213VZ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33788DD", "error": "Missing intermediate; no pathways to [G33788DD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82894XV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33802UM", "error": "Missing intermediate; no pathways to [G33802UM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33806LP", "error": "Missing intermediate; no pathways to [G33806LP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33817TY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G66665YI", "dp": 14 } ], "links": [ { "target": "G33817TY", "source": "G66665YI", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66665YI", "source": "G66282NU", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33833VC", "error": "Missing intermediate; no pathways to [G33833VC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86321OX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33841EB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00413UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G00413UF", "dp": 13 }, { "id": "G33841EB", "dp": 13 } ], "links": [ { "target": "G33841EB", "source": "G00413UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00413UF", "source": "G84376FR", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33862NZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G90703DJ", "dp": 13 } ], "links": [ { "target": "G33862NZ", "source": "G90703DJ", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G90703DJ", "source": "G74120DW", "residue_affected": { "residue_id": "N295", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33894ZI", "error": "Starting point for pathway to G33894ZI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G33909XJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 } ], "links": [ { "target": "G33909XJ", "source": "G81923ER", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33951DA", "error": "Missing intermediate; no pathways to [G33951DA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33960JW", "error": "Missing intermediate; no pathways to [G33960JW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G33970VN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G79809MM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G33970VN", "dp": 11 } ], "links": [ { "target": "G33970VN", "source": "G79809MM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G33981FE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16546ZZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G16546ZZ", "dp": 13 }, { "id": "G33981FE", "dp": 13 } ], "links": [ { "target": "G33981FE", "source": "G16546ZZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16546ZZ", "source": "G41331JX", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34018EC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96963QG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G34018EC", "dp": 12 } ], "links": [ { "target": "G34018EC", "source": "G96963QG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34028QA", "error": "Starting point for pathway to G34028QA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34029JA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G34029JA", "source": "G25520XG", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34059IB", "error": "Starting point for pathway to G34059IB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34059TG", "error": "Missing intermediate; no pathways to [G34059TG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57345HS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34072RB", "error": "Starting point for pathway to G34072RB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34080GN", "error": "Missing intermediate; no pathways to [G34080GN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16956YO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34108KW", "error": "Missing intermediate; no pathways to [G34108KW] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34126VO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G60564DP", "dp": 14 } ], "links": [ { "target": "G34126VO", "source": "G60564DP", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34175ZP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 } ], "links": [ { "target": "G34175ZP", "source": "G01265XZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34197QS", "error": "Starting point for pathway to G34197QS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34220DL", "error": "Starting point for pathway to G34220DL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34276SS", "error": "Missing intermediate; no pathways to [G34276SS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34291TF", "error": "Missing intermediate; no pathways to [G34291TF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34293AU", "error": "Missing intermediate; no pathways to [G34293AU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17465IO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34314SG", "error": "Starting point for pathway to G34314SG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34330HT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G24413UY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G24413UY", "dp": 11 }, { "id": "G34330HT", "dp": 11 } ], "links": [ { "target": "G34330HT", "source": "G24413UY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G24413UY", "source": "G78890OB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34343FT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79578JB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G34343FT", "dp": 12 } ], "links": [ { "target": "G34343FT", "source": "G79578JB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34383AG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99969SS]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G99969SS", "dp": 10 }, { "id": "G34383AG", "dp": 10 } ], "links": [ { "target": "G34383AG", "source": "G99969SS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99969SS", "source": "G13151XE", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34392KZ", "error": "Missing intermediate; no pathways to [G34392KZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40341NV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34394BR", "error": "Starting point for pathway to G34394BR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34394KR", "error": "Missing intermediate; no pathways to [G34394KR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85891FA]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G34424TR", "error": "Missing intermediate; no pathways to [G34424TR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34442SS", "error": "Starting point for pathway to G34442SS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34477EW", "error": "Missing intermediate; no pathways to [G34477EW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34483UH", "error": "Missing intermediate; no pathways to [G34483UH] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G34499SX", "error": "Starting point for pathway to G34499SX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34508UC", "error": "Missing intermediate; no pathways to [G34508UC] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34527RW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 } ], "links": [ { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34529TA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38291RB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G38291RB", "dp": 13 }, { "id": "G34529TA", "dp": 13 } ], "links": [ { "target": "G34529TA", "source": "G38291RB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38291RB", "source": "G45359RY", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34561BL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G57970NA", "dp": 13 } ], "links": [ { "target": "G34561BL", "source": "G57970NA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57970NA", "source": "G49515VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34569IX", "error": "Starting point for pathway to G34569IX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34585DT", "error": "Missing intermediate; no pathways to [G34585DT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66847YI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34595KJ", "error": "Starting point for pathway to G34595KJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34598MV", "error": "Starting point for pathway to G34598MV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34603JX", "error": "Missing intermediate; no pathways to [G34603JX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G67943IR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34611ON", "error": "Missing intermediate; no pathways to [G34611ON] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66765ZA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34612DX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80962OX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G80962OX", "dp": 9 }, { "id": "G34612DX", "dp": 9 } ], "links": [ { "target": "G34612DX", "source": "G80962OX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80962OX", "source": "G66937TJ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34626UE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G15998WM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G15998WM", "dp": 17 }, { "id": "G34626UE", "dp": 17 } ], "links": [ { "target": "G34626UE", "source": "G15998WM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G15998WM", "source": "G79950YS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34634NL", "error": "Starting point for pathway to G34634NL could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34650EM", "error": "Starting point for pathway to G34650EM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34669ZJ", "error": "Missing intermediate; no pathways to [G34669ZJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34725PD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 } ], "links": [ { "target": "G34725PD", "source": "G30302VM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34731QC", "error": "Missing intermediate; no pathways to [G34731QC] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G89865CB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34748WY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 } ], "links": [ { "target": "G34748WY", "source": "G91208VE", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34749PQ", "error": "Starting point for pathway to G34749PQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34754UR", "error": "Missing intermediate; no pathways to [G34754UR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84879CH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34784SE", "error": "Missing intermediate; no pathways to [G34784SE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34790RR", "error": "Starting point for pathway to G34790RR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34810SS", "error": "Missing intermediate; no pathways to [G34810SS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08520NM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G34815RA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53933HU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G53933HU", "dp": 8 }, { "id": "G34815RA", "dp": 8 } ], "links": [ { "target": "G34815RA", "source": "G53933HU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53933HU", "source": "G59741XZ", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34819LS", "error": "Missing intermediate; no pathways to [G34819LS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34821YB", "error": "Starting point for pathway to G34821YB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34822AT", "error": "Starting point for pathway to G34822AT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34838RM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 } ], "links": [ { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34841CD", "error": "Missing intermediate; no pathways to [G34841CD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G34852ZG", "error": "Starting point for pathway to G34852ZG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G34859KW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46470AD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G46470AD", "dp": 11 }, { "id": "G34859KW", "dp": 11 } ], "links": [ { "target": "G34859KW", "source": "G46470AD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46470AD", "source": "G01856RL", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34905OT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 } ], "links": [ { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34931KK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G62765SF", "dp": 14 } ], "links": [ { "target": "G34931KK", "source": "G62765SF", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62765SF", "source": "G04989WY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34947FX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G92777SG", "dp": 11 } ], "links": [ { "target": "G34947FX", "source": "G92777SG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92777SG", "source": "G62504BU", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34952XZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32611KT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G34952XZ", "dp": 8 } ], "links": [ { "target": "G34952XZ", "source": "G32611KT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34972BB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 } ], "links": [ { "target": "G34972BB", "source": "G91905FJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G34985DS", "error": "Missing intermediate; no pathways to [G34985DS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35053YZ", "error": "Starting point for pathway to G35053YZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35069CO", "error": "Missing intermediate; no pathways to [G35069CO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35087KV", "error": "Missing intermediate; no pathways to [G35087KV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G87807PF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35096EN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G35096EN", "source": "G20030CU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35109CW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32201IL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G35109CW", "dp": 10 } ], "links": [ { "target": "G35109CW", "source": "G32201IL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35139NO", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25097RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 }, { "id": "G35139NO", "dp": 15 } ], "links": [ { "target": "G35139NO", "source": "G25097RR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35257SQ", "error": "Starting point for pathway to G35257SQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35261RT", "error": "Starting point for pathway to G35261RT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35283JZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42240DE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G42240DE", "dp": 12 }, { "id": "G35283JZ", "dp": 12 } ], "links": [ { "target": "G35283JZ", "source": "G42240DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42240DE", "source": "G20815TK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35310KA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 } ], "links": [ { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35313CG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45209NR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G45209NR", "dp": 15 }, { "id": "G35313CG", "dp": 15 } ], "links": [ { "target": "G35313CG", "source": "G45209NR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45209NR", "source": "G91905FJ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35347OW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 } ], "links": [ { "target": "G35347OW", "source": "G71679MX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35382VN", "error": "Missing intermediate; no pathways to [G35382VN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35402TO", "error": "Missing intermediate; no pathways to [G35402TO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36787EI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35429JB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G67045LB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G35429JB", "dp": 8 } ], "links": [ { "target": "G35429JB", "source": "G67045LB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35438GZ", "error": "Missing intermediate; no pathways to [G35438GZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G24875YE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35442CG", "error": "Starting point for pathway to G35442CG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35455OM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 } ], "links": [ { "target": "G35455OM", "source": "G90870DG", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35459KZ", "error": "Starting point for pathway to G35459KZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35482NV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G46503KK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G46503KK", "dp": 12 }, { "id": "G35482NV", "dp": 12 } ], "links": [ { "target": "G35482NV", "source": "G46503KK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46503KK", "source": "G18219CJ", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35484EX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07410AW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 }, { "id": "G07410AW", "dp": 14 }, { "id": "G35484EX", "dp": 14 } ], "links": [ { "target": "G35484EX", "source": "G07410AW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07410AW", "source": "G37597FW", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35508EI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78555BT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G82540VC", "dp": 8 }, { "id": "G41278YY", "dp": 9 }, { "id": "G78555BT", "dp": 10 }, { "id": "G35508EI", "dp": 10 } ], "links": [ { "target": "G35508EI", "source": "G78555BT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78555BT", "source": "G41278YY", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41278YY", "source": "G82540VC", "residue_affected": { "residue_id": "N238", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G82540VC", "source": "G39213VZ", "residue_affected": { "residue_id": "N250", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35565NM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 } ], "links": [ { "target": "G35565NM", "source": "G53485VW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35594BH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52336LJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G52336LJ", "dp": 12 }, { "id": "G35594BH", "dp": 12 } ], "links": [ { "target": "G35594BH", "source": "G52336LJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52336LJ", "source": "G30302VM", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35599MZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G48277OH", "dp": 14 } ], "links": [ { "target": "G35599MZ", "source": "G48277OH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48277OH", "source": "G19726AG", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35599NO", "error": "Missing intermediate; no pathways to [G35599NO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G35610QW", "error": "Missing intermediate; no pathways to [G35610QW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35619UY", "error": "Starting point for pathway to G35619UY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35632UU", "error": "Missing intermediate; no pathways to [G35632UU] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35642GA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 }, { "id": "G37772CO", "dp": 11 } ], "links": [ { "target": "G35642GA", "source": "G37772CO", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37772CO", "source": "G06969ZX", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35655SC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G74574VX", "dp": 11 }, { "id": "G83499UD", "dp": 12 } ], "links": [ { "target": "G35655SC", "source": "G83499UD", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83499UD", "source": "G74574VX", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35675LO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14068WV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G14068WV", "dp": 12 }, { "id": "G35675LO", "dp": 12 } ], "links": [ { "target": "G35675LO", "source": "G14068WV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14068WV", "source": "G04743RS", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35679TE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89168LM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 }, { "id": "G16057DE", "dp": 14 }, { "id": "G89168LM", "dp": 15 }, { "id": "G35679TE", "dp": 15 } ], "links": [ { "target": "G35679TE", "source": "G89168LM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89168LM", "source": "G16057DE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16057DE", "source": "G67289UM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35692YN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36004BS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G36004BS", "dp": 9 }, { "id": "G35692YN", "dp": 9 } ], "links": [ { "target": "G35692YN", "source": "G36004BS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36004BS", "source": "G12398HZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35708JV", "error": "Missing intermediate; no pathways to [G35708JV] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G20885BK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35716TV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94363RH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G94363RH", "dp": 17 }, { "id": "G35716TV", "dp": 17 } ], "links": [ { "target": "G35716TV", "source": "G94363RH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94363RH", "source": "G79950YS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35722YG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G51793MY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G51793MY", "dp": 11 }, { "id": "G35722YG", "dp": 11 } ], "links": [ { "target": "G35722YG", "source": "G51793MY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51793MY", "source": "G45560HM", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35724PH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21788RU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G21788RU", "dp": 12 }, { "id": "G35724PH", "dp": 12 } ], "links": [ { "target": "G35724PH", "source": "G21788RU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21788RU", "source": "G25520XG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35732LD", "error": "Starting point for pathway to G35732LD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35734AU", "error": "Missing intermediate; no pathways to [G35734AU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G97865QM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35747ZX", "error": "Missing intermediate; no pathways to [G35747ZX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35769UV", "error": "Starting point for pathway to G35769UV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35774GX", "error": "Starting point for pathway to G35774GX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35787ED", "error": "Starting point for pathway to G35787ED could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G35798GO", "error": "Missing intermediate; no pathways to [G35798GO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76554SR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35823EX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85895SP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G85895SP", "dp": 7 }, { "id": "G35823EX", "dp": 7 } ], "links": [ { "target": "G35823EX", "source": "G85895SP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85895SP", "source": "G61751GZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G35837ET", "error": "Missing intermediate; no pathways to [G35837ET] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35878KK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 } ], "links": [ { "target": "G35878KK", "source": "G09782JM", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35888BV", "error": "Missing intermediate; no pathways to [G35888BV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35888WG", "error": "Missing intermediate; no pathways to [G35888WG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G35912PE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G74574VX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G74574VX", "dp": 11 }, { "id": "G35912PE", "dp": 11 } ], "links": [ { "target": "G35912PE", "source": "G74574VX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G35929YH", "error": "Missing intermediate; no pathways to [G35929YH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41811VQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36003IA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34725PD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G34725PD", "dp": 12 }, { "id": "G36003IA", "dp": 12 } ], "links": [ { "target": "G36003IA", "source": "G34725PD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34725PD", "source": "G30302VM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36004BS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G36004BS", "source": "G12398HZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36020VB", "error": "Missing intermediate; no pathways to [G36020VB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96925LL]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36036BI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81085EP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G81085EP", "dp": 11 }, { "id": "G36036BI", "dp": 11 } ], "links": [ { "target": "G36036BI", "source": "G81085EP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81085EP", "source": "G87073UP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36042WR", "error": "Missing intermediate; no pathways to [G36042WR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17964DY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36053YX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06131VP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G36053YX", "dp": 11 } ], "links": [ { "target": "G36053YX", "source": "G06131VP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36066DO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G65307KA", "dp": 12 } ], "links": [ { "target": "G36066DO", "source": "G65307KA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65307KA", "source": "G10691MJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36092HA", "error": "Starting point for pathway to G36092HA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36107TU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23709VK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G82357WL", "dp": 11 }, { "id": "G23709VK", "dp": 12 }, { "id": "G36107TU", "dp": 12 } ], "links": [ { "target": "G36107TU", "source": "G23709VK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23709VK", "source": "G82357WL", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82357WL", "source": "G28826SH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36108GD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 } ], "links": [ { "target": "G36108GD", "source": "G32305RZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36115SK", "error": "Missing intermediate; no pathways to [G36115SK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36118RA", "error": "Starting point for pathway to G36118RA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36129EU", "error": "Missing intermediate; no pathways to [G36129EU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57565TQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36157OV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G36157OV", "source": "G91365ZQ", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36159AI", "error": "Starting point for pathway to G36159AI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36171JA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43346PX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G43346PX", "dp": 12 }, { "id": "G36171JA", "dp": 12 } ], "links": [ { "target": "G36171JA", "source": "G43346PX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43346PX", "source": "G04743RS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36176RV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 } ], "links": [ { "target": "G36176RV", "source": "G30302VM", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36191CD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36200ZL", "error": "Missing intermediate; no pathways to [G36200ZL] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36211GH", "error": "Missing intermediate; no pathways to [G36211GH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71957GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36216PA", "error": "Starting point for pathway to G36216PA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36218DJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04791QM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G36218DJ", "dp": 9 } ], "links": [ { "target": "G36218DJ", "source": "G04791QM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36223VW", "error": "Missing intermediate; no pathways to [G36223VW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36225RM", "error": "Missing intermediate; no pathways to [G36225RM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36245DC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25326BM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G25326BM", "dp": 9 }, { "id": "G36245DC", "dp": 9 } ], "links": [ { "target": "G36245DC", "source": "G25326BM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25326BM", "source": "G89993FE", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36266PV", "error": "Starting point for pathway to G36266PV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36268TW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 } ], "links": [ { "target": "G36268TW", "source": "G77252PU", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36287XJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23340ZN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G71835BN", "dp": 10 }, { "id": "G01378OV", "dp": 11 }, { "id": "G23340ZN", "dp": 12 }, { "id": "G36287XJ", "dp": 12 } ], "links": [ { "target": "G36287XJ", "source": "G23340ZN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23340ZN", "source": "G01378OV", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01378OV", "source": "G71835BN", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36293DS", "error": "Starting point for pathway to G36293DS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36297RV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G14905MK", "dp": 10 } ], "links": [ { "target": "G36297RV", "source": "G14905MK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14905MK", "source": "G61207RZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36303CE", "error": "Missing intermediate; no pathways to [G36303CE] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G18594ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36306KM", "error": "Missing intermediate; no pathways to [G36306KM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50023BR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36311ZH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 } ], "links": [ { "target": "G36311ZH", "source": "G32305RZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36316RB", "error": "Missing intermediate; no pathways to [G36316RB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36324QX", "error": "Missing intermediate; no pathways to [G36324QX] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36341AR", "error": "Missing intermediate; no pathways to [G36341AR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68892PJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36352HE", "error": "Missing intermediate; no pathways to [G36352HE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36362BK", "error": "Missing intermediate; no pathways to [G36362BK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40428GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36378FM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01669LU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G36378FM", "dp": 12 } ], "links": [ { "target": "G36378FM", "source": "G01669LU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36400RA", "error": "Starting point for pathway to G36400RA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36484FP", "error": "Missing intermediate; no pathways to [G36484FP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85106DS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36501YX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38955TH]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 }, { "id": "G38955TH", "dp": 12 }, { "id": "G36501YX", "dp": 12 } ], "links": [ { "target": "G36501YX", "source": "G38955TH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38955TH", "source": "G40806JH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36519NW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 } ], "links": [ { "target": "G36519NW", "source": "G01669LU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36521AS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 } ], "links": [ { "target": "G36521AS", "source": "G91208VE", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36523TZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G36523TZ", "source": "G29857RC", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36533LR", "error": "Missing intermediate; no pathways to [G36533LR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57565TQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36542BE", "error": "Starting point for pathway to G36542BE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36581MF", "error": "Missing intermediate; no pathways to [G36581MF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36581PT", "error": "Starting point for pathway to G36581PT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36588OE", "error": "Starting point for pathway to G36588OE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36608LK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G27281KS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G18641OW", "dp": 11 }, { "id": "G27281KS", "dp": 12 }, { "id": "G36608LK", "dp": 12 } ], "links": [ { "target": "G36608LK", "source": "G27281KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27281KS", "source": "G18641OW", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18641OW", "source": "G88417ED", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36626AJ", "error": "Missing intermediate; no pathways to [G36626AJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49446SO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36684NC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28826SH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G36684NC", "dp": 10 } ], "links": [ { "target": "G36684NC", "source": "G28826SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36699DD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41720HN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G41720HN", "dp": 8 }, { "id": "G36699DD", "dp": 8 } ], "links": [ { "target": "G36699DD", "source": "G41720HN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41720HN", "source": "G07483YN", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36699PG", "error": "Starting point for pathway to G36699PG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36701GV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 } ], "links": [ { "target": "G36701GV", "source": "G53752TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36712XC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 } ], "links": [ { "target": "G36712XC", "source": "G09482NW", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36721QZ", "error": "Missing intermediate; no pathways to [G36721QZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19242QH]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G36727AR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66282NU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G36727AR", "dp": 13 } ], "links": [ { "target": "G36727AR", "source": "G66282NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36749ZK", "error": "Starting point for pathway to G36749ZK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36759VO", "error": "Missing intermediate; no pathways to [G36759VO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36766ZC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81528UX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G81528UX", "dp": 9 }, { "id": "G36766ZC", "dp": 9 } ], "links": [ { "target": "G36766ZC", "source": "G81528UX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81528UX", "source": "G89993FE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36772MC", "error": "Starting point for pathway to G36772MC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36776KM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G13267ZY", "dp": 10 }, { "id": "G86681BW", "dp": 11 }, { "id": "G54775DO", "dp": 12 } ], "links": [ { "target": "G36776KM", "source": "G54775DO", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G54775DO", "source": "G86681BW", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G86681BW", "source": "G13267ZY", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13267ZY", "source": "G46638GC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36787EI", "error": "Missing intermediate; no pathways to [G36787EI] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36806TM", "error": "Missing intermediate; no pathways to [G36806TM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36807HJ", "error": "Missing intermediate; no pathways to [G36807HJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G35599NO]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G36816DT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G00951UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G79198BK", "dp": 9 }, { "id": "G00951UF", "dp": 10 }, { "id": "G36816DT", "dp": 10 } ], "links": [ { "target": "G36816DT", "source": "G00951UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00951UF", "source": "G79198BK", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79198BK", "source": "G10219AA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36847DS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97674NY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G97674NY", "dp": 15 }, { "id": "G36847DS", "dp": 15 } ], "links": [ { "target": "G36847DS", "source": "G97674NY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97674NY", "source": "G89877QI", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36859SD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66937TJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36859SD", "dp": 8 } ], "links": [ { "target": "G36859SD", "source": "G66937TJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36868UY", "error": "Missing intermediate; no pathways to [G36868UY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G36898CO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77639OD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G36898CO", "dp": 10 } ], "links": [ { "target": "G36898CO", "source": "G77639OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36909MR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75185NU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G36909MR", "dp": 12 } ], "links": [ { "target": "G36909MR", "source": "G75185NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36909XX", "error": "Starting point for pathway to G36909XX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36960FP", "error": "Starting point for pathway to G36960FP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G36977EW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88417ED]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G36977EW", "dp": 10 } ], "links": [ { "target": "G36977EW", "source": "G88417ED", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G36978FH", "error": "Missing intermediate; no pathways to [G36978FH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75107JX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G37022BP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 } ], "links": [ { "target": "G37022BP", "source": "G30460NZ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37025FG", "error": "Starting point for pathway to G37025FG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37046CZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 } ], "links": [ { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37052HG", "error": "Starting point for pathway to G37052HG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37106KN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33909XJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G33909XJ", "dp": 11 }, { "id": "G37106KN", "dp": 11 } ], "links": [ { "target": "G37106KN", "source": "G33909XJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33909XJ", "source": "G81923ER", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37135JQ", "error": "Starting point for pathway to G37135JQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37140SO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 } ], "links": [ { "target": "G37140SO", "source": "G93500PH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37166HP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 } ], "links": [ { "target": "G37166HP", "source": "G11637WL", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37183DT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G31555TF", "dp": 11 } ], "links": [ { "target": "G37183DT", "source": "G31555TF", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G31555TF", "source": "G65597BI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37210VL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G79457WN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G79457WN", "dp": 11 }, { "id": "G37210VL", "dp": 11 } ], "links": [ { "target": "G37210VL", "source": "G79457WN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79457WN", "source": "G00176HZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37260FV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78276SQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G78276SQ", "dp": 12 }, { "id": "G37260FV", "dp": 12 } ], "links": [ { "target": "G37260FV", "source": "G78276SQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78276SQ", "source": "G11041DA", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37274WB", "error": "Starting point for pathway to G37274WB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37276TY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74438AB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G74438AB", "dp": 12 }, { "id": "G37276TY", "dp": 12 } ], "links": [ { "target": "G37276TY", "source": "G74438AB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74438AB", "source": "G34905OT", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37291PT", "error": "Missing intermediate; no pathways to [G37291PT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G37304XT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40542QP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G40542QP", "dp": 15 }, { "id": "G37304XT", "dp": 15 } ], "links": [ { "target": "G37304XT", "source": "G40542QP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40542QP", "source": "G10228OD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37306TB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80537QW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G80537QW", "dp": 14 }, { "id": "G37306TB", "dp": 14 } ], "links": [ { "target": "G37306TB", "source": "G80537QW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80537QW", "source": "G93582HM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37316YK", "error": "Missing intermediate; no pathways to [G37316YK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G22388FD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G37330EE", "error": "Missing intermediate; no pathways to [G37330EE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G37383BH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G37383BH", "source": "G78059CC", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37385TT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 } ], "links": [ { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37476QB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 } ], "links": [ { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37487GB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91413ZX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 }, { "id": "G37487GB", "dp": 15 } ], "links": [ { "target": "G37487GB", "source": "G91413ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37491LV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G91023GB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G37491LV", "dp": 12 } ], "links": [ { "target": "G37491LV", "source": "G91023GB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37492BZ", "error": "Missing intermediate; no pathways to [G37492BZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03260OU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G37552GO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65239SF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G65239SF", "dp": 11 }, { "id": "G37552GO", "dp": 11 } ], "links": [ { "target": "G37552GO", "source": "G65239SF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65239SF", "source": "G81923ER", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37562WX", "error": "Missing intermediate; no pathways to [G37562WX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98115AV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G37581LU", "error": "Missing intermediate; no pathways to [G37581LU] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G19242QH]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G37591JC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75850OP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G75850OP", "dp": 10 }, { "id": "G37591JC", "dp": 10 } ], "links": [ { "target": "G37591JC", "source": "G75850OP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75850OP", "source": "G36191CD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37597FW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 } ], "links": [ { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37601IJ", "error": "Starting point for pathway to G37601IJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37601UJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 } ], "links": [ { "target": "G37601UJ", "source": "G91208VE", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37612TM", "error": "Starting point for pathway to G37612TM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37626KE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99866WK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G38395YJ", "dp": 14 }, { "id": "G99866WK", "dp": 15 }, { "id": "G37626KE", "dp": 15 } ], "links": [ { "target": "G37626KE", "source": "G99866WK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99866WK", "source": "G38395YJ", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37626ZT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06131VP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G37626ZT", "dp": 11 } ], "links": [ { "target": "G37626ZT", "source": "G06131VP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37636YK", "error": "Starting point for pathway to G37636YK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37648ZH", "error": "Starting point for pathway to G37648ZH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37651YK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39089YD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G37651YK", "dp": 7 } ], "links": [ { "target": "G37651YK", "source": "G39089YD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G37718JO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 } ], "links": [ { "target": "G37718JO", "source": "G21755KD", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37745NY", "error": "Missing intermediate; no pathways to [G37745NY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G37772CO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 } ], "links": [ { "target": "G37772CO", "source": "G06969ZX", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37783EW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72698LT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G82861UH", "dp": 9 }, { "id": "G72698LT", "dp": 10 }, { "id": "G37783EW", "dp": 10 } ], "links": [ { "target": "G37783EW", "source": "G72698LT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72698LT", "source": "G82861UH", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82861UH", "source": "G59471TH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37809PL", "error": "Starting point for pathway to G37809PL could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37825LG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G44504SC", "dp": 10 } ], "links": [ { "target": "G37825LG", "source": "G44504SC", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44504SC", "source": "G20030CU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37827FY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52080WL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G52080WL", "dp": 9 }, { "id": "G37827FY", "dp": 9 } ], "links": [ { "target": "G37827FY", "source": "G52080WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52080WL", "source": "G66937TJ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37841NF", "error": "Missing intermediate; no pathways to [G37841NF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53168IY]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G37841WI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G55396DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G55396DW", "dp": 12 }, { "id": "G37841WI", "dp": 12 } ], "links": [ { "target": "G37841WI", "source": "G55396DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G55396DW", "source": "G25520XG", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37855JI", "error": "Starting point for pathway to G37855JI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37868JH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G87349YT", "dp": 13 } ], "links": [ { "target": "G37868JH", "source": "G87349YT", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G87349YT", "source": "G75049FP", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37884CG", "error": "Missing intermediate; no pathways to [G37884CG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G37885IZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05794RZ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 }, { "id": "G05794RZ", "dp": 12 }, { "id": "G37885IZ", "dp": 12 } ], "links": [ { "target": "G37885IZ", "source": "G05794RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05794RZ", "source": "G40806JH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37903FG", "error": "Starting point for pathway to G37903FG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G37919OJ", "error": "Missing intermediate; no pathways to [G37919OJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90065BD]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G37938RD", "error": "Missing intermediate; no pathways to [G37938RD] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G37944VQ", "error": "Missing intermediate; no pathways to [G37944VQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78980OK]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G37986HU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84852GW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G84852GW", "dp": 9 }, { "id": "G37986HU", "dp": 9 } ], "links": [ { "target": "G37986HU", "source": "G84852GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84852GW", "source": "G12398HZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37990ZT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 } ], "links": [ { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G37999UP", "error": "Starting point for pathway to G37999UP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38001FQ", "error": "Missing intermediate; no pathways to [G38001FQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38002QN", "error": "Starting point for pathway to G38002QN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38022PE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 } ], "links": [ { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38029ML", "error": "Starting point for pathway to G38029ML could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38032QG", "error": "Missing intermediate; no pathways to [G38032QG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00514XC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38047QV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34527RW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G38047QV", "dp": 8 } ], "links": [ { "target": "G38047QV", "source": "G34527RW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38085YD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G03445UI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G38085YD", "dp": 10 } ], "links": [ { "target": "G38085YD", "source": "G03445UI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38115KZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G71857KQ", "dp": 10 } ], "links": [ { "target": "G38115KZ", "source": "G71857KQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71857KQ", "source": "G29434RB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38121JC", "error": "Missing intermediate; no pathways to [G38121JC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38159EA", "error": "Missing intermediate; no pathways to [G38159EA] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G19739KB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38208CY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G61684ET", "dp": 12 } ], "links": [ { "target": "G38208CY", "source": "G61684ET", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61684ET", "source": "G25520XG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38235ZC", "error": "Missing intermediate; no pathways to [G38235ZC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75972ZC]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38236XZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G38236XZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38241TC", "error": "Missing intermediate; no pathways to [G38241TC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38249IZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17540HT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G17540HT", "dp": 12 }, { "id": "G38249IZ", "dp": 12 } ], "links": [ { "target": "G38249IZ", "source": "G17540HT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17540HT", "source": "G30460NZ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38267IW", "error": "Missing intermediate; no pathways to [G38267IW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80717KS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38271CW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28550OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G38271CW", "dp": 9 } ], "links": [ { "target": "G38271CW", "source": "G28550OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38278VW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56340GX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G56340GX", "dp": 10 }, { "id": "G38278VW", "dp": 10 } ], "links": [ { "target": "G38278VW", "source": "G56340GX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56340GX", "source": "G27919IH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38291RB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 } ], "links": [ { "target": "G38291RB", "source": "G45359RY", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38297TU", "error": "Missing intermediate; no pathways to [G38297TU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08520NM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G38322BG", "error": "Missing intermediate; no pathways to [G38322BG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08896RO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38362AS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14996IQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14996IQ", "dp": 8 }, { "id": "G38362AS", "dp": 8 } ], "links": [ { "target": "G38362AS", "source": "G14996IQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14996IQ", "source": "G69411IG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38371WW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50943ZX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G50943ZX", "dp": 9 }, { "id": "G38371WW", "dp": 9 } ], "links": [ { "target": "G38371WW", "source": "G50943ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50943ZX", "source": "G20956ZK", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38373BD", "error": "Missing intermediate; no pathways to [G38373BD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G44904UE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38395YJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 } ], "links": [ { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38404PP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25326BM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G25326BM", "dp": 9 }, { "id": "G38404PP", "dp": 9 } ], "links": [ { "target": "G38404PP", "source": "G25326BM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25326BM", "source": "G89993FE", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38407OC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 } ], "links": [ { "target": "G38407OC", "source": "G20815TK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38453JX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36191CD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G38453JX", "dp": 9 } ], "links": [ { "target": "G38453JX", "source": "G36191CD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38470IM", "error": "Starting point for pathway to G38470IM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38488ZJ", "error": "Starting point for pathway to G38488ZJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38549YL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G21679ID", "dp": 11 } ], "links": [ { "target": "G38549YL", "source": "G21679ID", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21679ID", "source": "G52934AK", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38579XX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98809PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G38579XX", "dp": 12 } ], "links": [ { "target": "G38579XX", "source": "G98809PE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38613YU", "error": "Missing intermediate; no pathways to [G38613YU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82234NO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38625SV", "error": "Missing intermediate; no pathways to [G38625SV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G67549HD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38637SA", "error": "Missing intermediate; no pathways to [G38637SA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38638WU", "error": "Starting point for pathway to G38638WU could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38658JL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G04273XP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G03385XG", "dp": 13 }, { "id": "G04273XP", "dp": 14 }, { "id": "G38658JL", "dp": 14 } ], "links": [ { "target": "G38658JL", "source": "G04273XP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04273XP", "source": "G03385XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38659HF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90670ZD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G97093EP", "dp": 12 }, { "id": "G90670ZD", "dp": 13 }, { "id": "G38659HF", "dp": 13 } ], "links": [ { "target": "G38659HF", "source": "G90670ZD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90670ZD", "source": "G97093EP", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97093EP", "source": "G43433FA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38663XJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G99645NK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G38663XJ", "dp": 11 } ], "links": [ { "target": "G38663XJ", "source": "G99645NK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38668OJ", "error": "Starting point for pathway to G38668OJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38748VM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33262YZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G33262YZ", "dp": 11 }, { "id": "G38748VM", "dp": 11 } ], "links": [ { "target": "G38748VM", "source": "G33262YZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33262YZ", "source": "G52934AK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38753OV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 } ], "links": [ { "target": "G38753OV", "source": "G52934AK", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38788GC", "error": "Starting point for pathway to G38788GC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38800CP", "error": "Missing intermediate; no pathways to [G38800CP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38817ZQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20956ZK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G38817ZQ", "dp": 8 } ], "links": [ { "target": "G38817ZQ", "source": "G20956ZK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38835AV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03272YQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G21788RU", "dp": 12 }, { "id": "G03272YQ", "dp": 13 }, { "id": "G38835AV", "dp": 13 } ], "links": [ { "target": "G38835AV", "source": "G03272YQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03272YQ", "source": "G21788RU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21788RU", "source": "G25520XG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38849GM", "error": "Missing intermediate; no pathways to [G38849GM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38867AF", "error": "Missing intermediate; no pathways to [G38867AF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38901GU", "error": "Missing intermediate; no pathways to [G38901GU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98453VS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38901YC", "error": "Starting point for pathway to G38901YC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G38922KN", "error": "Missing intermediate; no pathways to [G38922KN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51768ZH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G38951VC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G53000RQ", "dp": 11 } ], "links": [ { "target": "G38951VC", "source": "G53000RQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38955TH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 } ], "links": [ { "target": "G38955TH", "source": "G40806JH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G38966ID", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G39089YD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G38966ID", "dp": 7 } ], "links": [ { "target": "G38966ID", "source": "G39089YD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G38997JB", "error": "Missing intermediate; no pathways to [G38997JB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98115AV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39018CC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 } ], "links": [ { "target": "G39018CC", "source": "G25505UF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39027MU", "error": "Missing intermediate; no pathways to [G39027MU] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39029JR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 } ], "links": [ { "target": "G39029JR", "source": "G93500PH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39035OI", "error": "Missing intermediate; no pathways to [G39035OI] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G29857PJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39062YR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72821WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G72821WX", "dp": 9 }, { "id": "G39062YR", "dp": 9 } ], "links": [ { "target": "G39062YR", "source": "G72821WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39082VT", "error": "Starting point for pathway to G39082VT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39089YD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G39111QK", "error": "Starting point for pathway to G39111QK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39119ZF", "error": "Starting point for pathway to G39119ZF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39125OY", "error": "Missing intermediate; no pathways to [G39125OY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39132UF", "error": "Missing intermediate; no pathways to [G39132UF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78648QN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39174FS", "error": "Starting point for pathway to G39174FS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39181YB", "error": "Missing intermediate; no pathways to [G39181YB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39183DW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G28957FB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G39183DW", "dp": 15 } ], "links": [ { "target": "G39183DW", "source": "G28957FB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39213VZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39292VX", "error": "Missing intermediate; no pathways to [G39292VX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54300AX]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39296OW", "error": "Missing intermediate; no pathways to [G39296OW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85208SY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39298CN", "error": "Missing intermediate; no pathways to [G39298CN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40096SL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G39298RF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 } ], "links": [ { "target": "G39298RF", "source": "G71690HK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39299DH", "error": "Missing intermediate; no pathways to [G39299DH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39318IJ", "error": "Starting point for pathway to G39318IJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39323NG", "error": "Missing intermediate; no pathways to [G39323NG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75359HS]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G39338NX", "error": "Starting point for pathway to G39338NX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39340CD", "error": "Missing intermediate; no pathways to [G39340CD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00666EC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39342SG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26264SQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 }, { "id": "G26264SQ", "dp": 12 }, { "id": "G39342SG", "dp": 12 } ], "links": [ { "target": "G39342SG", "source": "G26264SQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26264SQ", "source": "G42028DN", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39344CL", "error": "Missing intermediate; no pathways to [G39344CL] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39353RT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 } ], "links": [ { "target": "G39353RT", "source": "G35310KA", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39370XG", "error": "Missing intermediate; no pathways to [G39370XG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39377DE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 } ], "links": [ { "target": "G39377DE", "source": "G09921WG", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39377JQ", "error": "Missing intermediate; no pathways to [G39377JQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G68313WI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39379ZG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69905CP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 }, { "id": "G69905CP", "dp": 11 }, { "id": "G39379ZG", "dp": 11 } ], "links": [ { "target": "G39379ZG", "source": "G69905CP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69905CP", "source": "G09670SR", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39383KR", "error": "Starting point for pathway to G39383KR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39394NX", "error": "Starting point for pathway to G39394NX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39407WQ", "error": "Starting point for pathway to G39407WQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39408YK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G39408YK", "source": "G25520XG", "residue_affected": { "residue_id": "N368", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39414NM", "error": "Missing intermediate; no pathways to [G39414NM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14520ZO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39421JD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58667NI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G39421JD", "dp": 9 } ], "links": [ { "target": "G39421JD", "source": "G58667NI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39437XQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99897FQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G99897FQ", "dp": 9 }, { "id": "G39437XQ", "dp": 9 } ], "links": [ { "target": "G39437XQ", "source": "G99897FQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99897FQ", "source": "G67045LB", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39439UR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 } ], "links": [ { "target": "G39439UR", "source": "G10209QU", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39452ZZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45359RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G39452ZZ", "dp": 12 } ], "links": [ { "target": "G39452ZZ", "source": "G45359RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39465KG", "error": "Missing intermediate; no pathways to [G39465KG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G91550OH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39473HX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65981EG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 }, { "id": "G65981EG", "dp": 12 }, { "id": "G39473HX", "dp": 12 } ], "links": [ { "target": "G39473HX", "source": "G65981EG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65981EG", "source": "G37385TT", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39478RR", "error": "Starting point for pathway to G39478RR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39487ZR", "error": "Starting point for pathway to G39487ZR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39504IG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 } ], "links": [ { "target": "G39504IG", "source": "G79809MM", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39509DP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G46021KV", "dp": 12 }, { "id": "G12203WB", "dp": 13 } ], "links": [ { "target": "G39509DP", "source": "G12203WB", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12203WB", "source": "G46021KV", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46021KV", "source": "G29857RC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39531LA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66665YI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G66665YI", "dp": 14 }, { "id": "G39531LA", "dp": 14 } ], "links": [ { "target": "G39531LA", "source": "G66665YI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66665YI", "source": "G66282NU", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39540XG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G10258MC", "dp": 11 } ], "links": [ { "target": "G39540XG", "source": "G10258MC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10258MC", "source": "G25835MT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39549VW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84376FR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G39549VW", "dp": 12 } ], "links": [ { "target": "G39549VW", "source": "G84376FR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39556JJ", "error": "Starting point for pathway to G39556JJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39565DV", "error": "Missing intermediate; no pathways to [G39565DV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39567LQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45209NR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G45209NR", "dp": 15 }, { "id": "G39567LQ", "dp": 15 } ], "links": [ { "target": "G39567LQ", "source": "G45209NR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45209NR", "source": "G91905FJ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39578OU", "error": "Starting point for pathway to G39578OU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39585RN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 } ], "links": [ { "target": "G39585RN", "source": "G08194HH", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39595CR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 } ], "links": [ { "target": "G39595CR", "source": "G80294GH", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39597XQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88382QE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G88382QE", "dp": 14 }, { "id": "G39597XQ", "dp": 14 } ], "links": [ { "target": "G39597XQ", "source": "G88382QE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88382QE", "source": "G18938DW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39600NF", "error": "Missing intermediate; no pathways to [G39600NF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94679TQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39601JQ", "error": "Missing intermediate; no pathways to [G39601JQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39602UU", "error": "Starting point for pathway to G39602UU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39623FZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G34527RW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G39623FZ", "dp": 8 } ], "links": [ { "target": "G39623FZ", "source": "G34527RW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39661KT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45603BW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G45603BW", "dp": 14 }, { "id": "G39661KT", "dp": 14 } ], "links": [ { "target": "G39661KT", "source": "G45603BW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45603BW", "source": "G56549DH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39662GV", "error": "Starting point for pathway to G39662GV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39687WG", "error": "Starting point for pathway to G39687WG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39691JY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17413FR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G17413FR", "dp": 13 }, { "id": "G39691JY", "dp": 13 } ], "links": [ { "target": "G39691JY", "source": "G17413FR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17413FR", "source": "G56749GV", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39722LF", "error": "Missing intermediate; no pathways to [G39722LF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39735TI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86730KO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G86730KO", "dp": 13 }, { "id": "G39735TI", "dp": 13 } ], "links": [ { "target": "G39735TI", "source": "G86730KO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86730KO", "source": "G48658PB", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39750GC", "error": "Starting point for pathway to G39750GC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39756ZC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G34725PD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G34725PD", "dp": 12 }, { "id": "G39756ZC", "dp": 12 } ], "links": [ { "target": "G39756ZC", "source": "G34725PD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34725PD", "source": "G30302VM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39760IQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10664FL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G10664FL", "dp": 10 }, { "id": "G39760IQ", "dp": 10 } ], "links": [ { "target": "G39760IQ", "source": "G10664FL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10664FL", "source": "G45262QY", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39764AC", "error": "Starting point for pathway to G39764AC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39765RY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G62880PC", "dp": 9 }, { "id": "G45686NF", "dp": 10 } ], "links": [ { "target": "G39765RY", "source": "G45686NF", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45686NF", "source": "G62880PC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62880PC", "source": "G59471TH", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39794DN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77639OD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G39794DN", "dp": 10 } ], "links": [ { "target": "G39794DN", "source": "G77639OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39809FW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88382QE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G88382QE", "dp": 14 }, { "id": "G39809FW", "dp": 14 } ], "links": [ { "target": "G39809FW", "source": "G88382QE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88382QE", "source": "G18938DW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39813YP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 } ], "links": [ { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39824OQ", "error": "Missing intermediate; no pathways to [G39824OQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39829HV", "error": "Starting point for pathway to G39829HV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39873VR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36108GD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G36108GD", "dp": 11 }, { "id": "G39873VR", "dp": 11 } ], "links": [ { "target": "G39873VR", "source": "G36108GD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36108GD", "source": "G32305RZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39893KL", "error": "Starting point for pathway to G39893KL could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39906AT", "error": "Missing intermediate; no pathways to [G39906AT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G39970RY", "error": "Missing intermediate; no pathways to [G39970RY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53667CH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39976KS", "error": "Starting point for pathway to G39976KS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G39977UQ", "error": "Missing intermediate; no pathways to [G39977UQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G39992DR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70708LW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G70708LW", "dp": 12 }, { "id": "G39992DR", "dp": 12 } ], "links": [ { "target": "G39992DR", "source": "G70708LW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70708LW", "source": "G74675FC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G39993XV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28948UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G28948UC", "dp": 12 }, { "id": "G39993XV", "dp": 12 } ], "links": [ { "target": "G39993XV", "source": "G28948UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28948UC", "source": "G10691MJ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40000FH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G67045LB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G40000FH", "dp": 8 } ], "links": [ { "target": "G40000FH", "source": "G67045LB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40027VO", "error": "Missing intermediate; no pathways to [G40027VO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40033UH", "error": "Starting point for pathway to G40033UH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40064GR", "error": "Missing intermediate; no pathways to [G40064GR] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40065EM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28298VW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G28298VW", "dp": 13 }, { "id": "G40065EM", "dp": 13 } ], "links": [ { "target": "G40065EM", "source": "G28298VW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28298VW", "source": "G48658PB", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40069AV", "error": "Missing intermediate; no pathways to [G40069AV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40079RD", "error": "Starting point for pathway to G40079RD could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40095NL", "error": "Missing intermediate; no pathways to [G40095NL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G24635ZS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40096SL", "error": "Missing intermediate; no pathways to [G40096SL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G40097PQ", "error": "Starting point for pathway to G40097PQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40099KS", "error": "Starting point for pathway to G40099KS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40138ED", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44152CO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G44152CO", "dp": 11 }, { "id": "G40138ED", "dp": 11 } ], "links": [ { "target": "G40138ED", "source": "G44152CO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44152CO", "source": "G66866LE", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40142NX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G80962OX", "dp": 9 } ], "links": [ { "target": "G40142NX", "source": "G80962OX", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80962OX", "source": "G66937TJ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40173TB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19615BB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G08242BT", "dp": 12 }, { "id": "G19615BB", "dp": 13 }, { "id": "G40173TB", "dp": 13 } ], "links": [ { "target": "G40173TB", "source": "G19615BB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19615BB", "source": "G08242BT", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08242BT", "source": "G26949IX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40181EN", "error": "Missing intermediate; no pathways to [G40181EN] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40194MN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 } ], "links": [ { "target": "G40194MN", "source": "G76842ZR", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40198OD", "error": "Starting point for pathway to G40198OD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40200RC", "error": "Missing intermediate; no pathways to [G40200RC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10295MW]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40219EV", "error": "Missing intermediate; no pathways to [G40219EV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25392ZR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40244KN", "error": "Starting point for pathway to G40244KN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40264QS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21311YA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G21311YA", "dp": 12 }, { "id": "G40264QS", "dp": 12 } ], "links": [ { "target": "G40264QS", "source": "G21311YA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21311YA", "source": "G11041DA", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40268BC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03272YQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G21788RU", "dp": 12 }, { "id": "G03272YQ", "dp": 13 }, { "id": "G40268BC", "dp": 13 } ], "links": [ { "target": "G40268BC", "source": "G03272YQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03272YQ", "source": "G21788RU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21788RU", "source": "G25520XG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40289RO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 } ], "links": [ { "target": "G40289RO", "source": "G20966TZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40317YZ", "error": "Starting point for pathway to G40317YZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40341NV", "error": "Missing intermediate; no pathways to [G40341NV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40343KH", "error": "Missing intermediate; no pathways to [G40343KH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57835AK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40352EF", "error": "Starting point for pathway to G40352EF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40358EZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G40358EZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40384AJ", "error": "Missing intermediate; no pathways to [G40384AJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40396FX", "error": "Missing intermediate; no pathways to [G40396FX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02679YX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40411HQ", "error": "Missing intermediate; no pathways to [G40411HQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40428GO", "error": "Missing intermediate; no pathways to [G40428GO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40447LJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98809PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G40447LJ", "dp": 12 } ], "links": [ { "target": "G40447LJ", "source": "G98809PE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40452FK", "error": "Missing intermediate; no pathways to [G40452FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40461OS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26018HD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G26018HD", "dp": 12 }, { "id": "G40461OS", "dp": 12 } ], "links": [ { "target": "G40461OS", "source": "G26018HD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26018HD", "source": "G90870DG", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40482NA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G28948UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G28948UC", "dp": 12 }, { "id": "G40482NA", "dp": 12 } ], "links": [ { "target": "G40482NA", "source": "G28948UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28948UC", "source": "G10691MJ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40493BL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G81085EP", "dp": 11 } ], "links": [ { "target": "G40493BL", "source": "G81085EP", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G81085EP", "source": "G87073UP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40513EI", "error": "Missing intermediate; no pathways to [G40513EI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13282WA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40514ET", "error": "Missing intermediate; no pathways to [G40514ET] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G40542QP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 } ], "links": [ { "target": "G40542QP", "source": "G10228OD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40554DX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 } ], "links": [ { "target": "G40554DX", "source": "G75120WS", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40558VT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38951VC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G53000RQ", "dp": 11 }, { "id": "G38951VC", "dp": 12 }, { "id": "G40558VT", "dp": 12 } ], "links": [ { "target": "G40558VT", "source": "G38951VC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38951VC", "source": "G53000RQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40569DS", "error": "Missing intermediate; no pathways to [G40569DS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G58827HR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40579SX", "error": "Starting point for pathway to G40579SX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40606GB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 } ], "links": [ { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40641DI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02582JY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G30901GC", "dp": 9 }, { "id": "G02582JY", "dp": 10 }, { "id": "G40641DI", "dp": 10 } ], "links": [ { "target": "G40641DI", "source": "G02582JY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02582JY", "source": "G30901GC", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40658KJ", "error": "Starting point for pathway to G40658KJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40670DJ", "error": "Missing intermediate; no pathways to [G40670DJ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40702WU", "error": "Starting point for pathway to G40702WU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40707SF", "error": "Missing intermediate; no pathways to [G40707SF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40732RC", "error": "Missing intermediate; no pathways to [G40732RC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40735XY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79198BK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G79198BK", "dp": 9 }, { "id": "G40735XY", "dp": 9 } ], "links": [ { "target": "G40735XY", "source": "G79198BK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79198BK", "source": "G10219AA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40762ZY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 } ], "links": [ { "target": "G40762ZY", "source": "G28826SH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40786FB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06216UH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G40786FB", "dp": 10 } ], "links": [ { "target": "G40786FB", "source": "G06216UH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40806JH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 } ], "links": [ { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40813TL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 } ], "links": [ { "target": "G40813TL", "source": "G20815TK", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40820FX", "error": "Missing intermediate; no pathways to [G40820FX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40821RK", "error": "Starting point for pathway to G40821RK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40825YQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79457WN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G79457WN", "dp": 11 }, { "id": "G40825YQ", "dp": 11 } ], "links": [ { "target": "G40825YQ", "source": "G79457WN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79457WN", "source": "G00176HZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40849ON", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93193OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G17473NR", "dp": 13 }, { "id": "G93193OD", "dp": 14 }, { "id": "G40849ON", "dp": 14 } ], "links": [ { "target": "G40849ON", "source": "G93193OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93193OD", "source": "G17473NR", "residue_affected": { "residue_id": "N267", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G17473NR", "source": "G10733HY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40896GF", "error": "Starting point for pathway to G40896GF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40900UQ", "error": "Starting point for pathway to G40900UQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40903ZD", "error": "Missing intermediate; no pathways to [G40903ZD] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G34819LS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40906DZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G40906DZ", "source": "G18938DW", "residue_affected": { "residue_id": "N43", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40909AN", "error": "Missing intermediate; no pathways to [G40909AN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G40915GX", "error": "Starting point for pathway to G40915GX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G40922OB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82420SH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G82420SH", "dp": 10 }, { "id": "G40922OB", "dp": 10 } ], "links": [ { "target": "G40922OB", "source": "G82420SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G40994FC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G45359RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G40994FC", "dp": 12 } ], "links": [ { "target": "G40994FC", "source": "G45359RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41012KL", "error": "Starting point for pathway to G41012KL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41015OA", "error": "Starting point for pathway to G41015OA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41030WJ", "error": "Missing intermediate; no pathways to [G41030WJ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41046RP", "error": "Starting point for pathway to G41046RP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41068PD", "error": "Missing intermediate; no pathways to [G41068PD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90784AP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41087ZA", "error": "Missing intermediate; no pathways to [G41087ZA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41095QB", "error": "Starting point for pathway to G41095QB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41107EH", "error": "Missing intermediate; no pathways to [G41107EH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08896RO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41125AS", "error": "Starting point for pathway to G41125AS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41171HL", "error": "Missing intermediate; no pathways to [G41171HL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41178NB", "error": "Starting point for pathway to G41178NB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41219SY", "error": "Starting point for pathway to G41219SY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41224TP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57117TO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G57117TO", "dp": 8 }, { "id": "G41224TP", "dp": 8 } ], "links": [ { "target": "G41224TP", "source": "G57117TO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57117TO", "source": "G69411IG", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41263IO", "error": "Starting point for pathway to G41263IO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41274AJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81392TU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G81392TU", "dp": 14 }, { "id": "G41274AJ", "dp": 14 } ], "links": [ { "target": "G41274AJ", "source": "G81392TU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81392TU", "source": "G85085MS", "residue_affected": { "residue_id": "N246", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41278YY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G82540VC", "dp": 8 } ], "links": [ { "target": "G41278YY", "source": "G82540VC", "residue_affected": { "residue_id": "N238", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G82540VC", "source": "G39213VZ", "residue_affected": { "residue_id": "N250", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41310VR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42028DN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 }, { "id": "G41310VR", "dp": 11 } ], "links": [ { "target": "G41310VR", "source": "G42028DN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41331JX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41352UL", "error": "Starting point for pathway to G41352UL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41389FB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 } ], "links": [ { "target": "G41389FB", "source": "G65597BI", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41389HP", "error": "Missing intermediate; no pathways to [G41389HP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24155DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41455NO", "error": "Missing intermediate; no pathways to [G41455NO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G12222NC]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41486SZ", "error": "Starting point for pathway to G41486SZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41504VL", "error": "Missing intermediate; no pathways to [G41504VL] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41510DX", "error": "Starting point for pathway to G41510DX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41511CE", "error": "Missing intermediate; no pathways to [G41511CE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41535JH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43677TG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G41535JH", "dp": 8 } ], "links": [ { "target": "G41535JH", "source": "G43677TG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41543HE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23295TF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G23295TF", "dp": 10 }, { "id": "G41543HE", "dp": 10 } ], "links": [ { "target": "G41543HE", "source": "G23295TF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23295TF", "source": "G27919IH", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41551CD", "error": "Missing intermediate; no pathways to [G41551CD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97039HI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41563EN", "error": "Missing intermediate; no pathways to [G41563EN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41576FY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79809MM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G41576FY", "dp": 11 } ], "links": [ { "target": "G41576FY", "source": "G79809MM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41596PV", "error": "Missing intermediate; no pathways to [G41596PV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41611UG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17264LS]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G17264LS", "dp": 10 }, { "id": "G41611UG", "dp": 10 } ], "links": [ { "target": "G41611UG", "source": "G17264LS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17264LS", "source": "G16828VN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41611UP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 } ], "links": [ { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41656NL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 } ], "links": [ { "target": "G41656NL", "source": "G23616ZX", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41658RK", "error": "Missing intermediate; no pathways to [G41658RK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41659QU", "error": "Missing intermediate; no pathways to [G41659QU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40428GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41670EF", "error": "Missing intermediate; no pathways to [G41670EF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41711ZZ", "error": "Missing intermediate; no pathways to [G41711ZZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41715PL", "error": "Starting point for pathway to G41715PL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41720HN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G41720HN", "source": "G07483YN", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41771ES", "error": "Starting point for pathway to G41771ES could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41797PU", "error": "Missing intermediate; no pathways to [G41797PU] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41800OU", "error": "Missing intermediate; no pathways to [G41800OU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G27273FD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41811PH", "error": "Starting point for pathway to G41811PH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41811VQ", "error": "Missing intermediate; no pathways to [G41811VQ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41817BL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17264LS]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G17264LS", "dp": 10 }, { "id": "G41817BL", "dp": 10 } ], "links": [ { "target": "G41817BL", "source": "G17264LS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17264LS", "source": "G16828VN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41820ZZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 } ], "links": [ { "target": "G41820ZZ", "source": "G45560HM", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41821MR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52880ZN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G52880ZN", "dp": 12 }, { "id": "G41821MR", "dp": 12 } ], "links": [ { "target": "G41821MR", "source": "G52880ZN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52880ZN", "source": "G82252QI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41823PK", "error": "Missing intermediate; no pathways to [G41823PK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64618XR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41823TY", "error": "Missing intermediate; no pathways to [G41823TY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30483FB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41824PC", "error": "Starting point for pathway to G41824PC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41827IE", "error": "Starting point for pathway to G41827IE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41847IM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89036WC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G89036WC", "dp": 8 }, { "id": "G41847IM", "dp": 8 } ], "links": [ { "target": "G41847IM", "source": "G89036WC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89036WC", "source": "G02427KF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41850YN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G91413ZX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 }, { "id": "G41850YN", "dp": 15 } ], "links": [ { "target": "G41850YN", "source": "G91413ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41865ZJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50779LX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G50779LX", "dp": 12 }, { "id": "G41865ZJ", "dp": 12 } ], "links": [ { "target": "G41865ZJ", "source": "G50779LX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50779LX", "source": "G25140TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41879EJ", "error": "Missing intermediate; no pathways to [G41879EJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41912CL", "error": "Missing intermediate; no pathways to [G41912CL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75097MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41923EO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G62504BU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G41923EO", "dp": 10 } ], "links": [ { "target": "G41923EO", "source": "G62504BU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41937ED", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G05794RZ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 }, { "id": "G05794RZ", "dp": 12 }, { "id": "G41937ED", "dp": 12 } ], "links": [ { "target": "G41937ED", "source": "G05794RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05794RZ", "source": "G40806JH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G41940YX", "error": "Starting point for pathway to G41940YX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41943OZ", "error": "Starting point for pathway to G41943OZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G41953RN", "error": "Missing intermediate; no pathways to [G41953RN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41974MG", "error": "Missing intermediate; no pathways to [G41974MG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G02025MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G41981MA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 } ], "links": [ { "target": "G41981MA", "source": "G38022PE", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42011CP", "error": "Missing intermediate; no pathways to [G42011CP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42013HP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20815TK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G42013HP", "dp": 11 } ], "links": [ { "target": "G42013HP", "source": "G20815TK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42022OY", "error": "Missing intermediate; no pathways to [G42022OY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42028DN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 } ], "links": [ { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42028VS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G01935FK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G01935FK", "dp": 10 }, { "id": "G42028VS", "dp": 10 } ], "links": [ { "target": "G42028VS", "source": "G01935FK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01935FK", "source": "G36191CD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42058RF", "error": "Missing intermediate; no pathways to [G42058RF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42061BV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G73492AT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G42061BV", "dp": 13 } ], "links": [ { "target": "G42061BV", "source": "G73492AT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42095CU", "error": "Missing intermediate; no pathways to [G42095CU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98537XO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42097JO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 } ], "links": [ { "target": "G42097JO", "source": "G85085MS", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42110JE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G21359NQ", "dp": 11 } ], "links": [ { "target": "G42110JE", "source": "G21359NQ", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21359NQ", "source": "G32305RZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42123IU", "error": "Missing intermediate; no pathways to [G42123IU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84163ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42130KX", "error": "Missing intermediate; no pathways to [G42130KX] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42133QN", "error": "Starting point for pathway to G42133QN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42175IR", "error": "Missing intermediate; no pathways to [G42175IR] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G42177JE", "error": "Missing intermediate; no pathways to [G42177JE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G97039HI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42193NQ", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 } ], "links": [ { "target": "G42193NQ", "source": "G56748EO", "residue_affected": { "residue_id": "N373", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42240DE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 } ], "links": [ { "target": "G42240DE", "source": "G20815TK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42295MA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91023GB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G42295MA", "dp": 12 } ], "links": [ { "target": "G42295MA", "source": "G91023GB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42322YV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 } ], "links": [ { "target": "G42322YV", "source": "G14782PJ", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42332HD", "error": "Starting point for pathway to G42332HD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42343WF", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G10989IB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 }, { "id": "G31004HS", "dp": 18 }, { "id": "G10989IB", "dp": 19 }, { "id": "G42343WF", "dp": 19 } ], "links": [ { "target": "G42343WF", "source": "G10989IB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10989IB", "source": "G31004HS", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42365AT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 } ], "links": [ { "target": "G42365AT", "source": "G77252PU", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42372YG", "error": "Starting point for pathway to G42372YG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42380GI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56318NV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 }, { "id": "G56318NV", "dp": 17 }, { "id": "G42380GI", "dp": 17 } ], "links": [ { "target": "G42380GI", "source": "G56318NV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56318NV", "source": "G75237SS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42394CB", "error": "Missing intermediate; no pathways to [G42394CB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17134VG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42400JK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G69086TY", "dp": 12 } ], "links": [ { "target": "G42400JK", "source": "G69086TY", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42415XD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91511MZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G91511MZ", "dp": 12 }, { "id": "G42415XD", "dp": 12 } ], "links": [ { "target": "G42415XD", "source": "G91511MZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91511MZ", "source": "G11041DA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42420NN", "error": "Missing intermediate; no pathways to [G42420NN] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42438ZG", "error": "Missing intermediate; no pathways to [G42438ZG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42439GB", "error": "Starting point for pathway to G42439GB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42477ZH", "error": "Missing intermediate; no pathways to [G42477ZH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G42482KG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54956ME]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G18641OW", "dp": 11 }, { "id": "G54956ME", "dp": 12 }, { "id": "G42482KG", "dp": 12 } ], "links": [ { "target": "G42482KG", "source": "G54956ME", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54956ME", "source": "G18641OW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18641OW", "source": "G88417ED", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42501VF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57863LA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G57863LA", "dp": 11 }, { "id": "G42501VF", "dp": 11 } ], "links": [ { "target": "G42501VF", "source": "G57863LA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57863LA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42504VW", "error": "Missing intermediate; no pathways to [G42504VW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42516QP", "error": "Missing intermediate; no pathways to [G42516QP] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42525DE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G49743VF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G49743VF", "dp": 11 }, { "id": "G42525DE", "dp": 11 } ], "links": [ { "target": "G42525DE", "source": "G49743VF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49743VF", "source": "G06216UH", "residue_affected": { "residue_id": "N470", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42530JA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38208CY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G61684ET", "dp": 12 }, { "id": "G38208CY", "dp": 13 }, { "id": "G42530JA", "dp": 13 } ], "links": [ { "target": "G42530JA", "source": "G38208CY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38208CY", "source": "G61684ET", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61684ET", "source": "G25520XG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42548XF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G42548XF", "source": "G61751GZ", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] } ] } , { "glytoucan_ac": "G42552PM", "error": "Starting point for pathway to G42552PM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42600SB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98366ZJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G98366ZJ", "dp": 14 }, { "id": "G42600SB", "dp": 14 } ], "links": [ { "target": "G42600SB", "source": "G98366ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98366ZJ", "source": "G99074EO", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42605KJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78097CL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 }, { "id": "G78097CL", "dp": 13 }, { "id": "G42605KJ", "dp": 13 } ], "links": [ { "target": "G42605KJ", "source": "G78097CL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78097CL", "source": "G09150LP", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42619IV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 } ], "links": [ { "target": "G42619IV", "source": "G75185NU", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42635DR", "error": "Missing intermediate; no pathways to [G42635DR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96719MC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42653GO", "error": "Starting point for pathway to G42653GO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42671TR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 } ], "links": [ { "target": "G42671TR", "source": "G72718TT", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42672MA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42674AX", "error": "Starting point for pathway to G42674AX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42674LI", "error": "Starting point for pathway to G42674LI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42674MT", "error": "Missing intermediate; no pathways to [G42674MT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64077VW]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42679AH", "error": "Starting point for pathway to G42679AH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42680EX", "error": "Missing intermediate; no pathways to [G42680EX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61751GZ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42681RK", "error": "Starting point for pathway to G42681RK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42686NP", "error": "Missing intermediate; no pathways to [G42686NP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G42686NQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 } ], "links": [ { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42712XS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G64633BH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G64633BH", "dp": 9 }, { "id": "G42712XS", "dp": 9 } ], "links": [ { "target": "G42712XS", "source": "G64633BH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G64633BH", "source": "G79348ZY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42713FO", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G56340GX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G56340GX", "dp": 10 }, { "id": "G42713FO", "dp": 10 } ], "links": [ { "target": "G42713FO", "source": "G56340GX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56340GX", "source": "G27919IH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42725VI", "error": "Missing intermediate; no pathways to [G42725VI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83402YY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42731RJ", "error": "Missing intermediate; no pathways to [G42731RJ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42746CP", "error": "Missing intermediate; no pathways to [G42746CP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42779AL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43346PX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G43346PX", "dp": 12 }, { "id": "G42779AL", "dp": 12 } ], "links": [ { "target": "G42779AL", "source": "G43346PX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43346PX", "source": "G04743RS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42824AQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92574YO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G42824AQ", "dp": 17 } ], "links": [ { "target": "G42824AQ", "source": "G92574YO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42830YF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G18938DW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G42830YF", "dp": 13 } ], "links": [ { "target": "G42830YF", "source": "G18938DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42841BX", "error": "Missing intermediate; no pathways to [G42841BX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42846BO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91365ZQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G42846BO", "dp": 10 } ], "links": [ { "target": "G42846BO", "source": "G91365ZQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42862VU", "error": "Missing intermediate; no pathways to [G42862VU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95298UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42866WF", "error": "Missing intermediate; no pathways to [G42866WF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42906YD", "error": "Missing intermediate; no pathways to [G42906YD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64761FU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42909GK", "error": "Missing intermediate; no pathways to [G42909GK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42924MA", "error": "Missing intermediate; no pathways to [G42924MA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G42941KJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84712FF", "dp": 12 } ], "links": [ { "target": "G42941KJ", "source": "G84712FF", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84712FF", "source": "G29857RC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G42984ZU", "error": "Starting point for pathway to G42984ZU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G42996MA", "error": "Starting point for pathway to G42996MA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43014FZ", "error": "Starting point for pathway to G43014FZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43040IL", "error": "Missing intermediate; no pathways to [G43040IL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43048HN", "error": "Starting point for pathway to G43048HN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43070PV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53485VW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 }, { "id": "G43070PV", "dp": 14 } ], "links": [ { "target": "G43070PV", "source": "G53485VW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43072YM", "error": "Starting point for pathway to G43072YM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43073RP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G18026EK", "dp": 12 } ], "links": [ { "target": "G43073RP", "source": "G18026EK", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18026EK", "source": "G37046CZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43088GK", "error": "Missing intermediate; no pathways to [G43088GK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43088UA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05260RH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G05260RH", "dp": 11 }, { "id": "G43088UA", "dp": 11 } ], "links": [ { "target": "G43088UA", "source": "G05260RH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05260RH", "source": "G56591LC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43095XB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85260RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G85260RY", "dp": 16 }, { "id": "G43095XB", "dp": 16 } ], "links": [ { "target": "G43095XB", "source": "G85260RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85260RY", "source": "G57955DP", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43131ZX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89168LM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 }, { "id": "G16057DE", "dp": 14 }, { "id": "G89168LM", "dp": 15 }, { "id": "G43131ZX", "dp": 15 } ], "links": [ { "target": "G43131ZX", "source": "G89168LM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89168LM", "source": "G16057DE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16057DE", "source": "G67289UM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43164CL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84712FF", "dp": 12 } ], "links": [ { "target": "G43164CL", "source": "G84712FF", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G84712FF", "source": "G29857RC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43242DB", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G88537BJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G88537BJ", "dp": 15 }, { "id": "G43242DB", "dp": 15 } ], "links": [ { "target": "G43242DB", "source": "G88537BJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88537BJ", "source": "G23616ZX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43255OW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G48954CA", "dp": 9 } ], "links": [ { "target": "G43255OW", "source": "G48954CA", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G48954CA", "source": "G12398HZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43280XO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21311YA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G21311YA", "dp": 12 }, { "id": "G43280XO", "dp": 12 } ], "links": [ { "target": "G43280XO", "source": "G21311YA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21311YA", "source": "G11041DA", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43288IJ", "error": "Missing intermediate; no pathways to [G43288IJ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43299SD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43301PF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G84376FR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G43301PF", "dp": 12 } ], "links": [ { "target": "G43301PF", "source": "G84376FR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43325ZI", "error": "Missing intermediate; no pathways to [G43325ZI] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G43343WJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59942FB]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 }, { "id": "G59942FB", "dp": 11 }, { "id": "G43343WJ", "dp": 11 } ], "links": [ { "target": "G43343WJ", "source": "G59942FB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59942FB", "source": "G56748EO", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43346IY", "error": "Missing intermediate; no pathways to [G43346IY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42438ZG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43346PX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 } ], "links": [ { "target": "G43346PX", "source": "G04743RS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43346UV", "error": "Missing intermediate; no pathways to [G43346UV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76554SR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43351VW", "error": "Missing intermediate; no pathways to [G43351VW] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43433FA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 } ], "links": [ { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43447HY", "error": "Missing intermediate; no pathways to [G43447HY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43473VD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09921WG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G43473VD", "dp": 10 } ], "links": [ { "target": "G43473VD", "source": "G09921WG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43475FH", "error": "Starting point for pathway to G43475FH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43499QE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19444JC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G19444JC", "dp": 15 }, { "id": "G43499QE", "dp": 15 } ], "links": [ { "target": "G43499QE", "source": "G19444JC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19444JC", "source": "G45720CA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43502GT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G37022BP", "dp": 12 } ], "links": [ { "target": "G43502GT", "source": "G37022BP", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37022BP", "source": "G30460NZ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43507KQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G09826WW", "dp": 11 } ], "links": [ { "target": "G43507KQ", "source": "G09826WW", "residue_affected": { "residue_id": "N272", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G09826WW", "source": "G85542KD", "residue_affected": { "residue_id": "N271", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43519BI", "error": "Starting point for pathway to G43519BI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43526DL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96674LJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G96674LJ", "dp": 18 }, { "id": "G43526DL", "dp": 18 } ], "links": [ { "target": "G43526DL", "source": "G96674LJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96674LJ", "source": "G50489VC", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43526DV", "error": "Starting point for pathway to G43526DV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43547MI", "error": "Starting point for pathway to G43547MI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43553YK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57092OJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G43553YK", "dp": 10 } ], "links": [ { "target": "G43553YK", "source": "G57092OJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43556OK", "error": "Missing intermediate; no pathways to [G43556OK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80264ZA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43558RC", "error": "Missing intermediate; no pathways to [G43558RC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42909GK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43563XU", "error": "Starting point for pathway to G43563XU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43596KL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92574YO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G43596KL", "dp": 17 } ], "links": [ { "target": "G43596KL", "source": "G92574YO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43603TQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G30651IU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G43603TQ", "dp": 13 } ], "links": [ { "target": "G43603TQ", "source": "G30651IU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43610AB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37140SO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G37140SO", "dp": 10 }, { "id": "G43610AB", "dp": 10 } ], "links": [ { "target": "G43610AB", "source": "G37140SO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37140SO", "source": "G93500PH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43638GS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27188NC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G27188NC", "dp": 8 }, { "id": "G43638GS", "dp": 8 } ], "links": [ { "target": "G43638GS", "source": "G27188NC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27188NC", "source": "G02427KF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43645EE", "error": "Missing intermediate; no pathways to [G43645EE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43648DB", "error": "Starting point for pathway to G43648DB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43649OO", "error": "Missing intermediate; no pathways to [G43649OO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43654PQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G80652ZF", "dp": 8 } ], "links": [ { "target": "G43654PQ", "source": "G80652ZF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80652ZF", "source": "G39213VZ", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43657WC", "error": "Starting point for pathway to G43657WC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43660IT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95919TI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G95919TI", "dp": 14 }, { "id": "G43660IT", "dp": 14 } ], "links": [ { "target": "G43660IT", "source": "G95919TI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95919TI", "source": "G30651IU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43664YB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 } ], "links": [ { "target": "G43664YB", "source": "G24420RT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43665PB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G79556AB", "dp": 12 } ], "links": [ { "target": "G43665PB", "source": "G79556AB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79556AB", "source": "G82252QI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43677TG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43680SH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88127MB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G88127MB", "dp": 13 }, { "id": "G43680SH", "dp": 13 } ], "links": [ { "target": "G43680SH", "source": "G88127MB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88127MB", "source": "G74120DW", "residue_affected": { "residue_id": "N46", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43685DC", "error": "Missing intermediate; no pathways to [G43685DC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85208SY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43694RQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 } ], "links": [ { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43702IX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 } ], "links": [ { "target": "G43702IX", "source": "G23616ZX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43708QI", "error": "Starting point for pathway to G43708QI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43761IQ", "error": "Missing intermediate; no pathways to [G43761IQ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G86321OX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43767FS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53985AY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G53985AY", "dp": 11 }, { "id": "G43767FS", "dp": 11 } ], "links": [ { "target": "G43767FS", "source": "G53985AY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53985AY", "source": "G78890OB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43790PG", "error": "Missing intermediate; no pathways to [G43790PG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43797QQ", "error": "Missing intermediate; no pathways to [G43797QQ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G32173NW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43814TV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G58281SK", "dp": 9 } ], "links": [ { "target": "G43814TV", "source": "G58281SK", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58281SK", "source": "G59471TH", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43830WV", "error": "Missing intermediate; no pathways to [G43830WV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43832DJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16774YZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G16774YZ", "dp": 18 }, { "id": "G43832DJ", "dp": 18 } ], "links": [ { "target": "G43832DJ", "source": "G16774YZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16774YZ", "source": "G86696LV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43839NY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G26018HD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G26018HD", "dp": 12 }, { "id": "G43839NY", "dp": 12 } ], "links": [ { "target": "G43839NY", "source": "G26018HD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26018HD", "source": "G90870DG", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43864TG", "error": "Missing intermediate; no pathways to [G43864TG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43869EE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25097RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 }, { "id": "G43869EE", "dp": 15 } ], "links": [ { "target": "G43869EE", "source": "G25097RR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43873AE", "error": "Missing intermediate; no pathways to [G43873AE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80085KS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43873BV", "error": "Missing intermediate; no pathways to [G43873BV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13659RH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43873MM", "error": "Missing intermediate; no pathways to [G43873MM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43923FO", "error": "Starting point for pathway to G43923FO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43939PS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46638GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G43939PS", "dp": 9 } ], "links": [ { "target": "G43939PS", "source": "G46638GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43981RC", "error": "Missing intermediate; no pathways to [G43981RC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G43989OI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G68845SP", "dp": 14 }, { "id": "G22079SE", "dp": 15 } ], "links": [ { "target": "G43989OI", "source": "G22079SE", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22079SE", "source": "G68845SP", "residue_affected": { "residue_id": "N48", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68845SP", "source": "G18938DW", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G43990ZC", "error": "Starting point for pathway to G43990ZC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G43991QD", "error": "Missing intermediate; no pathways to [G43991QD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44005DK", "error": "Missing intermediate; no pathways to [G44005DK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44027TT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G31532GK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G03895SR", "dp": 15 }, { "id": "G09118YK", "dp": 16 }, { "id": "G31532GK", "dp": 17 }, { "id": "G44027TT", "dp": 17 } ], "links": [ { "target": "G44027TT", "source": "G31532GK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31532GK", "source": "G09118YK", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G09118YK", "source": "G03895SR", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44030BX", "error": "Missing intermediate; no pathways to [G44030BX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G33802UM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44043ZX", "error": "Missing intermediate; no pathways to [G44043ZX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90130AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44046WQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74090KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G74090KZ", "dp": 7 }, { "id": "G44046WQ", "dp": 7 } ], "links": [ { "target": "G44046WQ", "source": "G74090KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74090KZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44070VR", "error": "Starting point for pathway to G44070VR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44073EJ", "error": "Starting point for pathway to G44073EJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44079HZ", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G06195HM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G04214MY", "dp": 11 }, { "id": "G06195HM", "dp": 12 }, { "id": "G44079HZ", "dp": 12 } ], "links": [ { "target": "G44079HZ", "source": "G06195HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06195HM", "source": "G04214MY", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04214MY", "source": "G28826SH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44084PP", "error": "Starting point for pathway to G44084PP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44085QQ", "error": "Missing intermediate; no pathways to [G44085QQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33608TH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44089VB", "error": "Missing intermediate; no pathways to [G44089VB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44092XR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G99411XJ", "dp": 14 } ], "links": [ { "target": "G44092XR", "source": "G99411XJ", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99411XJ", "source": "G92359VA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44137YR", "error": "Missing intermediate; no pathways to [G44137YR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G49446SO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44151FI", "error": "Starting point for pathway to G44151FI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44152CO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 } ], "links": [ { "target": "G44152CO", "source": "G66866LE", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44171LY", "error": "Missing intermediate; no pathways to [G44171LY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44182FH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G45660WC", "dp": 12 } ], "links": [ { "target": "G44182FH", "source": "G45660WC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45660WC", "source": "G99645NK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44183XJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52428MJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G52428MJ", "dp": 10 }, { "id": "G44183XJ", "dp": 10 } ], "links": [ { "target": "G44183XJ", "source": "G52428MJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52428MJ", "source": "G42672MA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44187XB", "error": "Missing intermediate; no pathways to [G44187XB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44201QD", "error": "Starting point for pathway to G44201QD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44202NB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G72821WX", "dp": 9 } ], "links": [ { "target": "G44202NB", "source": "G72821WX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44210FS", "error": "Starting point for pathway to G44210FS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44223QP", "error": "Missing intermediate; no pathways to [G44223QP] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G44264DI", "error": "Starting point for pathway to G44264DI could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44274UK", "error": "Missing intermediate; no pathways to [G44274UK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10563SE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44304NG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18768EK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G18768EK", "dp": 11 }, { "id": "G44304NG", "dp": 11 } ], "links": [ { "target": "G44304NG", "source": "G18768EK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18768EK", "source": "G78803YD", "residue_affected": { "residue_id": "N78", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44324HQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62765SF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G62765SF", "dp": 14 }, { "id": "G44324HQ", "dp": 14 } ], "links": [ { "target": "G44324HQ", "source": "G62765SF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62765SF", "source": "G04989WY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44325XR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G89168LM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 }, { "id": "G16057DE", "dp": 14 }, { "id": "G89168LM", "dp": 15 }, { "id": "G44325XR", "dp": 15 } ], "links": [ { "target": "G44325XR", "source": "G89168LM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89168LM", "source": "G16057DE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16057DE", "source": "G67289UM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44327JQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G86357DX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G44327JQ", "dp": 12 } ], "links": [ { "target": "G44327JQ", "source": "G86357DX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44339HI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 } ], "links": [ { "target": "G44339HI", "source": "G31010RQ", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44361OH", "error": "Missing intermediate; no pathways to [G44361OH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96503EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44364RM", "error": "Missing intermediate; no pathways to [G44364RM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53667CH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44414DH", "error": "Missing intermediate; no pathways to [G44414DH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44424DD", "error": "Missing intermediate; no pathways to [G44424DD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51050LD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44466VN", "error": "Missing intermediate; no pathways to [G44466VN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44489BZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29857RC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G44489BZ", "dp": 11 } ], "links": [ { "target": "G44489BZ", "source": "G29857RC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44504SC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G44504SC", "source": "G20030CU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44510KF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G87535DG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G87535DG", "dp": 12 }, { "id": "G44510KF", "dp": 12 } ], "links": [ { "target": "G44510KF", "source": "G87535DG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G87535DG", "source": "G74675FC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44515AZ", "error": "Missing intermediate; no pathways to [G44515AZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40027VO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44541JO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90017UO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G44541JO", "dp": 10 } ], "links": [ { "target": "G44541JO", "source": "G90017UO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44575RK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78030KJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G78030KJ", "dp": 14 }, { "id": "G44575RK", "dp": 14 } ], "links": [ { "target": "G44575RK", "source": "G78030KJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78030KJ", "source": "G53812BX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44576MS", "error": "Missing intermediate; no pathways to [G44576MS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44598QA", "error": "Missing intermediate; no pathways to [G44598QA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G22388FD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44617UT", "error": "Starting point for pathway to G44617UT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44618FI", "error": "Starting point for pathway to G44618FI could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44623TX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 } ], "links": [ { "target": "G44623TX", "source": "G79809MM", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44639PM", "error": "Missing intermediate; no pathways to [G44639PM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82847HG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44656CN", "error": "Starting point for pathway to G44656CN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44678XW", "error": "Missing intermediate; no pathways to [G44678XW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54953LX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44688UB", "error": "Missing intermediate; no pathways to [G44688UB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75972ZC]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44723YJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02311IE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G44723YJ", "dp": 16 } ], "links": [ { "target": "G44723YJ", "source": "G02311IE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44731OW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54611ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 }, { "id": "G44731OW", "dp": 11 } ], "links": [ { "target": "G44731OW", "source": "G54611ZT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44743IQ", "error": "Starting point for pathway to G44743IQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44747CU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16828VN]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G44747CU", "dp": 9 } ], "links": [ { "target": "G44747CU", "source": "G16828VN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44754DF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89993FE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G44754DF", "dp": 8 } ], "links": [ { "target": "G44754DF", "source": "G89993FE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44762SD", "error": "Missing intermediate; no pathways to [G44762SD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G44770ZI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88461FF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G44770ZI", "dp": 9 } ], "links": [ { "target": "G44770ZI", "source": "G88461FF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44790NU", "error": "Missing intermediate; no pathways to [G44790NU] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44792ZH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 } ], "links": [ { "target": "G44792ZH", "source": "G26182BM", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44799JP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19868AX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G19868AX", "dp": 8 }, { "id": "G44799JP", "dp": 8 } ], "links": [ { "target": "G44799JP", "source": "G19868AX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19868AX", "source": "G39213VZ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44809MP", "error": "Missing intermediate; no pathways to [G44809MP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44825LU", "error": "Missing intermediate; no pathways to [G44825LU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G84879CH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44825QL", "error": "Missing intermediate; no pathways to [G44825QL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44826KU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45560HM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G44826KU", "dp": 10 } ], "links": [ { "target": "G44826KU", "source": "G45560HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44845VH", "error": "Starting point for pathway to G44845VH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44865OQ", "error": "Starting point for pathway to G44865OQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44904UE", "error": "Missing intermediate; no pathways to [G44904UE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G44909WI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56748EO]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 }, { "id": "G44909WI", "dp": 10 } ], "links": [ { "target": "G44909WI", "source": "G56748EO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44924MQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56147VV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G56147VV", "dp": 15 }, { "id": "G44924MQ", "dp": 15 } ], "links": [ { "target": "G44924MQ", "source": "G56147VV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56147VV", "source": "G17168RO", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44946WH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 } ], "links": [ { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44962ZM", "error": "Missing intermediate; no pathways to [G44962ZM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30514JJ]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G44965BC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64633BH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G64633BH", "dp": 9 }, { "id": "G44965BC", "dp": 9 } ], "links": [ { "target": "G44965BC", "source": "G64633BH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G64633BH", "source": "G79348ZY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G44974AB", "error": "Starting point for pathway to G44974AB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44982DH", "error": "Starting point for pathway to G44982DH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44992KB", "error": "Starting point for pathway to G44992KB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G44996SV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72698LT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G82861UH", "dp": 9 }, { "id": "G72698LT", "dp": 10 }, { "id": "G44996SV", "dp": 10 } ], "links": [ { "target": "G44996SV", "source": "G72698LT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72698LT", "source": "G82861UH", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82861UH", "source": "G59471TH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45000ZN", "error": "Missing intermediate; no pathways to [G45000ZN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23419AQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45036WQ", "error": "Starting point for pathway to G45036WQ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45048TZ", "error": "Missing intermediate; no pathways to [G45048TZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G45050CR", "error": "Missing intermediate; no pathways to [G45050CR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45058LS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G40358EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G40358EZ", "dp": 11 }, { "id": "G45058LS", "dp": 11 } ], "links": [ { "target": "G45058LS", "source": "G40358EZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40358EZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45073MO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 } ], "links": [ { "target": "G45073MO", "source": "G84376FR", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45079TK", "error": "Missing intermediate; no pathways to [G45079TK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21459ST]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45104SZ", "error": "Missing intermediate; no pathways to [G45104SZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20885BK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45108QT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91832SW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G91832SW", "dp": 14 }, { "id": "G45108QT", "dp": 14 } ], "links": [ { "target": "G45108QT", "source": "G91832SW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91832SW", "source": "G85085MS", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45116MR", "error": "Missing intermediate; no pathways to [G45116MR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59742GY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45155FK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G44504SC", "dp": 10 } ], "links": [ { "target": "G45155FK", "source": "G44504SC", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44504SC", "source": "G20030CU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45187EI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 } ], "links": [ { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45201FL", "error": "Starting point for pathway to G45201FL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45209NR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 } ], "links": [ { "target": "G45209NR", "source": "G91905FJ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45217YN", "error": "Missing intermediate; no pathways to [G45217YN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54986EB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45229AI", "error": "Starting point for pathway to G45229AI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45250VC", "error": "Starting point for pathway to G45250VC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45256SO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93500PH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G45256SO", "dp": 9 } ], "links": [ { "target": "G45256SO", "source": "G93500PH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45258LH", "error": "Starting point for pathway to G45258LH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45262QY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 } ], "links": [ { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45264AM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 } ], "links": [ { "target": "G45264AM", "source": "G88461FF", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45284EU", "error": "Starting point for pathway to G45284EU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45325UV", "error": "Starting point for pathway to G45325UV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45332CP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07699XI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 }, { "id": "G07699XI", "dp": 11 }, { "id": "G45332CP", "dp": 11 } ], "links": [ { "target": "G45332CP", "source": "G07699XI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07699XI", "source": "G78155FK", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45332NZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61575RT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G61575RT", "dp": 14 }, { "id": "G45332NZ", "dp": 14 } ], "links": [ { "target": "G45332NZ", "source": "G61575RT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61575RT", "source": "G82050MN", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45358WU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G99770NO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G15103WJ", "dp": 12 }, { "id": "G99770NO", "dp": 13 }, { "id": "G45358WU", "dp": 13 } ], "links": [ { "target": "G45358WU", "source": "G99770NO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99770NO", "source": "G15103WJ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G15103WJ", "source": "G25520XG", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45359RY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 } ], "links": [ { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45365RV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45374ZW", "error": "Starting point for pathway to G45374ZW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45420PL", "error": "Missing intermediate; no pathways to [G45420PL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96235XM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45421AI", "error": "Missing intermediate; no pathways to [G45421AI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45422HF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72580QS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G72580QS", "dp": 14 }, { "id": "G45422HF", "dp": 14 } ], "links": [ { "target": "G45422HF", "source": "G72580QS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72580QS", "source": "G66282NU", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45469GB", "error": "Missing intermediate; no pathways to [G45469GB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51562OR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45492BK", "error": "Missing intermediate; no pathways to [G45492BK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45523IL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 } ], "links": [ { "target": "G45523IL", "source": "G59471TH", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45533OY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79556AB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G79556AB", "dp": 12 }, { "id": "G45533OY", "dp": 12 } ], "links": [ { "target": "G45533OY", "source": "G79556AB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79556AB", "source": "G82252QI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45560HM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 } ], "links": [ { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45573QR", "error": "Missing intermediate; no pathways to [G45573QR] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G16956YO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45574NI", "error": "Missing intermediate; no pathways to [G45574NI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45579UD", "error": "Missing intermediate; no pathways to [G45579UD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97453GF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45581BY", "error": "Missing intermediate; no pathways to [G45581BY] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G70830AN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45598BE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11041DA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G45598BE", "dp": 11 } ], "links": [ { "target": "G45598BE", "source": "G11041DA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45603BW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 } ], "links": [ { "target": "G45603BW", "source": "G56549DH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45629TR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G01669LU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G45629TR", "dp": 12 } ], "links": [ { "target": "G45629TR", "source": "G01669LU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45660WC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 } ], "links": [ { "target": "G45660WC", "source": "G99645NK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45664QZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 } ], "links": [ { "target": "G45664QZ", "source": "G81432SH", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45686NF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G62880PC", "dp": 9 } ], "links": [ { "target": "G45686NF", "source": "G62880PC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62880PC", "source": "G59471TH", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45719AB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59361OW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G59361OW", "dp": 11 }, { "id": "G45719AB", "dp": 11 } ], "links": [ { "target": "G45719AB", "source": "G59361OW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59361OW", "source": "G44946WH", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45720CA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 } ], "links": [ { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45747TC", "error": "Missing intermediate; no pathways to [G45747TC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06635WE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45772IP", "error": "Missing intermediate; no pathways to [G45772IP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02025MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45775AW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84064AY]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G84064AY", "dp": 9 }, { "id": "G45775AW", "dp": 9 } ], "links": [ { "target": "G45775AW", "source": "G84064AY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84064AY", "source": "G08520NM", "residue_affected": { "residue_id": "N365", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G45776ET", "error": "Missing intermediate; no pathways to [G45776ET] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78648QN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45777DE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G26939ZY", "dp": 8 } ], "links": [ { "target": "G45777DE", "source": "G26939ZY", "residue_affected": { "residue_id": "N305", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G26939ZY", "source": "G39213VZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45826PJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47108UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G47108UC", "dp": 9 }, { "id": "G45826PJ", "dp": 9 } ], "links": [ { "target": "G45826PJ", "source": "G47108UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47108UC", "source": "G80858MF", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45832UN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 }, { "id": "G05546WG", "dp": 9 } ], "links": [ { "target": "G45832UN", "source": "G05546WG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05546WG", "source": "G69812OF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45844BS", "error": "Missing intermediate; no pathways to [G45844BS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36316RB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45861YI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60215UL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G60215UL", "dp": 12 }, { "id": "G45861YI", "dp": 12 } ], "links": [ { "target": "G45861YI", "source": "G60215UL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60215UL", "source": "G47175EF", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45864QR", "error": "Missing intermediate; no pathways to [G45864QR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93655SG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45882CQ", "error": "Starting point for pathway to G45882CQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45888VL", "error": "Missing intermediate; no pathways to [G45888VL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G45889JQ", "error": "Starting point for pathway to G45889JQ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45893BA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63838JW]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G30588SI", "dp": 9 }, { "id": "G63838JW", "dp": 10 }, { "id": "G45893BA", "dp": 10 } ], "links": [ { "target": "G45893BA", "source": "G63838JW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63838JW", "source": "G30588SI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30588SI", "source": "G08520NM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G45995IV", "error": "Starting point for pathway to G45995IV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G45997JW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45187EI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 }, { "id": "G45997JW", "dp": 11 } ], "links": [ { "target": "G45997JW", "source": "G45187EI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46005PS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92617LF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G92617LF", "dp": 10 }, { "id": "G46005PS", "dp": 10 } ], "links": [ { "target": "G46005PS", "source": "G92617LF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92617LF", "source": "G27919IH", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46021KV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G46021KV", "source": "G29857RC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46031NV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G11041DA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G46031NV", "dp": 11 } ], "links": [ { "target": "G46031NV", "source": "G11041DA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46038XL", "error": "Starting point for pathway to G46038XL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46062IG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38115KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G71857KQ", "dp": 10 }, { "id": "G38115KZ", "dp": 11 }, { "id": "G46062IG", "dp": 11 } ], "links": [ { "target": "G46062IG", "source": "G38115KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38115KZ", "source": "G71857KQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71857KQ", "source": "G29434RB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46064CO", "error": "Missing intermediate; no pathways to [G46064CO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54260SD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46103YX", "error": "Missing intermediate; no pathways to [G46103YX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G50364FV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46108US", "error": "Missing intermediate; no pathways to [G46108US] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17964DY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46123YD", "error": "Starting point for pathway to G46123YD could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46139OZ", "error": "Starting point for pathway to G46139OZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46141DD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43702IX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G43702IX", "dp": 15 }, { "id": "G46141DD", "dp": 15 } ], "links": [ { "target": "G46141DD", "source": "G43702IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43702IX", "source": "G23616ZX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46152KR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23142YD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G84852GW", "dp": 9 }, { "id": "G23142YD", "dp": 10 }, { "id": "G46152KR", "dp": 10 } ], "links": [ { "target": "G46152KR", "source": "G23142YD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23142YD", "source": "G84852GW", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G84852GW", "source": "G12398HZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46185ND", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 } ], "links": [ { "target": "G46185ND", "source": "G53752TA", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46195GB", "error": "Missing intermediate; no pathways to [G46195GB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45048TZ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G46213JU", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G46213JU", "source": "G16828VN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46243SS", "error": "Starting point for pathway to G46243SS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46248YV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G12398HZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G46248YV", "dp": 8 } ], "links": [ { "target": "G46248YV", "source": "G12398HZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46260CP", "error": "Missing intermediate; no pathways to [G46260CP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25471TG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46264GY", "error": "Starting point for pathway to G46264GY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46298TE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23616ZX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G46298TE", "dp": 14 } ], "links": [ { "target": "G46298TE", "source": "G23616ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46308WD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11637WL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G46308WD", "dp": 10 } ], "links": [ { "target": "G46308WD", "source": "G11637WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46314PI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 } ], "links": [ { "target": "G46314PI", "source": "G27123NH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46328MP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02290KA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G02290KA", "dp": 10 }, { "id": "G46328MP", "dp": 10 } ], "links": [ { "target": "G46328MP", "source": "G02290KA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46346ED", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64669AQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G46346ED", "dp": 8 } ], "links": [ { "target": "G46346ED", "source": "G64669AQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G46355PL", "error": "Missing intermediate; no pathways to [G46355PL] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G31637BB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46361GO", "error": "Missing intermediate; no pathways to [G46361GO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46387UV", "error": "Starting point for pathway to G46387UV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46394FV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G86005HP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 }, { "id": "G86005HP", "dp": 16 }, { "id": "G46394FV", "dp": 16 } ], "links": [ { "target": "G46394FV", "source": "G86005HP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86005HP", "source": "G25097RR", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46406BL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G46406BL", "source": "G11041DA", "residue_affected": { "residue_id": "N276", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46407AA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G02582JY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G30901GC", "dp": 9 }, { "id": "G02582JY", "dp": 10 }, { "id": "G46407AA", "dp": 10 } ], "links": [ { "target": "G46407AA", "source": "G02582JY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02582JY", "source": "G30901GC", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46412RZ", "error": "Missing intermediate; no pathways to [G46412RZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46415RP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77974XY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77974XY", "dp": 10 }, { "id": "G46415RP", "dp": 10 } ], "links": [ { "target": "G46415RP", "source": "G77974XY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77974XY", "source": "G20030CU", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46425HN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 } ], "links": [ { "target": "G46425HN", "source": "G45720CA", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46432HW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39595CR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G39595CR", "dp": 14 }, { "id": "G46432HW", "dp": 14 } ], "links": [ { "target": "G46432HW", "source": "G39595CR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39595CR", "source": "G80294GH", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46447MC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32305RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G46447MC", "dp": 10 } ], "links": [ { "target": "G46447MC", "source": "G32305RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46449AK", "error": "Starting point for pathway to G46449AK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46460HO", "error": "Missing intermediate; no pathways to [G46460HO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53168IY]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G46470AD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 } ], "links": [ { "target": "G46470AD", "source": "G01856RL", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46479GT", "error": "Missing intermediate; no pathways to [G46479GT] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G85208SY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46491JP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G37597FW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 }, { "id": "G46491JP", "dp": 13 } ], "links": [ { "target": "G46491JP", "source": "G37597FW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46503KK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 } ], "links": [ { "target": "G46503KK", "source": "G18219CJ", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46511PG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G62883YA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G62883YA", "dp": 11 }, { "id": "G46511PG", "dp": 11 } ], "links": [ { "target": "G46511PG", "source": "G62883YA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62883YA", "source": "G66866LE", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46542RN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G68845SP", "dp": 14 } ], "links": [ { "target": "G46542RN", "source": "G68845SP", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68845SP", "source": "G18938DW", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46560SM", "error": "Missing intermediate; no pathways to [G46560SM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82853YO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46606FL", "error": "Missing intermediate; no pathways to [G46606FL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46620QA", "error": "Missing intermediate; no pathways to [G46620QA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46626ZQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43702IX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G43702IX", "dp": 15 }, { "id": "G46626ZQ", "dp": 15 } ], "links": [ { "target": "G46626ZQ", "source": "G43702IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43702IX", "source": "G23616ZX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46638GC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 } ], "links": [ { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46654QM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 } ], "links": [ { "target": "G46654QM", "source": "G91023GB", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46661UU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G73817GH", "dp": 10 }, { "id": "G57601AP", "dp": 11 }, { "id": "G11615SW", "dp": 12 } ], "links": [ { "target": "G46661UU", "source": "G11615SW", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11615SW", "source": "G57601AP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57601AP", "source": "G73817GH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46700WH", "error": "Starting point for pathway to G46700WH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46702DL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14782PJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G46702DL", "dp": 15 } ], "links": [ { "target": "G46702DL", "source": "G14782PJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46712PI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G46712PI", "source": "G00176HZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46746GZ", "error": "Starting point for pathway to G46746GZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46763GM", "error": "Missing intermediate; no pathways to [G46763GM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G46764NJ", "error": "Missing intermediate; no pathways to [G46764NJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46767VX", "error": "Missing intermediate; no pathways to [G46767VX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46799MV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25835MT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G46799MV", "dp": 10 } ], "links": [ { "target": "G46799MV", "source": "G25835MT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46836GH", "error": "Starting point for pathway to G46836GH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46851JU", "error": "Starting point for pathway to G46851JU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G46945LQ", "error": "Missing intermediate; no pathways to [G46945LQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46961WO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80393PG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G46961WO", "dp": 9 } ], "links": [ { "target": "G46961WO", "source": "G80393PG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46991EQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86005HP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 }, { "id": "G86005HP", "dp": 16 }, { "id": "G46991EQ", "dp": 16 } ], "links": [ { "target": "G46991EQ", "source": "G86005HP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86005HP", "source": "G25097RR", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G46992PB", "error": "Missing intermediate; no pathways to [G46992PB] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G46998LN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G01856RL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G46998LN", "dp": 10 } ], "links": [ { "target": "G46998LN", "source": "G01856RL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47000SB", "error": "Missing intermediate; no pathways to [G47000SB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47006SF", "error": "Starting point for pathway to G47006SF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47007PV", "error": "Missing intermediate; no pathways to [G47007PV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47011KD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 } ], "links": [ { "target": "G47011KD", "source": "G34527RW", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47031UJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 } ], "links": [ { "target": "G47031UJ", "source": "G71679MX", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47043LK", "error": "Missing intermediate; no pathways to [G47043LK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G83738AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47065QM", "error": "Missing intermediate; no pathways to [G47065QM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40707SF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47108UC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 } ], "links": [ { "target": "G47108UC", "source": "G80858MF", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47164CZ", "error": "Starting point for pathway to G47164CZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47169TB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43665PB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G79556AB", "dp": 12 }, { "id": "G43665PB", "dp": 13 }, { "id": "G47169TB", "dp": 13 } ], "links": [ { "target": "G47169TB", "source": "G43665PB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43665PB", "source": "G79556AB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79556AB", "source": "G82252QI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47171PS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82140BL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G08709JB", "dp": 13 }, { "id": "G82140BL", "dp": 14 }, { "id": "G47171PS", "dp": 14 } ], "links": [ { "target": "G47171PS", "source": "G82140BL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82140BL", "source": "G08709JB", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08709JB", "source": "G45359RY", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47171PW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88321DT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 }, { "id": "G88321DT", "dp": 15 }, { "id": "G47171PW", "dp": 15 } ], "links": [ { "target": "G47171PW", "source": "G88321DT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88321DT", "source": "G53485VW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47175EF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47179RN", "error": "Missing intermediate; no pathways to [G47179RN] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53168IY]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G47199SM", "error": "Starting point for pathway to G47199SM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47206MY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30553WH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G30553WH", "dp": 9 }, { "id": "G47206MY", "dp": 9 } ], "links": [ { "target": "G47206MY", "source": "G30553WH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30553WH", "source": "G20956ZK", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47216WH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27776PG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G27776PG", "dp": 9 }, { "id": "G47216WH", "dp": 9 } ], "links": [ { "target": "G47216WH", "source": "G27776PG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27776PG", "source": "G20956ZK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47273WV", "error": "Starting point for pathway to G47273WV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47279LF", "error": "Missing intermediate; no pathways to [G47279LF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47280HM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 } ], "links": [ { "target": "G47280HM", "source": "G41611UP", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47286YR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42028DN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 }, { "id": "G47286YR", "dp": 11 } ], "links": [ { "target": "G47286YR", "source": "G42028DN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47316OQ", "error": "Starting point for pathway to G47316OQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47379VH", "error": "Starting point for pathway to G47379VH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47384NK", "error": "Missing intermediate; no pathways to [G47384NK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47407FC", "error": "Missing intermediate; no pathways to [G47407FC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98117HW]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G47427YD", "error": "Missing intermediate; no pathways to [G47427YD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94394GK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47440YH", "error": "Starting point for pathway to G47440YH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47456CG", "error": "Missing intermediate; no pathways to [G47456CG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G94679TQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47497WE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99969SS]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G99969SS", "dp": 10 }, { "id": "G47497WE", "dp": 10 } ], "links": [ { "target": "G47497WE", "source": "G99969SS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99969SS", "source": "G13151XE", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47498FQ", "error": "Missing intermediate; no pathways to [G47498FQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G51367TM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G47501RA", "error": "Missing intermediate; no pathways to [G47501RA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47519VR", "error": "Missing intermediate; no pathways to [G47519VR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47525EV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11034PZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G47525EV", "dp": 12 } ], "links": [ { "target": "G47525EV", "source": "G11034PZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47531XE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60215UL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G60215UL", "dp": 12 }, { "id": "G47531XE", "dp": 12 } ], "links": [ { "target": "G47531XE", "source": "G60215UL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60215UL", "source": "G47175EF", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47554EG", "error": "Missing intermediate; no pathways to [G47554EG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47562LV", "error": "Missing intermediate; no pathways to [G47562LV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47566FL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G47566FL", "source": "G07483YN", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47596RR", "error": "Missing intermediate; no pathways to [G47596RR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47606XQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G26320VO", "dp": 10 } ], "links": [ { "target": "G47606XQ", "source": "G26320VO", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26320VO", "source": "G58667NI", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47645YK", "error": "Missing intermediate; no pathways to [G47645YK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G47675LW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G34527RW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G47675LW", "dp": 8 } ], "links": [ { "target": "G47675LW", "source": "G34527RW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47684RW", "error": "Starting point for pathway to G47684RW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47741BL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75120WS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G47741BL", "dp": 13 } ], "links": [ { "target": "G47741BL", "source": "G75120WS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47756FE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11953VE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G47756FE", "dp": 14 } ], "links": [ { "target": "G47756FE", "source": "G11953VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47766VH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30901GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G30901GC", "dp": 9 }, { "id": "G47766VH", "dp": 9 } ], "links": [ { "target": "G47766VH", "source": "G30901GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47782UT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 } ], "links": [ { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47788QH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70374KJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G70374KJ", "dp": 11 }, { "id": "G47788QH", "dp": 11 } ], "links": [ { "target": "G47788QH", "source": "G70374KJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70374KJ", "source": "G88417ED", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47816DI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53752TA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G47816DI", "dp": 11 } ], "links": [ { "target": "G47816DI", "source": "G53752TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47822QX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 } ], "links": [ { "target": "G47822QX", "source": "G16759KR", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47823SP", "error": "Starting point for pathway to G47823SP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47859DD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G33742YO", "dp": 9 } ], "links": [ { "target": "G47859DD", "source": "G33742YO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47866EC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56340GX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G56340GX", "dp": 10 }, { "id": "G47866EC", "dp": 10 } ], "links": [ { "target": "G47866EC", "source": "G56340GX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56340GX", "source": "G27919IH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47877IZ", "error": "Starting point for pathway to G47877IZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47892HA", "error": "Missing intermediate; no pathways to [G47892HA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57166CI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47910EX", "error": "Starting point for pathway to G47910EX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G47911PU", "error": "Missing intermediate; no pathways to [G47911PU] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47913QC", "error": "Missing intermediate; no pathways to [G47913QC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81328FA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47925EV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82252QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G47925EV", "dp": 11 } ], "links": [ { "target": "G47925EV", "source": "G82252QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47936PQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25520XG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G47936PQ", "dp": 11 } ], "links": [ { "target": "G47936PQ", "source": "G25520XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47961DI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91905FJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G47961DI", "dp": 14 } ], "links": [ { "target": "G47961DI", "source": "G91905FJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47963XB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 } ], "links": [ { "target": "G47963XB", "source": "G66282NU", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47973FK", "error": "Missing intermediate; no pathways to [G47973FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72919IM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G47975JA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G47975JA", "source": "G11041DA", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G47982BA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31555TF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G31555TF", "dp": 11 }, { "id": "G47982BA", "dp": 11 } ], "links": [ { "target": "G47982BA", "source": "G31555TF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31555TF", "source": "G65597BI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48020LQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90348RI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G90348RI", "dp": 12 }, { "id": "G48020LQ", "dp": 12 } ], "links": [ { "target": "G48020LQ", "source": "G90348RI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90348RI", "source": "G11041DA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48029ME", "error": "Missing intermediate; no pathways to [G48029ME] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48040FY", "error": "Missing intermediate; no pathways to [G48040FY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77812KJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48069JX", "error": "Missing intermediate; no pathways to [G48069JX] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48103NH", "error": "Missing intermediate; no pathways to [G48103NH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63065KG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48109OV", "error": "Missing intermediate; no pathways to [G48109OV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48148JS", "error": "Starting point for pathway to G48148JS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48148UW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G50730KL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G50730KL", "dp": 9 }, { "id": "G48148UW", "dp": 9 } ], "links": [ { "target": "G48148UW", "source": "G50730KL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50730KL", "source": "G08520NM", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G48168SI", "error": "Starting point for pathway to G48168SI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48185FI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53985AY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G53985AY", "dp": 11 }, { "id": "G48185FI", "dp": 11 } ], "links": [ { "target": "G48185FI", "source": "G53985AY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53985AY", "source": "G78890OB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48187RE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81432SH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 }, { "id": "G48187RE", "dp": 12 } ], "links": [ { "target": "G48187RE", "source": "G81432SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48205IY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G04783EJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G05600OX", "dp": 14 }, { "id": "G04783EJ", "dp": 15 }, { "id": "G48205IY", "dp": 15 } ], "links": [ { "target": "G48205IY", "source": "G04783EJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04783EJ", "source": "G05600OX", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05600OX", "source": "G01727PW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48265DV", "error": "Missing intermediate; no pathways to [G48265DV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18157KC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48266EY", "error": "Missing intermediate; no pathways to [G48266EY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48277OH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 } ], "links": [ { "target": "G48277OH", "source": "G19726AG", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48288NV", "error": "Starting point for pathway to G48288NV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48329CR", "error": "Missing intermediate; no pathways to [G48329CR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48330KH", "error": "Missing intermediate; no pathways to [G48330KH] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G51768ZH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48350AZ", "error": "Starting point for pathway to G48350AZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48369JO", "error": "Starting point for pathway to G48369JO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48390CO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25731WL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 }, { "id": "G66961CH", "dp": 15 }, { "id": "G83992YN", "dp": 16 }, { "id": "G25731WL", "dp": 17 }, { "id": "G48390CO", "dp": 17 } ], "links": [ { "target": "G48390CO", "source": "G25731WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25731WL", "source": "G83992YN", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83992YN", "source": "G66961CH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48405LH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50730KL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G50730KL", "dp": 9 }, { "id": "G48405LH", "dp": 9 } ], "links": [ { "target": "G48405LH", "source": "G50730KL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50730KL", "source": "G08520NM", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G48421GV", "error": "Starting point for pathway to G48421GV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48424TE", "error": "Starting point for pathway to G48424TE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48435YB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11535IB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 }, { "id": "G48435YB", "dp": 9 } ], "links": [ { "target": "G48435YB", "source": "G11535IB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48442VP", "error": "Starting point for pathway to G48442VP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48468PF", "error": "Starting point for pathway to G48468PF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48488XT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96963QG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G48488XT", "dp": 12 } ], "links": [ { "target": "G48488XT", "source": "G96963QG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48518DG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50584UT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G48518DG", "dp": 13 } ], "links": [ { "target": "G48518DG", "source": "G50584UT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48519QN", "error": "Missing intermediate; no pathways to [G48519QN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24635ZS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48527XN", "error": "Missing intermediate; no pathways to [G48527XN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G33608TH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48551GG", "error": "Starting point for pathway to G48551GG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48595FA", "error": "Missing intermediate; no pathways to [G48595FA] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G52302PL]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G48616UI", "error": "Starting point for pathway to G48616UI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48630BP", "error": "Starting point for pathway to G48630BP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48649JF", "error": "Starting point for pathway to G48649JF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48658CL", "error": "Starting point for pathway to G48658CL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48658PB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 } ], "links": [ { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48681GJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85213FQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G85213FQ", "dp": 7 }, { "id": "G48681GJ", "dp": 7 } ], "links": [ { "target": "G48681GJ", "source": "G85213FQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85213FQ", "source": "G61751GZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G48697FI", "error": "Missing intermediate; no pathways to [G48697FI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48698GX", "error": "Missing intermediate; no pathways to [G48698GX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48713OY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14127XU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G14127XU", "dp": 13 }, { "id": "G48713OY", "dp": 13 } ], "links": [ { "target": "G48713OY", "source": "G14127XU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14127XU", "source": "G91023GB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48714ZW", "error": "Missing intermediate; no pathways to [G48714ZW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58768FH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48753IC", "error": "Missing intermediate; no pathways to [G48753IC] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G48757CJ", "error": "Missing intermediate; no pathways to [G48757CJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G15859AU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48767NV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 } ], "links": [ { "target": "G48767NV", "source": "G53812BX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48768LA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45560HM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G48768LA", "dp": 10 } ], "links": [ { "target": "G48768LA", "source": "G45560HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48802KI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 } ], "links": [ { "target": "G48802KI", "source": "G43677TG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48809ZO", "error": "Missing intermediate; no pathways to [G48809ZO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38637SA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48822BJ", "error": "Starting point for pathway to G48822BJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48837AB", "error": "Missing intermediate; no pathways to [G48837AB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93464IM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G48860TK", "error": "Starting point for pathway to G48860TK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48872RO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G98140IX", "dp": 7 } ], "links": [ { "target": "G48872RO", "source": "G98140IX", "residue_affected": { "residue_id": "N316", "pubchem_name": "GlcNAc", "anomer": "a", "absolute": "D", "form_name": "GlcpNAc", "full_name": "α-D-GlcpNAc" }, "effect": "Add α-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G98140IX", "source": "G61751GZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48879CK", "error": "Missing intermediate; no pathways to [G48879CK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48882DX", "error": "Missing intermediate; no pathways to [G48882DX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G99943EE]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48886SH", "error": "Starting point for pathway to G48886SH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48912RQ", "error": "Starting point for pathway to G48912RQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G48945UO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 } ], "links": [ { "target": "G48945UO", "source": "G32305RZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48954CA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G48954CA", "source": "G12398HZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G48979ED", "error": "Missing intermediate; no pathways to [G48979ED] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03296OS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G48980RC", "error": "Starting point for pathway to G48980RC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49009JI", "error": "Starting point for pathway to G49009JI could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49020UX", "error": "Missing intermediate; no pathways to [G49020UX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G49022RM", "error": "Missing intermediate; no pathways to [G49022RM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49024AU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99935CU]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G99969SS", "dp": 10 }, { "id": "G99935CU", "dp": 11 }, { "id": "G49024AU", "dp": 11 } ], "links": [ { "target": "G49024AU", "source": "G99935CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99935CU", "source": "G99969SS", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G99969SS", "source": "G13151XE", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49053WC", "error": "Missing intermediate; no pathways to [G49053WC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74859XI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49071WQ", "error": "Missing intermediate; no pathways to [G49071WQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49084JY", "error": "Missing intermediate; no pathways to [G49084JY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49096WS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G28550OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G49096WS", "dp": 9 } ], "links": [ { "target": "G49096WS", "source": "G28550OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49104KI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G44504SC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G44504SC", "dp": 10 }, { "id": "G49104KI", "dp": 10 } ], "links": [ { "target": "G49104KI", "source": "G44504SC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44504SC", "source": "G20030CU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49130JL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G29112GC", "dp": 10 }, { "id": "G72060AW", "dp": 11 } ], "links": [ { "target": "G49130JL", "source": "G72060AW", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G72060AW", "source": "G29112GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29112GC", "source": "G20030CU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49168NM", "error": "Missing intermediate; no pathways to [G49168NM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94490EL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G49224NN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20966TZ]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G49224NN", "dp": 9 } ], "links": [ { "target": "G49224NN", "source": "G20966TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49225WK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59655SA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G59655SA", "dp": 12 }, { "id": "G49225WK", "dp": 12 } ], "links": [ { "target": "G49225WK", "source": "G59655SA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59655SA", "source": "G53752TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49232RW", "error": "Starting point for pathway to G49232RW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49235GA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80537QW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G80537QW", "dp": 14 }, { "id": "G49235GA", "dp": 14 } ], "links": [ { "target": "G49235GA", "source": "G80537QW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80537QW", "source": "G93582HM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49280JI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G33262YZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G33262YZ", "dp": 11 }, { "id": "G49280JI", "dp": 11 } ], "links": [ { "target": "G49280JI", "source": "G33262YZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33262YZ", "source": "G52934AK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49282JI", "error": "Starting point for pathway to G49282JI could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49295WF", "error": "Missing intermediate; no pathways to [G49295WF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74238CC]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49299ZV", "error": "Missing intermediate; no pathways to [G49299ZV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G49300EE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05808PZ]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G05808PZ", "dp": 11 }, { "id": "G49300EE", "dp": 11 } ], "links": [ { "target": "G49300EE", "source": "G05808PZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05808PZ", "source": "G03275SD", "residue_affected": { "residue_id": "N476", "pubchem_name": "phosphate", "anomer": "n", "absolute": "n", "form_name": "phosphate", "full_name": "-n-phosphate" }, "effect": "Add -n-phosphate", "enzymes": [] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49305IN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 } ], "links": [ { "target": "G49305IN", "source": "G86696LV", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49307MQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G78276SQ", "dp": 12 } ], "links": [ { "target": "G49307MQ", "source": "G78276SQ", "residue_affected": { "residue_id": "N408", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G78276SQ", "source": "G11041DA", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49353WO", "error": "Missing intermediate; no pathways to [G49353WO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44904UE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49357ZK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G89036WC", "dp": 8 } ], "links": [ { "target": "G49357ZK", "source": "G89036WC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89036WC", "source": "G02427KF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49359AJ", "error": "Starting point for pathway to G49359AJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49367OZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G22098NU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G22098NU", "dp": 11 }, { "id": "G49367OZ", "dp": 11 } ], "links": [ { "target": "G49367OZ", "source": "G22098NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G22098NU", "source": "G71013KY", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49369WH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00176HZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G49369WH", "dp": 10 } ], "links": [ { "target": "G49369WH", "source": "G00176HZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49383JW", "error": "Starting point for pathway to G49383JW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49401CB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G67215MI]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G67215MI", "dp": 11 }, { "id": "G49401CB", "dp": 11 } ], "links": [ { "target": "G49401CB", "source": "G67215MI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G67215MI", "source": "G11637WL", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49401NP", "error": "Starting point for pathway to G49401NP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49401WK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 }, { "id": "G88426SE", "dp": 11 } ], "links": [ { "target": "G49401WK", "source": "G88426SE", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88426SE", "source": "G78155FK", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49427FH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 } ], "links": [ { "target": "G49427FH", "source": "G11535IB", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49440XK", "error": "Starting point for pathway to G49440XK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49446SO", "error": "Missing intermediate; no pathways to [G49446SO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49478IU", "error": "Missing intermediate; no pathways to [G49478IU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49481UE", "error": "Starting point for pathway to G49481UE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49495MH", "error": "Missing intermediate; no pathways to [G49495MH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90987JA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49495US", "error": "Starting point for pathway to G49495US could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49503QY", "error": "Starting point for pathway to G49503QY could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49504OJ", "error": "Starting point for pathway to G49504OJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49515VE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49544FY", "error": "Missing intermediate; no pathways to [G49544FY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78885XB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49562JB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G01669LU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G49562JB", "dp": 12 } ], "links": [ { "target": "G49562JB", "source": "G01669LU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49580XQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06969ZX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 }, { "id": "G49580XQ", "dp": 10 } ], "links": [ { "target": "G49580XQ", "source": "G06969ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49582YX", "error": "Starting point for pathway to G49582YX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49585QR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21246OH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G21246OH", "dp": 11 }, { "id": "G49585QR", "dp": 11 } ], "links": [ { "target": "G49585QR", "source": "G21246OH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21246OH", "source": "G00176HZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49588KJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G42671TR", "dp": 10 } ], "links": [ { "target": "G49588KJ", "source": "G42671TR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42671TR", "source": "G72718TT", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49596EV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13151XE]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G49596EV", "dp": 9 } ], "links": [ { "target": "G49596EV", "source": "G13151XE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49601RS", "error": "Starting point for pathway to G49601RS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49616WZ", "error": "Missing intermediate; no pathways to [G49616WZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91199QX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49637LS", "error": "Missing intermediate; no pathways to [G49637LS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49638DJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21319HP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G40906DZ", "dp": 14 }, { "id": "G21319HP", "dp": 15 }, { "id": "G49638DJ", "dp": 15 } ], "links": [ { "target": "G49638DJ", "source": "G21319HP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21319HP", "source": "G40906DZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40906DZ", "source": "G18938DW", "residue_affected": { "residue_id": "N43", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49648IC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77363ER]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G77363ER", "dp": 11 }, { "id": "G49648IC", "dp": 11 } ], "links": [ { "target": "G49648IC", "source": "G77363ER", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77363ER", "source": "G91365ZQ", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49664YG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88417ED]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G49664YG", "dp": 10 } ], "links": [ { "target": "G49664YG", "source": "G88417ED", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49665PK", "error": "Missing intermediate; no pathways to [G49665PK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49705DA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21246OH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G21246OH", "dp": 11 }, { "id": "G49705DA", "dp": 11 } ], "links": [ { "target": "G49705DA", "source": "G21246OH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21246OH", "source": "G00176HZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49721VX", "error": "Starting point for pathway to G49721VX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49743VF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 } ], "links": [ { "target": "G49743VF", "source": "G06216UH", "residue_affected": { "residue_id": "N470", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49768YY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85767HW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 }, { "id": "G49768YY", "dp": 10 } ], "links": [ { "target": "G49768YY", "source": "G85767HW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49769PU", "error": "Starting point for pathway to G49769PU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49777JB", "error": "Missing intermediate; no pathways to [G49777JB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49785PR", "error": "Starting point for pathway to G49785PR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49800TU", "error": "Missing intermediate; no pathways to [G49800TU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G54260SD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49827WK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 } ], "links": [ { "target": "G49827WK", "source": "G09446VC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49830JU", "error": "Missing intermediate; no pathways to [G49830JU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49832FF", "error": "Missing intermediate; no pathways to [G49832FF] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G92848CF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49840MH", "error": "Starting point for pathway to G49840MH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49915LA", "error": "Missing intermediate; no pathways to [G49915LA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49923GC", "error": "Missing intermediate; no pathways to [G49923GC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76807JB]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G49930HB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99603GB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G99603GB", "dp": 9 }, { "id": "G49930HB", "dp": 9 } ], "links": [ { "target": "G49930HB", "source": "G99603GB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99603GB", "source": "G64669AQ", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G49933AX", "error": "Missing intermediate; no pathways to [G49933AX] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G49935CA", "error": "Missing intermediate; no pathways to [G49935CA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21459ST]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49951NR", "error": "Missing intermediate; no pathways to [G49951NR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99370TQ]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G49961MS", "error": "Starting point for pathway to G49961MS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G49961XO", "error": "Missing intermediate; no pathways to [G49961XO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G49963FN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 }, { "id": "G72221XM", "dp": 12 } ], "links": [ { "target": "G49963FN", "source": "G72221XM", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72221XM", "source": "G45187EI", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G49994RB", "error": "Missing intermediate; no pathways to [G49994RB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50013XL", "error": "Missing intermediate; no pathways to [G50013XL] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G23546LY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50023BR", "error": "Missing intermediate; no pathways to [G50023BR] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50064HP", "error": "Starting point for pathway to G50064HP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50068PO", "error": "Missing intermediate; no pathways to [G50068PO] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G78011JO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50076JD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79803HS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G74438AB", "dp": 12 }, { "id": "G79803HS", "dp": 13 }, { "id": "G50076JD", "dp": 13 } ], "links": [ { "target": "G50076JD", "source": "G79803HS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79803HS", "source": "G74438AB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74438AB", "source": "G34905OT", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50078RT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 } ], "links": [ { "target": "G50078RT", "source": "G79809MM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50103BI", "error": "Missing intermediate; no pathways to [G50103BI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18803PL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50112PT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05794RZ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 }, { "id": "G05794RZ", "dp": 12 }, { "id": "G50112PT", "dp": 12 } ], "links": [ { "target": "G50112PT", "source": "G05794RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05794RZ", "source": "G40806JH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50119EM", "error": "Starting point for pathway to G50119EM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50135PA", "error": "Missing intermediate; no pathways to [G50135PA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50139IU", "error": "Starting point for pathway to G50139IU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50159UX", "error": "Starting point for pathway to G50159UX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50165QT", "error": "Starting point for pathway to G50165QT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50179MC", "error": "Starting point for pathway to G50179MC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50205RT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G11535IB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 }, { "id": "G50205RT", "dp": 9 } ], "links": [ { "target": "G50205RT", "source": "G11535IB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50211SY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71704AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 }, { "id": "G71704AG", "dp": 15 }, { "id": "G50211SY", "dp": 15 } ], "links": [ { "target": "G50211SY", "source": "G71704AG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71704AG", "source": "G42686NQ", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50216QG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36523TZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G36523TZ", "dp": 12 }, { "id": "G50216QG", "dp": 12 } ], "links": [ { "target": "G50216QG", "source": "G36523TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36523TZ", "source": "G29857RC", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50222RE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G74090KZ", "dp": 7 } ], "links": [ { "target": "G50222RE", "source": "G74090KZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74090KZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50258QB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86730KO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G86730KO", "dp": 13 }, { "id": "G50258QB", "dp": 13 } ], "links": [ { "target": "G50258QB", "source": "G86730KO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86730KO", "source": "G48658PB", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50278HE", "error": "Missing intermediate; no pathways to [G50278HE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50343XZ", "error": "Missing intermediate; no pathways to [G50343XZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50364FV", "error": "Missing intermediate; no pathways to [G50364FV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50383SB", "error": "Missing intermediate; no pathways to [G50383SB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81326IN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50387OH", "error": "Missing intermediate; no pathways to [G50387OH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50392ZV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 } ], "links": [ { "target": "G50392ZV", "source": "G32201IL", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50398UZ", "error": "Starting point for pathway to G50398UZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50427EN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 }, { "id": "G26264SQ", "dp": 12 } ], "links": [ { "target": "G50427EN", "source": "G26264SQ", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G26264SQ", "source": "G42028DN", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50432VO", "error": "Missing intermediate; no pathways to [G50432VO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50448ZV", "error": "Starting point for pathway to G50448ZV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50451XH", "error": "Missing intermediate; no pathways to [G50451XH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50462VS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86696LV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G50462VS", "dp": 17 } ], "links": [ { "target": "G50462VS", "source": "G86696LV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50474FI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82420SH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G82420SH", "dp": 10 }, { "id": "G50474FI", "dp": 10 } ], "links": [ { "target": "G50474FI", "source": "G82420SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50489VC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 } ], "links": [ { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50507PS", "error": "Starting point for pathway to G50507PS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50508SG", "error": "Missing intermediate; no pathways to [G50508SG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57835AK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50518XT", "error": "Starting point for pathway to G50518XT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50525GP", "error": "Missing intermediate; no pathways to [G50525GP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50531NJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29026MS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G29026MS", "dp": 12 }, { "id": "G50531NJ", "dp": 12 } ], "links": [ { "target": "G50531NJ", "source": "G29026MS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29026MS", "source": "G59877NF", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50549VU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59300GC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G59300GC", "dp": 14 }, { "id": "G50549VU", "dp": 14 } ], "links": [ { "target": "G50549VU", "source": "G59300GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59300GC", "source": "G73492AT", "residue_affected": { "residue_id": "N78", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50554LM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G90564EX", "dp": 11 }, { "id": "G08949VK", "dp": 12 }, { "id": "G12450CJ", "dp": 13 } ], "links": [ { "target": "G50554LM", "source": "G12450CJ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12450CJ", "source": "G08949VK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08949VK", "source": "G90564EX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90564EX", "source": "G28826SH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50573QG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62883YA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G62883YA", "dp": 11 }, { "id": "G50573QG", "dp": 11 } ], "links": [ { "target": "G50573QG", "source": "G62883YA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62883YA", "source": "G66866LE", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50584UT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 } ], "links": [ { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50609NM", "error": "Starting point for pathway to G50609NM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50638US", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90825UM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G90825UM", "dp": 11 }, { "id": "G50638US", "dp": 11 } ], "links": [ { "target": "G50638US", "source": "G90825UM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90825UM", "source": "G01856RL", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50659JL", "error": "Missing intermediate; no pathways to [G50659JL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50660UT", "error": "Missing intermediate; no pathways to [G50660UT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50706US", "error": "Starting point for pathway to G50706US could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50709EY", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 } ], "links": [ { "target": "G50709EY", "source": "G13151XE", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50730KL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G50730KL", "source": "G08520NM", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G50774CV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 } ], "links": [ { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50775RM", "error": "Starting point for pathway to G50775RM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50779LX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 } ], "links": [ { "target": "G50779LX", "source": "G25140TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50782HI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66129DI]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G66129DI", "dp": 11 }, { "id": "G50782HI", "dp": 11 } ], "links": [ { "target": "G50782HI", "source": "G66129DI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66129DI", "source": "G03275SD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50782LR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91905FJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G50782LR", "dp": 14 } ], "links": [ { "target": "G50782LR", "source": "G91905FJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50798YC", "error": "Starting point for pathway to G50798YC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50821RC", "error": "Missing intermediate; no pathways to [G50821RC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50825VR", "error": "Starting point for pathway to G50825VR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50829CY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G76478FT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G76478FT", "dp": 11 }, { "id": "G50829CY", "dp": 11 } ], "links": [ { "target": "G50829CY", "source": "G76478FT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76478FT", "source": "G78059CC", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50837EH", "error": "Starting point for pathway to G50837EH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50842FY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G35096EN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G35096EN", "dp": 10 }, { "id": "G50842FY", "dp": 10 } ], "links": [ { "target": "G50842FY", "source": "G35096EN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G35096EN", "source": "G20030CU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50842MS", "error": "Starting point for pathway to G50842MS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50846BW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26255AN]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G26274XD", "dp": 11 }, { "id": "G26255AN", "dp": 12 }, { "id": "G50846BW", "dp": 12 } ], "links": [ { "target": "G50846BW", "source": "G26255AN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26255AN", "source": "G26274XD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26274XD", "source": "G08187GM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50880EE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10664FL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G10664FL", "dp": 10 }, { "id": "G50880EE", "dp": 10 } ], "links": [ { "target": "G50880EE", "source": "G10664FL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10664FL", "source": "G45262QY", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50901FO", "error": "Missing intermediate; no pathways to [G50901FO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G50915WK", "error": "Starting point for pathway to G50915WK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G50932PM", "error": "Missing intermediate; no pathways to [G50932PM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G50933UG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76075NA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G76075NA", "dp": 12 }, { "id": "G50933UG", "dp": 12 } ], "links": [ { "target": "G50933UG", "source": "G76075NA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76075NA", "source": "G90870DG", "residue_affected": { "residue_id": "N62", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50943ZX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 } ], "links": [ { "target": "G50943ZX", "source": "G20956ZK", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G50997KD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G86095OE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 }, { "id": "G86095OE", "dp": 17 }, { "id": "G50997KD", "dp": 17 } ], "links": [ { "target": "G50997KD", "source": "G86095OE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86095OE", "source": "G75237SS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51018GI", "error": "Missing intermediate; no pathways to [G51018GI] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51050LD", "error": "Missing intermediate; no pathways to [G51050LD] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51066TO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 } ], "links": [ { "target": "G51066TO", "source": "G10733HY", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51074KT", "error": "Missing intermediate; no pathways to [G51074KT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51086FE", "error": "Missing intermediate; no pathways to [G51086FE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65867II]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51098AA", "error": "Missing intermediate; no pathways to [G51098AA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51119RL", "error": "Starting point for pathway to G51119RL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51122PB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 }, { "id": "G16451PE", "dp": 11 } ], "links": [ { "target": "G51122PB", "source": "G16451PE", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16451PE", "source": "G45365RV", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51168MK", "error": "Missing intermediate; no pathways to [G51168MK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51170KR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65239SF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G65239SF", "dp": 11 }, { "id": "G51170KR", "dp": 11 } ], "links": [ { "target": "G51170KR", "source": "G65239SF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65239SF", "source": "G81923ER", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51175PR", "error": "Starting point for pathway to G51175PR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51212OK", "error": "Missing intermediate; no pathways to [G51212OK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17465IO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51229TU", "error": "Missing intermediate; no pathways to [G51229TU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96503EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51274LI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76528ZS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G76528ZS", "dp": 11 }, { "id": "G51274LI", "dp": 11 } ], "links": [ { "target": "G51274LI", "source": "G76528ZS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51304JG", "error": "Starting point for pathway to G51304JG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51333KM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50427EN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 }, { "id": "G26264SQ", "dp": 12 }, { "id": "G50427EN", "dp": 13 }, { "id": "G51333KM", "dp": 13 } ], "links": [ { "target": "G51333KM", "source": "G50427EN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50427EN", "source": "G26264SQ", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G26264SQ", "source": "G42028DN", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51367TM", "error": "Missing intermediate; no pathways to [G51367TM] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G51370GD", "error": "Starting point for pathway to G51370GD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51378TN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G73817GH", "dp": 10 } ], "links": [ { "target": "G51378TN", "source": "G73817GH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51402XK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92681HQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G98852TR", "dp": 16 }, { "id": "G92681HQ", "dp": 17 }, { "id": "G51402XK", "dp": 17 } ], "links": [ { "target": "G51402XK", "source": "G92681HQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92681HQ", "source": "G98852TR", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G98852TR", "source": "G28957FB", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51402YN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52770HR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G52770HR", "dp": 10 }, { "id": "G51402YN", "dp": 10 } ], "links": [ { "target": "G51402YN", "source": "G52770HR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52770HR", "source": "G36191CD", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51419BH", "error": "Starting point for pathway to G51419BH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51429SM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37046CZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G51429SM", "dp": 11 } ], "links": [ { "target": "G51429SM", "source": "G37046CZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51472TJ", "error": "Missing intermediate; no pathways to [G51472TJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11010AN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51490BW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51508GQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01935FK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G01935FK", "dp": 10 }, { "id": "G51508GQ", "dp": 10 } ], "links": [ { "target": "G51508GQ", "source": "G01935FK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01935FK", "source": "G36191CD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51530ER", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70511VE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G70511VE", "dp": 12 }, { "id": "G51530ER", "dp": 12 } ], "links": [ { "target": "G51530ER", "source": "G70511VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70511VE", "source": "G53752TA", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51562OR", "error": "Missing intermediate; no pathways to [G51562OR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51586BA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28550OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G51586BA", "dp": 9 } ], "links": [ { "target": "G51586BA", "source": "G28550OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51601CL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71812IK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G71812IK", "dp": 9 }, { "id": "G51601CL", "dp": 9 } ], "links": [ { "target": "G51601CL", "source": "G71812IK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71812IK", "source": "G80858MF", "residue_affected": { "residue_id": "N322", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51601UI", "error": "Missing intermediate; no pathways to [G51601UI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94394GK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51624KI", "error": "Starting point for pathway to G51624KI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51654CU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57092OJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G51654CU", "dp": 10 } ], "links": [ { "target": "G51654CU", "source": "G57092OJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51657FI", "error": "Starting point for pathway to G51657FI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51670CS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G90870DG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G51670CS", "dp": 11 } ], "links": [ { "target": "G51670CS", "source": "G90870DG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51677OC", "error": "Missing intermediate; no pathways to [G51677OC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G27783SY]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G51688VK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95956WE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G42548XF", "dp": 7 }, { "id": "G95956WE", "dp": 8 }, { "id": "G51688VK", "dp": 8 } ], "links": [ { "target": "G51688VK", "source": "G95956WE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95956WE", "source": "G42548XF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42548XF", "source": "G61751GZ", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] } ] } , { "glytoucan_ac": "G51695DM", "error": "Missing intermediate; no pathways to [G51695DM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66016NA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51699IR", "error": "Starting point for pathway to G51699IR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51699UE", "error": "Starting point for pathway to G51699UE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51710QD", "error": "Missing intermediate; no pathways to [G51710QD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80264ZA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51715FH", "error": "Missing intermediate; no pathways to [G51715FH] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G44223QP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G51768ZH", "error": "Missing intermediate; no pathways to [G51768ZH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51771NH", "error": "Starting point for pathway to G51771NH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51789EV", "error": "Starting point for pathway to G51789EV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51793MY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 } ], "links": [ { "target": "G51793MY", "source": "G45560HM", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51799AX", "error": "Missing intermediate; no pathways to [G51799AX] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51872EK", "error": "Starting point for pathway to G51872EK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51891DI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17473NR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G17473NR", "dp": 13 }, { "id": "G51891DI", "dp": 13 } ], "links": [ { "target": "G51891DI", "source": "G17473NR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17473NR", "source": "G10733HY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51896IF", "error": "Missing intermediate; no pathways to [G51896IF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51908QJ", "error": "Missing intermediate; no pathways to [G51908QJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40670DJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51921XC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72662IG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G80537QW", "dp": 14 }, { "id": "G72662IG", "dp": 15 }, { "id": "G51921XC", "dp": 15 } ], "links": [ { "target": "G51921XC", "source": "G72662IG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72662IG", "source": "G80537QW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80537QW", "source": "G93582HM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51929IB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43255OW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G48954CA", "dp": 9 }, { "id": "G43255OW", "dp": 10 }, { "id": "G51929IB", "dp": 10 } ], "links": [ { "target": "G51929IB", "source": "G43255OW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43255OW", "source": "G48954CA", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G48954CA", "source": "G12398HZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51930XP", "error": "Missing intermediate; no pathways to [G51930XP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G01342FO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51941IR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46425HN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G46425HN", "dp": 15 }, { "id": "G51941IR", "dp": 15 } ], "links": [ { "target": "G51941IR", "source": "G46425HN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46425HN", "source": "G45720CA", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G51956RJ", "error": "Missing intermediate; no pathways to [G51956RJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G51971TR", "error": "Starting point for pathway to G51971TR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51987NK", "error": "Starting point for pathway to G51987NK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G51995LA", "error": "Missing intermediate; no pathways to [G51995LA] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G79010UT]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52034SY", "error": "Starting point for pathway to G52034SY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52056FF", "error": "Missing intermediate; no pathways to [G52056FF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52070UO", "error": "Starting point for pathway to G52070UO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52080EW", "error": "Starting point for pathway to G52080EW could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52080WL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G52080WL", "source": "G66937TJ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52092BL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G23782KP", "dp": 14 } ], "links": [ { "target": "G52092BL", "source": "G23782KP", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G23782KP", "source": "G01727PW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52101PX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 } ], "links": [ { "target": "G52101PX", "source": "G95404EQ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52108KM", "error": "Missing intermediate; no pathways to [G52108KM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52112MC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G55396DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G55396DW", "dp": 12 }, { "id": "G52112MC", "dp": 12 } ], "links": [ { "target": "G52112MC", "source": "G55396DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G55396DW", "source": "G25520XG", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52153CS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G48802KI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G48802KI", "dp": 9 }, { "id": "G52153CS", "dp": 9 } ], "links": [ { "target": "G52153CS", "source": "G48802KI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48802KI", "source": "G43677TG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52166GV", "error": "Starting point for pathway to G52166GV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52187WF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G02290KA", "dp": 10 } ], "links": [ { "target": "G52187WF", "source": "G02290KA", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52210EC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02311IE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G52210EC", "dp": 16 } ], "links": [ { "target": "G52210EC", "source": "G02311IE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52216BO", "error": "Missing intermediate; no pathways to [G52216BO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G24155DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52224MB", "error": "Starting point for pathway to G52224MB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52225DV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29797YX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G89181JW", "dp": 11 }, { "id": "G29797YX", "dp": 12 }, { "id": "G52225DV", "dp": 12 } ], "links": [ { "target": "G52225DV", "source": "G29797YX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29797YX", "source": "G89181JW", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89181JW", "source": "G03445UI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52266YB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G04989WY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G52266YB", "dp": 13 } ], "links": [ { "target": "G52266YB", "source": "G04989WY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52286UI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G15998WM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G15998WM", "dp": 17 }, { "id": "G52286UI", "dp": 17 } ], "links": [ { "target": "G52286UI", "source": "G15998WM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G15998WM", "source": "G79950YS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52302PL", "error": "Missing intermediate; no pathways to [G52302PL] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G52303GC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G47031UJ", "dp": 12 } ], "links": [ { "target": "G52303GC", "source": "G47031UJ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47031UJ", "source": "G71679MX", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52333AW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 } ], "links": [ { "target": "G52333AW", "source": "G29492IF", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52333TF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G44504SC", "dp": 10 } ], "links": [ { "target": "G52333TF", "source": "G44504SC", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44504SC", "source": "G20030CU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52336LJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 } ], "links": [ { "target": "G52336LJ", "source": "G30302VM", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52345FK", "error": "Missing intermediate; no pathways to [G52345FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52351WJ", "error": "Missing intermediate; no pathways to [G52351WJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32977ZV]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G52358FD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G67045LB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G52358FD", "dp": 8 } ], "links": [ { "target": "G52358FD", "source": "G67045LB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52375WK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82357WL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G82357WL", "dp": 11 }, { "id": "G52375WK", "dp": 11 } ], "links": [ { "target": "G52375WK", "source": "G82357WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82357WL", "source": "G28826SH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52383QH", "error": "Missing intermediate; no pathways to [G52383QH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52428MJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 } ], "links": [ { "target": "G52428MJ", "source": "G42672MA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52441NC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G04764ON]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G04764ON", "dp": 12 }, { "id": "G52441NC", "dp": 12 } ], "links": [ { "target": "G52441NC", "source": "G04764ON", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04764ON", "source": "G30302VM", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52461YB", "error": "Starting point for pathway to G52461YB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52483OL", "error": "Missing intermediate; no pathways to [G52483OL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52498MU", "error": "Starting point for pathway to G52498MU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52522DG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84874EV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G84874EV", "dp": 11 }, { "id": "G52522DG", "dp": 11 } ], "links": [ { "target": "G52522DG", "source": "G84874EV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84874EV", "source": "G99270AV", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52576WH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89993FE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G52576WH", "dp": 8 } ], "links": [ { "target": "G52576WH", "source": "G89993FE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52621OJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G48767NV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G48767NV", "dp": 14 }, { "id": "G52621OJ", "dp": 14 } ], "links": [ { "target": "G52621OJ", "source": "G48767NV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48767NV", "source": "G53812BX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52622YD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29377XJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G29377XJ", "dp": 12 }, { "id": "G52622YD", "dp": 12 } ], "links": [ { "target": "G52622YD", "source": "G29377XJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29377XJ", "source": "G63585HN", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52633YA", "error": "Starting point for pathway to G52633YA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52645LW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 } ], "links": [ { "target": "G52645LW", "source": "G79578JB", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52663AD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52676LZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G32659RY", "dp": 12 } ], "links": [ { "target": "G52676LZ", "source": "G32659RY", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G32659RY", "source": "G59877NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52677OK", "error": "Missing intermediate; no pathways to [G52677OK] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52724WY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G05260RH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G05260RH", "dp": 11 }, { "id": "G52724WY", "dp": 11 } ], "links": [ { "target": "G52724WY", "source": "G05260RH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05260RH", "source": "G56591LC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52770HR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G52770HR", "source": "G36191CD", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52773YO", "error": "Missing intermediate; no pathways to [G52773YO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52781ZE", "error": "Starting point for pathway to G52781ZE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52783KP", "error": "Starting point for pathway to G52783KP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52790YS", "error": "Missing intermediate; no pathways to [G52790YS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68892PJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52793JJ", "error": "Missing intermediate; no pathways to [G52793JJ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G94838KN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52849RL", "error": "Starting point for pathway to G52849RL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52866KC", "error": "Starting point for pathway to G52866KC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52880ZN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 } ], "links": [ { "target": "G52880ZN", "source": "G82252QI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52882GL", "error": "Starting point for pathway to G52882GL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52886RR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G78503JC", "dp": 12 } ], "links": [ { "target": "G52886RR", "source": "G78503JC", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78503JC", "source": "G31010RQ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52892OT", "error": "Missing intermediate; no pathways to [G52892OT] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52916IV", "error": "Starting point for pathway to G52916IV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G52928OQ", "error": "Missing intermediate; no pathways to [G52928OQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G49933AX]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G52934AK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 } ], "links": [ { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52935OC", "error": "Missing intermediate; no pathways to [G52935OC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52956BX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G52956BX", "source": "G12398HZ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G52961JQ", "error": "Missing intermediate; no pathways to [G52961JQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G52971DE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14047PA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G14047PA", "dp": 11 }, { "id": "G52971DE", "dp": 11 } ], "links": [ { "target": "G52971DE", "source": "G14047PA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14047PA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53000RQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 } ], "links": [ { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53028BV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99074EO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G53028BV", "dp": 13 } ], "links": [ { "target": "G53028BV", "source": "G99074EO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53031JB", "error": "Starting point for pathway to G53031JB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G53054ED", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G78741RD", "dp": 9 } ], "links": [ { "target": "G53054ED", "source": "G78741RD", "residue_affected": { "residue_id": "N422", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G78741RD", "source": "G64669AQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G53096UD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26529EC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 }, { "id": "G16451PE", "dp": 11 }, { "id": "G26529EC", "dp": 12 }, { "id": "G53096UD", "dp": 12 } ], "links": [ { "target": "G53096UD", "source": "G26529EC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26529EC", "source": "G16451PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16451PE", "source": "G45365RV", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53098FA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 } ], "links": [ { "target": "G53098FA", "source": "G95898GD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53118DD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76422GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G76422GC", "dp": 12 }, { "id": "G53118DD", "dp": 12 } ], "links": [ { "target": "G53118DD", "source": "G76422GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76422GC", "source": "G25140TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53168IY", "error": "Missing intermediate; no pathways to [G53168IY] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G53170RJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G53170RJ", "source": "G11041DA", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53190JD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G64669AQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G53190JD", "dp": 8 } ], "links": [ { "target": "G53190JD", "source": "G64669AQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G53230JC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G79457WN", "dp": 11 } ], "links": [ { "target": "G53230JC", "source": "G79457WN", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79457WN", "source": "G00176HZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53234IR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50489VC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G53234IR", "dp": 17 } ], "links": [ { "target": "G53234IR", "source": "G50489VC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53235OX", "error": "Starting point for pathway to G53235OX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G53272SL", "error": "Missing intermediate; no pathways to [G53272SL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25406HP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53288JQ", "error": "Missing intermediate; no pathways to [G53288JQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53322JT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G53322JT", "source": "G00176HZ", "residue_affected": { "residue_id": "N502", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53342MA", "error": "Missing intermediate; no pathways to [G53342MA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30085SO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53347XD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76136FD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G86102AA", "dp": 11 }, { "id": "G76136FD", "dp": 12 }, { "id": "G53347XD", "dp": 12 } ], "links": [ { "target": "G53347XD", "source": "G76136FD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76136FD", "source": "G86102AA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86102AA", "source": "G85542KD", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53361RA", "error": "Missing intermediate; no pathways to [G53361RA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68080UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53396PX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 } ], "links": [ { "target": "G53396PX", "source": "G82050MN", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53401FX", "error": "Starting point for pathway to G53401FX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G53428EC", "error": "Starting point for pathway to G53428EC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G53454TA", "error": "Missing intermediate; no pathways to [G53454TA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53471VF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26274XD]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G26274XD", "dp": 11 }, { "id": "G53471VF", "dp": 11 } ], "links": [ { "target": "G53471VF", "source": "G26274XD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26274XD", "source": "G08187GM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53479GY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82312JY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G82312JY", "dp": 9 }, { "id": "G53479GY", "dp": 9 } ], "links": [ { "target": "G53479GY", "source": "G82312JY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82312JY", "source": "G80858MF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53485VW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53504BR", "error": "Missing intermediate; no pathways to [G53504BR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53527OK", "error": "Missing intermediate; no pathways to [G53527OK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16956YO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53562KP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 } ], "links": [ { "target": "G53562KP", "source": "G89993FE", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53567BY", "error": "Missing intermediate; no pathways to [G53567BY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53574BW", "error": "Missing intermediate; no pathways to [G53574BW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53582JE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G58667NI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G53582JE", "dp": 9 } ], "links": [ { "target": "G53582JE", "source": "G58667NI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53605PF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 } ], "links": [ { "target": "G53605PF", "source": "G59741XZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53667CH", "error": "Missing intermediate; no pathways to [G53667CH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53675DS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04743RS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G53675DS", "dp": 11 } ], "links": [ { "target": "G53675DS", "source": "G04743RS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53709ZS", "error": "Missing intermediate; no pathways to [G53709ZS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53723XK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36519NW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G36519NW", "dp": 13 }, { "id": "G53723XK", "dp": 13 } ], "links": [ { "target": "G53723XK", "source": "G36519NW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36519NW", "source": "G01669LU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53728DU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G53728DU", "source": "G91365ZQ", "residue_affected": { "residue_id": "N276", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53738ZH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27223CU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G27223CU", "dp": 12 }, { "id": "G53738ZH", "dp": 12 } ], "links": [ { "target": "G53738ZH", "source": "G27223CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27223CU", "source": "G82252QI", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53752QB", "error": "Starting point for pathway to G53752QB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G53752TA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 } ], "links": [ { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53795OV", "error": "Missing intermediate; no pathways to [G53795OV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10540LB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53800MQ", "error": "Missing intermediate; no pathways to [G53800MQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93698KA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53808AO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88417ED]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G53808AO", "dp": 10 } ], "links": [ { "target": "G53808AO", "source": "G88417ED", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53809CJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79556AB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G79556AB", "dp": 12 }, { "id": "G53809CJ", "dp": 12 } ], "links": [ { "target": "G53809CJ", "source": "G79556AB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79556AB", "source": "G82252QI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53812BX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 } ], "links": [ { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53817FJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74120DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G53817FJ", "dp": 12 } ], "links": [ { "target": "G53817FJ", "source": "G74120DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53840IC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03895SR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G03895SR", "dp": 15 }, { "id": "G53840IC", "dp": 15 } ], "links": [ { "target": "G53840IC", "source": "G03895SR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53854XZ", "error": "Missing intermediate; no pathways to [G53854XZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53858MF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G33742YO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G33742YO", "dp": 9 }, { "id": "G53858MF", "dp": 9 } ], "links": [ { "target": "G53858MF", "source": "G33742YO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53889SN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52880ZN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G52880ZN", "dp": 12 }, { "id": "G53889SN", "dp": 12 } ], "links": [ { "target": "G53889SN", "source": "G52880ZN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52880ZN", "source": "G82252QI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53899GT", "error": "Starting point for pathway to G53899GT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G53923UR", "error": "Starting point for pathway to G53923UR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G53931MC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G51490BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G53931MC", "dp": 8 } ], "links": [ { "target": "G53931MC", "source": "G51490BW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53933HU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 } ], "links": [ { "target": "G53933HU", "source": "G59741XZ", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53944MR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07337US]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G13156PQ", "dp": 12 }, { "id": "G07337US", "dp": 13 }, { "id": "G53944MR", "dp": 13 } ], "links": [ { "target": "G53944MR", "source": "G07337US", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07337US", "source": "G13156PQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13156PQ", "source": "G53752TA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53950KA", "error": "Missing intermediate; no pathways to [G53950KA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75107JX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53956RO", "error": "Starting point for pathway to G53956RO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G53962WT", "error": "Missing intermediate; no pathways to [G53962WT] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G53985AY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 } ], "links": [ { "target": "G53985AY", "source": "G78890OB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53989JC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25140TA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G53989JC", "dp": 11 } ], "links": [ { "target": "G53989JC", "source": "G25140TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G53989ZN", "error": "Missing intermediate; no pathways to [G53989ZN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53993HS", "error": "Missing intermediate; no pathways to [G53993HS] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G41797PU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G53996MC", "error": "Missing intermediate; no pathways to [G53996MC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23419AQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54010TZ", "error": "Missing intermediate; no pathways to [G54010TZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54018RP", "error": "Missing intermediate; no pathways to [G54018RP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54042WO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G59029AQ", "dp": 10 } ], "links": [ { "target": "G54042WO", "source": "G59029AQ", "residue_affected": { "residue_id": "N70", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59029AQ", "source": "G04791QM", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54067ZR", "error": "Starting point for pathway to G54067ZR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54073XZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G95919TI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G95919TI", "dp": 14 }, { "id": "G54073XZ", "dp": 14 } ], "links": [ { "target": "G54073XZ", "source": "G95919TI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95919TI", "source": "G30651IU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54076UX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43507KQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G09826WW", "dp": 11 }, { "id": "G43507KQ", "dp": 12 }, { "id": "G54076UX", "dp": 12 } ], "links": [ { "target": "G54076UX", "source": "G43507KQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43507KQ", "source": "G09826WW", "residue_affected": { "residue_id": "N272", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G09826WW", "source": "G85542KD", "residue_affected": { "residue_id": "N271", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54098EJ", "error": "Missing intermediate; no pathways to [G54098EJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82320NZ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54149OE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G11929SN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G11929SN", "dp": 14 }, { "id": "G54149OE", "dp": 14 } ], "links": [ { "target": "G54149OE", "source": "G11929SN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11929SN", "source": "G80294GH", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54151YB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47606XQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G26320VO", "dp": 10 }, { "id": "G47606XQ", "dp": 11 }, { "id": "G54151YB", "dp": 11 } ], "links": [ { "target": "G54151YB", "source": "G47606XQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47606XQ", "source": "G26320VO", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26320VO", "source": "G58667NI", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54158IT", "error": "Missing intermediate; no pathways to [G54158IT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90542MP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54177WI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G15727JK", "dp": 8 } ], "links": [ { "target": "G54177WI", "source": "G15727JK", "residue_affected": { "residue_id": "N400", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G15727JK", "source": "G69411IG", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54183MZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G05808PZ]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G05808PZ", "dp": 11 }, { "id": "G54183MZ", "dp": 11 } ], "links": [ { "target": "G54183MZ", "source": "G05808PZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05808PZ", "source": "G03275SD", "residue_affected": { "residue_id": "N476", "pubchem_name": "phosphate", "anomer": "n", "absolute": "n", "form_name": "phosphate", "full_name": "-n-phosphate" }, "effect": "Add -n-phosphate", "enzymes": [] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54191CU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38753OV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G38753OV", "dp": 11 }, { "id": "G54191CU", "dp": 11 } ], "links": [ { "target": "G54191CU", "source": "G38753OV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38753OV", "source": "G52934AK", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54195NF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G34175ZP", "dp": 10 } ], "links": [ { "target": "G54195NF", "source": "G34175ZP", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G34175ZP", "source": "G01265XZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54198RS", "error": "Starting point for pathway to G54198RS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54255OI", "error": "Missing intermediate; no pathways to [G54255OI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77562VR]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G54258NG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56749GV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G54258NG", "dp": 12 } ], "links": [ { "target": "G54258NG", "source": "G56749GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54260SD", "error": "Missing intermediate; no pathways to [G54260SD] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54262EN", "error": "Starting point for pathway to G54262EN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54263QD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84783XD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G44623TX", "dp": 12 }, { "id": "G84783XD", "dp": 13 }, { "id": "G54263QD", "dp": 13 } ], "links": [ { "target": "G54263QD", "source": "G84783XD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84783XD", "source": "G44623TX", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44623TX", "source": "G79809MM", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54269AZ", "error": "Starting point for pathway to G54269AZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54273KX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07410AW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 }, { "id": "G07410AW", "dp": 14 }, { "id": "G54273KX", "dp": 14 } ], "links": [ { "target": "G54273KX", "source": "G07410AW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07410AW", "source": "G37597FW", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54274NA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91023GB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G54274NA", "dp": 12 } ], "links": [ { "target": "G54274NA", "source": "G91023GB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54300AX", "error": "Missing intermediate; no pathways to [G54300AX] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54311AW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29434RB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G54311AW", "dp": 9 } ], "links": [ { "target": "G54311AW", "source": "G29434RB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54338PJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16150CJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G54338PJ", "dp": 14 } ], "links": [ { "target": "G54338PJ", "source": "G16150CJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54370BN", "error": "Missing intermediate; no pathways to [G54370BN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G54380FJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G68937TM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G54380FJ", "dp": 10 } ], "links": [ { "target": "G54380FJ", "source": "G68937TM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54386YN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20170YB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G20170YB", "dp": 12 }, { "id": "G54386YN", "dp": 12 } ], "links": [ { "target": "G54386YN", "source": "G20170YB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20170YB", "source": "G63585HN", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54411RI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39029JR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G39029JR", "dp": 10 }, { "id": "G54411RI", "dp": 10 } ], "links": [ { "target": "G54411RI", "source": "G39029JR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39029JR", "source": "G93500PH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54466RT", "error": "Missing intermediate; no pathways to [G54466RT] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G49933AX]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G54499PQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78890OB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G54499PQ", "dp": 10 } ], "links": [ { "target": "G54499PQ", "source": "G78890OB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54505OS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 } ], "links": [ { "target": "G54505OS", "source": "G65597BI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54507ZF", "error": "Starting point for pathway to G54507ZF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54513OG", "error": "Missing intermediate; no pathways to [G54513OG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46767VX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54533TM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36176RV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G36176RV", "dp": 12 }, { "id": "G54533TM", "dp": 12 } ], "links": [ { "target": "G54533TM", "source": "G36176RV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36176RV", "source": "G30302VM", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54569PE", "error": "Starting point for pathway to G54569PE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54584ER", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G54584ER", "source": "G18938DW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54587SM", "error": "Missing intermediate; no pathways to [G54587SM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G54590FS", "error": "Missing intermediate; no pathways to [G54590FS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54599TH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65449BO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G36519NW", "dp": 13 }, { "id": "G65449BO", "dp": 14 }, { "id": "G54599TH", "dp": 14 } ], "links": [ { "target": "G54599TH", "source": "G65449BO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65449BO", "source": "G36519NW", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G36519NW", "source": "G01669LU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54599TV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G83588YY", "dp": 15 } ], "links": [ { "target": "G54599TV", "source": "G83588YY", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83588YY", "source": "G11953VE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54611ZT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54626GN", "error": "Starting point for pathway to G54626GN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54642SQ", "error": "Starting point for pathway to G54642SQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54683UA", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G01069AK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G01069AK", "dp": 11 }, { "id": "G54683UA", "dp": 11 } ], "links": [ { "target": "G54683UA", "source": "G01069AK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01069AK", "source": "G91365ZQ", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54715UD", "error": "Starting point for pathway to G54715UD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54764AV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91337ZP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G91337ZP", "dp": 10 }, { "id": "G54764AV", "dp": 10 } ], "links": [ { "target": "G54764AV", "source": "G91337ZP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91337ZP", "source": "G58667NI", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54775DO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G13267ZY", "dp": 10 }, { "id": "G86681BW", "dp": 11 } ], "links": [ { "target": "G54775DO", "source": "G86681BW", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G86681BW", "source": "G13267ZY", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13267ZY", "source": "G46638GC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54842UT", "error": "Missing intermediate; no pathways to [G54842UT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G54884LT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29434RB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G54884LT", "dp": 9 } ], "links": [ { "target": "G54884LT", "source": "G29434RB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54893WF", "error": "Missing intermediate; no pathways to [G54893WF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54950JZ", "error": "Starting point for pathway to G54950JZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54953LX", "error": "Missing intermediate; no pathways to [G54953LX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G54956ME", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G18641OW", "dp": 11 } ], "links": [ { "target": "G54956ME", "source": "G18641OW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18641OW", "source": "G88417ED", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G54961LP", "error": "Missing intermediate; no pathways to [G54961LP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G97686QU]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G54963QY", "error": "Starting point for pathway to G54963QY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54977LV", "error": "Starting point for pathway to G54977LV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G54986EB", "error": "Missing intermediate; no pathways to [G54986EB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55013TE", "error": "Starting point for pathway to G55013TE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55015QS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 } ], "links": [ { "target": "G55015QS", "source": "G72718TT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55041IW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25835MT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G55041IW", "dp": 10 } ], "links": [ { "target": "G55041IW", "source": "G25835MT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55065WV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71857KQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G71857KQ", "dp": 10 }, { "id": "G55065WV", "dp": 10 } ], "links": [ { "target": "G55065WV", "source": "G71857KQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71857KQ", "source": "G29434RB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55067DH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40289RO]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G40289RO", "dp": 10 }, { "id": "G55067DH", "dp": 10 } ], "links": [ { "target": "G55067DH", "source": "G40289RO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40289RO", "source": "G20966TZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55070AA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G12699VT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G12699VT", "dp": 11 }, { "id": "G55070AA", "dp": 11 } ], "links": [ { "target": "G55070AA", "source": "G12699VT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12699VT", "source": "G78059CC", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55086SI", "error": "Starting point for pathway to G55086SI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55099PN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G44504SC", "dp": 10 } ], "links": [ { "target": "G55099PN", "source": "G44504SC", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G44504SC", "source": "G20030CU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55116NB", "error": "Missing intermediate; no pathways to [G55116NB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26844MI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55143WF", "error": "Starting point for pathway to G55143WF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55146FI", "error": "Starting point for pathway to G55146FI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55156EU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33742YO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G33742YO", "dp": 9 }, { "id": "G55156EU", "dp": 9 } ], "links": [ { "target": "G55156EU", "source": "G33742YO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33742YO", "source": "G29011JC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55157XP", "error": "Missing intermediate; no pathways to [G55157XP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55163RY", "error": "Starting point for pathway to G55163RY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55169KX", "error": "Missing intermediate; no pathways to [G55169KX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36581MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55182ZL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99257WS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G99257WS", "dp": 10 }, { "id": "G55182ZL", "dp": 10 } ], "links": [ { "target": "G55182ZL", "source": "G99257WS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99257WS", "source": "G36191CD", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55184GH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G18219CJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G55184GH", "dp": 11 } ], "links": [ { "target": "G55184GH", "source": "G18219CJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55192VG", "error": "Starting point for pathway to G55192VG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55220VL", "error": "Starting point for pathway to G55220VL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55224LJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78276SQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G78276SQ", "dp": 12 }, { "id": "G55224LJ", "dp": 12 } ], "links": [ { "target": "G55224LJ", "source": "G78276SQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78276SQ", "source": "G11041DA", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55250XM", "error": "Missing intermediate; no pathways to [G55250XM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26881SV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55251MD", "error": "Starting point for pathway to G55251MD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55257JO", "error": "Missing intermediate; no pathways to [G55257JO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55258MY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G26949IX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G55258MY", "dp": 11 } ], "links": [ { "target": "G55258MY", "source": "G26949IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55302QK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72974NP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 }, { "id": "G01354KL", "dp": 14 }, { "id": "G72974NP", "dp": 15 }, { "id": "G55302QK", "dp": 15 } ], "links": [ { "target": "G55302QK", "source": "G72974NP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72974NP", "source": "G01354KL", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55302WQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G20030CU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G55302WQ", "dp": 9 } ], "links": [ { "target": "G55302WQ", "source": "G20030CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55314RK", "error": "Missing intermediate; no pathways to [G55314RK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55327VV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G41331JX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G55327VV", "dp": 12 } ], "links": [ { "target": "G55327VV", "source": "G41331JX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55360MM", "error": "Missing intermediate; no pathways to [G55360MM] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55360NR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G59300GC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G59300GC", "dp": 14 }, { "id": "G55360NR", "dp": 14 } ], "links": [ { "target": "G55360NR", "source": "G59300GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59300GC", "source": "G73492AT", "residue_affected": { "residue_id": "N78", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55396DW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G55396DW", "source": "G25520XG", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55479DB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G11929SN", "dp": 14 } ], "links": [ { "target": "G55479DB", "source": "G11929SN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929SN", "source": "G80294GH", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55481KF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39439UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G39439UR", "dp": 9 }, { "id": "G55481KF", "dp": 9 } ], "links": [ { "target": "G55481KF", "source": "G39439UR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39439UR", "source": "G10209QU", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55505BS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66665YI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G66665YI", "dp": 14 }, { "id": "G55505BS", "dp": 14 } ], "links": [ { "target": "G55505BS", "source": "G66665YI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66665YI", "source": "G66282NU", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55505PJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90725ZC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G90725ZC", "dp": 9 }, { "id": "G55505PJ", "dp": 9 } ], "links": [ { "target": "G55505PJ", "source": "G90725ZC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90725ZC", "source": "G89993FE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55507EY", "error": "Missing intermediate; no pathways to [G55507EY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58547FH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55508HJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83992YN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 }, { "id": "G66961CH", "dp": 15 }, { "id": "G83992YN", "dp": 16 }, { "id": "G55508HJ", "dp": 16 } ], "links": [ { "target": "G55508HJ", "source": "G83992YN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G83992YN", "source": "G66961CH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55600PH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82811EP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82811EP", "dp": 13 }, { "id": "G55600PH", "dp": 13 } ], "links": [ { "target": "G55600PH", "source": "G82811EP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82811EP", "source": "G84376FR", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55630OZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23345GE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 }, { "id": "G23345GE", "dp": 15 }, { "id": "G55630OZ", "dp": 15 } ], "links": [ { "target": "G55630OZ", "source": "G23345GE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23345GE", "source": "G42686NQ", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55645TD", "error": "Missing intermediate; no pathways to [G55645TD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55653LB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80294GH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G55653LB", "dp": 13 } ], "links": [ { "target": "G55653LB", "source": "G80294GH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55719AB", "error": "Missing intermediate; no pathways to [G55719AB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79302PB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55742WA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82779CI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G55742WA", "dp": 11 } ], "links": [ { "target": "G55742WA", "source": "G82779CI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55743SL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G74090KZ", "dp": 7 }, { "id": "G50222RE", "dp": 8 } ], "links": [ { "target": "G55743SL", "source": "G50222RE", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G50222RE", "source": "G74090KZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74090KZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55781KV", "error": "Missing intermediate; no pathways to [G55781KV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57166CI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55786MG", "error": "Starting point for pathway to G55786MG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55805LU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17339LD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G52770HR", "dp": 10 }, { "id": "G17339LD", "dp": 11 }, { "id": "G55805LU", "dp": 11 } ], "links": [ { "target": "G55805LU", "source": "G17339LD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17339LD", "source": "G52770HR", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G52770HR", "source": "G36191CD", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55818EE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17689DH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 }, { "id": "G55818EE", "dp": 12 } ], "links": [ { "target": "G55818EE", "source": "G17689DH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55827GK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21737WY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 }, { "id": "G21737WY", "dp": 19 }, { "id": "G55827GK", "dp": 19 } ], "links": [ { "target": "G55827GK", "source": "G21737WY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21737WY", "source": "G94531EZ", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55828KH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G32201IL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G55828KH", "dp": 10 } ], "links": [ { "target": "G55828KH", "source": "G32201IL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55832RR", "error": "Starting point for pathway to G55832RR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G55837RK", "error": "Missing intermediate; no pathways to [G55837RK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55861FV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G18768EK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G18768EK", "dp": 11 }, { "id": "G55861FV", "dp": 11 } ], "links": [ { "target": "G55861FV", "source": "G18768EK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18768EK", "source": "G78803YD", "residue_affected": { "residue_id": "N78", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55867TY", "error": "Missing intermediate; no pathways to [G55867TY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25471TG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55879PV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26320VO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G26320VO", "dp": 10 }, { "id": "G55879PV", "dp": 10 } ], "links": [ { "target": "G55879PV", "source": "G26320VO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26320VO", "source": "G58667NI", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55890VR", "error": "Missing intermediate; no pathways to [G55890VR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62619LG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G55953GF", "error": "Missing intermediate; no pathways to [G55953GF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45048TZ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G55959FD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80319WU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 }, { "id": "G99891PR", "dp": 16 }, { "id": "G80319WU", "dp": 17 }, { "id": "G55959FD", "dp": 17 } ], "links": [ { "target": "G55959FD", "source": "G80319WU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80319WU", "source": "G99891PR", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55974RB", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 } ], "links": [ { "target": "G55974RB", "source": "G08187GM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55979JS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G66665YI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G66665YI", "dp": 14 }, { "id": "G55979JS", "dp": 14 } ], "links": [ { "target": "G55979JS", "source": "G66665YI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66665YI", "source": "G66282NU", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G55992IN", "error": "Starting point for pathway to G55992IN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56014GC", "error": "Starting point for pathway to G56014GC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56017FW", "error": "Starting point for pathway to G56017FW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56038AR", "error": "Starting point for pathway to G56038AR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56095ZZ", "error": "Missing intermediate; no pathways to [G56095ZZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29130SY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56144XM", "error": "Starting point for pathway to G56144XM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56147VV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 } ], "links": [ { "target": "G56147VV", "source": "G17168RO", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56163DR", "error": "Starting point for pathway to G56163DR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56175ED", "error": "Starting point for pathway to G56175ED could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56175MM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74807KC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 }, { "id": "G78097CL", "dp": 13 }, { "id": "G74807KC", "dp": 14 }, { "id": "G56175MM", "dp": 14 } ], "links": [ { "target": "G56175MM", "source": "G74807KC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74807KC", "source": "G78097CL", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78097CL", "source": "G09150LP", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56202TA", "error": "Starting point for pathway to G56202TA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56204RV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82942ZJ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G82942ZJ", "dp": 9 }, { "id": "G56204RV", "dp": 9 } ], "links": [ { "target": "G56204RV", "source": "G82942ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82942ZJ", "source": "G08520NM", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56224WF", "error": "Starting point for pathway to G56224WF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56265BA", "error": "Missing intermediate; no pathways to [G56265BA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G58473KL]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56269EA", "error": "Starting point for pathway to G56269EA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56271ML", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95617FJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G95617FJ", "dp": 12 }, { "id": "G56271ML", "dp": 12 } ], "links": [ { "target": "G56271ML", "source": "G95617FJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95617FJ", "source": "G25520XG", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56271TF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 } ], "links": [ { "target": "G56271TF", "source": "G59741XZ", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56297BE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78059CC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G56297BE", "dp": 10 } ], "links": [ { "target": "G56297BE", "source": "G78059CC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56318NV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 } ], "links": [ { "target": "G56318NV", "source": "G75237SS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56328RB", "error": "Starting point for pathway to G56328RB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56329KE", "error": "Starting point for pathway to G56329KE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56339QG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G56339QG", "source": "G29857RC", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56340GX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 } ], "links": [ { "target": "G56340GX", "source": "G27919IH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56354PO", "error": "Missing intermediate; no pathways to [G56354PO] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56376TA", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G17213JF", "dp": 11 } ], "links": [ { "target": "G56376TA", "source": "G17213JF", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56381GU", "error": "Starting point for pathway to G56381GU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56408DR", "error": "Missing intermediate; no pathways to [G56408DR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24875YE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56461GY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18938DW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G56461GY", "dp": 13 } ], "links": [ { "target": "G56461GY", "source": "G18938DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56469EY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66204OA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G66204OA", "dp": 8 }, { "id": "G56469EY", "dp": 8 } ], "links": [ { "target": "G56469EY", "source": "G66204OA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66204OA", "source": "G39089YD", "residue_affected": { "residue_id": "N477", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylf", "full_name": "β-D-Xylf" }, "effect": "Add β-D-Xylf", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G56485SI", "error": "Missing intermediate; no pathways to [G56485SI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56492IM", "error": "Missing intermediate; no pathways to [G56492IM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56492TA", "error": "Starting point for pathway to G56492TA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56499YQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 } ], "links": [ { "target": "G56499YQ", "source": "G57955DP", "residue_affected": { "residue_id": "N228", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56505IP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74645FT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G56505IP", "dp": 12 } ], "links": [ { "target": "G56505IP", "source": "G74645FT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56512DX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01856RL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G56512DX", "dp": 10 } ], "links": [ { "target": "G56512DX", "source": "G01856RL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56513YH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47566FL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G47566FL", "dp": 8 }, { "id": "G56513YH", "dp": 8 } ], "links": [ { "target": "G56513YH", "source": "G47566FL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47566FL", "source": "G07483YN", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56516KW", "error": "Missing intermediate; no pathways to [G56516KW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56546LQ", "error": "Missing intermediate; no pathways to [G56546LQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56549DH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 } ], "links": [ { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56553LA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G32699RJ", "dp": 10 }, { "id": "G86566MF", "dp": 11 } ], "links": [ { "target": "G56553LA", "source": "G86566MF", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G86566MF", "source": "G32699RJ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32699RJ", "source": "G63074CQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56577TY", "error": "Missing intermediate; no pathways to [G56577TY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56591LC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56621NM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G08205LJ", "dp": 13 } ], "links": [ { "target": "G56621NM", "source": "G08205LJ", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G08205LJ", "source": "G48658PB", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56634KC", "error": "Starting point for pathway to G56634KC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56653RI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10219AA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G56653RI", "dp": 8 } ], "links": [ { "target": "G56653RI", "source": "G10219AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56655CC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63889NK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G56655CC", "dp": 14 } ], "links": [ { "target": "G56655CC", "source": "G63889NK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56657CK", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G77252PU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G56657CK", "dp": 11 } ], "links": [ { "target": "G56657CK", "source": "G77252PU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56676FE", "error": "Missing intermediate; no pathways to [G56676FE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56678WD", "error": "Missing intermediate; no pathways to [G56678WD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56690OG", "error": "Starting point for pathway to G56690OG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56691CA", "error": "Missing intermediate; no pathways to [G56691CA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56696EG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05600OX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G05600OX", "dp": 14 }, { "id": "G56696EG", "dp": 14 } ], "links": [ { "target": "G56696EG", "source": "G05600OX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05600OX", "source": "G01727PW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56703XH", "error": "Missing intermediate; no pathways to [G56703XH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50135PA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56720TK", "error": "Missing intermediate; no pathways to [G56720TK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56737NO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10209QU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G56737NO", "dp": 8 } ], "links": [ { "target": "G56737NO", "source": "G10209QU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56748EO", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 } ], "links": [ { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56749GV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56770AH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10228OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G56770AH", "dp": 14 } ], "links": [ { "target": "G56770AH", "source": "G10228OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56791SN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95898GD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 }, { "id": "G56791SN", "dp": 13 } ], "links": [ { "target": "G56791SN", "source": "G95898GD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56809FB", "error": "Missing intermediate; no pathways to [G56809FB] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G66595IQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56811RE", "error": "Missing intermediate; no pathways to [G56811RE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56830SM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G57943ZV", "dp": 11 } ], "links": [ { "target": "G56830SM", "source": "G57943ZV", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56837YQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50489VC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G56837YQ", "dp": 17 } ], "links": [ { "target": "G56837YQ", "source": "G50489VC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56840FF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53396PX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G53396PX", "dp": 14 }, { "id": "G56840FF", "dp": 14 } ], "links": [ { "target": "G56840FF", "source": "G53396PX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53396PX", "source": "G82050MN", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56850HF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75120WS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G56850HF", "dp": 13 } ], "links": [ { "target": "G56850HF", "source": "G75120WS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56851CO", "error": "Starting point for pathway to G56851CO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56852BX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72221XM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 }, { "id": "G72221XM", "dp": 12 }, { "id": "G56852BX", "dp": 12 } ], "links": [ { "target": "G56852BX", "source": "G72221XM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72221XM", "source": "G45187EI", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56867YK", "error": "Starting point for pathway to G56867YK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56869RQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96091LW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G07228BR", "dp": 10 }, { "id": "G96091LW", "dp": 11 }, { "id": "G56869RQ", "dp": 11 } ], "links": [ { "target": "G56869RQ", "source": "G96091LW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96091LW", "source": "G07228BR", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07228BR", "source": "G93500PH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56891ZN", "error": "Missing intermediate; no pathways to [G56891ZN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54590FS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G56893CG", "error": "Starting point for pathway to G56893CG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56923VL", "error": "Starting point for pathway to G56923VL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56963QZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56318NV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 }, { "id": "G56318NV", "dp": 17 }, { "id": "G56963QZ", "dp": 17 } ], "links": [ { "target": "G56963QZ", "source": "G56318NV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56318NV", "source": "G75237SS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G56972PM", "error": "Starting point for pathway to G56972PM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56977BH", "error": "Starting point for pathway to G56977BH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G56988MG", "error": "Missing intermediate; no pathways to [G56988MG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74497TS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57007KH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40554DX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G40554DX", "dp": 14 }, { "id": "G57007KH", "dp": 14 } ], "links": [ { "target": "G57007KH", "source": "G40554DX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40554DX", "source": "G75120WS", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57040DY", "error": "Missing intermediate; no pathways to [G57040DY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57044IA", "error": "Missing intermediate; no pathways to [G57044IA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94838KN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57051OG", "error": "Missing intermediate; no pathways to [G57051OG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10295MW]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57065EQ", "error": "Missing intermediate; no pathways to [G57065EQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57075KG", "error": "Missing intermediate; no pathways to [G57075KG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95695ZV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57075OH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41981MA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G41981MA", "dp": 15 }, { "id": "G57075OH", "dp": 15 } ], "links": [ { "target": "G57075OH", "source": "G41981MA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41981MA", "source": "G38022PE", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57083FO", "error": "Missing intermediate; no pathways to [G57083FO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57084IU", "error": "Missing intermediate; no pathways to [G57084IU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57092OJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 } ], "links": [ { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57117TO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G57117TO", "source": "G69411IG", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57125VL", "error": "Missing intermediate; no pathways to [G57125VL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57158CS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G72974NP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 }, { "id": "G01354KL", "dp": 14 }, { "id": "G72974NP", "dp": 15 }, { "id": "G57158CS", "dp": 15 } ], "links": [ { "target": "G57158CS", "source": "G72974NP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72974NP", "source": "G01354KL", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57166CI", "error": "Missing intermediate; no pathways to [G57166CI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57208CK", "error": "Starting point for pathway to G57208CK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57220BY", "error": "Missing intermediate; no pathways to [G57220BY] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G78648QN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57239MG", "error": "Starting point for pathway to G57239MG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57245TH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36701GV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G36701GV", "dp": 12 }, { "id": "G57245TH", "dp": 12 } ], "links": [ { "target": "G57245TH", "source": "G36701GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36701GV", "source": "G53752TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57250WI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28298VW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G28298VW", "dp": 13 }, { "id": "G57250WI", "dp": 13 } ], "links": [ { "target": "G57250WI", "source": "G28298VW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28298VW", "source": "G48658PB", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57260LH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 } ], "links": [ { "target": "G57260LH", "source": "G89877QI", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57262WV", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G06209KS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G06209KS", "dp": 8 }, { "id": "G57262WV", "dp": 8 } ], "links": [ { "target": "G57262WV", "source": "G06209KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06209KS", "source": "G69411IG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57267KB", "error": "Starting point for pathway to G57267KB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57277JN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95490LA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95490LA", "dp": 14 }, { "id": "G57277JN", "dp": 14 } ], "links": [ { "target": "G57277JN", "source": "G95490LA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95490LA", "source": "G18938DW", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57295PS", "error": "Missing intermediate; no pathways to [G57295PS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16600BL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57300MW", "error": "Missing intermediate; no pathways to [G57300MW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75445NA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57320FY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 } ], "links": [ { "target": "G57320FY", "source": "G90017UO", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57338PU", "error": "Missing intermediate; no pathways to [G57338PU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G90130AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57345HS", "error": "Missing intermediate; no pathways to [G57345HS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57449OF", "error": "Starting point for pathway to G57449OF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57462FC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30404XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G53000RQ", "dp": 11 }, { "id": "G38951VC", "dp": 12 }, { "id": "G30404XZ", "dp": 13 }, { "id": "G57462FC", "dp": 13 } ], "links": [ { "target": "G57462FC", "source": "G30404XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30404XZ", "source": "G38951VC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38951VC", "source": "G53000RQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53000RQ", "source": "G12740VA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57466QX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 } ], "links": [ { "target": "G57466QX", "source": "G86357DX", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57484FV", "error": "Starting point for pathway to G57484FV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57504TA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G28723UT", "dp": 11 } ], "links": [ { "target": "G57504TA", "source": "G28723UT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28723UT", "source": "G87073UP", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57511DS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G85650LS", "dp": 11 } ], "links": [ { "target": "G57511DS", "source": "G85650LS", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85650LS", "source": "G28826SH", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57521CV", "error": "Missing intermediate; no pathways to [G57521CV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34819LS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57522MT", "error": "Starting point for pathway to G57522MT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57565TQ", "error": "Missing intermediate; no pathways to [G57565TQ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57580SM", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G43664YB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G43664YB", "dp": 9 }, { "id": "G57580SM", "dp": 9 } ], "links": [ { "target": "G57580SM", "source": "G43664YB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43664YB", "source": "G24420RT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57595UE", "error": "Starting point for pathway to G57595UE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57601AP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G73817GH", "dp": 10 } ], "links": [ { "target": "G57601AP", "source": "G73817GH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57601KU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 } ], "links": [ { "target": "G57601KU", "source": "G81663ZI", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57626SM", "error": "Missing intermediate; no pathways to [G57626SM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57671LP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G57647XA", "error": "Missing intermediate; no pathways to [G57647XA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57667LR", "error": "Starting point for pathway to G57667LR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57671LP", "error": "Missing intermediate; no pathways to [G57671LP] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G57675TR", "error": "Missing intermediate; no pathways to [G57675TR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57707WO", "error": "Starting point for pathway to G57707WO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57710DC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49515VE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G57710DC", "dp": 12 } ], "links": [ { "target": "G57710DC", "source": "G49515VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57710XG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G32699RJ", "dp": 10 } ], "links": [ { "target": "G57710XG", "source": "G32699RJ", "residue_affected": { "residue_id": "N422", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G32699RJ", "source": "G63074CQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57740WC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16546ZZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G16546ZZ", "dp": 13 }, { "id": "G57740WC", "dp": 13 } ], "links": [ { "target": "G57740WC", "source": "G16546ZZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16546ZZ", "source": "G41331JX", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57741SS", "error": "Missing intermediate; no pathways to [G57741SS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G57762GE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92359VA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G57762GE", "dp": 13 } ], "links": [ { "target": "G57762GE", "source": "G92359VA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57774MT", "error": "Missing intermediate; no pathways to [G57774MT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74074HU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57787IU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85542KD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G57787IU", "dp": 10 } ], "links": [ { "target": "G57787IU", "source": "G85542KD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57835AK", "error": "Missing intermediate; no pathways to [G57835AK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57843KJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G61088TM", "dp": 12 } ], "links": [ { "target": "G57843KJ", "source": "G61088TM", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61088TM", "source": "G90870DG", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57863LA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G57863LA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57881VN", "error": "Missing intermediate; no pathways to [G57881VN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G24327OK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57930PW", "error": "Starting point for pathway to G57930PW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57937LQ", "error": "Missing intermediate; no pathways to [G57937LQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G57941UT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G61553DD", "dp": 9 } ], "links": [ { "target": "G57941UT", "source": "G61553DD", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61553DD", "source": "G29011JC", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57943ZV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 } ], "links": [ { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57955DP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 } ], "links": [ { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57956SV", "error": "Starting point for pathway to G57956SV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G57970NA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 } ], "links": [ { "target": "G57970NA", "source": "G49515VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57976DO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G55396DW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G55396DW", "dp": 12 }, { "id": "G57976DO", "dp": 12 } ], "links": [ { "target": "G57976DO", "source": "G55396DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G55396DW", "source": "G25520XG", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G57997IN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11509RN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G11509RN", "dp": 12 }, { "id": "G57997IN", "dp": 12 } ], "links": [ { "target": "G57997IN", "source": "G11509RN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11509RN", "source": "G30302VM", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58004KD", "error": "Missing intermediate; no pathways to [G58004KD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16873YG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58029XR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85260RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G85260RY", "dp": 16 }, { "id": "G58029XR", "dp": 16 } ], "links": [ { "target": "G58029XR", "source": "G85260RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85260RY", "source": "G57955DP", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58111YY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82033VN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G82033VN", "dp": 14 }, { "id": "G58111YY", "dp": 14 } ], "links": [ { "target": "G58111YY", "source": "G82033VN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82033VN", "source": "G20926BB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58141VU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31010RQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G58141VU", "dp": 11 } ], "links": [ { "target": "G58141VU", "source": "G31010RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58143RL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07802IC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G07802IC", "dp": 13 }, { "id": "G58143RL", "dp": 13 } ], "links": [ { "target": "G58143RL", "source": "G07802IC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07802IC", "source": "G56749GV", "residue_affected": { "residue_id": "N483", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58183RP", "error": "Starting point for pathway to G58183RP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G58194JW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19469VZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G19469VZ", "dp": 18 }, { "id": "G58194JW", "dp": 18 } ], "links": [ { "target": "G58194JW", "source": "G19469VZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19469VZ", "source": "G92574YO", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58198HJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82487CR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G82487CR", "dp": 15 }, { "id": "G58198HJ", "dp": 15 } ], "links": [ { "target": "G58198HJ", "source": "G82487CR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82487CR", "source": "G08194HH", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58207MU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36004BS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G36004BS", "dp": 9 }, { "id": "G58207MU", "dp": 9 } ], "links": [ { "target": "G58207MU", "source": "G36004BS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36004BS", "source": "G12398HZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58214IQ", "error": "Starting point for pathway to G58214IQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G58216EF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82050MN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G58216EF", "dp": 13 } ], "links": [ { "target": "G58216EF", "source": "G82050MN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58217PP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G91413ZX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 }, { "id": "G58217PP", "dp": 15 } ], "links": [ { "target": "G58217PP", "source": "G91413ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58233BW", "error": "Missing intermediate; no pathways to [G58233BW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88582ZD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58236FD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07995VK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G58236FD", "dp": 10 } ], "links": [ { "target": "G58236FD", "source": "G07995VK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58244GN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G33202XC", "dp": 13 } ], "links": [ { "target": "G58244GN", "source": "G33202XC", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33202XC", "source": "G75185NU", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58251YC", "error": "Missing intermediate; no pathways to [G58251YC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58278VO", "error": "Missing intermediate; no pathways to [G58278VO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G12222NC]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58281SK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 } ], "links": [ { "target": "G58281SK", "source": "G59471TH", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58315CQ", "error": "Missing intermediate; no pathways to [G58315CQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58328JK", "error": "Starting point for pathway to G58328JK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G58331OS", "error": "Missing intermediate; no pathways to [G58331OS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G31637BB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58350LJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G29857RC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G58350LJ", "dp": 11 } ], "links": [ { "target": "G58350LJ", "source": "G29857RC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58381OV", "error": "Starting point for pathway to G58381OV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G58403SV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 } ], "links": [ { "target": "G58403SV", "source": "G99270AV", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58404RD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40906DZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G40906DZ", "dp": 14 }, { "id": "G58404RD", "dp": 14 } ], "links": [ { "target": "G58404RD", "source": "G40906DZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40906DZ", "source": "G18938DW", "residue_affected": { "residue_id": "N43", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58413WQ", "error": "Missing intermediate; no pathways to [G58413WQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G58422UX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 } ], "links": [ { "target": "G58422UX", "source": "G91208VE", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58424NI", "error": "Missing intermediate; no pathways to [G58424NI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58473KL", "error": "Missing intermediate; no pathways to [G58473KL] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58516UP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G14512NS", "dp": 9 } ], "links": [ { "target": "G58516UP", "source": "G14512NS", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G14512NS", "source": "G24420RT", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58517TJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45187EI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 }, { "id": "G58517TJ", "dp": 11 } ], "links": [ { "target": "G58517TJ", "source": "G45187EI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58547FH", "error": "Missing intermediate; no pathways to [G58547FH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58561KE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91023GB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G58561KE", "dp": 12 } ], "links": [ { "target": "G58561KE", "source": "G91023GB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58571IP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10228OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G58571IP", "dp": 14 } ], "links": [ { "target": "G58571IP", "source": "G10228OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58585VA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcNAc]", "homologous pathway end-point [G62504BU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G58585VA", "dp": 10 } ], "links": [ { "target": "G58585VA", "source": "G62504BU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58599KY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10258MC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G10258MC", "dp": 11 }, { "id": "G58599KY", "dp": 11 } ], "links": [ { "target": "G58599KY", "source": "G10258MC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10258MC", "source": "G25835MT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58655LE", "error": "Missing intermediate; no pathways to [G58655LE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58660FK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G73492AT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G58660FK", "dp": 13 } ], "links": [ { "target": "G58660FK", "source": "G73492AT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58667NI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58692HO", "error": "Starting point for pathway to G58692HO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G58746AB", "error": "Starting point for pathway to G58746AB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G58768FH", "error": "Missing intermediate; no pathways to [G58768FH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58780EA", "error": "Starting point for pathway to G58780EA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G58783PZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60660BN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G60660BN", "dp": 15 }, { "id": "G58783PZ", "dp": 15 } ], "links": [ { "target": "G58783PZ", "source": "G60660BN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60660BN", "source": "G10228OD", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58788RE", "error": "Missing intermediate; no pathways to [G58788RE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20711NK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58807XI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G29026MS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G29026MS", "dp": 12 }, { "id": "G58807XI", "dp": 12 } ], "links": [ { "target": "G58807XI", "source": "G29026MS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29026MS", "source": "G59877NF", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58808TX", "error": "Missing intermediate; no pathways to [G58808TX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95658PH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58809AD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G84852GW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G84852GW", "dp": 9 }, { "id": "G58809AD", "dp": 9 } ], "links": [ { "target": "G58809AD", "source": "G84852GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84852GW", "source": "G12398HZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58824LL", "error": "Starting point for pathway to G58824LL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G58827HR", "error": "Missing intermediate; no pathways to [G58827HR] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58839SI", "error": "Missing intermediate; no pathways to [G58839SI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58918TF", "error": "Missing intermediate; no pathways to [G58918TF] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G30880RA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58931VV", "error": "Missing intermediate; no pathways to [G58931VV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G51098AA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58932AD", "error": "Missing intermediate; no pathways to [G58932AD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G58955OJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00951UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G79198BK", "dp": 9 }, { "id": "G00951UF", "dp": 10 }, { "id": "G58955OJ", "dp": 10 } ], "links": [ { "target": "G58955OJ", "source": "G00951UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00951UF", "source": "G79198BK", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79198BK", "source": "G10219AA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G58969RU", "error": "Missing intermediate; no pathways to [G58969RU] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G58992VJ", "error": "Missing intermediate; no pathways to [G58992VJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G58969RU]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G58995TS", "error": "Starting point for pathway to G58995TS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59003TR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93582HM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G59003TR", "dp": 13 } ], "links": [ { "target": "G59003TR", "source": "G93582HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59005MI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39595CR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G39595CR", "dp": 14 }, { "id": "G59005MI", "dp": 14 } ], "links": [ { "target": "G59005MI", "source": "G39595CR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39595CR", "source": "G80294GH", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59024DC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G45187EI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 }, { "id": "G59024DC", "dp": 11 } ], "links": [ { "target": "G59024DC", "source": "G45187EI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59029AQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 } ], "links": [ { "target": "G59029AQ", "source": "G04791QM", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59041MP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G97674NY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G97674NY", "dp": 15 }, { "id": "G59041MP", "dp": 15 } ], "links": [ { "target": "G59041MP", "source": "G97674NY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97674NY", "source": "G89877QI", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59069FV", "error": "Missing intermediate; no pathways to [G59069FV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66847YI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59081JJ", "error": "Missing intermediate; no pathways to [G59081JJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59092NO", "error": "Missing intermediate; no pathways to [G59092NO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G73977KO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59128IS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G56147VV", "dp": 15 } ], "links": [ { "target": "G59128IS", "source": "G56147VV", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56147VV", "source": "G17168RO", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59141EN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57863LA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G57863LA", "dp": 11 }, { "id": "G59141EN", "dp": 11 } ], "links": [ { "target": "G59141EN", "source": "G57863LA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57863LA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59149SL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00743WU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 }, { "id": "G59149SL", "dp": 11 } ], "links": [ { "target": "G59149SL", "source": "G00743WU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59159PE", "error": "Missing intermediate; no pathways to [G59159PE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59182CT", "error": "Starting point for pathway to G59182CT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59204MG", "error": "Missing intermediate; no pathways to [G59204MG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32173NW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59231NT", "error": "Missing intermediate; no pathways to [G59231NT] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G59255VT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G70520DS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G24083XE", "dp": 12 }, { "id": "G70520DS", "dp": 13 }, { "id": "G59255VT", "dp": 13 } ], "links": [ { "target": "G59255VT", "source": "G70520DS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70520DS", "source": "G24083XE", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24083XE", "source": "G82252QI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59256VO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74675FC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G59256VO", "dp": 11 } ], "links": [ { "target": "G59256VO", "source": "G74675FC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59258LC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82050MN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G59258LC", "dp": 13 } ], "links": [ { "target": "G59258LC", "source": "G82050MN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59272DZ", "error": "Missing intermediate; no pathways to [G59272DZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59277TZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 } ], "links": [ { "target": "G59277TZ", "source": "G30159WR", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59300GC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 } ], "links": [ { "target": "G59300GC", "source": "G73492AT", "residue_affected": { "residue_id": "N78", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59311AO", "error": "Starting point for pathway to G59311AO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59345UT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16150CJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G59345UT", "dp": 14 } ], "links": [ { "target": "G59345UT", "source": "G16150CJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59361OW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 } ], "links": [ { "target": "G59361OW", "source": "G44946WH", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59377NB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74574VX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G74574VX", "dp": 11 }, { "id": "G59377NB", "dp": 11 } ], "links": [ { "target": "G59377NB", "source": "G74574VX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59406KS", "error": "Starting point for pathway to G59406KS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59451NL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G59451NL", "source": "G39213VZ", "residue_affected": { "residue_id": "N299", "pubchem_name": "Fuc", "anomer": "b", "absolute": "L", "form_name": "Fucp", "full_name": "β-L-Fucp" }, "effect": "Add β-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59454IE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G48954CA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G48954CA", "dp": 9 }, { "id": "G59454IE", "dp": 9 } ], "links": [ { "target": "G59454IE", "source": "G48954CA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48954CA", "source": "G12398HZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59456VR", "error": "Missing intermediate; no pathways to [G59456VR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59458AW", "error": "Missing intermediate; no pathways to [G59458AW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59471JC", "error": "Missing intermediate; no pathways to [G59471JC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53854XZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59471TH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59489PX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26182BM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G59489PX", "dp": 8 } ], "links": [ { "target": "G59489PX", "source": "G26182BM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59513YA", "error": "Starting point for pathway to G59513YA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59532XE", "error": "Starting point for pathway to G59532XE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59575FI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G66129DI", "dp": 11 } ], "links": [ { "target": "G59575FI", "source": "G66129DI", "residue_affected": { "residue_id": "N476", "pubchem_name": "phosphate", "anomer": "n", "absolute": "n", "form_name": "phosphate", "full_name": "-n-phosphate" }, "effect": "Add -n-phosphate", "enzymes": [] }, { "target": "G66129DI", "source": "G03275SD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59579TL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G86753CK", "dp": 17 } ], "links": [ { "target": "G59579TL", "source": "G86753CK", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59594CP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G66282NU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G59594CP", "dp": 13 } ], "links": [ { "target": "G59594CP", "source": "G66282NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59619LB", "error": "Missing intermediate; no pathways to [G59619LB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14393TF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59621EZ", "error": "Starting point for pathway to G59621EZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59636XZ", "error": "Missing intermediate; no pathways to [G59636XZ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G41087ZA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59654XN", "error": "Starting point for pathway to G59654XN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59655SA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 } ], "links": [ { "target": "G59655SA", "source": "G53752TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59679CG", "error": "Missing intermediate; no pathways to [G59679CG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59688ZS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 } ], "links": [ { "target": "G59688ZS", "source": "G01856RL", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59716UA", "error": "Starting point for pathway to G59716UA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59733QQ", "error": "Missing intermediate; no pathways to [G59733QQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13210XL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59741XZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59742GY", "error": "Missing intermediate; no pathways to [G59742GY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59742ZT", "error": "Missing intermediate; no pathways to [G59742ZT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59746QC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 } ], "links": [ { "target": "G59746QC", "source": "G00909PI", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59752BW", "error": "Missing intermediate; no pathways to [G59752BW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59761EF", "error": "Missing intermediate; no pathways to [G59761EF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98453VS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59804RR", "error": "Starting point for pathway to G59804RR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59869XG", "error": "Starting point for pathway to G59869XG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G59877NF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 } ], "links": [ { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59897WN", "error": "Missing intermediate; no pathways to [G59897WN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G59910CM", "error": "Missing intermediate; no pathways to [G59910CM] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G86555OF]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G59915YZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 } ], "links": [ { "target": "G59915YZ", "source": "G79609RF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59942FB", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 } ], "links": [ { "target": "G59942FB", "source": "G56748EO", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59984BF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23626NI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G23626NI", "dp": 11 }, { "id": "G59984BF", "dp": 11 } ], "links": [ { "target": "G59984BF", "source": "G23626NI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23626NI", "source": "G85542KD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G59989VG", "error": "Missing intermediate; no pathways to [G59989VG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60012HO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96921ZU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G96921ZU", "dp": 12 }, { "id": "G60012HO", "dp": 12 } ], "links": [ { "target": "G60012HO", "source": "G96921ZU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60103QI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 } ], "links": [ { "target": "G60103QI", "source": "G54611ZT", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60149QJ", "error": "Starting point for pathway to G60149QJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60176QG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46661UU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G73817GH", "dp": 10 }, { "id": "G57601AP", "dp": 11 }, { "id": "G11615SW", "dp": 12 }, { "id": "G46661UU", "dp": 13 }, { "id": "G60176QG", "dp": 13 } ], "links": [ { "target": "G60176QG", "source": "G46661UU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46661UU", "source": "G11615SW", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11615SW", "source": "G57601AP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57601AP", "source": "G73817GH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60186EO", "error": "Missing intermediate; no pathways to [G60186EO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60215UL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 } ], "links": [ { "target": "G60215UL", "source": "G47175EF", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60227QI", "error": "Missing intermediate; no pathways to [G60227QI] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60230HH", "error": "Starting point for pathway to G60230HH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60233QP", "error": "Missing intermediate; no pathways to [G60233QP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47554EG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60255MW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50943ZX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G50943ZX", "dp": 9 }, { "id": "G60255MW", "dp": 9 } ], "links": [ { "target": "G60255MW", "source": "G50943ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50943ZX", "source": "G20956ZK", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60269YM", "error": "Starting point for pathway to G60269YM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60274JN", "error": "Starting point for pathway to G60274JN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60284TY", "error": "Missing intermediate; no pathways to [G60284TY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G60320IS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94045IP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G94045IP", "dp": 13 }, { "id": "G60320IS", "dp": 13 } ], "links": [ { "target": "G60320IS", "source": "G94045IP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94045IP", "source": "G91023GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60330MA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56147VV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G56147VV", "dp": 15 }, { "id": "G60330MA", "dp": 15 } ], "links": [ { "target": "G60330MA", "source": "G56147VV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56147VV", "source": "G17168RO", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60343KO", "error": "Missing intermediate; no pathways to [G60343KO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60345PE", "error": "Starting point for pathway to G60345PE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60359JC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62883YA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G62883YA", "dp": 11 }, { "id": "G60359JC", "dp": 11 } ], "links": [ { "target": "G60359JC", "source": "G62883YA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62883YA", "source": "G66866LE", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60370CP", "error": "Starting point for pathway to G60370CP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60383WH", "error": "Starting point for pathway to G60383WH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60396VE", "error": "Missing intermediate; no pathways to [G60396VE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41596PV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60413OP", "error": "Missing intermediate; no pathways to [G60413OP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60415BS", "error": "Starting point for pathway to G60415BS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60419KX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G73759SD", "dp": 13 } ], "links": [ { "target": "G60419KX", "source": "G73759SD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73759SD", "source": "G96963QG", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60439QY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 }, { "id": "G99891PR", "dp": 16 } ], "links": [ { "target": "G60439QY", "source": "G99891PR", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60464IB", "error": "Starting point for pathway to G60464IB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60483MG", "error": "Missing intermediate; no pathways to [G60483MG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60485RX", "error": "Missing intermediate; no pathways to [G60485RX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G36581MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60496TU", "error": "Missing intermediate; no pathways to [G60496TU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03296OS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60527VO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94531EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 }, { "id": "G60527VO", "dp": 18 } ], "links": [ { "target": "G60527VO", "source": "G94531EZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60532CM", "error": "Missing intermediate; no pathways to [G60532CM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G58768FH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60534NQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52934AK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G60534NQ", "dp": 10 } ], "links": [ { "target": "G60534NQ", "source": "G52934AK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60564DP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60604SE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17339LD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G52770HR", "dp": 10 }, { "id": "G17339LD", "dp": 11 }, { "id": "G60604SE", "dp": 11 } ], "links": [ { "target": "G60604SE", "source": "G17339LD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17339LD", "source": "G52770HR", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G52770HR", "source": "G36191CD", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60605VB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 } ], "links": [ { "target": "G60605VB", "source": "G04791QM", "residue_affected": { "residue_id": "N422", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60610NA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, 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"gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20018DL", "source": "G18938DW", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { 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"gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60646UB", "error": "Starting point for pathway to G60646UB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60653VD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85542KD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G60653VD", "dp": 10 } ], "links": [ { "target": "G60653VD", "source": "G85542KD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60660BN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 } ], "links": [ { "target": "G60660BN", "source": "G10228OD", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60663ZP", "error": "Starting point for pathway to G60663ZP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60667OL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 } ], "links": [ { "target": "G60667OL", "source": "G11535IB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60673DJ", "error": "Missing intermediate; no pathways to [G60673DJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47384NK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60692DB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10182XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G60692DB", "dp": 7 } ], "links": [ { "target": "G60692DB", "source": "G10182XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60700QY", "error": "Missing intermediate; no pathways to [G60700QY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60704KF", "error": "Missing intermediate; no pathways to [G60704KF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10650OV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60705KN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79394LC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 }, { "id": "G79394LC", "dp": 13 }, { "id": "G60705KN", "dp": 13 } ], "links": [ { "target": "G60705KN", "source": "G79394LC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79394LC", "source": "G97765TT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60736DD", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G84467IZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 }, { "id": "G60736DD", "dp": 11 } ], "links": [ { "target": "G60736DD", "source": "G84467IZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60765GV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G04554UL", "dp": 11 } ], "links": [ { "target": "G60765GV", "source": "G04554UL", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04554UL", "source": "G91365ZQ", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60782IE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G01935FK", "dp": 10 } ], "links": [ { "target": "G60782IE", "source": "G01935FK", "residue_affected": { "residue_id": "N483", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G01935FK", "source": "G36191CD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60785FE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcNAc]", "homologous pathway end-point [G83717YJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G83717YJ", "dp": 9 }, { "id": "G60785FE", "dp": 9 } ], "links": [ { "target": "G60785FE", "source": "G83717YJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G83717YJ", "source": "G10219AA", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60814ZB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 } ], "links": [ { "target": "G60814ZB", "source": "G28106CM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60826VF", "error": "Starting point for pathway to G60826VF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60829NM", "error": "Starting point for pathway to G60829NM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60859QN", "error": "Missing intermediate; no pathways to [G60859QN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53288JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60860OP", "error": "Missing intermediate; no pathways to [G60860OP] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60875XB", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G16828VN]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G60875XB", "dp": 9 } ], "links": [ { "target": "G60875XB", "source": "G16828VN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60878OX", "error": "Missing intermediate; no pathways to [G60878OX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76294TY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G60887NT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 }, { "id": "G58422UX", "dp": 10 } ], "links": [ { "target": "G60887NT", "source": "G58422UX", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G58422UX", "source": "G91208VE", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60926LS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 }, { "id": "G39298RF", "dp": 11 } ], "links": [ { "target": "G60926LS", "source": "G39298RF", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39298RF", "source": "G71690HK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60926SE", "error": "Starting point for pathway to G60926SE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60929YB", "error": "Starting point for pathway to G60929YB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G60941RE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 } ], "links": [ { "target": "G60941RE", "source": "G75185NU", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60956VN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30159WR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G60956VN", "dp": 9 } ], "links": [ { "target": "G60956VN", "source": "G30159WR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60963AS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G65796FM", "dp": 13 } ], "links": [ { "target": "G60963AS", "source": "G65796FM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65796FM", "source": "G79344MI", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G60988FT", "error": "Missing intermediate; no pathways to [G60988FT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61008CN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G21246OH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G21246OH", "dp": 11 }, { "id": "G61008CN", "dp": 11 } ], "links": [ { "target": "G61008CN", "source": "G21246OH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21246OH", "source": "G00176HZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61049GY", "error": "Missing intermediate; no pathways to [G61049GY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59752BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61071ZB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38208CY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G61684ET", "dp": 12 }, { "id": "G38208CY", "dp": 13 }, { "id": "G61071ZB", "dp": 13 } ], "links": [ { "target": "G61071ZB", "source": "G38208CY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38208CY", "source": "G61684ET", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61684ET", "source": "G25520XG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61086WG", "error": "Missing intermediate; no pathways to [G61086WG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54260SD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61088TM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 } ], "links": [ { "target": "G61088TM", "source": "G90870DG", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61107IC", "error": "Starting point for pathway to G61107IC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61133SM", "error": "Missing intermediate; no pathways to [G61133SM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61153TX", "error": "Missing intermediate; no pathways to [G61153TX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61203OK", "error": "Missing intermediate; no pathways to [G61203OK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61207RZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 } ], "links": [ { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61209FM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01856RL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G61209FM", "dp": 10 } ], "links": [ { "target": "G61209FM", "source": "G01856RL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61250GU", "error": "Missing intermediate; no pathways to [G61250GU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62619LG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61261HA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G40906DZ", "dp": 14 } ], "links": [ { "target": "G61261HA", "source": "G40906DZ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40906DZ", "source": "G18938DW", "residue_affected": { "residue_id": "N43", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61274OD", "error": "Missing intermediate; no pathways to [G61274OD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61283FH", "error": "Starting point for pathway to G61283FH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61291WY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G67215MI]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G67215MI", "dp": 11 }, { "id": "G61291WY", "dp": 11 } ], "links": [ { "target": "G61291WY", "source": "G67215MI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G67215MI", "source": "G11637WL", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61312PU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 }, { "id": "G01010HW", "dp": 9 }, { "id": "G11588II", "dp": 10 } ], "links": [ { "target": "G61312PU", "source": "G11588II", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11588II", "source": "G01010HW", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61334IA", "error": "Starting point for pathway to G61334IA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61434JL", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G17213JF", "dp": 11 }, { "id": "G61530CE", "dp": 12 } ], "links": [ { "target": "G61434JL", "source": "G61530CE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61530CE", "source": "G17213JF", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61456PF", "error": "Starting point for pathway to G61456PF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61457CY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11509RN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G11509RN", "dp": 12 }, { "id": "G61457CY", "dp": 12 } ], "links": [ { "target": "G61457CY", "source": "G11509RN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11509RN", "source": "G30302VM", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61519GA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G22098NU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G22098NU", "dp": 11 }, { "id": "G61519GA", "dp": 11 } ], "links": [ { "target": "G61519GA", "source": "G22098NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G22098NU", "source": "G71013KY", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61530CE", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G17213JF", "dp": 11 } ], "links": [ { "target": "G61530CE", "source": "G17213JF", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61539GW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G60215UL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G60215UL", "dp": 12 }, { "id": "G61539GW", "dp": 12 } ], "links": [ { "target": "G61539GW", "source": "G60215UL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60215UL", "source": "G47175EF", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61551YB", "error": "Starting point for pathway to G61551YB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61553DD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G61553DD", "source": "G29011JC", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61575RT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 } ], "links": [ { "target": "G61575RT", "source": "G82050MN", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61601ZZ", "error": "Starting point for pathway to G61601ZZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61614JZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86270DU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G86270DU", "dp": 12 }, { "id": "G61614JZ", "dp": 12 } ], "links": [ { "target": "G61614JZ", "source": "G86270DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86270DU", "source": "G11041DA", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61640TZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G90725ZC", "dp": 9 } ], "links": [ { "target": "G61640TZ", "source": "G90725ZC", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G90725ZC", "source": "G89993FE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61676ER", "error": "Starting point for pathway to G61676ER could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61684ET", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G61684ET", "source": "G25520XG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61692RF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16774YZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G16774YZ", "dp": 18 }, { "id": "G61692RF", "dp": 18 } ], "links": [ { "target": "G61692RF", "source": "G16774YZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16774YZ", "source": "G86696LV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61702UX", "error": "Starting point for pathway to G61702UX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61705AR", "error": "Missing intermediate; no pathways to [G61705AR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G83402YY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61706MD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36191CD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G61706MD", "dp": 9 } ], "links": [ { "target": "G61706MD", "source": "G36191CD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61707PW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G74928QN", "dp": 14 } ], "links": [ { "target": "G61707PW", "source": "G74928QN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74928QN", "source": "G29449JO", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61717JN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G12398HZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G61717JN", "dp": 8 } ], "links": [ { "target": "G61717JN", "source": "G12398HZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61718TK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 } ], "links": [ { "target": "G61718TK", "source": "G43694RQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61734US", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28218GE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 }, { "id": "G28218GE", "dp": 13 }, { "id": "G61734US", "dp": 13 } ], "links": [ { "target": "G61734US", "source": "G28218GE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28218GE", "source": "G17689DH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61751GZ", "error": "Missing intermediate; no pathways to [G61751GZ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61809IS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59579TL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G86753CK", "dp": 17 }, { "id": "G59579TL", "dp": 18 }, { "id": "G61809IS", "dp": 18 } ], "links": [ { "target": "G61809IS", "source": "G59579TL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59579TL", "source": "G86753CK", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61819UR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03962UN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G03962UN", "dp": 9 }, { "id": "G61819UR", "dp": 9 } ], "links": [ { "target": "G61819UR", "source": "G03962UN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03962UN", "source": "G43677TG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61842MB", "error": "Missing intermediate; no pathways to [G61842MB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61846BY", "error": "Starting point for pathway to G61846BY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G61866NY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90348RI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G90348RI", "dp": 12 }, { "id": "G61866NY", "dp": 12 } ], "links": [ { "target": "G61866NY", "source": "G90348RI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90348RI", "source": "G11041DA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61878VZ", "error": "Missing intermediate; no pathways to [G61878VZ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G95542JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61903HE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36268TW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G36268TW", "dp": 12 }, { "id": "G61903HE", "dp": 12 } ], "links": [ { "target": "G61903HE", "source": "G36268TW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36268TW", "source": "G77252PU", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61924UW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77363ER]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G77363ER", "dp": 11 }, { "id": "G61924UW", "dp": 11 } ], "links": [ { "target": "G61924UW", "source": "G77363ER", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77363ER", "source": "G91365ZQ", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61941WO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G48767NV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G48767NV", "dp": 14 }, { "id": "G61941WO", "dp": 14 } ], "links": [ { "target": "G61941WO", "source": "G48767NV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48767NV", "source": "G53812BX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61956VN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G70945OS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G70945OS", "dp": 13 }, { "id": "G61956VN", "dp": 13 } ], "links": [ { "target": "G61956VN", "source": "G70945OS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70945OS", "source": "G41331JX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G61964QE", "error": "Missing intermediate; no pathways to [G61964QE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G61970XW", "error": "Missing intermediate; no pathways to [G61970XW] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62046IZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26756VT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G26756VT", "dp": 11 }, { "id": "G62046IZ", "dp": 11 } ], "links": [ { "target": "G62046IZ", "source": "G26756VT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26756VT", "source": "G08863NS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62048AU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G44504SC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G44504SC", "dp": 10 }, { "id": "G62048AU", "dp": 10 } ], "links": [ { "target": "G62048AU", "source": "G44504SC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44504SC", "source": "G20030CU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62074BC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17155VX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G62074BC", "dp": 16 } ], "links": [ { "target": "G62074BC", "source": "G17155VX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62083JR", "error": "Starting point for pathway to G62083JR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62095WZ", "error": "Missing intermediate; no pathways to [G62095WZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98115AV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62112AO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06209KS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G06209KS", "dp": 8 }, { "id": "G62112AO", "dp": 8 } ], "links": [ { "target": "G62112AO", "source": "G06209KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06209KS", "source": "G69411IG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62135TC", "error": "Missing intermediate; no pathways to [G62135TC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66595IQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62145FH", "error": "Missing intermediate; no pathways to [G62145FH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G48109OV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62167DK", "error": "Starting point for pathway to G62167DK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62187QU", "error": "Starting point for pathway to G62187QU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62196IB", "error": "Missing intermediate; no pathways to [G62196IB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78011JO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62223BD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63166WT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G63166WT", "dp": 12 }, { "id": "G62223BD", "dp": 12 } ], "links": [ { "target": "G62223BD", "source": "G63166WT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63166WT", "source": "G30302VM", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62232KJ", "error": "Missing intermediate; no pathways to [G62232KJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62306AO", "error": "Missing intermediate; no pathways to [G62306AO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75398ZA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62307SM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G60564DP", "dp": 14 }, { "id": "G14488UY", "dp": 15 } ], "links": [ { "target": "G62307SM", "source": "G14488UY", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G14488UY", "source": "G60564DP", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62316AI", "error": "Starting point for pathway to G62316AI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62326NX", "error": "Missing intermediate; no pathways to [G62326NX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62333MG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06581HO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G06581HO", "dp": 12 }, { "id": "G62333MG", "dp": 12 } ], "links": [ { "target": "G62333MG", "source": "G06581HO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06581HO", "source": "G71679MX", "residue_affected": { "residue_id": "N59", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62339AO", "error": "Missing intermediate; no pathways to [G62339AO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62349ZP", "error": "Starting point for pathway to G62349ZP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62360SN", "error": "Missing intermediate; no pathways to [G62360SN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G62364JZ", "error": "Starting point for pathway to G62364JZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62387ZO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14047PA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G14047PA", "dp": 11 }, { "id": "G62387ZO", "dp": 11 } ], "links": [ { "target": "G62387ZO", "source": "G14047PA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14047PA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62389NM", "error": "Missing intermediate; no pathways to [G62389NM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G62428XG", "error": "Missing intermediate; no pathways to [G62428XG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62437ME", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41820ZZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G41820ZZ", "dp": 11 }, { "id": "G62437ME", "dp": 11 } ], "links": [ { "target": "G62437ME", "source": "G41820ZZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41820ZZ", "source": "G45560HM", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62446JD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G90725ZC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G90725ZC", "dp": 9 }, { "id": "G62446JD", "dp": 9 } ], "links": [ { "target": "G62446JD", "source": "G90725ZC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90725ZC", "source": "G89993FE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62447TX", "error": "Missing intermediate; no pathways to [G62447TX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62464EH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45603BW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G45603BW", "dp": 14 }, { "id": "G62464EH", "dp": 14 } ], "links": [ { "target": "G62464EH", "source": "G45603BW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45603BW", "source": "G56549DH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62470WX", "error": "Missing intermediate; no pathways to [G62470WX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62480RR", "error": "Missing intermediate; no pathways to [G62480RR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54590FS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62488UG", "error": "Starting point for pathway to G62488UG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62489DB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59128IS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G56147VV", "dp": 15 }, { "id": "G59128IS", "dp": 16 }, { "id": "G62489DB", "dp": 16 } ], "links": [ { "target": "G62489DB", "source": "G59128IS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59128IS", "source": "G56147VV", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56147VV", "source": "G17168RO", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62504BU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62516GL", "error": "Missing intermediate; no pathways to [G62516GL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54986EB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62517DC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78155FK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 }, { "id": "G62517DC", "dp": 10 } ], "links": [ { "target": "G62517DC", "source": "G78155FK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62519IY", "error": "Missing intermediate; no pathways to [G62519IY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36581MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62527ZD", "error": "Missing intermediate; no pathways to [G62527ZD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62553AU", "error": "Missing intermediate; no pathways to [G62553AU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G64789SR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62591VF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61207RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G62591VF", "dp": 9 } ], "links": [ { "target": "G62591VF", "source": "G61207RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62592GA", "error": "Starting point for pathway to G62592GA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62606MC", "error": "Missing intermediate; no pathways to [G62606MC] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G30293NE]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62608YY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45264AM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G45264AM", "dp": 10 }, { "id": "G62608YY", "dp": 10 } ], "links": [ { "target": "G62608YY", "source": "G45264AM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45264AM", "source": "G88461FF", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62619LG", "error": "Missing intermediate; no pathways to [G62619LG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62647PO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82487CR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G82487CR", "dp": 15 }, { "id": "G62647PO", "dp": 15 } ], "links": [ { "target": "G62647PO", "source": "G82487CR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82487CR", "source": "G08194HH", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62684WO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63333DU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G16529MG", "dp": 14 }, { "id": "G63333DU", "dp": 15 }, { "id": "G62684WO", "dp": 15 } ], "links": [ { "target": "G62684WO", "source": "G63333DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63333DU", "source": "G16529MG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16529MG", "source": "G56549DH", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62720NT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23901NY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G23901NY", "dp": 11 }, { "id": "G62720NT", "dp": 11 } ], "links": [ { "target": "G62720NT", "source": "G23901NY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23901NY", "source": "G52934AK", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62746IY", "error": "Missing intermediate; no pathways to [G62746IY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G13322RS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62765SF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 } ], "links": [ { "target": "G62765SF", "source": "G04989WY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62779OI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G87073UP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G62779OI", "dp": 10 } ], "links": [ { "target": "G62779OI", "source": "G87073UP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62781GE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14998UC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G14998UC", "dp": 12 }, { "id": "G62781GE", "dp": 12 } ], "links": [ { "target": "G62781GE", "source": "G14998UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14998UC", "source": "G25140TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62798PI", "error": "Starting point for pathway to G62798PI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62808KR", "error": "Starting point for pathway to G62808KR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62826CL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 } ], "links": [ { "target": "G62826CL", "source": "G80858MF", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62836JK", "error": "Missing intermediate; no pathways to [G62836JK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84330VA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G62866HT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G73418FX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 }, { "id": "G73418FX", "dp": 12 }, { "id": "G62866HT", "dp": 12 } ], "links": [ { "target": "G62866HT", "source": "G73418FX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73418FX", "source": "G00743WU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62880PC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 } ], "links": [ { "target": "G62880PC", "source": "G59471TH", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62883YA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 } ], "links": [ { "target": "G62883YA", "source": "G66866LE", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62894AU", "error": "Starting point for pathway to G62894AU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62945MQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G78503JC", "dp": 12 }, { "id": "G86202BL", "dp": 13 } ], "links": [ { "target": "G62945MQ", "source": "G86202BL", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G86202BL", "source": "G78503JC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78503JC", "source": "G31010RQ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62955ZH", "error": "Missing intermediate; no pathways to [G62955ZH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G62968IF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G63889NK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G62968IF", "dp": 14 } ], "links": [ { "target": "G62968IF", "source": "G63889NK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62973JK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30651IU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G62973JK", "dp": 13 } ], "links": [ { "target": "G62973JK", "source": "G30651IU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G62989HM", "error": "Starting point for pathway to G62989HM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G62989ND", "error": "Missing intermediate; no pathways to [G62989ND] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63013HR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59575FI]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G66129DI", "dp": 11 }, { "id": "G59575FI", "dp": 12 }, { "id": "G63013HR", "dp": 12 } ], "links": [ { "target": "G63013HR", "source": "G59575FI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59575FI", "source": "G66129DI", "residue_affected": { "residue_id": "N476", "pubchem_name": "phosphate", "anomer": "n", "absolute": "n", "form_name": "phosphate", "full_name": "-n-phosphate" }, "effect": "Add -n-phosphate", "enzymes": [] }, { "target": "G66129DI", "source": "G03275SD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63020PM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00536FZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G00536FZ", "dp": 12 }, { "id": "G63020PM", "dp": 12 } ], "links": [ { "target": "G63020PM", "source": "G00536FZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00536FZ", "source": "G71679MX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63024BG", "error": "Starting point for pathway to G63024BG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63035DM", "error": "Starting point for pathway to G63035DM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63045FB", "error": "Starting point for pathway to G63045FB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63065KG", "error": "Missing intermediate; no pathways to [G63065KG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63065ZE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94733WZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G94733WZ", "dp": 15 }, { "id": "G63065ZE", "dp": 15 } ], "links": [ { "target": "G63065ZE", "source": "G94733WZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94733WZ", "source": "G89877QI", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63074CQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 } ], "links": [ { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63075AF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G62880PC", "dp": 9 }, { "id": "G45686NF", "dp": 10 } ], "links": [ { "target": "G63075AF", "source": "G45686NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45686NF", "source": "G62880PC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62880PC", "source": "G59471TH", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63078AB", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G94363RH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G94363RH", "dp": 17 }, { "id": "G63078AB", "dp": 17 } ], "links": [ { "target": "G63078AB", "source": "G94363RH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94363RH", "source": "G79950YS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63100CN", "error": "Missing intermediate; no pathways to [G63100CN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63125IE", "error": "Missing intermediate; no pathways to [G63125IE] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G94163JZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63136MB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89941FZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 }, { "id": "G89941FZ", "dp": 12 }, { "id": "G63136MB", "dp": 12 } ], "links": [ { "target": "G63136MB", "source": "G89941FZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89941FZ", "source": "G00743WU", "residue_affected": { "residue_id": "N70", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63142AA", "error": "Starting point for pathway to G63142AA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63158IX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42240DE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G42240DE", "dp": 12 }, { "id": "G63158IX", "dp": 12 } ], "links": [ { "target": "G63158IX", "source": "G42240DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42240DE", "source": "G20815TK", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63160UE", "error": "Starting point for pathway to G63160UE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63166WT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 } ], "links": [ { "target": "G63166WT", "source": "G30302VM", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63170HT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43664YB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G43664YB", "dp": 9 }, { "id": "G63170HT", "dp": 9 } ], "links": [ { "target": "G63170HT", "source": "G43664YB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43664YB", "source": "G24420RT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63208BT", "error": "Missing intermediate; no pathways to [G63208BT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02679YX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63240YA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G44152CO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G44152CO", "dp": 11 }, { "id": "G63240YA", "dp": 11 } ], "links": [ { "target": "G63240YA", "source": "G44152CO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44152CO", "source": "G66866LE", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63256WN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G22354SF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G00368HM", "dp": 13 }, { "id": "G07505KH", "dp": 14 }, { "id": "G22354SF", "dp": 15 }, { "id": "G63256WN", "dp": 15 } ], "links": [ { "target": "G63256WN", "source": "G22354SF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G22354SF", "source": "G07505KH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07505KH", "source": "G00368HM", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00368HM", "source": "G86357DX", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63274OH", "error": "Starting point for pathway to G63274OH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63308HG", "error": "Missing intermediate; no pathways to [G63308HG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G73977KO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63333DU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G16529MG", "dp": 14 } ], "links": [ { "target": "G63333DU", "source": "G16529MG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16529MG", "source": "G56549DH", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63337DU", "error": "Starting point for pathway to G63337DU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63337SS", "error": "Starting point for pathway to G63337SS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63366CP", "error": "Starting point for pathway to G63366CP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63378BN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31670BC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G97093EP", "dp": 12 }, { "id": "G31670BC", "dp": 13 }, { "id": "G63378BN", "dp": 13 } ], "links": [ { "target": "G63378BN", "source": "G31670BC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31670BC", "source": "G97093EP", "residue_affected": { "residue_id": "N246", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G97093EP", "source": "G43433FA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63396ZU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01669LU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G63396ZU", "dp": 12 } ], "links": [ { "target": "G63396ZU", "source": "G01669LU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63403SN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06581HO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G06581HO", "dp": 12 }, { "id": "G63403SN", "dp": 12 } ], "links": [ { "target": "G63403SN", "source": "G06581HO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06581HO", "source": "G71679MX", "residue_affected": { "residue_id": "N59", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63411NB", "error": "Missing intermediate; no pathways to [G63411NB] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G61751GZ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63413QV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66282NU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G63413QV", "dp": 13 } ], "links": [ { "target": "G63413QV", "source": "G66282NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63420HM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07483YN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G63420HM", "dp": 7 } ], "links": [ { "target": "G63420HM", "source": "G07483YN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63429EI", "error": "Missing intermediate; no pathways to [G63429EI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63480NF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72718TT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G63480NF", "dp": 9 } ], "links": [ { "target": "G63480NF", "source": "G72718TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63485VW", "error": "Starting point for pathway to G63485VW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63515IC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60814ZB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 }, { "id": "G60814ZB", "dp": 18 }, { "id": "G63515IC", "dp": 18 } ], "links": [ { "target": "G63515IC", "source": "G60814ZB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60814ZB", "source": "G28106CM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63517NT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14998UC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G14998UC", "dp": 12 }, { "id": "G63517NT", "dp": 12 } ], "links": [ { "target": "G63517NT", "source": "G14998UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14998UC", "source": "G25140TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63536HB", "error": "Starting point for pathway to G63536HB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63539AZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59655SA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G59655SA", "dp": 12 }, { "id": "G63539AZ", "dp": 12 } ], "links": [ { "target": "G63539AZ", "source": "G59655SA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59655SA", "source": "G53752TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63545GS", "error": "Missing intermediate; no pathways to [G63545GS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63547QM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57955DP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G63547QM", "dp": 15 } ], "links": [ { "target": "G63547QM", "source": "G57955DP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63561NG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89168LM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 }, { "id": "G16057DE", "dp": 14 }, { "id": "G89168LM", "dp": 15 }, { "id": "G63561NG", "dp": 15 } ], "links": [ { "target": "G63561NG", "source": "G89168LM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89168LM", "source": "G16057DE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16057DE", "source": "G67289UM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63565MO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G69982RY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G69982RY", "dp": 11 }, { "id": "G63565MO", "dp": 11 } ], "links": [ { "target": "G63565MO", "source": "G69982RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69982RY", "source": "G45560HM", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63574RK", "error": "Starting point for pathway to G63574RK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63575JI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G33001NX", "dp": 8 } ], "links": [ { "target": "G63575JI", "source": "G33001NX", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] }, { "target": "G33001NX", "source": "G39089YD", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G63585HN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 } ], "links": [ { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63596DU", "error": "Missing intermediate; no pathways to [G63596DU] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63617UP", "error": "Missing intermediate; no pathways to [G63617UP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47554EG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63644AZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G63644AZ", "source": "G18938DW", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63659FK", "error": "Missing intermediate; no pathways to [G63659FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63665MU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59746QC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G59746QC", "dp": 14 }, { "id": "G63665MU", "dp": 14 } ], "links": [ { "target": "G63665MU", "source": "G59746QC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59746QC", "source": "G00909PI", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63681JP", "error": "Starting point for pathway to G63681JP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63699VG", "error": "Starting point for pathway to G63699VG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63708BZ", "error": "Starting point for pathway to G63708BZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63710WS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95898GD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 }, { "id": "G63710WS", "dp": 13 } ], "links": [ { "target": "G63710WS", "source": "G95898GD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63712AL", "error": "Missing intermediate; no pathways to [G63712AL] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G26844MI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G63714PL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25350TT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G59361OW", "dp": 11 }, { "id": "G25350TT", "dp": 12 }, { "id": "G63714PL", "dp": 12 } ], "links": [ { "target": "G63714PL", "source": "G25350TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25350TT", "source": "G59361OW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59361OW", "source": "G44946WH", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63720BV", "error": "Starting point for pathway to G63720BV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63734KU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 } ], "links": [ { "target": "G63734KU", "source": "G32201IL", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63782AK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G03385XG", "dp": 13 } ], "links": [ { "target": "G63782AK", "source": "G03385XG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63787RZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 } ], "links": [ { "target": "G63787RZ", "source": "G27919IH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63820GM", "error": "Starting point for pathway to G63820GM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63821SF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36176RV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G36176RV", "dp": 12 }, { "id": "G63821SF", "dp": 12 } ], "links": [ { "target": "G63821SF", "source": "G36176RV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36176RV", "source": "G30302VM", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63838JW", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G30588SI", "dp": 9 } ], "links": [ { "target": "G63838JW", "source": "G30588SI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30588SI", "source": "G08520NM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63879IK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23616ZX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G63879IK", "dp": 14 } ], "links": [ { "target": "G63879IK", "source": "G23616ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63889NK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 } ], "links": [ { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63899VB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90223GH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G90223GH", "dp": 9 }, { "id": "G63899VB", "dp": 9 } ], "links": [ { "target": "G63899VB", "source": "G90223GH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90223GH", "source": "G29011JC", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63902MT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G33241WC", "dp": 15 } ], "links": [ { "target": "G63902MT", "source": "G33241WC", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33241WC", "source": "G45720CA", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63904YT", "error": "Starting point for pathway to G63904YT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G63919RG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60419KX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G73759SD", "dp": 13 }, { "id": "G60419KX", "dp": 14 }, { "id": "G63919RG", "dp": 14 } ], "links": [ { "target": "G63919RG", "source": "G60419KX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60419KX", "source": "G73759SD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73759SD", "source": "G96963QG", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G63966HF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90348RI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G90348RI", "dp": 12 }, { "id": "G63966HF", "dp": 12 } ], "links": [ { "target": "G63966HF", "source": "G90348RI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90348RI", "source": "G11041DA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64044IT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10219AA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G64044IT", "dp": 8 } ], "links": [ { "target": "G64044IT", "source": "G10219AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64048GU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45720CA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G64048GU", "dp": 14 } ], "links": [ { "target": "G64048GU", "source": "G45720CA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64077VW", "error": "Missing intermediate; no pathways to [G64077VW] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64098AY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60419KX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G73759SD", "dp": 13 }, { "id": "G60419KX", "dp": 14 }, { "id": "G64098AY", "dp": 14 } ], "links": [ { "target": "G64098AY", "source": "G60419KX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60419KX", "source": "G73759SD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73759SD", "source": "G96963QG", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64098LT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14767DF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14767DF", "dp": 8 }, { "id": "G64098LT", "dp": 8 } ], "links": [ { "target": "G64098LT", "source": "G14767DF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14767DF", "source": "G69411IG", "residue_affected": { "residue_id": "N205", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64098MP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 } ], "links": [ { "target": "G64098MP", "source": "G10691MJ", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64127GJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G78661LW", "dp": 11 }, { "id": "G24767EG", "dp": 12 } ], "links": [ { "target": "G64127GJ", "source": "G24767EG", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24767EG", "source": "G78661LW", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78661LW", "source": "G32201IL", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64175SO", "error": "Starting point for pathway to G64175SO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64257JI", "error": "Missing intermediate; no pathways to [G64257JI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76807JB]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G64261IK", "error": "Starting point for pathway to G64261IK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64271PC", "error": "Starting point for pathway to G64271PC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64280VU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92466WU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G92466WU", "dp": 10 }, { "id": "G64280VU", "dp": 10 } ], "links": [ { "target": "G64280VU", "source": "G92466WU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92466WU", "source": "G46638GC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64306QY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80147LG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G80147LG", "dp": 10 }, { "id": "G64306QY", "dp": 10 } ], "links": [ { "target": "G64306QY", "source": "G80147LG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80147LG", "source": "G27919IH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64321PA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95081VM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G64321PA", "dp": 9 } ], "links": [ { "target": "G64321PA", "source": "G95081VM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64321QR", "error": "Missing intermediate; no pathways to [G64321QR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G64324VB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 } ], "links": [ { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64330NA", "error": "Missing intermediate; no pathways to [G64330NA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19242QH]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G64334QQ", "error": "Starting point for pathway to G64334QQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64343WH", "error": "Starting point for pathway to G64343WH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64357NA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38291RB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G38291RB", "dp": 13 }, { "id": "G64357NA", "dp": 13 } ], "links": [ { "target": "G64357NA", "source": "G38291RB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38291RB", "source": "G45359RY", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64389UN", "error": "Missing intermediate; no pathways to [G64389UN] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G72919IM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64398GR", "error": "Missing intermediate; no pathways to [G64398GR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G67173FM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64401HW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45359RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G64401HW", "dp": 12 } ], "links": [ { "target": "G64401HW", "source": "G45359RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64418SR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G69912LP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G41720HN", "dp": 8 }, { "id": "G69912LP", "dp": 9 }, { "id": "G64418SR", "dp": 9 } ], "links": [ { "target": "G64418SR", "source": "G69912LP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69912LP", "source": "G41720HN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41720HN", "source": "G07483YN", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64468KS", "error": "Starting point for pathway to G64468KS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64481DJ", "error": "Starting point for pathway to G64481DJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64501OO", "error": "Missing intermediate; no pathways to [G64501OO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64518MK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41720HN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G41720HN", "dp": 8 }, { "id": "G64518MK", "dp": 8 } ], "links": [ { "target": "G64518MK", "source": "G41720HN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41720HN", "source": "G07483YN", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64526UJ", "error": "Missing intermediate; no pathways to [G64526UJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19739KB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64538ZR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G35096EN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G35096EN", "dp": 10 }, { "id": "G64538ZR", "dp": 10 } ], "links": [ { "target": "G64538ZR", "source": "G35096EN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G35096EN", "source": "G20030CU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64544UC", "error": "Missing intermediate; no pathways to [G64544UC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24327OK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64545GA", "error": "Missing intermediate; no pathways to [G64545GA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16753NR]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G64550WP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44946WH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G64550WP", "dp": 10 } ], "links": [ { "target": "G64550WP", "source": "G44946WH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64582TJ", "error": "Starting point for pathway to G64582TJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64586PM", "error": "Missing intermediate; no pathways to [G64586PM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64618XR", "error": "Missing intermediate; no pathways to [G64618XR] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64633BH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 } ], "links": [ { "target": "G64633BH", "source": "G79348ZY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64652EG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 } ], "links": [ { "target": "G64652EG", "source": "G92024SL", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64660QV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65981EG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 }, { "id": "G65981EG", "dp": 12 }, { "id": "G64660QV", "dp": 12 } ], "links": [ { "target": "G64660QV", "source": "G65981EG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65981EG", "source": "G37385TT", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64661YG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G85767HW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 }, { "id": "G64661YG", "dp": 10 } ], "links": [ { "target": "G64661YG", "source": "G85767HW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64662SH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88127MB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G88127MB", "dp": 13 }, { "id": "G64662SH", "dp": 13 } ], "links": [ { "target": "G64662SH", "source": "G88127MB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88127MB", "source": "G74120DW", "residue_affected": { "residue_id": "N46", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64666BO", "error": "Missing intermediate; no pathways to [G64666BO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09576QH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64669AQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 } ], "links": [ { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G64687CT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53562KP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G53562KP", "dp": 9 }, { "id": "G64687CT", "dp": 9 } ], "links": [ { "target": "G64687CT", "source": "G53562KP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53562KP", "source": "G89993FE", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64693IG", "error": "Missing intermediate; no pathways to [G64693IG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64697JB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 } ], "links": [ { "target": "G64697JB", "source": "G12740VA", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64713KE", "error": "Starting point for pathway to G64713KE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64725VJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61088TM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G61088TM", "dp": 12 }, { "id": "G64725VJ", "dp": 12 } ], "links": [ { "target": "G64725VJ", "source": "G61088TM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61088TM", "source": "G90870DG", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64741WD", "error": "Starting point for pathway to G64741WD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64761FU", "error": "Missing intermediate; no pathways to [G64761FU] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64774OU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50730KL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G50730KL", "dp": 9 }, { "id": "G64774OU", "dp": 9 } ], "links": [ { "target": "G64774OU", "source": "G50730KL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50730KL", "source": "G08520NM", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G64789SR", "error": "Missing intermediate; no pathways to [G64789SR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64803AP", "error": "Starting point for pathway to G64803AP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64803HZ", "error": "Starting point for pathway to G64803HZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64813JD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G17437BX", "dp": 14 } ], "links": [ { "target": "G64813JD", "source": "G17437BX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17437BX", "source": "G92359VA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64813XA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46470AD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G46470AD", "dp": 11 }, { "id": "G64813XA", "dp": 11 } ], "links": [ { "target": "G64813XA", "source": "G46470AD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46470AD", "source": "G01856RL", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64823DM", "error": "Missing intermediate; no pathways to [G64823DM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64827NU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G64827NU", "source": "G29857RC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64830WP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G64830WP", "source": "G39213VZ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64850DY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G46021KV", "dp": 12 } ], "links": [ { "target": "G64850DY", "source": "G46021KV", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46021KV", "source": "G29857RC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64856PW", "error": "Starting point for pathway to G64856PW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64857LW", "error": "Missing intermediate; no pathways to [G64857LW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59989VG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64860JB", "error": "Missing intermediate; no pathways to [G64860JB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64860JV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56591LC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G64860JV", "dp": 10 } ], "links": [ { "target": "G64860JV", "source": "G56591LC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64893OU", "error": "Missing intermediate; no pathways to [G64893OU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20885BK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64894MA", "error": "Missing intermediate; no pathways to [G64894MA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59742GY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64897QL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61707PW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G74928QN", "dp": 14 }, { "id": "G61707PW", "dp": 15 }, { "id": "G64897QL", "dp": 15 } ], "links": [ { "target": "G64897QL", "source": "G61707PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61707PW", "source": "G74928QN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74928QN", "source": "G29449JO", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64933IQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79950YS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G64933IQ", "dp": 16 } ], "links": [ { "target": "G64933IQ", "source": "G79950YS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64936OS", "error": "Missing intermediate; no pathways to [G64936OS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64945YR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45262QY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G64945YR", "dp": 9 } ], "links": [ { "target": "G64945YR", "source": "G45262QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G64950NP", "error": "Missing intermediate; no pathways to [G64950NP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G64965ZH", "error": "Starting point for pathway to G64965ZH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G64979EW", "error": "Starting point for pathway to G64979EW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65009JH", "error": "Missing intermediate; no pathways to [G65009JH] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G21459ST]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65030HB", "error": "Starting point for pathway to G65030HB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65079ZY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G90564EX", "dp": 11 }, { "id": "G08949VK", "dp": 12 }, { "id": "G12450CJ", "dp": 13 } ], "links": [ { "target": "G65079ZY", "source": "G12450CJ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12450CJ", "source": "G08949VK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08949VK", "source": "G90564EX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90564EX", "source": "G28826SH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65084YX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96113SZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G82420SH", "dp": 10 }, { "id": "G96113SZ", "dp": 11 }, { "id": "G65084YX", "dp": 11 } ], "links": [ { "target": "G65084YX", "source": "G96113SZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96113SZ", "source": "G82420SH", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65117HG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G29676WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G49743VF", "dp": 11 }, { "id": "G29676WX", "dp": 12 }, { "id": "G65117HG", "dp": 12 } ], "links": [ { "target": "G65117HG", "source": "G29676WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29676WX", "source": "G49743VF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49743VF", "source": "G06216UH", "residue_affected": { "residue_id": "N470", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65183DD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99603GB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G99603GB", "dp": 9 }, { "id": "G65183DD", "dp": 9 } ], "links": [ { "target": "G65183DD", "source": "G99603GB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99603GB", "source": "G64669AQ", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G65221OO", "error": "Starting point for pathway to G65221OO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65226QM", "error": "Missing intermediate; no pathways to [G65226QM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52483OL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65239SF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 } ], "links": [ { "target": "G65239SF", "source": "G81923ER", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65243FP", "error": "Missing intermediate; no pathways to [G65243FP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84390MS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65282FW", "error": "Missing intermediate; no pathways to [G65282FW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65287XE", "error": "Missing intermediate; no pathways to [G65287XE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65294YU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82252QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G65294YU", "dp": 11 } ], "links": [ { "target": "G65294YU", "source": "G82252QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65296TL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 } ], "links": [ { "target": "G65296TL", "source": "G50774CV", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65299LG", "error": "Missing intermediate; no pathways to [G65299LG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G20924UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65302CF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07015TW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G10664FL", "dp": 10 }, { "id": "G07015TW", "dp": 11 }, { "id": "G65302CF", "dp": 11 } ], "links": [ { "target": "G65302CF", "source": "G07015TW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07015TW", "source": "G10664FL", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10664FL", "source": "G45262QY", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65305LF", "error": "Missing intermediate; no pathways to [G65305LF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65307KA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 } ], "links": [ { "target": "G65307KA", "source": "G10691MJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65327EP", "error": "Missing intermediate; no pathways to [G65327EP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91199QX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65340BF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03727RK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G03727RK", "dp": 14 }, { "id": "G65340BF", "dp": 14 } ], "links": [ { "target": "G65340BF", "source": "G03727RK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03727RK", "source": "G66282NU", "residue_affected": { "residue_id": "N251", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65356DX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19843TY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G19843TY", "dp": 10 }, { "id": "G65356DX", "dp": 10 } ], "links": [ { "target": "G65356DX", "source": "G19843TY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19843TY", "source": "G27919IH", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65370RS", "error": "Starting point for pathway to G65370RS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65380CT", "error": "Missing intermediate; no pathways to [G65380CT] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65406QA", "error": "Missing intermediate; no pathways to [G65406QA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65415JG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29011JC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G65415JG", "dp": 8 } ], "links": [ { "target": "G65415JG", "source": "G29011JC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65419YA", "error": "Starting point for pathway to G65419YA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65447JX", "error": "Starting point for pathway to G65447JX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65449BO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G36519NW", "dp": 13 } ], "links": [ { "target": "G65449BO", "source": "G36519NW", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G36519NW", "source": "G01669LU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65464PI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61718TK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G61718TK", "dp": 11 }, { "id": "G65464PI", "dp": 11 } ], "links": [ { "target": "G65464PI", "source": "G61718TK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61718TK", "source": "G43694RQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65500VO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G85213FQ", "dp": 7 } ], "links": [ { "target": "G65500VO", "source": "G85213FQ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85213FQ", "source": "G61751GZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G65508FE", "error": "Missing intermediate; no pathways to [G65508FE] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65515HD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G48802KI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G48802KI", "dp": 9 }, { "id": "G65515HD", "dp": 9 } ], "links": [ { "target": "G65515HD", "source": "G48802KI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48802KI", "source": "G43677TG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65518IK", "error": "Starting point for pathway to G65518IK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65593RU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G15727JK", "dp": 8 } ], "links": [ { "target": "G65593RU", "source": "G15727JK", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G15727JK", "source": "G69411IG", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65597BI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 } ], "links": [ { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65603XA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G80352NL", "dp": 14 } ], "links": [ { "target": "G65603XA", "source": "G80352NL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80352NL", "source": "G66282NU", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65617KZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43665PB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G79556AB", "dp": 12 }, { "id": "G43665PB", "dp": 13 }, { "id": "G65617KZ", "dp": 13 } ], "links": [ { "target": "G65617KZ", "source": "G43665PB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43665PB", "source": "G79556AB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79556AB", "source": "G82252QI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65665US", "error": "Starting point for pathway to G65665US could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65680SX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 } ], "links": [ { "target": "G65680SX", "source": "G08863NS", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65683ZU", "error": "Missing intermediate; no pathways to [G65683ZU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65697SK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66866LE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G65697SK", "dp": 10 } ], "links": [ { "target": "G65697SK", "source": "G66866LE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65703ID", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08340FW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G08340FW", "dp": 8 }, { "id": "G65703ID", "dp": 8 } ], "links": [ { "target": "G65703ID", "source": "G08340FW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08340FW", "source": "G39089YD", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G65721TS", "error": "Starting point for pathway to G65721TS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65735GD", "error": "Missing intermediate; no pathways to [G65735GD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65760UO", "error": "Missing intermediate; no pathways to [G65760UO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65761WK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07392QY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G07392QY", "dp": 11 }, { "id": "G65761WK", "dp": 11 } ], "links": [ { "target": "G65761WK", "source": "G07392QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07392QY", "source": "G78059CC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65796FM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 } ], "links": [ { "target": "G65796FM", "source": "G79344MI", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65799WV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32156DB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G80661IW", "dp": 10 }, { "id": "G32156DB", "dp": 11 }, { "id": "G65799WV", "dp": 11 } ], "links": [ { "target": "G65799WV", "source": "G32156DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32156DB", "source": "G80661IW", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G80661IW", "source": "G46638GC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65825CX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G31604HF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G31604HF", "dp": 8 }, { "id": "G65825CX", "dp": 8 } ], "links": [ { "target": "G65825CX", "source": "G31604HF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31604HF", "source": "G07483YN", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65832JS", "error": "Missing intermediate; no pathways to [G65832JS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65840VR", "error": "Missing intermediate; no pathways to [G65840VR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65850ES", "error": "Missing intermediate; no pathways to [G65850ES] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65855MN", "error": "Missing intermediate; no pathways to [G65855MN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76807JB]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G65867II", "error": "Missing intermediate; no pathways to [G65867II] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65890UA", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G65890UA", "source": "G16828VN", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65893EZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82942ZJ]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G82942ZJ", "dp": 9 }, { "id": "G65893EZ", "dp": 9 } ], "links": [ { "target": "G65893EZ", "source": "G82942ZJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82942ZJ", "source": "G08520NM", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65898FK", "error": "Starting point for pathway to G65898FK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65937DK", "error": "Missing intermediate; no pathways to [G65937DK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65937EW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G12398HZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G65937EW", "dp": 8 } ], "links": [ { "target": "G65937EW", "source": "G12398HZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65948NJ", "error": "Starting point for pathway to G65948NJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G65968OK", "error": "Missing intermediate; no pathways to [G65968OK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83635VI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G65981EG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 } ], "links": [ { "target": "G65981EG", "source": "G37385TT", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G65984FE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80858MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G65984FE", "dp": 8 } ], "links": [ { "target": "G65984FE", "source": "G80858MF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66006PP", "error": "Missing intermediate; no pathways to [G66006PP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66016NA", "error": "Missing intermediate; no pathways to [G66016NA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66034LU", "error": "Missing intermediate; no pathways to [G66034LU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G66044FT", "error": "Missing intermediate; no pathways to [G66044FT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66098KC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G66098KC", "source": "G18938DW", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66106WQ", "error": "Missing intermediate; no pathways to [G66106WQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03754YM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66111ZR", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G91365ZQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G66111ZR", "dp": 10 } ], "links": [ { "target": "G66111ZR", "source": "G91365ZQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66118UZ", "error": "Starting point for pathway to G66118UZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66121LF", "error": "Starting point for pathway to G66121LF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66122ZT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G68946DB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G76528ZS", "dp": 11 }, { "id": "G68946DB", "dp": 12 }, { "id": "G66122ZT", "dp": 12 } ], "links": [ { "target": "G66122ZT", "source": "G68946DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G68946DB", "source": "G76528ZS", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66129DI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 } ], "links": [ { "target": "G66129DI", "source": "G03275SD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66153IB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47975JA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G47975JA", "dp": 12 }, { "id": "G66153IB", "dp": 12 } ], "links": [ { "target": "G66153IB", "source": "G47975JA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47975JA", "source": "G11041DA", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66190PM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 } ], "links": [ { "target": "G66190PM", "source": "G78155FK", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66193EV", "error": "Starting point for pathway to G66193EV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66204OA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 } ], "links": [ { "target": "G66204OA", "source": "G39089YD", "residue_affected": { "residue_id": "N477", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylf", "full_name": "β-D-Xylf" }, "effect": "Add β-D-Xylf", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G66215MG", "error": "Missing intermediate; no pathways to [G66215MG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66227UG", "error": "Starting point for pathway to G66227UG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66257KQ", "error": "Starting point for pathway to G66257KQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66265KN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G33262YZ", "dp": 11 } ], "links": [ { "target": "G66265KN", "source": "G33262YZ", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33262YZ", "source": "G52934AK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66276TK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36521AS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 }, { "id": "G36521AS", "dp": 10 }, { "id": "G66276TK", "dp": 10 } ], "links": [ { "target": "G66276TK", "source": "G36521AS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36521AS", "source": "G91208VE", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66281YY", "error": "Missing intermediate; no pathways to [G66281YY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66282NU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 } ], "links": [ { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66286VU", "error": "Missing intermediate; no pathways to [G66286VU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66290TX", "error": "Starting point for pathway to G66290TX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66313YW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 } ], "links": [ { "target": "G66313YW", "source": "G74645FT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66348MF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59471TH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G66348MF", "dp": 8 } ], "links": [ { "target": "G66348MF", "source": "G59471TH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66359LV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82955EQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G82955EQ", "dp": 11 }, { "id": "G66359LV", "dp": 11 } ], "links": [ { "target": "G66359LV", "source": "G82955EQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82955EQ", "source": "G87073UP", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66362JB", "error": "Missing intermediate; no pathways to [G66362JB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42438ZG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66368ZD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04989WY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G66368ZD", "dp": 13 } ], "links": [ { "target": "G66368ZD", "source": "G04989WY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66375VY", "error": "Missing intermediate; no pathways to [G66375VY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47279LF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66408EY", "error": "Missing intermediate; no pathways to [G66408EY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66408GD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G11012KS", "dp": 12 } ], "links": [ { "target": "G66408GD", "source": "G11012KS", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11012KS", "source": "G37046CZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66422NV", "error": "Missing intermediate; no pathways to [G66422NV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66457HD", "error": "Missing intermediate; no pathways to [G66457HD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66471SN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G65307KA", "dp": 12 } ], "links": [ { "target": "G66471SN", "source": "G65307KA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G65307KA", "source": "G10691MJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66474IG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33909XJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G33909XJ", "dp": 11 }, { "id": "G66474IG", "dp": 11 } ], "links": [ { "target": "G66474IG", "source": "G33909XJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33909XJ", "source": "G81923ER", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66488GE", "error": "Starting point for pathway to G66488GE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66513RC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G49307MQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G78276SQ", "dp": 12 }, { "id": "G49307MQ", "dp": 13 }, { "id": "G66513RC", "dp": 13 } ], "links": [ { "target": "G66513RC", "source": "G49307MQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49307MQ", "source": "G78276SQ", "residue_affected": { "residue_id": "N408", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G78276SQ", "source": "G11041DA", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66544RE", "error": "Missing intermediate; no pathways to [G66544RE] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G78980OK]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G66572SF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 } ], "links": [ { "target": "G66572SF", "source": "G48658PB", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66595IQ", "error": "Missing intermediate; no pathways to [G66595IQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66634LZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 } ], "links": [ { "target": "G66634LZ", "source": "G29492IF", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66634ZW", "error": "Starting point for pathway to G66634ZW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66653BX", "error": "Missing intermediate; no pathways to [G66653BX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66655HQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G63585HN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G66655HQ", "dp": 11 } ], "links": [ { "target": "G66655HQ", "source": "G63585HN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66656YR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26939ZY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G26939ZY", "dp": 8 }, { "id": "G66656YR", "dp": 8 } ], "links": [ { "target": "G66656YR", "source": "G26939ZY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26939ZY", "source": "G39213VZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66661ZY", "error": "Missing intermediate; no pathways to [G66661ZY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88864RV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66665YI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 } ], "links": [ { "target": "G66665YI", "source": "G66282NU", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66674JW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G17857ZF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G57970NA", "dp": 13 }, { "id": "G17857ZF", "dp": 14 }, { "id": "G66674JW", "dp": 14 } ], "links": [ { "target": "G66674JW", "source": "G17857ZF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17857ZF", "source": "G57970NA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57970NA", "source": "G49515VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66689PB", "error": "Missing intermediate; no pathways to [G66689PB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66692CW", "error": "Starting point for pathway to G66692CW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66724VW", "error": "Missing intermediate; no pathways to [G66724VW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G83845ZV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66728LX", "error": "Starting point for pathway to G66728LX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66741YQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36191CD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G66741YQ", "dp": 9 } ], "links": [ { "target": "G66741YQ", "source": "G36191CD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66765ZA", "error": "Missing intermediate; no pathways to [G66765ZA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66846ML", "error": "Missing intermediate; no pathways to [G66846ML] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G84777MO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66847YI", "error": "Missing intermediate; no pathways to [G66847YI] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G66866LE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 } ], "links": [ { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66895SL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43299SD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G66895SL", "dp": 9 } ], "links": [ { "target": "G66895SL", "source": "G43299SD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66932MV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99866WK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G38395YJ", "dp": 14 }, { "id": "G99866WK", "dp": 15 }, { "id": "G66932MV", "dp": 15 } ], "links": [ { "target": "G66932MV", "source": "G99866WK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99866WK", "source": "G38395YJ", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66937TJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66942CJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23345GE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 }, { "id": "G23345GE", "dp": 15 }, { "id": "G66942CJ", "dp": 15 } ], "links": [ { "target": "G66942CJ", "source": "G23345GE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23345GE", "source": "G42686NQ", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66961CH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 } ], "links": [ { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66963AS", "error": "Starting point for pathway to G66963AS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G66964CR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G17168RO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G66964CR", "dp": 14 } ], "links": [ { "target": "G66964CR", "source": "G17168RO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G66992XO", "error": "Missing intermediate; no pathways to [G66992XO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67031FP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14047PA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G14047PA", "dp": 11 }, { "id": "G67031FP", "dp": 11 } ], "links": [ { "target": "G67031FP", "source": "G14047PA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14047PA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67042FO", "error": "Missing intermediate; no pathways to [G67042FO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79302PB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67045LB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67066JI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52663AD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G67066JI", "dp": 9 } ], "links": [ { "target": "G67066JI", "source": "G52663AD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67070ZZ", "error": "Starting point for pathway to G67070ZZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67076JN", "error": "Missing intermediate; no pathways to [G67076JN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51098AA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67079AO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17740GV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G17740GV", "dp": 15 }, { "id": "G67079AO", "dp": 15 } ], "links": [ { "target": "G67079AO", "source": "G17740GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17740GV", "source": "G89877QI", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67118IN", "error": "Starting point for pathway to G67118IN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67167QM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G85213FQ", "dp": 7 } ], "links": [ { "target": "G67167QM", "source": "G85213FQ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85213FQ", "source": "G61751GZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G67173FM", "error": "Missing intermediate; no pathways to [G67173FM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67215MI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 } ], "links": [ { "target": "G67215MI", "source": "G11637WL", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67223RN", "error": "Missing intermediate; no pathways to [G67223RN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G95989NQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67226SQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G41389FB", "dp": 11 } ], "links": [ { "target": "G67226SQ", "source": "G41389FB", "residue_affected": { "residue_id": "N483", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G41389FB", "source": "G65597BI", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67269NB", "error": "Missing intermediate; no pathways to [G67269NB] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G67289UM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 } ], "links": [ { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67307LA", "error": "Starting point for pathway to G67307LA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67342MA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G70708LW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G70708LW", "dp": 12 }, { "id": "G67342MA", "dp": 12 } ], "links": [ { "target": "G67342MA", "source": "G70708LW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70708LW", "source": "G74675FC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67358EC", "error": "Missing intermediate; no pathways to [G67358EC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67362UI", "error": "Missing intermediate; no pathways to [G67362UI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G83541HL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67410LQ", "error": "Missing intermediate; no pathways to [G67410LQ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67411ST", "error": "Starting point for pathway to G67411ST could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67413BG", "error": "Missing intermediate; no pathways to [G67413BG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94876HV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67465JK", "error": "Missing intermediate; no pathways to [G67465JK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67505LV", "error": "Missing intermediate; no pathways to [G67505LV] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G49915LA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67509BD", "error": "Missing intermediate; no pathways to [G67509BD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96235XM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67534LV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60963AS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G65796FM", "dp": 13 }, { "id": "G60963AS", "dp": 14 }, { "id": "G67534LV", "dp": 14 } ], "links": [ { "target": "G67534LV", "source": "G60963AS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60963AS", "source": "G65796FM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65796FM", "source": "G79344MI", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67536FA", "error": "Starting point for pathway to G67536FA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67549HD", "error": "Missing intermediate; no pathways to [G67549HD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67556VZ", "error": "Missing intermediate; no pathways to [G67556VZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67608DN", "error": "Missing intermediate; no pathways to [G67608DN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74264KM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67610IY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G58281SK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G58281SK", "dp": 9 }, { "id": "G67610IY", "dp": 9 } ], "links": [ { "target": "G67610IY", "source": "G58281SK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58281SK", "source": "G59471TH", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67612NO", "error": "Starting point for pathway to G67612NO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67623NK", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G89877QI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G67623NK", "dp": 14 } ], "links": [ { "target": "G67623NK", "source": "G89877QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67628PC", "error": "Starting point for pathway to G67628PC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67642SS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16155TD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G16155TD", "dp": 13 }, { "id": "G67642SS", "dp": 13 } ], "links": [ { "target": "G67642SS", "source": "G16155TD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16155TD", "source": "G01669LU", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67646EV", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G17213JF", "dp": 11 } ], "links": [ { "target": "G67646EV", "source": "G17213JF", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67660KD", "error": "Starting point for pathway to G67660KD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67662PT", "error": "Missing intermediate; no pathways to [G67662PT] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67715OS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G92024SL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G67715OS", "dp": 7 } ], "links": [ { "target": "G67715OS", "source": "G92024SL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67719WQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G48954CA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G48954CA", "dp": 9 }, { "id": "G67719WQ", "dp": 9 } ], "links": [ { "target": "G67719WQ", "source": "G48954CA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48954CA", "source": "G12398HZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67728UJ", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G66634LZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G66634LZ", "dp": 9 }, { "id": "G67728UJ", "dp": 9 } ], "links": [ { "target": "G67728UJ", "source": "G66634LZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66634LZ", "source": "G29492IF", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67767BR", "error": "Missing intermediate; no pathways to [G67767BR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G02679YX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67776GR", "error": "Starting point for pathway to G67776GR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67776JA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 } ], "links": [ { "target": "G67776JA", "source": "G29492IF", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67782JV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 } ], "links": [ { "target": "G67782JV", "source": "G35310KA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67783LJ", "error": "Missing intermediate; no pathways to [G67783LJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56354PO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67855QE", "error": "Starting point for pathway to G67855QE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67878HD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08863NS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G67878HD", "dp": 10 } ], "links": [ { "target": "G67878HD", "source": "G08863NS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67898UK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57955DP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G67898UK", "dp": 15 } ], "links": [ { "target": "G67898UK", "source": "G57955DP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67915MO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11535IB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 }, { "id": "G67915MO", "dp": 9 } ], "links": [ { "target": "G67915MO", "source": "G11535IB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67924FL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16828VN]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G67924FL", "dp": 9 } ], "links": [ { "target": "G67924FL", "source": "G16828VN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67924LE", "error": "Missing intermediate; no pathways to [G67924LE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52302PL]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G67942CH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 } ], "links": [ { "target": "G67942CH", "source": "G71013KY", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67943IR", "error": "Missing intermediate; no pathways to [G67943IR] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67954RA", "error": "Starting point for pathway to G67954RA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G67966WT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79578JB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G67966WT", "dp": 12 } ], "links": [ { "target": "G67966WT", "source": "G79578JB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G67966YH", "error": "Missing intermediate; no pathways to [G67966YH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G67978NC", "error": "Missing intermediate; no pathways to [G67978NC] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G80717KS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68026AP", "error": "Missing intermediate; no pathways to [G68026AP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92848CF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68054GF", "error": "Starting point for pathway to G68054GF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68059HB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24413UY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G24413UY", "dp": 11 }, { "id": "G68059HB", "dp": 11 } ], "links": [ { "target": "G68059HB", "source": "G24413UY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G24413UY", "source": "G78890OB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68080UR", "error": "Missing intermediate; no pathways to [G68080UR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68140PE", "error": "Starting point for pathway to G68140PE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68175NA", "error": "Starting point for pathway to G68175NA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68189FR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G05307LM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G05307LM", "dp": 13 }, { "id": "G68189FR", "dp": 13 } ], "links": [ { "target": "G68189FR", "source": "G05307LM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05307LM", "source": "G91023GB", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68194UU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36521AS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G91208VE", "dp": 9 }, { "id": "G36521AS", "dp": 10 }, { "id": "G68194UU", "dp": 10 } ], "links": [ { "target": "G68194UU", "source": "G36521AS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36521AS", "source": "G91208VE", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68203DZ", "error": "Missing intermediate; no pathways to [G68203DZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59742GY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68221KD", "error": "Starting point for pathway to G68221KD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68226HM", "error": "Missing intermediate; no pathways to [G68226HM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68283NG", "error": "Missing intermediate; no pathways to [G68283NG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68312DR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60103QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 }, { "id": "G60103QI", "dp": 12 }, { "id": "G68312DR", "dp": 12 } ], "links": [ { "target": "G68312DR", "source": "G60103QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60103QI", "source": "G54611ZT", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68313WI", "error": "Missing intermediate; no pathways to [G68313WI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68318SH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45560HM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G68318SH", "dp": 10 } ], "links": [ { "target": "G68318SH", "source": "G45560HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68337CZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79565XA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G19469VZ", "dp": 18 }, { "id": "G79565XA", "dp": 19 }, { "id": "G68337CZ", "dp": 19 } ], "links": [ { "target": "G68337CZ", "source": "G79565XA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79565XA", "source": "G19469VZ", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G19469VZ", "source": "G92574YO", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68349PE", "error": "Starting point for pathway to G68349PE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68354TY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54611ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 }, { "id": "G68354TY", "dp": 11 } ], "links": [ { "target": "G68354TY", "source": "G54611ZT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68395LV", "error": "Starting point for pathway to G68395LV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68398MF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 } ], "links": [ { "target": "G68398MF", "source": "G39089YD", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G68411DS", "error": "Missing intermediate; no pathways to [G68411DS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G68430WO", "error": "Missing intermediate; no pathways to [G68430WO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49915LA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68528OI", "error": "Missing intermediate; no pathways to [G68528OI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59159PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68538KA", "error": "Starting point for pathway to G68538KA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68546CJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G28826SH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G68546CJ", "dp": 10 } ], "links": [ { "target": "G68546CJ", "source": "G28826SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68551IQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G21246OH", "dp": 11 } ], "links": [ { "target": "G68551IQ", "source": "G21246OH", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21246OH", "source": "G00176HZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68557OH", "error": "Missing intermediate; no pathways to [G68557OH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26080SE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68560PY", "error": "Missing intermediate; no pathways to [G68560PY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17964DY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68572OG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98190RD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G98190RD", "dp": 11 }, { "id": "G68572OG", "dp": 11 } ], "links": [ { "target": "G68572OG", "source": "G98190RD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98190RD", "source": "G52934AK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68578NZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G80652ZF", "dp": 8 }, { "id": "G43654PQ", "dp": 9 } ], "links": [ { "target": "G68578NZ", "source": "G43654PQ", "residue_affected": { "residue_id": "N255", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43654PQ", "source": "G80652ZF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80652ZF", "source": "G39213VZ", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68603JE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10716SX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 }, { "id": "G10716SX", "dp": 12 }, { "id": "G68603JE", "dp": 12 } ], "links": [ { "target": "G68603JE", "source": "G10716SX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10716SX", "source": "G37385TT", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68651MF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86102AA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G86102AA", "dp": 11 }, { "id": "G68651MF", "dp": 11 } ], "links": [ { "target": "G68651MF", "source": "G86102AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86102AA", "source": "G85542KD", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68654BA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60667OL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 }, { "id": "G60667OL", "dp": 10 }, { "id": "G68654BA", "dp": 10 } ], "links": [ { "target": "G68654BA", "source": "G60667OL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60667OL", "source": "G11535IB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68668TB", "error": "Starting point for pathway to G68668TB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68679LW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23626NI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G23626NI", "dp": 11 }, { "id": "G68679LW", "dp": 11 } ], "links": [ { "target": "G68679LW", "source": "G23626NI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23626NI", "source": "G85542KD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68748RA", "error": "Starting point for pathway to G68748RA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68758PE", "error": "Missing intermediate; no pathways to [G68758PE] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68765US", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G52880ZN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G52880ZN", "dp": 12 }, { "id": "G68765US", "dp": 12 } ], "links": [ { "target": "G68765US", "source": "G52880ZN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52880ZN", "source": "G82252QI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68774DG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64633BH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G64633BH", "dp": 9 }, { "id": "G68774DG", "dp": 9 } ], "links": [ { "target": "G68774DG", "source": "G64633BH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G64633BH", "source": "G79348ZY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68783EM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10292TC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G68783EM", "dp": 15 } ], "links": [ { "target": "G68783EM", "source": "G10292TC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68795JE", "error": "Starting point for pathway to G68795JE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68801RI", "error": "Missing intermediate; no pathways to [G68801RI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30437YI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68803QA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10219AA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G68803QA", "dp": 8 } ], "links": [ { "target": "G68803QA", "source": "G10219AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68804CO", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G04273XP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G03385XG", "dp": 13 }, { "id": "G04273XP", "dp": 14 }, { "id": "G68804CO", "dp": 14 } ], "links": [ { "target": "G68804CO", "source": "G04273XP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04273XP", "source": "G03385XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68808AO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90223GH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G90223GH", "dp": 9 }, { "id": "G68808AO", "dp": 9 } ], "links": [ { "target": "G68808AO", "source": "G90223GH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90223GH", "source": "G29011JC", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68817WF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07041CT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 }, { "id": "G07041CT", "dp": 13 }, { "id": "G68817WF", "dp": 13 } ], "links": [ { "target": "G68817WF", "source": "G07041CT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07041CT", "source": "G97765TT", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68845SP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G68845SP", "source": "G18938DW", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68873AT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52676LZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G32659RY", "dp": 12 }, { "id": "G52676LZ", "dp": 13 }, { "id": "G68873AT", "dp": 13 } ], "links": [ { "target": "G68873AT", "source": "G52676LZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52676LZ", "source": "G32659RY", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G32659RY", "source": "G59877NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68892PJ", "error": "Missing intermediate; no pathways to [G68892PJ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68894GU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29492IF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G68894GU", "dp": 8 } ], "links": [ { "target": "G68894GU", "source": "G29492IF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68903PJ", "error": "Missing intermediate; no pathways to [G68903PJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68907ZA", "error": "Missing intermediate; no pathways to [G68907ZA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41811VQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68912OX", "error": "Starting point for pathway to G68912OX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68915EJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62826CL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G62826CL", "dp": 9 }, { "id": "G68915EJ", "dp": 9 } ], "links": [ { "target": "G68915EJ", "source": "G62826CL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62826CL", "source": "G80858MF", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68937TM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 } ], "links": [ { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68946DB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G76528ZS", "dp": 11 } ], "links": [ { "target": "G68946DB", "source": "G76528ZS", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68950LW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97765TT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 }, { "id": "G68950LW", "dp": 12 } ], "links": [ { "target": "G68950LW", "source": "G97765TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68955EJ", "error": "Missing intermediate; no pathways to [G68955EJ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G68957QP", "error": "Starting point for pathway to G68957QP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G68963BB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45777DE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G26939ZY", "dp": 8 }, { "id": "G45777DE", "dp": 9 }, { "id": "G68963BB", "dp": 9 } ], "links": [ { "target": "G68963BB", "source": "G45777DE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45777DE", "source": "G26939ZY", "residue_affected": { "residue_id": "N305", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G26939ZY", "source": "G39213VZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G68985NT", "error": "Missing intermediate; no pathways to [G68985NT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G68991BW", "error": "Starting point for pathway to G68991BW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G69018AJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G78661LW", "dp": 11 } ], "links": [ { "target": "G69018AJ", "source": "G78661LW", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78661LW", "source": "G32201IL", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69060LX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G31010RQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G69060LX", "dp": 11 } ], "links": [ { "target": "G69060LX", "source": "G31010RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69083KH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84874EV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G84874EV", "dp": 11 }, { "id": "G69083KH", "dp": 11 } ], "links": [ { "target": "G69083KH", "source": "G84874EV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84874EV", "source": "G99270AV", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69083WH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29011JC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G69083WH", "dp": 8 } ], "links": [ { "target": "G69083WH", "source": "G29011JC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69086TY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 } ], "links": [ { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69089FP", "error": "Missing intermediate; no pathways to [G69089FP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G69103XG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G96113SZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G82420SH", "dp": 10 }, { "id": "G96113SZ", "dp": 11 }, { "id": "G69103XG", "dp": 11 } ], "links": [ { "target": "G69103XG", "source": "G96113SZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96113SZ", "source": "G82420SH", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69113LL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G32659RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G32659RY", "dp": 12 }, { "id": "G69113LL", "dp": 12 } ], "links": [ { "target": "G69113LL", "source": "G32659RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32659RY", "source": "G59877NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69121YI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54956ME]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G18641OW", "dp": 11 }, { "id": "G54956ME", "dp": 12 }, { "id": "G69121YI", "dp": 12 } ], "links": [ { "target": "G69121YI", "source": "G54956ME", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54956ME", "source": "G18641OW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18641OW", "source": "G88417ED", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69137CP", "error": "Starting point for pathway to G69137CP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G69159WK", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G43694RQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G69159WK", "dp": 10 } ], "links": [ { "target": "G69159WK", "source": "G43694RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69163UZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65890UA]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G65890UA", "dp": 10 }, { "id": "G69163UZ", "dp": 10 } ], "links": [ { "target": "G69163UZ", "source": "G65890UA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65890UA", "source": "G16828VN", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69170UT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 } ], "links": [ { "target": "G69170UT", "source": "G82050MN", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69175BJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45262QY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G69175BJ", "dp": 9 } ], "links": [ { "target": "G69175BJ", "source": "G45262QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69319YQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79950YS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G69319YQ", "dp": 16 } ], "links": [ { "target": "G69319YQ", "source": "G79950YS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69332GG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G71690HK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 }, { "id": "G69332GG", "dp": 10 } ], "links": [ { "target": "G69332GG", "source": "G71690HK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69337UU", "error": "Starting point for pathway to G69337UU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G69381LS", "error": "Missing intermediate; no pathways to [G69381LS] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G52483OL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G69390GI", "error": "Starting point for pathway to G69390GI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G69411IG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69438ML", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36157OV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G36157OV", "dp": 11 }, { "id": "G69438ML", "dp": 11 } ], "links": [ { "target": "G69438ML", "source": "G36157OV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36157OV", "source": "G91365ZQ", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69458AV", "error": "Starting point for pathway to G69458AV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G69461KL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78059CC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G69461KL", "dp": 10 } ], "links": [ { "target": "G69461KL", "source": "G78059CC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69480BN", "error": "Starting point for pathway to G69480BN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G69485SE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86928UZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 }, { "id": "G86928UZ", "dp": 11 }, { "id": "G69485SE", "dp": 11 } ], "links": [ { "target": "G69485SE", "source": "G86928UZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86928UZ", "source": "G85767HW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69533GA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10664FL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G10664FL", "dp": 10 }, { "id": "G69533GA", "dp": 10 } ], "links": [ { "target": "G69533GA", "source": "G10664FL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10664FL", "source": "G45262QY", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69576GO", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G63787RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G63787RZ", "dp": 10 }, { "id": "G69576GO", "dp": 10 } ], "links": [ { "target": "G69576GO", "source": "G63787RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63787RZ", "source": "G27919IH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69584VD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61640TZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G90725ZC", "dp": 9 }, { "id": "G61640TZ", "dp": 10 }, { "id": "G69584VD", "dp": 10 } ], "links": [ { "target": "G69584VD", "source": "G61640TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61640TZ", "source": "G90725ZC", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G90725ZC", "source": "G89993FE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69600TI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 } ], "links": [ { "target": "G69600TI", "source": "G64669AQ", "residue_affected": { "residue_id": "N477", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylf", "full_name": "β-D-Xylf" }, "effect": "Add β-D-Xylf", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G69622NY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04764ON]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G04764ON", "dp": 12 }, { "id": "G69622NY", "dp": 12 } ], "links": [ { "target": "G69622NY", "source": "G04764ON", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04764ON", "source": "G30302VM", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69627PQ", "error": "Missing intermediate; no pathways to [G69627PQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24875YE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G69672LF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75120WS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G69672LF", "dp": 13 } ], "links": [ { "target": "G69672LF", "source": "G75120WS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69704YD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39540XG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G10258MC", "dp": 11 }, { "id": "G39540XG", "dp": 12 }, { "id": "G69704YD", "dp": 12 } ], "links": [ { "target": "G69704YD", "source": "G39540XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39540XG", "source": "G10258MC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10258MC", "source": "G25835MT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69725KG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96921ZU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G96921ZU", "dp": 12 }, { "id": "G69725KG", "dp": 12 } ], "links": [ { "target": "G69725KG", "source": "G96921ZU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69731BT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59746QC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G59746QC", "dp": 14 }, { "id": "G69731BT", "dp": 14 } ], "links": [ { "target": "G69731BT", "source": "G59746QC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59746QC", "source": "G00909PI", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69738ZU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G83926PC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 }, { "id": "G01354KL", "dp": 14 }, { "id": "G83926PC", "dp": 15 }, { "id": "G69738ZU", "dp": 15 } ], "links": [ { "target": "G69738ZU", "source": "G83926PC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G83926PC", "source": "G01354KL", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69749VJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G99935CU]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G99969SS", "dp": 10 }, { "id": "G99935CU", "dp": 11 }, { "id": "G69749VJ", "dp": 11 } ], "links": [ { "target": "G69749VJ", "source": "G99935CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99935CU", "source": "G99969SS", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G99969SS", "source": "G13151XE", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69752OZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G45560HM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G69752OZ", "dp": 10 } ], "links": [ { "target": "G69752OZ", "source": "G45560HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69753WV", "error": "Starting point for pathway to G69753WV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G69758TR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G55974RB", "dp": 11 }, { "id": "G93707PO", "dp": 12 } ], "links": [ { "target": "G69758TR", "source": "G93707PO", "residue_affected": { "residue_id": "N72", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93707PO", "source": "G55974RB", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G55974RB", "source": "G08187GM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69812OF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69905CP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 } ], "links": [ { "target": "G69905CP", "source": "G09670SR", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69912LP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G41720HN", "dp": 8 } ], "links": [ { "target": "G69912LP", "source": "G41720HN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41720HN", "source": "G07483YN", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69931GF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42548XF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G42548XF", "dp": 7 }, { "id": "G69931GF", "dp": 7 } ], "links": [ { "target": "G69931GF", "source": "G42548XF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42548XF", "source": "G61751GZ", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] } ] } , { "glytoucan_ac": "G69957XS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14127XU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G14127XU", "dp": 13 }, { "id": "G69957XS", "dp": 13 } ], "links": [ { "target": "G69957XS", "source": "G14127XU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14127XU", "source": "G91023GB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69960SA", "error": "Missing intermediate; no pathways to [G69960SA] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G69964CA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99770NO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G15103WJ", "dp": 12 }, { "id": "G99770NO", "dp": 13 }, { "id": "G69964CA", "dp": 13 } ], "links": [ { "target": "G69964CA", "source": "G99770NO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99770NO", "source": "G15103WJ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G15103WJ", "source": "G25520XG", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69976JD", "error": "Missing intermediate; no pathways to [G69976JD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40670DJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G69982RY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 } ], "links": [ { "target": "G69982RY", "source": "G45560HM", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69985ZX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G34905OT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G69985ZX", "dp": 11 } ], "links": [ { "target": "G69985ZX", "source": "G34905OT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G69987TD", "error": "Starting point for pathway to G69987TD could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G69996RR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53752TA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G69996RR", "dp": 11 } ], "links": [ { "target": "G69996RR", "source": "G53752TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70052MF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40806JH]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 }, { "id": "G70052MF", "dp": 11 } ], "links": [ { "target": "G70052MF", "source": "G40806JH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70059SD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27919IH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G70059SD", "dp": 9 } ], "links": [ { "target": "G70059SD", "source": "G27919IH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70068WW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17213JF]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G17213JF", "dp": 11 }, { "id": "G70068WW", "dp": 11 } ], "links": [ { "target": "G70068WW", "source": "G17213JF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17213JF", "source": "G08187GM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70069EN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 }, { "id": "G05546WG", "dp": 9 } ], "links": [ { "target": "G70069EN", "source": "G05546WG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05546WG", "source": "G69812OF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70072FZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60439QY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 }, { "id": "G99891PR", "dp": 16 }, { "id": "G60439QY", "dp": 17 }, { "id": "G70072FZ", "dp": 17 } ], "links": [ { "target": "G70072FZ", "source": "G60439QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60439QY", "source": "G99891PR", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70073SG", "error": "Missing intermediate; no pathways to [G70073SG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61751GZ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70076VV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G63333DU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G16529MG", "dp": 14 }, { "id": "G63333DU", "dp": 15 }, { "id": "G70076VV", "dp": 15 } ], "links": [ { "target": "G70076VV", "source": "G63333DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63333DU", "source": "G16529MG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16529MG", "source": "G56549DH", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70081QS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G31670BC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G97093EP", "dp": 12 }, { "id": "G31670BC", "dp": 13 }, { "id": "G70081QS", "dp": 13 } ], "links": [ { "target": "G70081QS", "source": "G31670BC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31670BC", "source": "G97093EP", "residue_affected": { "residue_id": "N246", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G97093EP", "source": "G43433FA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70081SZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41656NL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G41656NL", "dp": 15 }, { "id": "G70081SZ", "dp": 15 } ], "links": [ { "target": "G70081SZ", "source": "G41656NL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41656NL", "source": "G23616ZX", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70113QZ", "error": "Starting point for pathway to G70113QZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70116BN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80319WU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 }, { "id": "G99891PR", "dp": 16 }, { "id": "G80319WU", "dp": 17 }, { "id": "G70116BN", "dp": 17 } ], "links": [ { "target": "G70116BN", "source": "G80319WU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80319WU", "source": "G99891PR", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70163ZD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G93427DE", "dp": 12 } ], "links": [ { "target": "G70163ZD", "source": "G93427DE", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93427DE", "source": "G29857RC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70192AL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G34972BB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G34972BB", "dp": 15 }, { "id": "G70192AL", "dp": 15 } ], "links": [ { "target": "G70192AL", "source": "G34972BB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34972BB", "source": "G91905FJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70194YY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85260RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G85260RY", "dp": 16 }, { "id": "G70194YY", "dp": 16 } ], "links": [ { "target": "G70194YY", "source": "G85260RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85260RY", "source": "G57955DP", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70229DF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G73057DA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G73057DA", "dp": 9 }, { "id": "G70229DF", "dp": 9 } ], "links": [ { "target": "G70229DF", "source": "G73057DA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73057DA", "source": "G34527RW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70236HL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G33241WC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G33241WC", "dp": 15 }, { "id": "G70236HL", "dp": 15 } ], "links": [ { "target": "G70236HL", "source": "G33241WC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33241WC", "source": "G45720CA", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70246WA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52428MJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G52428MJ", "dp": 10 }, { "id": "G70246WA", "dp": 10 } ], "links": [ { "target": "G70246WA", "source": "G52428MJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52428MJ", "source": "G42672MA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70301QJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 } ], "links": [ { "target": "G70301QJ", "source": "G48658PB", "residue_affected": { "residue_id": "N223", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70342DW", "error": "Missing intermediate; no pathways to [G70342DW] could be generated at this time", "notes": [ "reducing end mismatch [b-D-GlcNAc]", "homologous pathway end-point [G48109OV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70358QM", "error": "Starting point for pathway to G70358QM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70364ZU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G73759SD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G73759SD", "dp": 13 }, { "id": "G70364ZU", "dp": 13 } ], "links": [ { "target": "G70364ZU", "source": "G73759SD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73759SD", "source": "G96963QG", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70374BH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G27919IH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G70374BH", "dp": 9 } ], "links": [ { "target": "G70374BH", "source": "G27919IH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70374KJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 } ], "links": [ { "target": "G70374KJ", "source": "G88417ED", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70377VS", "error": "Starting point for pathway to G70377VS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70378BO", "error": "Missing intermediate; no pathways to [G70378BO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G87192TH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70382WT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30460NZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G70382WT", "dp": 11 } ], "links": [ { "target": "G70382WT", "source": "G30460NZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70387YT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52956BX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G52956BX", "dp": 9 }, { "id": "G70387YT", "dp": 9 } ], "links": [ { "target": "G70387YT", "source": "G52956BX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52956BX", "source": "G12398HZ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70410NP", "error": "Missing intermediate; no pathways to [G70410NP] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G70439DD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23484GM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G69086TY", "dp": 12 }, { "id": "G42400JK", "dp": 13 }, { "id": "G23484GM", "dp": 14 }, { "id": "G70439DD", "dp": 14 } ], "links": [ { "target": "G70439DD", "source": "G23484GM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23484GM", "source": "G42400JK", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42400JK", "source": "G69086TY", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70490JW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82811EP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82811EP", "dp": 13 }, { "id": "G70490JW", "dp": 13 } ], "links": [ { "target": "G70490JW", "source": "G82811EP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82811EP", "source": "G84376FR", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70494TJ", "error": "Missing intermediate; no pathways to [G70494TJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92848CF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70511VE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 } ], "links": [ { "target": "G70511VE", "source": "G53752TA", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70520DS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G24083XE", "dp": 12 } ], "links": [ { "target": "G70520DS", "source": "G24083XE", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24083XE", "source": "G82252QI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70548CP", "error": "Missing intermediate; no pathways to [G70548CP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75445NA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70583LH", "error": "Missing intermediate; no pathways to [G70583LH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70584KM", "error": "Starting point for pathway to G70584KM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70586HR", "error": "Starting point for pathway to G70586HR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70593DF", "error": "Starting point for pathway to G70593DF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70594XD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G40358EZ", "dp": 11 } ], "links": [ { "target": "G70594XD", "source": "G40358EZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40358EZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70617CF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84783XD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G44623TX", "dp": 12 }, { "id": "G84783XD", "dp": 13 }, { "id": "G70617CF", "dp": 13 } ], "links": [ { "target": "G70617CF", "source": "G84783XD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84783XD", "source": "G44623TX", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44623TX", "source": "G79809MM", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70642RS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26182BM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G70642RS", "dp": 8 } ], "links": [ { "target": "G70642RS", "source": "G26182BM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70651SI", "error": "Starting point for pathway to G70651SI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70651XZ", "error": "Starting point for pathway to G70651XZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70652JZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81528UX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G81528UX", "dp": 9 }, { "id": "G70652JZ", "dp": 9 } ], "links": [ { "target": "G70652JZ", "source": "G81528UX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81528UX", "source": "G89993FE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70670FB", "error": "Starting point for pathway to G70670FB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70681VG", "error": "Starting point for pathway to G70681VG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70684QL", "error": "Missing intermediate; no pathways to [G70684QL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70708DA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94733WZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G94733WZ", "dp": 15 }, { "id": "G70708DA", "dp": 15 } ], "links": [ { "target": "G70708DA", "source": "G94733WZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94733WZ", "source": "G89877QI", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70708LW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 } ], "links": [ { "target": "G70708LW", "source": "G74675FC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70736PI", "error": "Starting point for pathway to G70736PI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70743LN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95998QK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G49827WK", "dp": 11 }, { "id": "G95998QK", "dp": 12 }, { "id": "G70743LN", "dp": 12 } ], "links": [ { "target": "G70743LN", "source": "G95998QK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95998QK", "source": "G49827WK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49827WK", "source": "G09446VC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70744VQ", "error": "Missing intermediate; no pathways to [G70744VQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97039HI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70765RP", "error": "Missing intermediate; no pathways to [G70765RP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30514JJ]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G70800WO", "error": "Starting point for pathway to G70800WO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70812GK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39029JR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G39029JR", "dp": 10 }, { "id": "G70812GK", "dp": 10 } ], "links": [ { "target": "G70812GK", "source": "G39029JR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39029JR", "source": "G93500PH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70819AR", "error": "Starting point for pathway to G70819AR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G70830AN", "error": "Missing intermediate; no pathways to [G70830AN] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70851FQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90725ZC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G90725ZC", "dp": 9 }, { "id": "G70851FQ", "dp": 9 } ], "links": [ { "target": "G70851FQ", "source": "G90725ZC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90725ZC", "source": "G89993FE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70859XP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16523AO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G70859XP", "dp": 9 } ], "links": [ { "target": "G70859XP", "source": "G16523AO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70868QU", "error": "Missing intermediate; no pathways to [G70868QU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70881GL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81923ER]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G81923ER", "dp": 10 }, { "id": "G70881GL", "dp": 10 } ], "links": [ { "target": "G70881GL", "source": "G81923ER", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70927FR", "error": "Missing intermediate; no pathways to [G70927FR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89285HT]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70945OS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 } ], "links": [ { "target": "G70945OS", "source": "G41331JX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G70947EQ", "error": "Missing intermediate; no pathways to [G70947EQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54300AX]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70958LU", "error": "Missing intermediate; no pathways to [G70958LU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16600BL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G70979VF", "error": "Starting point for pathway to G70979VF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71013KY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 } ], "links": [ { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71063DT", "error": "Missing intermediate; no pathways to [G71063DT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42022OY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71069MN", "error": "Starting point for pathway to G71069MN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71076CH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G64324VB", "dp": 8 }, { "id": "G01010HW", "dp": 9 } ], "links": [ { "target": "G71076CH", "source": "G01010HW", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01010HW", "source": "G64324VB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64324VB", "source": "G59741XZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71094TJ", "error": "Missing intermediate; no pathways to [G71094TJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19687OL]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71098ZR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65597BI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G71098ZR", "dp": 10 } ], "links": [ { "target": "G71098ZR", "source": "G65597BI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71102UV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G40289RO", "dp": 10 } ], "links": [ { "target": "G71102UV", "source": "G40289RO", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40289RO", "source": "G20966TZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71105IW", "error": "Missing intermediate; no pathways to [G71105IW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G87377KZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71118NV", "error": "Missing intermediate; no pathways to [G71118NV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71125UE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29449JO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G71125UE", "dp": 13 } ], "links": [ { "target": "G71125UE", "source": "G29449JO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71153ZE", "error": "Starting point for pathway to G71153ZE could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71156OO", "error": "Missing intermediate; no pathways to [G71156OO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71185WF", "error": "Missing intermediate; no pathways to [G71185WF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71204PH", "error": "Starting point for pathway to G71204PH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71212FT", "error": "Starting point for pathway to G71212FT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71226JJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G48802KI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G48802KI", "dp": 9 }, { "id": "G71226JJ", "dp": 9 } ], "links": [ { "target": "G71226JJ", "source": "G48802KI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48802KI", "source": "G43677TG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71272JH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G67942CH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G67942CH", "dp": 11 }, { "id": "G71272JH", "dp": 11 } ], "links": [ { "target": "G71272JH", "source": "G67942CH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G67942CH", "source": "G71013KY", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71295UC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51066TO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G51066TO", "dp": 13 }, { "id": "G71295UC", "dp": 13 } ], "links": [ { "target": "G71295UC", "source": "G51066TO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51066TO", "source": "G10733HY", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71296WI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63585HN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G71296WI", "dp": 11 } ], "links": [ { "target": "G71296WI", "source": "G63585HN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71320DE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29377XJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G29377XJ", "dp": 12 }, { "id": "G71320DE", "dp": 12 } ], "links": [ { "target": "G71320DE", "source": "G29377XJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29377XJ", "source": "G63585HN", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71323UV", "error": "Missing intermediate; no pathways to [G71323UV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71332MU", "error": "Missing intermediate; no pathways to [G71332MU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06635WE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71333AK", "error": "Starting point for pathway to G71333AK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71333BH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G71333BH", "source": "G18938DW", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71360BB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38395YJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G38395YJ", "dp": 14 }, { "id": "G71360BB", "dp": 14 } ], "links": [ { "target": "G71360BB", "source": "G38395YJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71397MM", "error": "Missing intermediate; no pathways to [G71397MM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71407IE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G71407IE", "source": "G69411IG", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71426FU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28957FB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G71426FU", "dp": 15 } ], "links": [ { "target": "G71426FU", "source": "G28957FB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71442FU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 } ], "links": [ { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71451NN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71679MX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G71451NN", "dp": 11 } ], "links": [ { "target": "G71451NN", "source": "G71679MX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71470CO", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G71470CO", "source": "G08520NM", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71496TN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72260GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 }, { "id": "G72260GO", "dp": 12 }, { "id": "G71496TN", "dp": 12 } ], "links": [ { "target": "G71496TN", "source": "G72260GO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72260GO", "source": "G04743RS", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71513XV", "error": "Starting point for pathway to G71513XV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71529OW", "error": "Missing intermediate; no pathways to [G71529OW] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G04791YX]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71550UL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96063MG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G71550UL", "dp": 9 } ], "links": [ { "target": "G71550UL", "source": "G96063MG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71602GO", "error": "Starting point for pathway to G71602GO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71606HZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25520XG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G71606HZ", "dp": 11 } ], "links": [ { "target": "G71606HZ", "source": "G25520XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71662HP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03445UI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G71662HP", "dp": 10 } ], "links": [ { "target": "G71662HP", "source": "G03445UI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71679MX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71690HK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 } ], "links": [ { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71704AG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 } ], "links": [ { "target": "G71704AG", "source": "G42686NQ", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71714EQ", "error": "Starting point for pathway to G71714EQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71765ZO", "error": "Starting point for pathway to G71765ZO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G71774LK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61640TZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G90725ZC", "dp": 9 }, { "id": "G61640TZ", "dp": 10 }, { "id": "G71774LK", "dp": 10 } ], "links": [ { "target": "G71774LK", "source": "G61640TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61640TZ", "source": "G90725ZC", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G90725ZC", "source": "G89993FE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71782CJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43694RQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G71782CJ", "dp": 10 } ], "links": [ { "target": "G71782CJ", "source": "G43694RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71812IK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 } ], "links": [ { "target": "G71812IK", "source": "G80858MF", "residue_affected": { "residue_id": "N322", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71828FH", "error": "Missing intermediate; no pathways to [G71828FH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71835BN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71857KQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 } ], "links": [ { "target": "G71857KQ", "source": "G29434RB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71865NO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11535IB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 }, { "id": "G71865NO", "dp": 9 } ], "links": [ { "target": "G71865NO", "source": "G11535IB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71869FP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58281SK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G58281SK", "dp": 9 }, { "id": "G71869FP", "dp": 9 } ], "links": [ { "target": "G71869FP", "source": "G58281SK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58281SK", "source": "G59471TH", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71888DL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G80294GH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G71888DL", "dp": 13 } ], "links": [ { "target": "G71888DL", "source": "G80294GH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71906BW", "error": "Missing intermediate; no pathways to [G71906BW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71914DZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84376FR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G71914DZ", "dp": 12 } ], "links": [ { "target": "G71914DZ", "source": "G84376FR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71923IX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G66313YW", "dp": 13 } ], "links": [ { "target": "G71923IX", "source": "G66313YW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66313YW", "source": "G74645FT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G71957GO", "error": "Missing intermediate; no pathways to [G71957GO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G71972AT", "error": "Missing intermediate; no pathways to [G71972AT] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G71989MV", "error": "Starting point for pathway to G71989MV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G72018SI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G72082VM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G72018SI", "dp": 10 } ], "links": [ { "target": "G72018SI", "source": "G72082VM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72060AW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G29112GC", "dp": 10 } ], "links": [ { "target": "G72060AW", "source": "G29112GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29112GC", "source": "G20030CU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72075FO", "error": "Missing intermediate; no pathways to [G72075FO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58547FH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72079JG", "error": "Starting point for pathway to G72079JG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G72080JO", "error": "Missing intermediate; no pathways to [G72080JO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24984RR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72082VM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 } ], "links": [ { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72083DS", "error": "Missing intermediate; no pathways to [G72083DS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42022OY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72085DL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26939ZY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G26939ZY", "dp": 8 }, { "id": "G72085DL", "dp": 8 } ], "links": [ { "target": "G72085DL", "source": "G26939ZY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26939ZY", "source": "G39213VZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72103RY", "error": "Starting point for pathway to G72103RY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G72107SE", "error": "Missing intermediate; no pathways to [G72107SE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42731RJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72108VJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98140IX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G98140IX", "dp": 7 }, { "id": "G72108VJ", "dp": 7 } ], "links": [ { "target": "G72108VJ", "source": "G98140IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98140IX", "source": "G61751GZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72112RK", "error": "Missing intermediate; no pathways to [G72112RK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72125QI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94047VH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G94047VH", "dp": 11 }, { "id": "G72125QI", "dp": 11 } ], "links": [ { "target": "G72125QI", "source": "G94047VH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94047VH", "source": "G07995VK", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72128LZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89877QI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G72128LZ", "dp": 14 } ], "links": [ { "target": "G72128LZ", "source": "G89877QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72131JM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94531EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 }, { "id": "G72131JM", "dp": 18 } ], "links": [ { "target": "G72131JM", "source": "G94531EZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72217GT", "error": "Starting point for pathway to G72217GT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G72221XM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 } ], "links": [ { "target": "G72221XM", "source": "G45187EI", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72231RH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34905OT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G72231RH", "dp": 11 } ], "links": [ { "target": "G72231RH", "source": "G34905OT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72233LJ", "error": "Missing intermediate; no pathways to [G72233LJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57671LP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G72260GO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G04743RS", "dp": 11 } ], "links": [ { "target": "G72260GO", "source": "G04743RS", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04743RS", "source": "G88417ED", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72272ID", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G76384QV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G98852TR", "dp": 16 }, { "id": "G76384QV", "dp": 17 }, { "id": "G72272ID", "dp": 17 } ], "links": [ { "target": "G72272ID", "source": "G76384QV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76384QV", "source": "G98852TR", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98852TR", "source": "G28957FB", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72281FQ", "error": "Missing intermediate; no pathways to [G72281FQ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G97453GF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72317JJ", "error": "Missing intermediate; no pathways to [G72317JJ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G29130SY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72321SC", "error": "Missing intermediate; no pathways to [G72321SC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77485UZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72334XM", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G32156DB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G80661IW", "dp": 10 }, { "id": "G32156DB", "dp": 11 }, { "id": "G72334XM", "dp": 11 } ], "links": [ { "target": "G72334XM", "source": "G32156DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32156DB", "source": "G80661IW", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G80661IW", "source": "G46638GC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72353NN", "error": "Missing intermediate; no pathways to [G72353NN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41953RN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72356JA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25140TA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G72356JA", "dp": 11 } ], "links": [ { "target": "G72356JA", "source": "G25140TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72356TB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G73817GH", "dp": 10 }, { "id": "G57601AP", "dp": 11 } ], "links": [ { "target": "G72356TB", "source": "G57601AP", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57601AP", "source": "G73817GH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72356VO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72580QS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G72580QS", "dp": 14 }, { "id": "G72356VO", "dp": 14 } ], "links": [ { "target": "G72356VO", "source": "G72580QS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72580QS", "source": "G66282NU", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72369ZI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71690HK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 }, { "id": "G72369ZI", "dp": 10 } ], "links": [ { "target": "G72369ZI", "source": "G71690HK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72406BE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32659RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G32659RY", "dp": 12 }, { "id": "G72406BE", "dp": 12 } ], "links": [ { "target": "G72406BE", "source": "G32659RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32659RY", "source": "G59877NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72407FN", "error": "Starting point for pathway to G72407FN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G72407WU", "error": "Missing intermediate; no pathways to [G72407WU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72411HX", "error": "Missing intermediate; no pathways to [G72411HX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72460OS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88948CY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G72460OS", "dp": 11 } ], "links": [ { "target": "G72460OS", "source": "G88948CY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72462NP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52080WL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G52080WL", "dp": 9 }, { "id": "G72462NP", "dp": 9 } ], "links": [ { "target": "G72462NP", "source": "G52080WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52080WL", "source": "G66937TJ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72475NE", "error": "Missing intermediate; no pathways to [G72475NE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30483FB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72533FB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52663AD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G72533FB", "dp": 9 } ], "links": [ { "target": "G72533FB", "source": "G52663AD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72536JI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 } ], "links": [ { "target": "G72536JI", "source": "G81432SH", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72544HW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83926PC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 }, { "id": "G01354KL", "dp": 14 }, { "id": "G83926PC", "dp": 15 }, { "id": "G72544HW", "dp": 15 } ], "links": [ { "target": "G72544HW", "source": "G83926PC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G83926PC", "source": "G01354KL", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72547ZD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06209KS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G06209KS", "dp": 8 }, { "id": "G72547ZD", "dp": 8 } ], "links": [ { "target": "G72547ZD", "source": "G06209KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06209KS", "source": "G69411IG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72553QP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69812OF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 }, { "id": "G72553QP", "dp": 8 } ], "links": [ { "target": "G72553QP", "source": "G69812OF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72578SV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 } ], "links": [ { "target": "G72578SV", "source": "G17689DH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72580QS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 } ], "links": [ { "target": "G72580QS", "source": "G66282NU", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72587UU", "error": "Starting point for pathway to G72587UU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G72601EC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G32305RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G72601EC", "dp": 10 } ], "links": [ { "target": "G72601EC", "source": "G32305RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72645FS", "error": "Missing intermediate; no pathways to [G72645FS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G72654FE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01069AK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G01069AK", "dp": 11 }, { "id": "G72654FE", "dp": 11 } ], "links": [ { "target": "G72654FE", "source": "G01069AK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01069AK", "source": "G91365ZQ", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72662IG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G80537QW", "dp": 14 } ], "links": [ { "target": "G72662IG", "source": "G80537QW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80537QW", "source": "G93582HM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72687PY", "error": "Missing intermediate; no pathways to [G72687PY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92918FJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72690KN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11929SN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G11929SN", "dp": 14 }, { "id": "G72690KN", "dp": 14 } ], "links": [ { "target": "G72690KN", "source": "G11929SN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11929SN", "source": "G80294GH", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72698LT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G82861UH", "dp": 9 } ], "links": [ { "target": "G72698LT", "source": "G82861UH", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82861UH", "source": "G59471TH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72718TT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 } ], "links": [ { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72728PS", "error": "Missing intermediate; no pathways to [G72728PS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G22865RK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72758KY", "error": "Missing intermediate; no pathways to [G72758KY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72758WN", "error": "Starting point for pathway to G72758WN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G72771HB", "error": "Missing intermediate; no pathways to [G72771HB] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72775LZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34972BB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G34972BB", "dp": 15 }, { "id": "G72775LZ", "dp": 15 } ], "links": [ { "target": "G72775LZ", "source": "G34972BB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34972BB", "source": "G91905FJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72821WX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72851IY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66204OA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G66204OA", "dp": 8 }, { "id": "G72851IY", "dp": 8 } ], "links": [ { "target": "G72851IY", "source": "G66204OA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66204OA", "source": "G39089YD", "residue_affected": { "residue_id": "N477", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylf", "full_name": "β-D-Xylf" }, "effect": "Add β-D-Xylf", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G72893LL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G14512NS", "dp": 9 } ], "links": [ { "target": "G72893LL", "source": "G14512NS", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14512NS", "source": "G24420RT", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72905QH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10733HY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G72905QH", "dp": 12 } ], "links": [ { "target": "G72905QH", "source": "G10733HY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72906WU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G73211XU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G95919TI", "dp": 14 }, { "id": "G73211XU", "dp": 15 }, { "id": "G72906WU", "dp": 15 } ], "links": [ { "target": "G72906WU", "source": "G73211XU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73211XU", "source": "G95919TI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95919TI", "source": "G30651IU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72919IM", "error": "Missing intermediate; no pathways to [G72919IM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72952WX", "error": "Missing intermediate; no pathways to [G72952WX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66595IQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G72954XC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56749GV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G56749GV", "dp": 12 }, { "id": "G72954XC", "dp": 12 } ], "links": [ { "target": "G72954XC", "source": "G56749GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56749GV", "source": "G11041DA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G72974NP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 }, { "id": "G01354KL", "dp": 14 } ], "links": [ { "target": "G72974NP", "source": "G01354KL", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73051OD", "error": "Starting point for pathway to G73051OD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73057DA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 } ], "links": [ { "target": "G73057DA", "source": "G34527RW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73100ZP", "error": "Starting point for pathway to G73100ZP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73111YU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G56318NV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 }, { "id": "G56318NV", "dp": 17 }, { "id": "G73111YU", "dp": 17 } ], "links": [ { "target": "G73111YU", "source": "G56318NV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56318NV", "source": "G75237SS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73119DN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16523AO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G73119DN", "dp": 9 } ], "links": [ { "target": "G73119DN", "source": "G16523AO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73135FO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 } ], "links": [ { "target": "G73135FO", "source": "G09782JM", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73161ZQ", "error": "Missing intermediate; no pathways to [G73161ZQ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G40909AN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73170HU", "error": "Missing intermediate; no pathways to [G73170HU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78885XB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73178TM", "error": "Starting point for pathway to G73178TM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73211XU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 }, { "id": "G95919TI", "dp": 14 } ], "links": [ { "target": "G73211XU", "source": "G95919TI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95919TI", "source": "G30651IU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73234BV", "error": "Starting point for pathway to G73234BV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73271AZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72082VM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G73271AZ", "dp": 10 } ], "links": [ { "target": "G73271AZ", "source": "G72082VM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73271RJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74107UT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74107UT", "dp": 11 }, { "id": "G73271RJ", "dp": 11 } ], "links": [ { "target": "G73271RJ", "source": "G74107UT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74107UT", "source": "G78059CC", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73292AI", "error": "Missing intermediate; no pathways to [G73292AI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73293TU", "error": "Missing intermediate; no pathways to [G73293TU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73302KW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74645FT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G73302KW", "dp": 12 } ], "links": [ { "target": "G73302KW", "source": "G74645FT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73308YY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75185NU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G73308YY", "dp": 12 } ], "links": [ { "target": "G73308YY", "source": "G75185NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73363SU", "error": "Missing intermediate; no pathways to [G73363SU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54018RP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73367DT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G44202NB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G72821WX", "dp": 9 }, { "id": "G44202NB", "dp": 10 }, { "id": "G73367DT", "dp": 10 } ], "links": [ { "target": "G73367DT", "source": "G44202NB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44202NB", "source": "G72821WX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73394YA", "error": "Starting point for pathway to G73394YA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73402RN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06969ZX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 }, { "id": "G73402RN", "dp": 10 } ], "links": [ { "target": "G73402RN", "source": "G06969ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73418FX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 } ], "links": [ { "target": "G73418FX", "source": "G00743WU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73439VG", "error": "Missing intermediate; no pathways to [G73439VG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40909AN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73481GN", "error": "Starting point for pathway to G73481GN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73492AT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 } ], "links": [ { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73499UJ", "error": "Missing intermediate; no pathways to [G73499UJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10385EY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73517CY", "error": "Starting point for pathway to G73517CY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73520AV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 }, { "id": "G66961CH", "dp": 15 }, { "id": "G83992YN", "dp": 16 } ], "links": [ { "target": "G73520AV", "source": "G83992YN", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G83992YN", "source": "G66961CH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73539WK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86005HP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 }, { "id": "G86005HP", "dp": 16 }, { "id": "G73539WK", "dp": 16 } ], "links": [ { "target": "G73539WK", "source": "G86005HP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86005HP", "source": "G25097RR", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73551SV", "error": "Missing intermediate; no pathways to [G73551SV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G67943IR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73560HZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G73560HZ", "source": "G66937TJ", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73567NI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G23616ZX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G73567NI", "dp": 14 } ], "links": [ { "target": "G73567NI", "source": "G23616ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73574GH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 } ], "links": [ { "target": "G73574GH", "source": "G75185NU", "residue_affected": { "residue_id": "N441", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73614SN", "error": "Starting point for pathway to G73614SN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73663PS", "error": "Missing intermediate; no pathways to [G73663PS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93655SG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73683LQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25407RZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G25407RZ", "dp": 11 }, { "id": "G73683LQ", "dp": 11 } ], "links": [ { "target": "G73683LQ", "source": "G25407RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25407RZ", "source": "G65597BI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73687MV", "error": "Missing intermediate; no pathways to [G73687MV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65867II]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73697AO", "error": "Starting point for pathway to G73697AO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73759SD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 } ], "links": [ { "target": "G73759SD", "source": "G96963QG", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73763NQ", "error": "Missing intermediate; no pathways to [G73763NQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63065KG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73775WR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73817GH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 } ], "links": [ { "target": "G73817GH", "source": "G09782JM", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73825BL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17540HT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G17540HT", "dp": 12 }, { "id": "G73825BL", "dp": 12 } ], "links": [ { "target": "G73825BL", "source": "G17540HT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17540HT", "source": "G30460NZ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73836ED", "error": "Missing intermediate; no pathways to [G73836ED] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G18594ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73839CW", "error": "Missing intermediate; no pathways to [G73839CW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95658PH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73849MH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03962UN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G03962UN", "dp": 9 }, { "id": "G73849MH", "dp": 9 } ], "links": [ { "target": "G73849MH", "source": "G03962UN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03962UN", "source": "G43677TG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73866ZM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84467IZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 }, { "id": "G73866ZM", "dp": 11 } ], "links": [ { "target": "G73866ZM", "source": "G84467IZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73869CT", "error": "Starting point for pathway to G73869CT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73907HE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G93204KY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G57943ZV", "dp": 11 }, { "id": "G93204KY", "dp": 12 }, { "id": "G73907HE", "dp": 12 } ], "links": [ { "target": "G73907HE", "source": "G93204KY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93204KY", "source": "G57943ZV", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G73915OF", "error": "Starting point for pathway to G73915OF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73917BT", "error": "Starting point for pathway to G73917BT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73946HM", "error": "Missing intermediate; no pathways to [G73946HM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G73964QN", "error": "Missing intermediate; no pathways to [G73964QN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73968KM", "error": "Starting point for pathway to G73968KM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G73971XH", "error": "Missing intermediate; no pathways to [G73971XH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73977KO", "error": "Missing intermediate; no pathways to [G73977KO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G73994XG", "error": "Starting point for pathway to G73994XG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74004KO", "error": "Starting point for pathway to G74004KO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74012OU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 } ], "links": [ { "target": "G74012OU", "source": "G28550OD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74018VM", "error": "Missing intermediate; no pathways to [G74018VM] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G17134VG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74026TS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G17689DH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 }, { "id": "G74026TS", "dp": 12 } ], "links": [ { "target": "G74026TS", "source": "G17689DH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74033PJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53728DU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G53728DU", "dp": 11 }, { "id": "G74033PJ", "dp": 11 } ], "links": [ { "target": "G74033PJ", "source": "G53728DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53728DU", "source": "G91365ZQ", "residue_affected": { "residue_id": "N276", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74054RO", "error": "Starting point for pathway to G74054RO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74066YL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04576KS]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G04576KS", "dp": 10 }, { "id": "G74066YL", "dp": 10 } ], "links": [ { "target": "G74066YL", "source": "G04576KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04576KS", "source": "G16828VN", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74068WP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G74068WP", "source": "G00176HZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74074HU", "error": "Missing intermediate; no pathways to [G74074HU] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74090KZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G74090KZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74107UT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G74107UT", "source": "G78059CC", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74111MH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43677TG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G74111MH", "dp": 8 } ], "links": [ { "target": "G74111MH", "source": "G43677TG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74120DW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 } ], "links": [ { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74154RA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82050MN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G74154RA", "dp": 13 } ], "links": [ { "target": "G74154RA", "source": "G82050MN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74155HM", "error": "Starting point for pathway to G74155HM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74161MJ", "error": "Missing intermediate; no pathways to [G74161MJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74238CC", "error": "Missing intermediate; no pathways to [G74238CC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74248TD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03275SD]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G74248TD", "dp": 10 } ], "links": [ { "target": "G74248TD", "source": "G03275SD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74264DI", "error": "Missing intermediate; no pathways to [G74264DI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74264KM", "error": "Missing intermediate; no pathways to [G74264KM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74286KY", "error": "Missing intermediate; no pathways to [G74286KY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74290AC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65890UA]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G65890UA", "dp": 10 }, { "id": "G74290AC", "dp": 10 } ], "links": [ { "target": "G74290AC", "source": "G65890UA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65890UA", "source": "G16828VN", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74292MB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 } ], "links": [ { "target": "G74292MB", "source": "G30302VM", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74300NT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G89036WC", "dp": 8 } ], "links": [ { "target": "G74300NT", "source": "G89036WC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89036WC", "source": "G02427KF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74312RU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46406BL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G46406BL", "dp": 12 }, { "id": "G74312RU", "dp": 12 } ], "links": [ { "target": "G74312RU", "source": "G46406BL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46406BL", "source": "G11041DA", "residue_affected": { "residue_id": "N276", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74324QB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G60564DP", "dp": 14 } ], "links": [ { "target": "G74324QB", "source": "G60564DP", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74325TG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25520XG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G74325TG", "dp": 11 } ], "links": [ { "target": "G74325TG", "source": "G25520XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74364UH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32699RJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G32699RJ", "dp": 10 }, { "id": "G74364UH", "dp": 10 } ], "links": [ { "target": "G74364UH", "source": "G32699RJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32699RJ", "source": "G63074CQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74369SL", "error": "Missing intermediate; no pathways to [G74369SL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G72919IM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74388HZ", "error": "Starting point for pathway to G74388HZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74388OG", "error": "Missing intermediate; no pathways to [G74388OG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G97309BN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74438AB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 } ], "links": [ { "target": "G74438AB", "source": "G34905OT", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74459BD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98140IX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G98140IX", "dp": 7 }, { "id": "G74459BD", "dp": 7 } ], "links": [ { "target": "G74459BD", "source": "G98140IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98140IX", "source": "G61751GZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74465ET", "error": "Starting point for pathway to G74465ET could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74493GE", "error": "Missing intermediate; no pathways to [G74493GE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21050RT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74497TS", "error": "Missing intermediate; no pathways to [G74497TS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74498IP", "error": "Starting point for pathway to G74498IP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74517ZR", "error": "Missing intermediate; no pathways to [G74517ZR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G33802UM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74541EU", "error": "Starting point for pathway to G74541EU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74554WD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47011KD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G47011KD", "dp": 9 }, { "id": "G74554WD", "dp": 9 } ], "links": [ { "target": "G74554WD", "source": "G47011KD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47011KD", "source": "G34527RW", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74571ZF", "error": "Starting point for pathway to G74571ZF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74574VX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 } ], "links": [ { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74575XC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00176HZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G74575XC", "dp": 10 } ], "links": [ { "target": "G74575XC", "source": "G00176HZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74608QW", "error": "Starting point for pathway to G74608QW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74645FT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 } ], "links": [ { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74673OI", "error": "Starting point for pathway to G74673OI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74675FC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74683SL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G88461FF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G74683SL", "dp": 9 } ], "links": [ { "target": "G74683SL", "source": "G88461FF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74716XL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G09150LP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 }, { "id": "G74716XL", "dp": 12 } ], "links": [ { "target": "G74716XL", "source": "G09150LP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74807KC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 }, { "id": "G78097CL", "dp": 13 } ], "links": [ { "target": "G74807KC", "source": "G78097CL", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78097CL", "source": "G09150LP", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74809RD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86357DX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G74809RD", "dp": 12 } ], "links": [ { "target": "G74809RD", "source": "G86357DX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74817FV", "error": "Missing intermediate; no pathways to [G74817FV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74837KH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58667NI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G74837KH", "dp": 9 } ], "links": [ { "target": "G74837KH", "source": "G58667NI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74837NO", "error": "Missing intermediate; no pathways to [G74837NO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36316RB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74859XI", "error": "Missing intermediate; no pathways to [G74859XI] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74864OW", "error": "Missing intermediate; no pathways to [G74864OW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G74910NC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G73057DA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G73057DA", "dp": 9 }, { "id": "G74910NC", "dp": 9 } ], "links": [ { "target": "G74910NC", "source": "G73057DA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G73057DA", "source": "G34527RW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74912VG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 }, { "id": "G97958KV", "dp": 11 }, { "id": "G05143WC", "dp": 12 } ], "links": [ { "target": "G74912VG", "source": "G05143WC", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05143WC", "source": "G97958KV", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97958KV", "source": "G45365RV", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74916CC", "error": "Starting point for pathway to G74916CC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G74928QN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 } ], "links": [ { "target": "G74928QN", "source": "G29449JO", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G74961IU", "error": "Starting point for pathway to G74961IU could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75039HL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 } ], "links": [ { "target": "G75039HL", "source": "G52934AK", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75049FP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 } ], "links": [ { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75082OS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99074EO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G75082OS", "dp": 13 } ], "links": [ { "target": "G75082OS", "source": "G99074EO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75087EW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G39595CR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G39595CR", "dp": 14 }, { "id": "G75087EW", "dp": 14 } ], "links": [ { "target": "G75087EW", "source": "G39595CR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39595CR", "source": "G80294GH", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75097MF", "error": "Missing intermediate; no pathways to [G75097MF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75100GD", "error": "Missing intermediate; no pathways to [G75100GD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75107JX", "error": "Missing intermediate; no pathways to [G75107JX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75120WS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 } ], "links": [ { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75143LK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 } ], "links": [ { "target": "G75143LK", "source": "G71013KY", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75159YA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72718TT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G75159YA", "dp": 9 } ], "links": [ { "target": "G75159YA", "source": "G72718TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75185KR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42193NQ]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 }, { "id": "G42193NQ", "dp": 11 }, { "id": "G75185KR", "dp": 11 } ], "links": [ { "target": "G75185KR", "source": "G42193NQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42193NQ", "source": "G56748EO", "residue_affected": { "residue_id": "N373", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75185NU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 } ], "links": [ { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75197HN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G47175EF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G75197HN", "dp": 11 } ], "links": [ { "target": "G75197HN", "source": "G47175EF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75236EF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G63889NK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G75236EF", "dp": 14 } ], "links": [ { "target": "G75236EF", "source": "G63889NK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75237AB", "error": "Missing intermediate; no pathways to [G75237AB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75237SS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 } ], "links": [ { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75266XJ", "error": "Missing intermediate; no pathways to [G75266XJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62326NX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75308SV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G88966ZO", "dp": 15 } ], "links": [ { "target": "G75308SV", "source": "G88966ZO", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88966ZO", "source": "G63889NK", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75311GD", "error": "Starting point for pathway to G75311GD could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75318VB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G28298VW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G28298VW", "dp": 13 }, { "id": "G75318VB", "dp": 13 } ], "links": [ { "target": "G75318VB", "source": "G28298VW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28298VW", "source": "G48658PB", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75333EX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29676WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G49743VF", "dp": 11 }, { "id": "G29676WX", "dp": 12 }, { "id": "G75333EX", "dp": 12 } ], "links": [ { "target": "G75333EX", "source": "G29676WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29676WX", "source": "G49743VF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49743VF", "source": "G06216UH", "residue_affected": { "residue_id": "N470", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75345ZM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G73057DA", "dp": 9 } ], "links": [ { "target": "G75345ZM", "source": "G73057DA", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] }, { "target": "G73057DA", "source": "G34527RW", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75355YV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G61553DD", "dp": 9 } ], "links": [ { "target": "G75355YV", "source": "G61553DD", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61553DD", "source": "G29011JC", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75359HS", "error": "Missing intermediate; no pathways to [G75359HS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G75359YM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20983SP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 }, { "id": "G20983SP", "dp": 19 }, { "id": "G75359YM", "dp": 19 } ], "links": [ { "target": "G75359YM", "source": "G20983SP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20983SP", "source": "G94531EZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75367YS", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G00176HZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G75367YS", "dp": 10 } ], "links": [ { "target": "G75367YS", "source": "G00176HZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75381NI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30460NZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G75381NI", "dp": 11 } ], "links": [ { "target": "G75381NI", "source": "G30460NZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75398ZA", "error": "Missing intermediate; no pathways to [G75398ZA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75412QZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G75412QZ", "source": "G18938DW", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75426EV", "error": "Starting point for pathway to G75426EV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75445NA", "error": "Missing intermediate; no pathways to [G75445NA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75448JJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G06209KS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G06209KS", "dp": 8 }, { "id": "G75448JJ", "dp": 8 } ], "links": [ { "target": "G75448JJ", "source": "G06209KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06209KS", "source": "G69411IG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75465ST", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66866LE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G75465ST", "dp": 10 } ], "links": [ { "target": "G75465ST", "source": "G66866LE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75475RA", "error": "Missing intermediate; no pathways to [G75475RA] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G40428GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75501QM", "error": "Missing intermediate; no pathways to [G75501QM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75502NG", "error": "Starting point for pathway to G75502NG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75531GC", "error": "Missing intermediate; no pathways to [G75531GC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21756MV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75554MB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 } ], "links": [ { "target": "G75554MB", "source": "G10733HY", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75564FK", "error": "Starting point for pathway to G75564FK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75584LU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29011JC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G75584LU", "dp": 8 } ], "links": [ { "target": "G75584LU", "source": "G29011JC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75595FQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 } ], "links": [ { "target": "G75595FQ", "source": "G71013KY", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75597AP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27919IH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G75597AP", "dp": 9 } ], "links": [ { "target": "G75597AP", "source": "G27919IH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75671DO", "error": "Missing intermediate; no pathways to [G75671DO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75672FW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57863LA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G57863LA", "dp": 11 }, { "id": "G75672FW", "dp": 11 } ], "links": [ { "target": "G75672FW", "source": "G57863LA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57863LA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75698LJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90870DG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G75698LJ", "dp": 11 } ], "links": [ { "target": "G75698LJ", "source": "G90870DG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75700IQ", "error": "Missing intermediate; no pathways to [G75700IQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24748QU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75701BM", "error": "Starting point for pathway to G75701BM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75704ZB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91413ZX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 }, { "id": "G75704ZB", "dp": 15 } ], "links": [ { "target": "G75704ZB", "source": "G91413ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75720YC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 } ], "links": [ { "target": "G75720YC", "source": "G01856RL", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75734VP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29676WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G49743VF", "dp": 11 }, { "id": "G29676WX", "dp": 12 }, { "id": "G75734VP", "dp": 12 } ], "links": [ { "target": "G75734VP", "source": "G29676WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29676WX", "source": "G49743VF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49743VF", "source": "G06216UH", "residue_affected": { "residue_id": "N470", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75757LG", "error": "Starting point for pathway to G75757LG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75764FQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91511MZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G91511MZ", "dp": 12 }, { "id": "G75764FQ", "dp": 12 } ], "links": [ { "target": "G75764FQ", "source": "G91511MZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91511MZ", "source": "G11041DA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75794LV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09482NW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G75794LV", "dp": 9 } ], "links": [ { "target": "G75794LV", "source": "G09482NW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75800VI", "error": "Missing intermediate; no pathways to [G75800VI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75811ON", "error": "Starting point for pathway to G75811ON could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75824WJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60814ZB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 }, { "id": "G60814ZB", "dp": 18 }, { "id": "G75824WJ", "dp": 18 } ], "links": [ { "target": "G75824WJ", "source": "G60814ZB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60814ZB", "source": "G28106CM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75825ZR", "error": "Starting point for pathway to G75825ZR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75829ZK", "error": "Starting point for pathway to G75829ZK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75839SN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45359RY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G75839SN", "dp": 12 } ], "links": [ { "target": "G75839SN", "source": "G45359RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75850OP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G75850OP", "source": "G36191CD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75853FN", "error": "Missing intermediate; no pathways to [G75853FN] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75870RQ", "error": "Starting point for pathway to G75870RQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75886II", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07392QY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G07392QY", "dp": 11 }, { "id": "G75886II", "dp": 11 } ], "links": [ { "target": "G75886II", "source": "G07392QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07392QY", "source": "G78059CC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75886KR", "error": "Missing intermediate; no pathways to [G75886KR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75896PD", "error": "Missing intermediate; no pathways to [G75896PD] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G75896QL", "error": "Starting point for pathway to G75896QL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G75899KQ", "error": "Missing intermediate; no pathways to [G75899KQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75902JL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 } ], "links": [ { "target": "G75902JL", "source": "G93582HM", "residue_affected": { "residue_id": "N57", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75903TQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 } ], "links": [ { "target": "G75903TQ", "source": "G82252QI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75937YG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38549YL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G21679ID", "dp": 11 }, { "id": "G38549YL", "dp": 12 }, { "id": "G75937YG", "dp": 12 } ], "links": [ { "target": "G75937YG", "source": "G38549YL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38549YL", "source": "G21679ID", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21679ID", "source": "G52934AK", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G75972ZC", "error": "Missing intermediate; no pathways to [G75972ZC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G75983CF", "error": "Starting point for pathway to G75983CF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76044PX", "error": "Missing intermediate; no pathways to [G76044PX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41087ZA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76073FF", "error": "Missing intermediate; no pathways to [G76073FF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76075NA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 } ], "links": [ { "target": "G76075NA", "source": "G90870DG", "residue_affected": { "residue_id": "N62", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76084VW", "error": "Starting point for pathway to G76084VW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76108MN", "error": "Starting point for pathway to G76108MN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76127VR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G99465IE", "dp": 12 } ], "links": [ { "target": "G76127VR", "source": "G99465IE", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G99465IE", "source": "G06131VP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76136FD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G86102AA", "dp": 11 } ], "links": [ { "target": "G76136FD", "source": "G86102AA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86102AA", "source": "G85542KD", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76167HQ", "error": "Starting point for pathway to G76167HQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76190UX", "error": "Missing intermediate; no pathways to [G76190UX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76195PM", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G26264SQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 }, { "id": "G26264SQ", "dp": 12 }, { "id": "G76195PM", "dp": 12 } ], "links": [ { "target": "G76195PM", "source": "G26264SQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26264SQ", "source": "G42028DN", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76225JQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00743WU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 }, { "id": "G76225JQ", "dp": 11 } ], "links": [ { "target": "G76225JQ", "source": "G00743WU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76241TN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59471TH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G76241TN", "dp": 8 } ], "links": [ { "target": "G76241TN", "source": "G59471TH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76292WC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96921ZU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G96921ZU", "dp": 12 }, { "id": "G76292WC", "dp": 12 } ], "links": [ { "target": "G76292WC", "source": "G96921ZU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76294TY", "error": "Missing intermediate; no pathways to [G76294TY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76326JS", "error": "Starting point for pathway to G76326JS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76345AA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G76345AA", "source": "G12398HZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76373XZ", "error": "Missing intermediate; no pathways to [G76373XZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G48329CR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76384QV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G98852TR", "dp": 16 } ], "links": [ { "target": "G76384QV", "source": "G98852TR", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98852TR", "source": "G28957FB", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76408BJ", "error": "Starting point for pathway to G76408BJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76408CE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G83588YY", "dp": 15 }, { "id": "G54599TV", "dp": 16 } ], "links": [ { "target": "G76408CE", "source": "G54599TV", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G54599TV", "source": "G83588YY", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83588YY", "source": "G11953VE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76420EN", "error": "Missing intermediate; no pathways to [G76420EN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76422GC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 } ], "links": [ { "target": "G76422GC", "source": "G25140TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76436VC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09150LP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 }, { "id": "G76436VC", "dp": 12 } ], "links": [ { "target": "G76436VC", "source": "G09150LP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76464YC", "error": "Starting point for pathway to G76464YC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76478FT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 } ], "links": [ { "target": "G76478FT", "source": "G78059CC", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76489QB", "error": "Missing intermediate; no pathways to [G76489QB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G13659RH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76496FO", "error": "Starting point for pathway to G76496FO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76505NV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60963AS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G65796FM", "dp": 13 }, { "id": "G60963AS", "dp": 14 }, { "id": "G76505NV", "dp": 14 } ], "links": [ { "target": "G76505NV", "source": "G60963AS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60963AS", "source": "G65796FM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65796FM", "source": "G79344MI", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76515LR", "error": "Missing intermediate; no pathways to [G76515LR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10540LB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76518ZU", "error": "Starting point for pathway to G76518ZU could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76528ZS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 } ], "links": [ { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76531WT", "error": "Missing intermediate; no pathways to [G76531WT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30437YI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76554SR", "error": "Missing intermediate; no pathways to [G76554SR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76582OA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G22354SF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G00368HM", "dp": 13 }, { "id": "G07505KH", "dp": 14 }, { "id": "G22354SF", "dp": 15 }, { "id": "G76582OA", "dp": 15 } ], "links": [ { "target": "G76582OA", "source": "G22354SF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G22354SF", "source": "G07505KH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07505KH", "source": "G00368HM", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00368HM", "source": "G86357DX", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76583MP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93500PH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G76583MP", "dp": 9 } ], "links": [ { "target": "G76583MP", "source": "G93500PH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76603UJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 } ], "links": [ { "target": "G76603UJ", "source": "G09782JM", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76646HT", "error": "Missing intermediate; no pathways to [G76646HT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76666KS", "error": "Starting point for pathway to G76666KS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76705RJ", "error": "Starting point for pathway to G76705RJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76705YY", "error": "Missing intermediate; no pathways to [G76705YY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43873MM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G76713YY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G28747XN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G96921ZU", "dp": 12 }, { "id": "G28747XN", "dp": 13 }, { "id": "G76713YY", "dp": 13 } ], "links": [ { "target": "G76713YY", "source": "G28747XN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28747XN", "source": "G96921ZU", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76802ZU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 } ], "links": [ { "target": "G76802ZU", "source": "G12740VA", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76807JB", "error": "Missing intermediate; no pathways to [G76807JB] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G76842ZR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 } ], "links": [ { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76867MC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74090KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G74090KZ", "dp": 7 }, { "id": "G76867MC", "dp": 7 } ], "links": [ { "target": "G76867MC", "source": "G74090KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74090KZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76873LU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 } ], "links": [ { "target": "G76873LU", "source": "G62504BU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76882CO", "error": "Starting point for pathway to G76882CO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76884TE", "error": "Starting point for pathway to G76884TE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76907BP", "error": "Starting point for pathway to G76907BP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76924RW", "error": "Starting point for pathway to G76924RW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76931AL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23782KP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G23782KP", "dp": 14 }, { "id": "G76931AL", "dp": 14 } ], "links": [ { "target": "G76931AL", "source": "G23782KP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23782KP", "source": "G01727PW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76945TE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80294GH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G80294GH", "dp": 13 }, { "id": "G76945TE", "dp": 13 } ], "links": [ { "target": "G76945TE", "source": "G80294GH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76956DJ", "error": "Starting point for pathway to G76956DJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76979BI", "error": "Starting point for pathway to G76979BI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G76983CM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G71812IK", "dp": 9 } ], "links": [ { "target": "G76983CM", "source": "G71812IK", "residue_affected": { "residue_id": "N223", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G71812IK", "source": "G80858MF", "residue_affected": { "residue_id": "N322", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G76986IU", "error": "Missing intermediate; no pathways to [G76986IU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G77025HC", "error": "Starting point for pathway to G77025HC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G77035LA", "error": "Missing intermediate; no pathways to [G77035LA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43351VW]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77058YR", "error": "Starting point for pathway to G77058YR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G77097TR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84874EV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G84874EV", "dp": 11 }, { "id": "G77097TR", "dp": 11 } ], "links": [ { "target": "G77097TR", "source": "G84874EV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84874EV", "source": "G99270AV", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77136ZM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91832SW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G91832SW", "dp": 14 }, { "id": "G77136ZM", "dp": 14 } ], "links": [ { "target": "G77136ZM", "source": "G91832SW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91832SW", "source": "G85085MS", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77147GI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95288UB]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G95288UB", "dp": 10 }, { "id": "G77147GI", "dp": 10 } ], "links": [ { "target": "G77147GI", "source": "G95288UB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95288UB", "source": "G16828VN", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77147RP", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G60814ZB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 }, { "id": "G60814ZB", "dp": 18 }, { "id": "G77147RP", "dp": 18 } ], "links": [ { "target": "G77147RP", "source": "G60814ZB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60814ZB", "source": "G28106CM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77174TF", "error": "Missing intermediate; no pathways to [G77174TF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82639GQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77207RR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99533GU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 }, { "id": "G99533GU", "dp": 18 }, { "id": "G77207RR", "dp": 18 } ], "links": [ { "target": "G77207RR", "source": "G99533GU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99533GU", "source": "G28106CM", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77244ZA", "error": "Missing intermediate; no pathways to [G77244ZA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31991IV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77252PU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 } ], "links": [ { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77253ZO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56748EO]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 }, { "id": "G77253ZO", "dp": 10 } ], "links": [ { "target": "G77253ZO", "source": "G56748EO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77291EZ", "error": "Missing intermediate; no pathways to [G77291EZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77363ER", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G77363ER", "source": "G91365ZQ", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77384FE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G91337ZP", "dp": 10 } ], "links": [ { "target": "G77384FE", "source": "G91337ZP", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91337ZP", "source": "G58667NI", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77396HT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58403SV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G58403SV", "dp": 11 }, { "id": "G77396HT", "dp": 11 } ], "links": [ { "target": "G77396HT", "source": "G58403SV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58403SV", "source": "G99270AV", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77434JL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49307MQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G78276SQ", "dp": 12 }, { "id": "G49307MQ", "dp": 13 }, { "id": "G77434JL", "dp": 13 } ], "links": [ { "target": "G77434JL", "source": "G49307MQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49307MQ", "source": "G78276SQ", "residue_affected": { "residue_id": "N408", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G78276SQ", "source": "G11041DA", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77445IQ", "error": "Missing intermediate; no pathways to [G77445IQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77466MH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 } ], "links": [ { "target": "G77466MH", "source": "G89993FE", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77467SI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42097JO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G42097JO", "dp": 14 }, { "id": "G77467SI", "dp": 14 } ], "links": [ { "target": "G77467SI", "source": "G42097JO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42097JO", "source": "G85085MS", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77475MM", "error": "Missing intermediate; no pathways to [G77475MM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77479VH", "error": "Starting point for pathway to G77479VH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G77480AW", "error": "Starting point for pathway to G77480AW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G77485UZ", "error": "Missing intermediate; no pathways to [G77485UZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77498XG", "error": "Missing intermediate; no pathways to [G77498XG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77521TX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 } ], "links": [ { "target": "G77521TX", "source": "G78155FK", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77537OB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 } ], "links": [ { "target": "G77537OB", "source": "G03445UI", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77562VR", "error": "Missing intermediate; no pathways to [G77562VR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G77572QA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52187WF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G02290KA", "dp": 10 }, { "id": "G52187WF", "dp": 11 }, { "id": "G77572QA", "dp": 11 } ], "links": [ { "target": "G77572QA", "source": "G52187WF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52187WF", "source": "G02290KA", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77576VI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcNAc]", "homologous pathway end-point [G75185NU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G77576VI", "dp": 12 } ], "links": [ { "target": "G77576VI", "source": "G75185NU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77589SS", "error": "Starting point for pathway to G77589SS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G77608VQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G33862NZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G90703DJ", "dp": 13 }, { "id": "G33862NZ", "dp": 14 }, { "id": "G77608VQ", "dp": 14 } ], "links": [ { "target": "G77608VQ", "source": "G33862NZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33862NZ", "source": "G90703DJ", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G90703DJ", "source": "G74120DW", "residue_affected": { "residue_id": "N295", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77627UV", "error": "Missing intermediate; no pathways to [G77627UV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86555OF]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G77638EE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G56147VV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G56147VV", "dp": 15 }, { "id": "G77638EE", "dp": 15 } ], "links": [ { "target": "G77638EE", "source": "G56147VV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56147VV", "source": "G17168RO", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77639OD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77643ZX", "error": "Missing intermediate; no pathways to [G77643ZX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77646FX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G69170UT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G69170UT", "dp": 14 }, { "id": "G77646FX", "dp": 14 } ], "links": [ { "target": "G77646FX", "source": "G69170UT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69170UT", "source": "G82050MN", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77670FL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82420SH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G82420SH", "dp": 10 }, { "id": "G77670FL", "dp": 10 } ], "links": [ { "target": "G77670FL", "source": "G82420SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77680AI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17437BX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G17437BX", "dp": 14 }, { "id": "G77680AI", "dp": 14 } ], "links": [ { "target": "G77680AI", "source": "G17437BX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17437BX", "source": "G92359VA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77685RD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03385XG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G03385XG", "dp": 13 }, { "id": "G77685RD", "dp": 13 } ], "links": [ { "target": "G77685RD", "source": "G03385XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77687SU", "error": "Missing intermediate; no pathways to [G77687SU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G77812KJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77712UR", "error": "Starting point for pathway to G77712UR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G77748PL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19444JC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G19444JC", "dp": 15 }, { "id": "G77748PL", "dp": 15 } ], "links": [ { "target": "G77748PL", "source": "G19444JC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19444JC", "source": "G45720CA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77755RE", "error": "Missing intermediate; no pathways to [G77755RE] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77791EJ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G39439UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G39439UR", "dp": 9 }, { "id": "G77791EJ", "dp": 9 } ], "links": [ { "target": "G77791EJ", "source": "G39439UR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39439UR", "source": "G10209QU", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77812EW", "error": "Missing intermediate; no pathways to [G77812EW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96925LL]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77812KJ", "error": "Missing intermediate; no pathways to [G77812KJ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77859TT", "error": "Missing intermediate; no pathways to [G77859TT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G77861QN", "error": "Missing intermediate; no pathways to [G77861QN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77889NO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85180ML]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G85180ML", "dp": 10 }, { "id": "G77889NO", "dp": 10 } ], "links": [ { "target": "G77889NO", "source": "G85180ML", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85180ML", "source": "G96063MG", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77901JG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86270DU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G86270DU", "dp": 12 }, { "id": "G77901JG", "dp": 12 } ], "links": [ { "target": "G77901JG", "source": "G86270DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86270DU", "source": "G11041DA", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77915NM", "error": "Missing intermediate; no pathways to [G77915NM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47007PV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77922WZ", "error": "Starting point for pathway to G77922WZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G77939BF", "error": "Missing intermediate; no pathways to [G77939BF] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G24748QU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G77969OS", "error": "Starting point for pathway to G77969OS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G77974XY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G77974XY", "source": "G20030CU", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G77977RG", "error": "Missing intermediate; no pathways to [G77977RG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78000JX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06290ZS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G78000JX", "dp": 9 } ], "links": [ { "target": "G78000JX", "source": "G06290ZS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78003VE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G37022BP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G37022BP", "dp": 12 }, { "id": "G78003VE", "dp": 12 } ], "links": [ { "target": "G78003VE", "source": "G37022BP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37022BP", "source": "G30460NZ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78009PP", "error": "Missing intermediate; no pathways to [G78009PP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78011JO", "error": "Missing intermediate; no pathways to [G78011JO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78030KJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 } ], "links": [ { "target": "G78030KJ", "source": "G53812BX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78034VF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50779LX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G50779LX", "dp": 12 }, { "id": "G78034VF", "dp": 12 } ], "links": [ { "target": "G78034VF", "source": "G50779LX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50779LX", "source": "G25140TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78059CC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 } ], "links": [ { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78097CL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 } ], "links": [ { "target": "G78097CL", "source": "G09150LP", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78126EU", "error": "Missing intermediate; no pathways to [G78126EU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G57675TR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78129VV", "error": "Missing intermediate; no pathways to [G78129VV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G12241WD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78155FK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 } ], "links": [ { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78161IO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17168RO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G39813YP", "dp": 13 }, { "id": "G17168RO", "dp": 14 }, { "id": "G78161IO", "dp": 14 } ], "links": [ { "target": "G78161IO", "source": "G17168RO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17168RO", "source": "G39813YP", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39813YP", "source": "G03951JJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78173WX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 } ], "links": [ { "target": "G78173WX", "source": "G43694RQ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78205VT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G60564DP", "dp": 14 }, { "id": "G31494OZ", "dp": 15 } ], "links": [ { "target": "G78205VT", "source": "G31494OZ", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G31494OZ", "source": "G60564DP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78231ZN", "error": "Starting point for pathway to G78231ZN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78255XL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G11535IB", "dp": 9 } ], "links": [ { "target": "G78255XL", "source": "G11535IB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11535IB", "source": "G59471TH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78276SQ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G78276SQ", "source": "G11041DA", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78279JR", "error": "Missing intermediate; no pathways to [G78279JR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78280YO", "error": "Starting point for pathway to G78280YO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78295SU", "error": "Missing intermediate; no pathways to [G78295SU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92918FJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78300IO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49827WK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G49827WK", "dp": 11 }, { "id": "G78300IO", "dp": 11 } ], "links": [ { "target": "G78300IO", "source": "G49827WK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49827WK", "source": "G09446VC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78304UB", "error": "Missing intermediate; no pathways to [G78304UB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50278HE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78325SJ", "error": "Starting point for pathway to G78325SJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78341DP", "error": "Missing intermediate; no pathways to [G78341DP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08520NM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G78341OF", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G28231AL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 }, { "id": "G31004HS", "dp": 18 }, { "id": "G28231AL", "dp": 19 }, { "id": "G78341OF", "dp": 19 } ], "links": [ { "target": "G78341OF", "source": "G28231AL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28231AL", "source": "G31004HS", "residue_affected": { "residue_id": "N362", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78342SP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20956ZK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G78342SP", "dp": 8 } ], "links": [ { "target": "G78342SP", "source": "G20956ZK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78368CZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98140IX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G98140IX", "dp": 7 }, { "id": "G78368CZ", "dp": 7 } ], "links": [ { "target": "G78368CZ", "source": "G98140IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98140IX", "source": "G61751GZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78370NE", "error": "Starting point for pathway to G78370NE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78375NC", "error": "Starting point for pathway to G78375NC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78391CU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G88537BJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G88537BJ", "dp": 15 }, { "id": "G78391CU", "dp": 15 } ], "links": [ { "target": "G78391CU", "source": "G88537BJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88537BJ", "source": "G23616ZX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78402VR", "error": "Starting point for pathway to G78402VR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78405EA", "error": "Starting point for pathway to G78405EA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78407ZS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98559XP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G98559XP", "dp": 14 }, { "id": "G78407ZS", "dp": 14 } ], "links": [ { "target": "G78407ZS", "source": "G98559XP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98559XP", "source": "G18938DW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78420WJ", "error": "Starting point for pathway to G78420WJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78432NH", "error": "Starting point for pathway to G78432NH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78434AN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40906DZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G40906DZ", "dp": 14 }, { "id": "G78434AN", "dp": 14 } ], "links": [ { "target": "G78434AN", "source": "G40906DZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40906DZ", "source": "G18938DW", "residue_affected": { "residue_id": "N43", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78497UW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18026EK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G18026EK", "dp": 12 }, { "id": "G78497UW", "dp": 12 } ], "links": [ { "target": "G78497UW", "source": "G18026EK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18026EK", "source": "G37046CZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78501IM", "error": "Missing intermediate; no pathways to [G78501IM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78503JC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 } ], "links": [ { "target": "G78503JC", "source": "G31010RQ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78509IY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77974XY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77974XY", "dp": 10 }, { "id": "G78509IY", "dp": 10 } ], "links": [ { "target": "G78509IY", "source": "G77974XY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77974XY", "source": "G20030CU", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78513KA", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G61088TM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G61088TM", "dp": 12 }, { "id": "G78513KA", "dp": 12 } ], "links": [ { "target": "G78513KA", "source": "G61088TM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61088TM", "source": "G90870DG", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78513VM", "error": "Starting point for pathway to G78513VM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78519ZX", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G63333DU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G16529MG", "dp": 14 }, { "id": "G63333DU", "dp": 15 }, { "id": "G78519ZX", "dp": 15 } ], "links": [ { "target": "G78519ZX", "source": "G63333DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63333DU", "source": "G16529MG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16529MG", "source": "G56549DH", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78520ZK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80858MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G78520ZK", "dp": 8 } ], "links": [ { "target": "G78520ZK", "source": "G80858MF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78555BT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G82540VC", "dp": 8 }, { "id": "G41278YY", "dp": 9 } ], "links": [ { "target": "G78555BT", "source": "G41278YY", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41278YY", "source": "G82540VC", "residue_affected": { "residue_id": "N238", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G82540VC", "source": "G39213VZ", "residue_affected": { "residue_id": "N250", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78580RN", "error": "Starting point for pathway to G78580RN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78599IE", "error": "Missing intermediate; no pathways to [G78599IE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44005DK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78603IZ", "error": "Missing intermediate; no pathways to [G78603IZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78625LN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52187WF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G02290KA", "dp": 10 }, { "id": "G52187WF", "dp": 11 }, { "id": "G78625LN", "dp": 11 } ], "links": [ { "target": "G78625LN", "source": "G52187WF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52187WF", "source": "G02290KA", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02290KA", "source": "G20030CU", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78648QN", "error": "Missing intermediate; no pathways to [G78648QN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78661LW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 } ], "links": [ { "target": "G78661LW", "source": "G32201IL", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78681QL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61207RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G78681QL", "dp": 9 } ], "links": [ { "target": "G78681QL", "source": "G61207RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78727VW", "error": "Starting point for pathway to G78727VW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78730ZV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99533GU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 }, { "id": "G99533GU", "dp": 18 }, { "id": "G78730ZV", "dp": 18 } ], "links": [ { "target": "G78730ZV", "source": "G99533GU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99533GU", "source": "G28106CM", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78741RD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 } ], "links": [ { "target": "G78741RD", "source": "G64669AQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G78768UQ", "error": "Missing intermediate; no pathways to [G78768UQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78797VK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 } ], "links": [ { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78803YD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 } ], "links": [ { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78807JW", "error": "Missing intermediate; no pathways to [G78807JW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78813BX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69905CP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 }, { "id": "G69905CP", "dp": 11 }, { "id": "G78813BX", "dp": 11 } ], "links": [ { "target": "G78813BX", "source": "G69905CP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69905CP", "source": "G09670SR", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78838PJ", "error": "Starting point for pathway to G78838PJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78841KJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 } ], "links": [ { "target": "G78841KJ", "source": "G69812OF", "residue_affected": { "residue_id": "N250", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78885XB", "error": "Missing intermediate; no pathways to [G78885XB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78890OB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 } ], "links": [ { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78894EE", "error": "Missing intermediate; no pathways to [G78894EE] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G39601JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G78944YP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38115KZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G71857KQ", "dp": 10 }, { "id": "G38115KZ", "dp": 11 }, { "id": "G78944YP", "dp": 11 } ], "links": [ { "target": "G78944YP", "source": "G38115KZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38115KZ", "source": "G71857KQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71857KQ", "source": "G29434RB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78956IC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 } ], "links": [ { "target": "G78956IC", "source": "G91413ZX", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G78961ZT", "error": "Starting point for pathway to G78961ZT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G78980OK", "error": "Missing intermediate; no pathways to [G78980OK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G78992HS", "error": "Missing intermediate; no pathways to [G78992HS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79002WQ", "error": "Starting point for pathway to G79002WQ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79010UT", "error": "Missing intermediate; no pathways to [G79010UT] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79018NX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57504TA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G28723UT", "dp": 11 }, { "id": "G57504TA", "dp": 12 }, { "id": "G79018NX", "dp": 12 } ], "links": [ { "target": "G79018NX", "source": "G57504TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57504TA", "source": "G28723UT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28723UT", "source": "G87073UP", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79037RU", "error": "Missing intermediate; no pathways to [G79037RU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25392ZR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79044TC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G64669AQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G79044TC", "dp": 8 } ], "links": [ { "target": "G79044TC", "source": "G64669AQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G79071YL", "error": "Starting point for pathway to G79071YL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79077OL", "error": "Missing intermediate; no pathways to [G79077OL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00666EC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79083TK", "error": "Starting point for pathway to G79083TK could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79084MU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16679DU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G69086TY", "dp": 12 }, { "id": "G42400JK", "dp": 13 }, { "id": "G16679DU", "dp": 14 }, { "id": "G79084MU", "dp": 14 } ], "links": [ { "target": "G79084MU", "source": "G16679DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16679DU", "source": "G42400JK", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42400JK", "source": "G69086TY", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79088GV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 } ], "links": [ { "target": "G79088GV", "source": "G66282NU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79089IH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G64633BH", "dp": 9 } ], "links": [ { "target": "G79089IH", "source": "G64633BH", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G64633BH", "source": "G79348ZY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79099UV", "error": "Missing intermediate; no pathways to [G79099UV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79115EW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34527RW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G79115EW", "dp": 8 } ], "links": [ { "target": "G79115EW", "source": "G34527RW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79183WP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 } ], "links": [ { "target": "G79183WP", "source": "G48658PB", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79189II", "error": "Starting point for pathway to G79189II could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79198BK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G79198BK", "source": "G10219AA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79198HM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G47011KD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G92024SL", "dp": 7 }, { "id": "G34527RW", "dp": 8 }, { "id": "G47011KD", "dp": 9 }, { "id": "G79198HM", "dp": 9 } ], "links": [ { "target": "G79198HM", "source": "G47011KD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47011KD", "source": "G34527RW", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34527RW", "source": "G92024SL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79202GR", "error": "Missing intermediate; no pathways to [G79202GR] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G66765ZA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79202RS", "error": "Missing intermediate; no pathways to [G79202RS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70830AN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79215ZS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32592IB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G32592IB", "dp": 15 }, { "id": "G79215ZS", "dp": 15 } ], "links": [ { "target": "G79215ZS", "source": "G32592IB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32592IB", "source": "G10228OD", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79224FW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56318NV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 }, { "id": "G56318NV", "dp": 17 }, { "id": "G79224FW", "dp": 17 } ], "links": [ { "target": "G79224FW", "source": "G56318NV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56318NV", "source": "G75237SS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79249GP", "error": "Starting point for pathway to G79249GP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79302PB", "error": "Missing intermediate; no pathways to [G79302PB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79344MI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 } ], "links": [ { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79345FD", "error": "Missing intermediate; no pathways to [G79345FD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G79345TW", "error": "Missing intermediate; no pathways to [G79345TW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79348ZY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 } ], "links": [ { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79349EV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84712FF", "dp": 12 }, { "id": "G42941KJ", "dp": 13 } ], "links": [ { "target": "G79349EV", "source": "G42941KJ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42941KJ", "source": "G84712FF", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84712FF", "source": "G29857RC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79351ZW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53396PX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G53396PX", "dp": 14 }, { "id": "G79351ZW", "dp": 14 } ], "links": [ { "target": "G79351ZW", "source": "G53396PX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53396PX", "source": "G82050MN", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79368CP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G46185ND]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G46185ND", "dp": 12 }, { "id": "G79368CP", "dp": 12 } ], "links": [ { "target": "G79368CP", "source": "G46185ND", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46185ND", "source": "G53752TA", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79369FE", "error": "Missing intermediate; no pathways to [G79369FE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79370VG", "error": "Starting point for pathway to G79370VG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79371XG", "error": "Starting point for pathway to G79371XG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79394LC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 } ], "links": [ { "target": "G79394LC", "source": "G97765TT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79404OF", "error": "Missing intermediate; no pathways to [G79404OF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79412GP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 } ], "links": [ { "target": "G79412GP", "source": "G35310KA", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79446WY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G91365ZQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G79446WY", "dp": 10 } ], "links": [ { "target": "G79446WY", "source": "G91365ZQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79457WN", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G79457WN", "source": "G00176HZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79469HB", "error": "Starting point for pathway to G79469HB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79477YQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65890UA]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G65890UA", "dp": 10 }, { "id": "G79477YQ", "dp": 10 } ], "links": [ { "target": "G79477YQ", "source": "G65890UA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65890UA", "source": "G16828VN", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79499QH", "error": "Starting point for pathway to G79499QH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79508WH", "error": "Missing intermediate; no pathways to [G79508WH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42175IR]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G79518SC", "error": "Missing intermediate; no pathways to [G79518SC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G64077VW]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79520GQ", "error": "Missing intermediate; no pathways to [G79520GQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00320ZP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79523YN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G52333AW", "dp": 9 } ], "links": [ { "target": "G79523YN", "source": "G52333AW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52333AW", "source": "G29492IF", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79530JS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32065BG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G79530JS", "dp": 12 } ], "links": [ { "target": "G79530JS", "source": "G32065BG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79538ZU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 } ], "links": [ { "target": "G79538ZU", "source": "G29434RB", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79546WW", "error": "Missing intermediate; no pathways to [G79546WW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G79556AB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 } ], "links": [ { "target": "G79556AB", "source": "G82252QI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79565XA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G19469VZ", "dp": 18 } ], "links": [ { "target": "G79565XA", "source": "G19469VZ", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G19469VZ", "source": "G92574YO", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79578JB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79588PU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G14905MK", "dp": 10 } ], "links": [ { "target": "G79588PU", "source": "G14905MK", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14905MK", "source": "G61207RZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79598BZ", "error": "Missing intermediate; no pathways to [G79598BZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80943NY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79609RF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 } ], "links": [ { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79610JI", "error": "Missing intermediate; no pathways to [G79610JI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79617NL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G29112GC", "dp": 10 } ], "links": [ { "target": "G79617NL", "source": "G29112GC", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G29112GC", "source": "G20030CU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79634CE", "error": "Missing intermediate; no pathways to [G79634CE] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G97865QM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79643VQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90175OT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G90175OT", "dp": 9 }, { "id": "G79643VQ", "dp": 9 } ], "links": [ { "target": "G79643VQ", "source": "G90175OT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90175OT", "source": "G37476QB", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79661CG", "error": "Starting point for pathway to G79661CG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79662AK", "error": "Missing intermediate; no pathways to [G79662AK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79702QE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98565KP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 }, { "id": "G98565KP", "dp": 15 }, { "id": "G79702QE", "dp": 15 } ], "links": [ { "target": "G79702QE", "source": "G98565KP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98565KP", "source": "G53485VW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79713BZ", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G04576KS]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G04576KS", "dp": 10 }, { "id": "G79713BZ", "dp": 10 } ], "links": [ { "target": "G79713BZ", "source": "G04576KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04576KS", "source": "G16828VN", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79726CC", "error": "Missing intermediate; no pathways to [G79726CC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40027VO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79726HB", "error": "Starting point for pathway to G79726HB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79753ZN", "error": "Missing intermediate; no pathways to [G79753ZN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40670DJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79754SY", "error": "Starting point for pathway to G79754SY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79771YZ", "error": "Starting point for pathway to G79771YZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79781PS", "error": "Starting point for pathway to G79781PS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79790LK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G29112GC", "dp": 10 }, { "id": "G72060AW", "dp": 11 }, { "id": "G06032HI", "dp": 12 } ], "links": [ { "target": "G79790LK", "source": "G06032HI", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G06032HI", "source": "G72060AW", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72060AW", "source": "G29112GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29112GC", "source": "G20030CU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79803HS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G74438AB", "dp": 12 } ], "links": [ { "target": "G79803HS", "source": "G74438AB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74438AB", "source": "G34905OT", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79804QG", "error": "Missing intermediate; no pathways to [G79804QG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79809MM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 } ], "links": [ { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79810PX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G37166HP]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G37166HP", "dp": 11 }, { "id": "G79810PX", "dp": 11 } ], "links": [ { "target": "G79810PX", "source": "G37166HP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37166HP", "source": "G11637WL", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79815MA", "error": "Missing intermediate; no pathways to [G79815MA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79852UE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41981MA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G41981MA", "dp": 15 }, { "id": "G79852UE", "dp": 15 } ], "links": [ { "target": "G79852UE", "source": "G41981MA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41981MA", "source": "G38022PE", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79897UN", "error": "Starting point for pathway to G79897UN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79898XM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32704TW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G32704TW", "dp": 9 }, { "id": "G79898XM", "dp": 9 } ], "links": [ { "target": "G79898XM", "source": "G32704TW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32704TW", "source": "G12398HZ", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79906AG", "error": "Missing intermediate; no pathways to [G79906AG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27844UM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79916NT", "error": "Missing intermediate; no pathways to [G79916NT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G65832JS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G79924QN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G12699VT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G12699VT", "dp": 11 }, { "id": "G79924QN", "dp": 11 } ], "links": [ { "target": "G79924QN", "source": "G12699VT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12699VT", "source": "G78059CC", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79945BC", "error": "Starting point for pathway to G79945BC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G79950YS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 } ], "links": [ { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79968QL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92359VA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G79968QL", "dp": 13 } ], "links": [ { "target": "G79968QL", "source": "G92359VA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G79996DQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G58403SV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G58403SV", "dp": 11 }, { "id": "G79996DQ", "dp": 11 } ], "links": [ { "target": "G79996DQ", "source": "G58403SV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58403SV", "source": "G99270AV", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80019MD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37476QB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G80019MD", "dp": 8 } ], "links": [ { "target": "G80019MD", "source": "G37476QB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80030LD", "error": "Missing intermediate; no pathways to [G80030LD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G80031DC", "error": "Missing intermediate; no pathways to [G80031DC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95298UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80047AR", "error": "Missing intermediate; no pathways to [G80047AR] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G03260OU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80056AS", "error": "Missing intermediate; no pathways to [G80056AS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74859XI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80060TZ", "error": "Missing intermediate; no pathways to [G80060TZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G81738MQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80064DH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38549YL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G21679ID", "dp": 11 }, { "id": "G38549YL", "dp": 12 }, { "id": "G80064DH", "dp": 12 } ], "links": [ { "target": "G80064DH", "source": "G38549YL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38549YL", "source": "G21679ID", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21679ID", "source": "G52934AK", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80085KS", "error": "Missing intermediate; no pathways to [G80085KS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80098ET", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G38208CY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G61684ET", "dp": 12 }, { "id": "G38208CY", "dp": 13 }, { "id": "G80098ET", "dp": 13 } ], "links": [ { "target": "G80098ET", "source": "G38208CY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38208CY", "source": "G61684ET", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61684ET", "source": "G25520XG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80099PR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70945OS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G70945OS", "dp": 13 }, { "id": "G80099PR", "dp": 13 } ], "links": [ { "target": "G80099PR", "source": "G70945OS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70945OS", "source": "G41331JX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80115FI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06969ZX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 }, { "id": "G80115FI", "dp": 10 } ], "links": [ { "target": "G80115FI", "source": "G06969ZX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80124PG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29449JO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G80124PG", "dp": 13 } ], "links": [ { "target": "G80124PG", "source": "G29449JO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80142NN", "error": "Starting point for pathway to G80142NN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80147LG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 } ], "links": [ { "target": "G80147LG", "source": "G27919IH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80163ME", "error": "Starting point for pathway to G80163ME could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80177VT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94047VH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G94047VH", "dp": 11 }, { "id": "G80177VT", "dp": 11 } ], "links": [ { "target": "G80177VT", "source": "G94047VH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94047VH", "source": "G07995VK", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80180FJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16201LW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14996IQ", "dp": 8 }, { "id": "G16201LW", "dp": 9 }, { "id": "G80180FJ", "dp": 9 } ], "links": [ { "target": "G80180FJ", "source": "G16201LW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16201LW", "source": "G14996IQ", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G14996IQ", "source": "G69411IG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80180SI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G68946DB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G76528ZS", "dp": 11 }, { "id": "G68946DB", "dp": 12 }, { "id": "G80180SI", "dp": 12 } ], "links": [ { "target": "G80180SI", "source": "G68946DB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G68946DB", "source": "G76528ZS", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80200DN", "error": "Missing intermediate; no pathways to [G80200DN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56354PO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80201UB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36268TW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G36268TW", "dp": 12 }, { "id": "G80201UB", "dp": 12 } ], "links": [ { "target": "G80201UB", "source": "G36268TW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36268TW", "source": "G77252PU", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80202YF", "error": "Missing intermediate; no pathways to [G80202YF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80211PE", "error": "Missing intermediate; no pathways to [G80211PE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25406HP]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80223WC", "error": "Starting point for pathway to G80223WC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80264ZA", "error": "Missing intermediate; no pathways to [G80264ZA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80268ZC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86095OE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 }, { "id": "G86095OE", "dp": 17 }, { "id": "G80268ZC", "dp": 17 } ], "links": [ { "target": "G80268ZC", "source": "G86095OE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86095OE", "source": "G75237SS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80285YU", "error": "Missing intermediate; no pathways to [G80285YU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80294GH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 } ], "links": [ { "target": "G80294GH", "source": "G86357DX", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80298HR", "error": "Missing intermediate; no pathways to [G80298HR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G51768ZH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80302UK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 }, { "id": "G16451PE", "dp": 11 }, { "id": "G26529EC", "dp": 12 } ], "links": [ { "target": "G80302UK", "source": "G26529EC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26529EC", "source": "G16451PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16451PE", "source": "G45365RV", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80319WU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 }, { "id": "G99891PR", "dp": 16 } ], "links": [ { "target": "G80319WU", "source": "G99891PR", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80343LW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29857RC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G80343LW", "dp": 11 } ], "links": [ { "target": "G80343LW", "source": "G29857RC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80344NL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79556AB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G79556AB", "dp": 12 }, { "id": "G80344NL", "dp": 12 } ], "links": [ { "target": "G80344NL", "source": "G79556AB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79556AB", "source": "G82252QI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80352NL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 } ], "links": [ { "target": "G80352NL", "source": "G66282NU", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80355WT", "error": "Starting point for pathway to G80355WT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80357ON", "error": "Starting point for pathway to G80357ON could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80366RR", "error": "Starting point for pathway to G80366RR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80391ZU", "error": "Missing intermediate; no pathways to [G80391ZU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80393PG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80415EJ", "error": "Missing intermediate; no pathways to [G80415EJ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G91199QX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80439QE", "error": "Missing intermediate; no pathways to [G80439QE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80443OV", "error": "Missing intermediate; no pathways to [G80443OV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80474MG", "error": "Missing intermediate; no pathways to [G80474MG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80499JV", "error": "Missing intermediate; no pathways to [G80499JV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82410AF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80510YA", "error": "Missing intermediate; no pathways to [G80510YA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00797ZX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80513FH", "error": "Starting point for pathway to G80513FH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80514ZZ", "error": "Missing intermediate; no pathways to [G80514ZZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98117HW]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G80537QW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 } ], "links": [ { "target": "G80537QW", "source": "G93582HM", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80552MJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94531EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G94531EZ", "dp": 18 }, { "id": "G80552MJ", "dp": 18 } ], "links": [ { "target": "G80552MJ", "source": "G94531EZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80566CZ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G99866WK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G38395YJ", "dp": 14 }, { "id": "G99866WK", "dp": 15 }, { "id": "G80566CZ", "dp": 15 } ], "links": [ { "target": "G80566CZ", "source": "G99866WK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99866WK", "source": "G38395YJ", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80567MC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19615BB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G08242BT", "dp": 12 }, { "id": "G19615BB", "dp": 13 }, { "id": "G80567MC", "dp": 13 } ], "links": [ { "target": "G80567MC", "source": "G19615BB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19615BB", "source": "G08242BT", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08242BT", "source": "G26949IX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80570FW", "error": "Missing intermediate; no pathways to [G80570FW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90065BD]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G80578OK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 } ], "links": [ { "target": "G80578OK", "source": "G85767HW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80583XN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74012OU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G74012OU", "dp": 10 }, { "id": "G80583XN", "dp": 10 } ], "links": [ { "target": "G80583XN", "source": "G74012OU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74012OU", "source": "G28550OD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80612BO", "error": "Missing intermediate; no pathways to [G80612BO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99808VS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80633OU", "error": "Missing intermediate; no pathways to [G80633OU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46767VX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80637VS", "error": "Starting point for pathway to G80637VS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80647PR", "error": "Missing intermediate; no pathways to [G80647PR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80650PW", "error": "Starting point for pathway to G80650PW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80652ZF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G80652ZF", "source": "G39213VZ", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80654ZK", "error": "Missing intermediate; no pathways to [G80654ZK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G13282WA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80661IW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G80661IW", "source": "G46638GC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80664ZC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G70520DS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G24083XE", "dp": 12 }, { "id": "G70520DS", "dp": 13 }, { "id": "G80664ZC", "dp": 13 } ], "links": [ { "target": "G80664ZC", "source": "G70520DS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70520DS", "source": "G24083XE", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24083XE", "source": "G82252QI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80673NC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78173WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G78173WX", "dp": 11 }, { "id": "G80673NC", "dp": 11 } ], "links": [ { "target": "G80673NC", "source": "G78173WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78173WX", "source": "G43694RQ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80674SM", "error": "Starting point for pathway to G80674SM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80710QD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G24402OX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G66098KC", "dp": 14 }, { "id": "G24402OX", "dp": 15 }, { "id": "G80710QD", "dp": 15 } ], "links": [ { "target": "G80710QD", "source": "G24402OX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G24402OX", "source": "G66098KC", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66098KC", "source": "G18938DW", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80713VB", "error": "Missing intermediate; no pathways to [G80713VB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78011JO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80715XM", "error": "Missing intermediate; no pathways to [G80715XM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42909GK]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80717KS", "error": "Missing intermediate; no pathways to [G80717KS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80728XN", "error": "Missing intermediate; no pathways to [G80728XN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80756MK", "error": "Starting point for pathway to G80756MK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80762EP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99270AV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G80762EP", "dp": 10 } ], "links": [ { "target": "G80762EP", "source": "G99270AV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80764EX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20815TK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G80764EX", "dp": 11 } ], "links": [ { "target": "G80764EX", "source": "G20815TK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80822MI", "error": "Starting point for pathway to G80822MI could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80825SQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98862GW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G98862GW", "dp": 13 }, { "id": "G80825SQ", "dp": 13 } ], "links": [ { "target": "G80825SQ", "source": "G98862GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98862GW", "source": "G75049FP", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80848DN", "error": "Missing intermediate; no pathways to [G80848DN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80858MF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 } ], "links": [ { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80861DM", "error": "Missing intermediate; no pathways to [G80861DM] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G80943NY", "error": "Missing intermediate; no pathways to [G80943NY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80945SX", "error": "Starting point for pathway to G80945SX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80952QT", "error": "Missing intermediate; no pathways to [G80952QT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30293NE]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G80962OX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G80962OX", "source": "G66937TJ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G80966KZ", "error": "Starting point for pathway to G80966KZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G80986RU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 } ], "links": [ { "target": "G80986RU", "source": "G81432SH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81060HV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46185ND]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G46185ND", "dp": 12 }, { "id": "G81060HV", "dp": 12 } ], "links": [ { "target": "G81060HV", "source": "G46185ND", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46185ND", "source": "G53752TA", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81085EP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 } ], "links": [ { "target": "G81085EP", "source": "G87073UP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81096RM", "error": "Missing intermediate; no pathways to [G81096RM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81114MS", "error": "Missing intermediate; no pathways to [G81114MS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42731RJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81121OC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26949IX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G81121OC", "dp": 11 } ], "links": [ { "target": "G81121OC", "source": "G26949IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81128IY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G07410AW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 }, { "id": "G07410AW", "dp": 14 }, { "id": "G81128IY", "dp": 14 } ], "links": [ { "target": "G81128IY", "source": "G07410AW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07410AW", "source": "G37597FW", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81147VU", "error": "Starting point for pathway to G81147VU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81153QC", "error": "Missing intermediate; no pathways to [G81153QC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G68758PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81201TR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G71333BH", "dp": 14 } ], "links": [ { "target": "G81201TR", "source": "G71333BH", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G71333BH", "source": "G18938DW", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81230EA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62504BU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G81230EA", "dp": 10 } ], "links": [ { "target": "G81230EA", "source": "G62504BU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81247WU", "error": "Missing intermediate; no pathways to [G81247WU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84536BM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81253FL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10219AA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G81253FL", "dp": 8 } ], "links": [ { "target": "G81253FL", "source": "G10219AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81294AE", "error": "Missing intermediate; no pathways to [G81294AE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50023BR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81294ZY", "error": "Missing intermediate; no pathways to [G81294ZY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G08493GY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81295TF", "error": "Missing intermediate; no pathways to [G81295TF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81326IN", "error": "Missing intermediate; no pathways to [G81326IN] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81328FA", "error": "Missing intermediate; no pathways to [G81328FA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81333SO", "error": "Missing intermediate; no pathways to [G81333SO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G48329CR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81356NS", "error": "Starting point for pathway to G81356NS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81358TE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G45264AM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G45264AM", "dp": 10 }, { "id": "G81358TE", "dp": 10 } ], "links": [ { "target": "G81358TE", "source": "G45264AM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45264AM", "source": "G88461FF", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81362AC", "error": "Starting point for pathway to G81362AC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81380NE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G39018CC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 }, { "id": "G39018CC", "dp": 15 }, { "id": "G81380NE", "dp": 15 } ], "links": [ { "target": "G81380NE", "source": "G39018CC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39018CC", "source": "G25505UF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81386GM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85213FQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G85213FQ", "dp": 7 }, { "id": "G81386GM", "dp": 7 } ], "links": [ { "target": "G81386GM", "source": "G85213FQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85213FQ", "source": "G61751GZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G81389EF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G81389EF", "source": "G46638GC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81392TU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 } ], "links": [ { "target": "G81392TU", "source": "G85085MS", "residue_affected": { "residue_id": "N246", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81397LO", "error": "Starting point for pathway to G81397LO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81422ZI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G11637WL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G81422ZI", "dp": 10 } ], "links": [ { "target": "G81422ZI", "source": "G11637WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81430ON", "error": "Starting point for pathway to G81430ON could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81432SH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 } ], "links": [ { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81436EU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G30159WR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G81436EU", "dp": 9 } ], "links": [ { "target": "G81436EU", "source": "G30159WR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81473LO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 } ], "links": [ { "target": "G81473LO", "source": "G01856RL", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81505ER", "error": "Starting point for pathway to G81505ER could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81528UX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 } ], "links": [ { "target": "G81528UX", "source": "G89993FE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81536GE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 }, { "id": "G19124KK", "dp": 12 } ], "links": [ { "target": "G81536GE", "source": "G19124KK", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19124KK", "source": "G84467IZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81554CS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08577ZR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G81554CS", "dp": 10 } ], "links": [ { "target": "G81554CS", "source": "G08577ZR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81561UL", "error": "Missing intermediate; no pathways to [G81561UL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80085KS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81575FZ", "error": "Missing intermediate; no pathways to [G81575FZ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G13322RS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81591DR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99533GU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 }, { "id": "G99533GU", "dp": 18 }, { "id": "G81591DR", "dp": 18 } ], "links": [ { "target": "G81591DR", "source": "G99533GU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99533GU", "source": "G28106CM", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81601EB", "error": "Missing intermediate; no pathways to [G81601EB] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G76554SR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81604KV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G02582JY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G30901GC", "dp": 9 }, { "id": "G02582JY", "dp": 10 }, { "id": "G81604KV", "dp": 10 } ], "links": [ { "target": "G81604KV", "source": "G02582JY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02582JY", "source": "G30901GC", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81617NU", "error": "Missing intermediate; no pathways to [G81617NU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23419AQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81654JV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93500PH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G81654JV", "dp": 9 } ], "links": [ { "target": "G81654JV", "source": "G93500PH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81663ZI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 } ], "links": [ { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81699VA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G49743VF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G49743VF", "dp": 11 }, { "id": "G81699VA", "dp": 11 } ], "links": [ { "target": "G81699VA", "source": "G49743VF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49743VF", "source": "G06216UH", "residue_affected": { "residue_id": "N470", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81711SM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86753CK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G86753CK", "dp": 17 }, { "id": "G81711SM", "dp": 17 } ], "links": [ { "target": "G81711SM", "source": "G86753CK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81713YZ", "error": "Starting point for pathway to G81713YZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81738MQ", "error": "Missing intermediate; no pathways to [G81738MQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81773XZ", "error": "Missing intermediate; no pathways to [G81773XZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81796XK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05151WT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G05151WT", "dp": 12 }, { "id": "G81796XK", "dp": 12 } ], "links": [ { "target": "G81796XK", "source": "G05151WT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05151WT", "source": "G59877NF", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81819VG", "error": "Missing intermediate; no pathways to [G81819VG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40096SL]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G81852HN", "error": "Missing intermediate; no pathways to [G81852HN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81873QA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11034PZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G81873QA", "dp": 12 } ], "links": [ { "target": "G81873QA", "source": "G11034PZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81874XM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16529MG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G16529MG", "dp": 14 }, { "id": "G81874XM", "dp": 14 } ], "links": [ { "target": "G81874XM", "source": "G16529MG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16529MG", "source": "G56549DH", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81896KF", "error": "Missing intermediate; no pathways to [G81896KF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00797ZX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G81906GK", "error": "Starting point for pathway to G81906GK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81912AC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G70708LW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G70708LW", "dp": 12 }, { "id": "G81912AC", "dp": 12 } ], "links": [ { "target": "G81912AC", "source": "G70708LW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G70708LW", "source": "G74675FC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81915YU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G24413UY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G24413UY", "dp": 11 }, { "id": "G81915YU", "dp": 11 } ], "links": [ { "target": "G81915YU", "source": "G24413UY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G24413UY", "source": "G78890OB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81923ER", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 } ], "links": [ { "target": "G81923ER", "source": "G16523AO", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81929UP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76345AA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G76345AA", "dp": 9 }, { "id": "G81929UP", "dp": 9 } ], "links": [ { "target": "G81929UP", "source": "G76345AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76345AA", "source": "G12398HZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81933FO", "error": "Starting point for pathway to G81933FO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G81960EK", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G14996IQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14996IQ", "dp": 8 }, { "id": "G81960EK", "dp": 8 } ], "links": [ { "target": "G81960EK", "source": "G14996IQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14996IQ", "source": "G69411IG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G81980VO", "error": "Starting point for pathway to G81980VO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82011YF", "error": "Missing intermediate; no pathways to [G82011YF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82033VN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 } ], "links": [ { "target": "G82033VN", "source": "G20926BB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82036CW", "error": "Missing intermediate; no pathways to [G82036CW] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82050MN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 } ], "links": [ { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82052RE", "error": "Missing intermediate; no pathways to [G82052RE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10385EY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82057XC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69982RY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G69982RY", "dp": 11 }, { "id": "G82057XC", "dp": 11 } ], "links": [ { "target": "G82057XC", "source": "G69982RY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69982RY", "source": "G45560HM", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82081LV", "error": "Starting point for pathway to G82081LV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82107QK", "error": "Starting point for pathway to G82107QK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82126PQ", "error": "Missing intermediate; no pathways to [G82126PQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82127HP", "error": "Starting point for pathway to G82127HP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82130LG", "error": "Starting point for pathway to G82130LG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82140BL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G08709JB", "dp": 13 } ], "links": [ { "target": "G82140BL", "source": "G08709JB", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08709JB", "source": "G45359RY", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82168GG", "error": "Missing intermediate; no pathways to [G82168GG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82169SQ", "error": "Starting point for pathway to G82169SQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82188BV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G62880PC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G62880PC", "dp": 9 }, { "id": "G82188BV", "dp": 9 } ], "links": [ { "target": "G82188BV", "source": "G62880PC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62880PC", "source": "G59471TH", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82195FD", "error": "Missing intermediate; no pathways to [G82195FD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10540LB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82201IZ", "error": "Missing intermediate; no pathways to [G82201IZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40027VO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82207VX", "error": "Starting point for pathway to G82207VX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82221BU", "error": "Missing intermediate; no pathways to [G82221BU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82227EQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G26756VT", "dp": 11 }, { "id": "G14617QG", "dp": 12 } ], "links": [ { "target": "G82227EQ", "source": "G14617QG", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G14617QG", "source": "G26756VT", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26756VT", "source": "G08863NS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82233UN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20966TZ]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G82233UN", "dp": 9 } ], "links": [ { "target": "G82233UN", "source": "G20966TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82234HV", "error": "Missing intermediate; no pathways to [G82234HV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G82234NO", "error": "Missing intermediate; no pathways to [G82234NO] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82252QI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 } ], "links": [ { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82258GN", "error": "Missing intermediate; no pathways to [G82258GN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11671GQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82261XI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G86928UZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 }, { "id": "G86928UZ", "dp": 11 }, { "id": "G82261XI", "dp": 11 } ], "links": [ { "target": "G82261XI", "source": "G86928UZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86928UZ", "source": "G85767HW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82265ZR", "error": "Starting point for pathway to G82265ZR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82312JY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 } ], "links": [ { "target": "G82312JY", "source": "G80858MF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82320NZ", "error": "Missing intermediate; no pathways to [G82320NZ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82333QI", "error": "Starting point for pathway to G82333QI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82348BZ", "error": "Starting point for pathway to G82348BZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82350PP", "error": "Starting point for pathway to G82350PP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82357WL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 } ], "links": [ { "target": "G82357WL", "source": "G28826SH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82393PY", "error": "Starting point for pathway to G82393PY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82405LP", "error": "Starting point for pathway to G82405LP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82410AF", "error": "Missing intermediate; no pathways to [G82410AF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82420SH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 } ], "links": [ { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82458BB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96063MG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G82458BB", "dp": 9 } ], "links": [ { "target": "G82458BB", "source": "G96063MG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82459SD", "error": "Starting point for pathway to G82459SD could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82487CR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 } ], "links": [ { "target": "G82487CR", "source": "G08194HH", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82503FV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71857KQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G71857KQ", "dp": 10 }, { "id": "G82503FV", "dp": 10 } ], "links": [ { "target": "G82503FV", "source": "G71857KQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71857KQ", "source": "G29434RB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82529OA", "error": "Starting point for pathway to G82529OA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82540VC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G82540VC", "source": "G39213VZ", "residue_affected": { "residue_id": "N250", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82572FN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98862GW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G98862GW", "dp": 13 }, { "id": "G82572FN", "dp": 13 } ], "links": [ { "target": "G82572FN", "source": "G98862GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98862GW", "source": "G75049FP", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82579AX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G45209NR", "dp": 15 } ], "links": [ { "target": "G82579AX", "source": "G45209NR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45209NR", "source": "G91905FJ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82639GQ", "error": "Missing intermediate; no pathways to [G82639GQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82659LR", "error": "Missing intermediate; no pathways to [G82659LR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82664ZC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03445UI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G82664ZC", "dp": 10 } ], "links": [ { "target": "G82664ZC", "source": "G03445UI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82680EC", "error": "Starting point for pathway to G82680EC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82687NY", "error": "Missing intermediate; no pathways to [G82687NY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82699NN", "error": "Missing intermediate; no pathways to [G82699NN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82719GT", "error": "Starting point for pathway to G82719GT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82724NW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G49515VE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G82724NW", "dp": 12 } ], "links": [ { "target": "G82724NW", "source": "G49515VE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82728DG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 } ], "links": [ { "target": "G82728DG", "source": "G06131VP", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82730QA", "error": "Missing intermediate; no pathways to [G82730QA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89865CB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82761BO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07699XI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 }, { "id": "G07699XI", "dp": 11 }, { "id": "G82761BO", "dp": 11 } ], "links": [ { "target": "G82761BO", "source": "G07699XI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07699XI", "source": "G78155FK", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82773SI", "error": "Missing intermediate; no pathways to [G82773SI] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G31991IV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82779CI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 } ], "links": [ { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82782PE", "error": "Starting point for pathway to G82782PE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82801WV", "error": "Missing intermediate; no pathways to [G82801WV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84163ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82811EP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 } ], "links": [ { "target": "G82811EP", "source": "G84376FR", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82829MF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90223GH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G90223GH", "dp": 9 }, { "id": "G82829MF", "dp": 9 } ], "links": [ { "target": "G82829MF", "source": "G90223GH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90223GH", "source": "G29011JC", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82841UV", "error": "Missing intermediate; no pathways to [G82841UV] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G67549HD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82845MH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14782PJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G82845MH", "dp": 15 } ], "links": [ { "target": "G82845MH", "source": "G14782PJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82847HG", "error": "Missing intermediate; no pathways to [G82847HG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82853YO", "error": "Missing intermediate; no pathways to [G82853YO] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82861UH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 } ], "links": [ { "target": "G82861UH", "source": "G59471TH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82864KM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17155VX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G82864KM", "dp": 16 } ], "links": [ { "target": "G82864KM", "source": "G17155VX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82868SO", "error": "Starting point for pathway to G82868SO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82894XV", "error": "Missing intermediate; no pathways to [G82894XV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82907NZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72821WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G72821WX", "dp": 9 }, { "id": "G82907NZ", "dp": 9 } ], "links": [ { "target": "G82907NZ", "source": "G72821WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82917RE", "error": "Starting point for pathway to G82917RE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G82942MD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G27802LV", "dp": 10 }, { "id": "G24700EX", "dp": 11 } ], "links": [ { "target": "G82942MD", "source": "G24700EX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24700EX", "source": "G27802LV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27802LV", "source": "G36191CD", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82942ZJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G82942ZJ", "source": "G08520NM", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82954PR", "error": "Missing intermediate; no pathways to [G82954PR] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G82955EQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 } ], "links": [ { "target": "G82955EQ", "source": "G87073UP", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G82959GZ", "error": "Starting point for pathway to G82959GZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83003BM", "error": "Missing intermediate; no pathways to [G83003BM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83006TR", "error": "Starting point for pathway to G83006TR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83022ZQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46185ND]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G46185ND", "dp": 12 }, { "id": "G83022ZQ", "dp": 12 } ], "links": [ { "target": "G83022ZQ", "source": "G46185ND", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46185ND", "source": "G53752TA", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83041DU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41981MA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G41981MA", "dp": 15 }, { "id": "G83041DU", "dp": 15 } ], "links": [ { "target": "G83041DU", "source": "G41981MA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41981MA", "source": "G38022PE", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83062JW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09482NW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G83062JW", "dp": 9 } ], "links": [ { "target": "G83062JW", "source": "G09482NW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83101KA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G90564EX", "dp": 11 }, { "id": "G08949VK", "dp": 12 }, { "id": "G12450CJ", "dp": 13 }, { "id": "G65079ZY", "dp": 14 } ], "links": [ { "target": "G83101KA", "source": "G65079ZY", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65079ZY", "source": "G12450CJ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12450CJ", "source": "G08949VK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08949VK", "source": "G90564EX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90564EX", "source": "G28826SH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83106XM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39018CC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G25505UF", "dp": 14 }, { "id": "G39018CC", "dp": 15 }, { "id": "G83106XM", "dp": 15 } ], "links": [ { "target": "G83106XM", "source": "G39018CC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39018CC", "source": "G25505UF", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25505UF", "source": "G20926BB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83131MU", "error": "Starting point for pathway to G83131MU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83161QT", "error": "Starting point for pathway to G83161QT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83216FM", "error": "Missing intermediate; no pathways to [G83216FM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83269PQ", "error": "Missing intermediate; no pathways to [G83269PQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G21459ST]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83312UD", "error": "Starting point for pathway to G83312UD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83393GK", "error": "Missing intermediate; no pathways to [G83393GK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53962WT]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G83401TR", "error": "Missing intermediate; no pathways to [G83401TR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47007PV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83402YY", "error": "Missing intermediate; no pathways to [G83402YY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83417GO", "error": "Starting point for pathway to G83417GO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83423JP", "error": "Missing intermediate; no pathways to [G83423JP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54590FS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83425EJ", "error": "Missing intermediate; no pathways to [G83425EJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G64789SR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83433HW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G95898GD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 }, { "id": "G83433HW", "dp": 13 } ], "links": [ { "target": "G83433HW", "source": "G95898GD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83442GS", "error": "Missing intermediate; no pathways to [G83442GS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34508UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83455QZ", "error": "Missing intermediate; no pathways to [G83455QZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G51562OR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83458ED", "error": "Missing intermediate; no pathways to [G83458ED] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83465VL", "error": "Missing intermediate; no pathways to [G83465VL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09576QH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83469RK", "error": "Missing intermediate; no pathways to [G83469RK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83490LO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46638GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G83490LO", "dp": 9 } ], "links": [ { "target": "G83490LO", "source": "G46638GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83492DO", "error": "Missing intermediate; no pathways to [G83492DO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83499UD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G74574VX", "dp": 11 } ], "links": [ { "target": "G83499UD", "source": "G74574VX", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83508KY", "error": "Missing intermediate; no pathways to [G83508KY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83534FD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G31604HF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G31604HF", "dp": 8 }, { "id": "G83534FD", "dp": 8 } ], "links": [ { "target": "G83534FD", "source": "G31604HF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31604HF", "source": "G07483YN", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83540SE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40554DX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G40554DX", "dp": 14 }, { "id": "G83540SE", "dp": 14 } ], "links": [ { "target": "G83540SE", "source": "G40554DX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40554DX", "source": "G75120WS", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83541HL", "error": "Missing intermediate; no pathways to [G83541HL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83582BK", "error": "Starting point for pathway to G83582BK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83588YY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 } ], "links": [ { "target": "G83588YY", "source": "G11953VE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83594ZB", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G11929CD", "dp": 10 }, { "id": "G26795PW", "dp": 11 } ], "links": [ { "target": "G83594ZB", "source": "G26795PW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26795PW", "source": "G11929CD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11929CD", "source": "G09782JM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83600PQ", "error": "Starting point for pathway to G83600PQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83612SF", "error": "Missing intermediate; no pathways to [G83612SF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94876HV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83619SL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82140BL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G08709JB", "dp": 13 }, { "id": "G82140BL", "dp": 14 }, { "id": "G83619SL", "dp": 14 } ], "links": [ { "target": "G83619SL", "source": "G82140BL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82140BL", "source": "G08709JB", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08709JB", "source": "G45359RY", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83635VI", "error": "Missing intermediate; no pathways to [G83635VI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83642WS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30901GC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G79348ZY", "dp": 8 }, { "id": "G30901GC", "dp": 9 }, { "id": "G83642WS", "dp": 9 } ], "links": [ { "target": "G83642WS", "source": "G30901GC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30901GC", "source": "G79348ZY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79348ZY", "source": "G10182XZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83643YY", "error": "Missing intermediate; no pathways to [G83643YY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G64789SR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83644CC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76136FD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G86102AA", "dp": 11 }, { "id": "G76136FD", "dp": 12 }, { "id": "G83644CC", "dp": 12 } ], "links": [ { "target": "G83644CC", "source": "G76136FD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76136FD", "source": "G86102AA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86102AA", "source": "G85542KD", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83651JX", "error": "Missing intermediate; no pathways to [G83651JX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83662TS", "error": "Missing intermediate; no pathways to [G83662TS] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G62326NX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83666RE", "error": "Starting point for pathway to G83666RE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83682YJ", "error": "Missing intermediate; no pathways to [G83682YJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83689NL", "error": "Missing intermediate; no pathways to [G83689NL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83697UR", "error": "Missing intermediate; no pathways to [G83697UR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83717YJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 } ], "links": [ { "target": "G83717YJ", "source": "G10219AA", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83737UD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86357DX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G83737UD", "dp": 12 } ], "links": [ { "target": "G83737UD", "source": "G86357DX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83738AG", "error": "Missing intermediate; no pathways to [G83738AG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83768CW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19444JC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G19444JC", "dp": 15 }, { "id": "G83768CW", "dp": 15 } ], "links": [ { "target": "G83768CW", "source": "G19444JC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19444JC", "source": "G45720CA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83829LQ", "error": "Missing intermediate; no pathways to [G83829LQ] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G83845ZV", "error": "Missing intermediate; no pathways to [G83845ZV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83864PP", "error": "Missing intermediate; no pathways to [G83864PP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G07262RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83875GK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53985AY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G53985AY", "dp": 11 }, { "id": "G83875GK", "dp": 11 } ], "links": [ { "target": "G83875GK", "source": "G53985AY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53985AY", "source": "G78890OB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83895FM", "error": "Missing intermediate; no pathways to [G83895FM] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G83541HL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83905AA", "error": "Starting point for pathway to G83905AA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83920CD", "error": "Missing intermediate; no pathways to [G83920CD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17140UR]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G83926PC", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G41611UP", "dp": 13 }, { "id": "G01354KL", "dp": 14 } ], "links": [ { "target": "G83926PC", "source": "G01354KL", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01354KL", "source": "G41611UP", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41611UP", "source": "G86357DX", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G83945MQ", "error": "Missing intermediate; no pathways to [G83945MQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G83948CA", "error": "Starting point for pathway to G83948CA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83957LU", "error": "Starting point for pathway to G83957LU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83958MI", "error": "Starting point for pathway to G83958MI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G83992YN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 }, { "id": "G66961CH", "dp": 15 } ], "links": [ { "target": "G83992YN", "source": "G66961CH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84033EZ", "error": "Missing intermediate; no pathways to [G84033EZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G34483UH]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G84041GN", "error": "Missing intermediate; no pathways to [G84041GN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36787EI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84052CD", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53812BX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G84052CD", "dp": 13 } ], "links": [ { "target": "G84052CD", "source": "G53812BX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84053BQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G80858MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G84053BQ", "dp": 8 } ], "links": [ { "target": "G84053BQ", "source": "G80858MF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84064AY", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G84064AY", "source": "G08520NM", "residue_affected": { "residue_id": "N365", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G84068IS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65796FM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G12061IK", "dp": 11 }, { "id": "G79344MI", "dp": 12 }, { "id": "G65796FM", "dp": 13 }, { "id": "G84068IS", "dp": 13 } ], "links": [ { "target": "G84068IS", "source": "G65796FM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65796FM", "source": "G79344MI", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79344MI", "source": "G12061IK", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12061IK", "source": "G00176HZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84072VB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17857ZF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G49515VE", "dp": 12 }, { "id": "G57970NA", "dp": 13 }, { "id": "G17857ZF", "dp": 14 }, { "id": "G84072VB", "dp": 14 } ], "links": [ { "target": "G84072VB", "source": "G17857ZF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17857ZF", "source": "G57970NA", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57970NA", "source": "G49515VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49515VE", "source": "G29857RC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84108IZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G65307KA", "dp": 12 } ], "links": [ { "target": "G84108IZ", "source": "G65307KA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65307KA", "source": "G10691MJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84145LH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42686NQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G42686NQ", "dp": 14 }, { "id": "G84145LH", "dp": 14 } ], "links": [ { "target": "G84145LH", "source": "G42686NQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42686NQ", "source": "G19726AG", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84148GL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07995VK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G84148GL", "dp": 10 } ], "links": [ { "target": "G84148GL", "source": "G07995VK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84153KU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G37597FW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 }, { "id": "G84153KU", "dp": 13 } ], "links": [ { "target": "G84153KU", "source": "G37597FW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84163ZT", "error": "Missing intermediate; no pathways to [G84163ZT] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84167AV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G44152CO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G66866LE", "dp": 10 }, { "id": "G44152CO", "dp": 11 }, { "id": "G84167AV", "dp": 11 } ], "links": [ { "target": "G84167AV", "source": "G44152CO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44152CO", "source": "G66866LE", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66866LE", "source": "G96063MG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84170WO", "error": "Starting point for pathway to G84170WO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G84186YN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96674LJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G96674LJ", "dp": 18 }, { "id": "G84186YN", "dp": 18 } ], "links": [ { "target": "G84186YN", "source": "G96674LJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96674LJ", "source": "G50489VC", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84223RT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62765SF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G62765SF", "dp": 14 }, { "id": "G84223RT", "dp": 14 } ], "links": [ { "target": "G84223RT", "source": "G62765SF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62765SF", "source": "G04989WY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84228AV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26756VT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G26756VT", "dp": 11 }, { "id": "G84228AV", "dp": 11 } ], "links": [ { "target": "G84228AV", "source": "G26756VT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26756VT", "source": "G08863NS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84260SO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74574VX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G74574VX", "dp": 11 }, { "id": "G84260SO", "dp": 11 } ], "links": [ { "target": "G84260SO", "source": "G74574VX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84287MH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G25835MT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G84287MH", "dp": 10 } ], "links": [ { "target": "G84287MH", "source": "G25835MT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84301XG", "error": "Missing intermediate; no pathways to [G84301XG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G51562OR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84316BO", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G49827WK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G49827WK", "dp": 11 }, { "id": "G84316BO", "dp": 11 } ], "links": [ { "target": "G84316BO", "source": "G49827WK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G49827WK", "source": "G09446VC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84329MX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10258MC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G10258MC", "dp": 11 }, { "id": "G84329MX", "dp": 11 } ], "links": [ { "target": "G84329MX", "source": "G10258MC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10258MC", "source": "G25835MT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84330VA", "error": "Missing intermediate; no pathways to [G84330VA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84347HP", "error": "Missing intermediate; no pathways to [G84347HP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84362IY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82312JY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G82312JY", "dp": 9 }, { "id": "G84362IY", "dp": 9 } ], "links": [ { "target": "G84362IY", "source": "G82312JY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82312JY", "source": "G80858MF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84363RQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 } ], "links": [ { "target": "G84363RQ", "source": "G07995VK", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84365LE", "error": "Missing intermediate; no pathways to [G84365LE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84368MT", "error": "Missing intermediate; no pathways to [G84368MT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84374OK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10182XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G84374OK", "dp": 7 } ], "links": [ { "target": "G84374OK", "source": "G10182XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84376FR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84377QA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79198BK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G79198BK", "dp": 9 }, { "id": "G84377QA", "dp": 9 } ], "links": [ { "target": "G84377QA", "source": "G79198BK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79198BK", "source": "G10219AA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84386LM", "error": "Starting point for pathway to G84386LM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G84390MS", "error": "Missing intermediate; no pathways to [G84390MS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84396LL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G68937TM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G84396LL", "dp": 10 } ], "links": [ { "target": "G84396LL", "source": "G68937TM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84410MY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 } ], "links": [ { "target": "G84410MY", "source": "G91413ZX", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84423SZ", "error": "Missing intermediate; no pathways to [G84423SZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93464IM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G84440YT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G52934AK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G84440YT", "dp": 10 } ], "links": [ { "target": "G84440YT", "source": "G52934AK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84441GS", "error": "Missing intermediate; no pathways to [G84441GS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84456HG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G71013KY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G84456HG", "dp": 10 } ], "links": [ { "target": "G84456HG", "source": "G71013KY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84467IZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 } ], "links": [ { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84495HF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88461FF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G84495HF", "dp": 9 } ], "links": [ { "target": "G84495HF", "source": "G88461FF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84504LI", "error": "Missing intermediate; no pathways to [G84504LI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95658PH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84517ZY", "error": "Starting point for pathway to G84517ZY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G84523VQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 } ], "links": [ { "target": "G84523VQ", "source": "G06969ZX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84536BM", "error": "Missing intermediate; no pathways to [G84536BM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84542XB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43255OW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G48954CA", "dp": 9 }, { "id": "G43255OW", "dp": 10 }, { "id": "G84542XB", "dp": 10 } ], "links": [ { "target": "G84542XB", "source": "G43255OW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43255OW", "source": "G48954CA", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G48954CA", "source": "G12398HZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84543LI", "error": "Missing intermediate; no pathways to [G84543LI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82894XV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84558OA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99074EO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 }, { "id": "G84558OA", "dp": 13 } ], "links": [ { "target": "G84558OA", "source": "G99074EO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84560PS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 } ], "links": [ { "target": "G84560PS", "source": "G63889NK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84573GL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G14767DF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G14767DF", "dp": 8 }, { "id": "G84573GL", "dp": 8 } ], "links": [ { "target": "G84573GL", "source": "G14767DF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14767DF", "source": "G69411IG", "residue_affected": { "residue_id": "N205", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84648AY", "error": "Starting point for pathway to G84648AY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G84656AH", "error": "Starting point for pathway to G84656AH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G84674JQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G54611ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 }, { "id": "G84674JQ", "dp": 11 } ], "links": [ { "target": "G84674JQ", "source": "G54611ZT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84678BK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39213VZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G84678BK", "dp": 7 } ], "links": [ { "target": "G84678BK", "source": "G39213VZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84680HD", "error": "Missing intermediate; no pathways to [G84680HD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84692YW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27776PG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G27776PG", "dp": 9 }, { "id": "G84692YW", "dp": 9 } ], "links": [ { "target": "G84692YW", "source": "G27776PG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G27776PG", "source": "G20956ZK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84709FG", "error": "Missing intermediate; no pathways to [G84709FG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84712FF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G84712FF", "source": "G29857RC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84712FX", "error": "Missing intermediate; no pathways to [G84712FX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41596PV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84718MC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G44202NB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G72821WX", "dp": 9 }, { "id": "G44202NB", "dp": 10 }, { "id": "G84718MC", "dp": 10 } ], "links": [ { "target": "G84718MC", "source": "G44202NB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44202NB", "source": "G72821WX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84749RM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11509RN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G11509RN", "dp": 12 }, { "id": "G84749RM", "dp": 12 } ], "links": [ { "target": "G84749RM", "source": "G11509RN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11509RN", "source": "G30302VM", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84753IL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G29797YX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G89181JW", "dp": 11 }, { "id": "G29797YX", "dp": 12 }, { "id": "G84753IL", "dp": 12 } ], "links": [ { "target": "G84753IL", "source": "G29797YX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29797YX", "source": "G89181JW", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89181JW", "source": "G03445UI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84764CL", "error": "Starting point for pathway to G84764CL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G84775PY", "error": "Missing intermediate; no pathways to [G84775PY] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84776VF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 } ], "links": [ { "target": "G84776VF", "source": "G99270AV", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84777MO", "error": "Missing intermediate; no pathways to [G84777MO] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84778XH", "error": "Missing intermediate; no pathways to [G84778XH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84783MC", "error": "Missing intermediate; no pathways to [G84783MC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50364FV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84783XD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G44623TX", "dp": 12 } ], "links": [ { "target": "G84783XD", "source": "G44623TX", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44623TX", "source": "G79809MM", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84800HV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G61707PW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G74928QN", "dp": 14 }, { "id": "G61707PW", "dp": 15 }, { "id": "G84800HV", "dp": 15 } ], "links": [ { "target": "G84800HV", "source": "G61707PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61707PW", "source": "G74928QN", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74928QN", "source": "G29449JO", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84852GW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G84852GW", "source": "G12398HZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84874EV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 } ], "links": [ { "target": "G84874EV", "source": "G99270AV", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84879CH", "error": "Missing intermediate; no pathways to [G84879CH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84881ST", "error": "Starting point for pathway to G84881ST could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G84887KU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G31604HF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G31604HF", "dp": 8 }, { "id": "G84887KU", "dp": 8 } ], "links": [ { "target": "G84887KU", "source": "G31604HF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31604HF", "source": "G07483YN", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84901UD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G01378OV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G71835BN", "dp": 10 }, { "id": "G01378OV", "dp": 11 }, { "id": "G84901UD", "dp": 11 } ], "links": [ { "target": "G84901UD", "source": "G01378OV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01378OV", "source": "G71835BN", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84908OR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85116XO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G36701GV", "dp": 12 }, { "id": "G85116XO", "dp": 13 }, { "id": "G84908OR", "dp": 13 } ], "links": [ { "target": "G84908OR", "source": "G85116XO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85116XO", "source": "G36701GV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36701GV", "source": "G53752TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84942UA", "error": "Missing intermediate; no pathways to [G84942UA] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84959GE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47108UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G47108UC", "dp": 9 }, { "id": "G84959GE", "dp": 9 } ], "links": [ { "target": "G84959GE", "source": "G47108UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47108UC", "source": "G80858MF", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84964KJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G84964KJ", "source": "G29857RC", "residue_affected": { "residue_id": "N130", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G84975AL", "error": "Missing intermediate; no pathways to [G84975AL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G00514XC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G84975VY", "error": "Starting point for pathway to G84975VY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85041WE", "error": "Starting point for pathway to G85041WE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85046IS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G06969ZX", "dp": 10 } ], "links": [ { "target": "G85046IS", "source": "G06969ZX", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06969ZX", "source": "G46638GC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85059ID", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66129DI]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G03275SD", "dp": 10 }, { "id": "G66129DI", "dp": 11 }, { "id": "G85059ID", "dp": 11 } ], "links": [ { "target": "G85059ID", "source": "G66129DI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66129DI", "source": "G03275SD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03275SD", "source": "G16828VN", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85085MS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 } ], "links": [ { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85093QP", "error": "Missing intermediate; no pathways to [G85093QP] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85100QD", "error": "Starting point for pathway to G85100QD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85101OA", "error": "Missing intermediate; no pathways to [G85101OA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G97453GF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85106DS", "error": "Missing intermediate; no pathways to [G85106DS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85115PB", "error": "Missing intermediate; no pathways to [G85115PB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89285HT]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85116XO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G36701GV", "dp": 12 } ], "links": [ { "target": "G85116XO", "source": "G36701GV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36701GV", "source": "G53752TA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85121UD", "error": "Missing intermediate; no pathways to [G85121UD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G35599NO]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G85141ZP", "error": "Starting point for pathway to G85141ZP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85159UF", "error": "Missing intermediate; no pathways to [G85159UF] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85180ML", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 } ], "links": [ { "target": "G85180ML", "source": "G96063MG", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85200FA", "error": "Starting point for pathway to G85200FA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85208SY", "error": "Missing intermediate; no pathways to [G85208SY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85213FQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G85213FQ", "source": "G61751GZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G85226CQ", "error": "Missing intermediate; no pathways to [G85226CQ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G61203OK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85238RP", "error": "Starting point for pathway to G85238RP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85250EQ", "error": "Missing intermediate; no pathways to [G85250EQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85260RY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 } ], "links": [ { "target": "G85260RY", "source": "G57955DP", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85291WT", "error": "Starting point for pathway to G85291WT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85300QB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13156PQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G13156PQ", "dp": 12 }, { "id": "G85300QB", "dp": 12 } ], "links": [ { "target": "G85300QB", "source": "G13156PQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G13156PQ", "source": "G53752TA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85304RG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G75412QZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G75412QZ", "dp": 14 }, { "id": "G85304RG", "dp": 14 } ], "links": [ { "target": "G85304RG", "source": "G75412QZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75412QZ", "source": "G18938DW", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85317AM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G43677TG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G85317AM", "dp": 8 } ], "links": [ { "target": "G85317AM", "source": "G43677TG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85319UV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G80661IW", "dp": 10 } ], "links": [ { "target": "G85319UV", "source": "G80661IW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80661IW", "source": "G46638GC", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85324DR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46425HN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G45720CA", "dp": 14 }, { "id": "G46425HN", "dp": 15 }, { "id": "G85324DR", "dp": 15 } ], "links": [ { "target": "G85324DR", "source": "G46425HN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46425HN", "source": "G45720CA", "residue_affected": { "residue_id": "N39", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45720CA", "source": "G19726AG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85422ZY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75049FP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G85422ZY", "dp": 12 } ], "links": [ { "target": "G85422ZY", "source": "G75049FP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85439GN", "error": "Starting point for pathway to G85439GN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85440DN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G60439QY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 }, { "id": "G99891PR", "dp": 16 }, { "id": "G60439QY", "dp": 17 }, { "id": "G85440DN", "dp": 17 } ], "links": [ { "target": "G85440DN", "source": "G60439QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60439QY", "source": "G99891PR", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85458AY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G91337ZP", "dp": 10 }, { "id": "G77384FE", "dp": 11 } ], "links": [ { "target": "G85458AY", "source": "G77384FE", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77384FE", "source": "G91337ZP", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91337ZP", "source": "G58667NI", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85460ZG", "error": "Starting point for pathway to G85460ZG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85471HV", "error": "Missing intermediate; no pathways to [G85471HV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85530IT", "error": "Missing intermediate; no pathways to [G85530IT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32977ZV]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G85542KD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 } ], "links": [ { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85545IG", "error": "Missing intermediate; no pathways to [G85545IG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03260OU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85599NG", "error": "Starting point for pathway to G85599NG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85620PG", "error": "Missing intermediate; no pathways to [G85620PG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99370TQ]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G85623YE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71470CO]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G71470CO", "dp": 9 }, { "id": "G85623YE", "dp": 9 } ], "links": [ { "target": "G85623YE", "source": "G71470CO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71470CO", "source": "G08520NM", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85624MU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86095OE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 }, { "id": "G86095OE", "dp": 17 }, { "id": "G85624MU", "dp": 17 } ], "links": [ { "target": "G85624MU", "source": "G86095OE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86095OE", "source": "G75237SS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85628JQ", "error": "Missing intermediate; no pathways to [G85628JQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85650LS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 } ], "links": [ { "target": "G85650LS", "source": "G28826SH", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85652EW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36157OV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G36157OV", "dp": 11 }, { "id": "G85652EW", "dp": 11 } ], "links": [ { "target": "G85652EW", "source": "G36157OV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36157OV", "source": "G91365ZQ", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85652RK", "error": "Missing intermediate; no pathways to [G85652RK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30627OI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85657EG", "error": "Missing intermediate; no pathways to [G85657EG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07262RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85750HN", "error": "Missing intermediate; no pathways to [G85750HN] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G74238CC]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85755BV", "error": "Missing intermediate; no pathways to [G85755BV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G68080UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85767HW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 } ], "links": [ { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85768QF", "error": "Missing intermediate; no pathways to [G85768QF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85785GS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76528ZS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G76528ZS", "dp": 11 }, { "id": "G85785GS", "dp": 11 } ], "links": [ { "target": "G85785GS", "source": "G76528ZS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85790MP", "error": "Starting point for pathway to G85790MP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85795PL", "error": "Missing intermediate; no pathways to [G85795PL] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G85843WY", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G66937TJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G85843WY", "dp": 8 } ], "links": [ { "target": "G85843WY", "source": "G66937TJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85878DB", "error": "Missing intermediate; no pathways to [G85878DB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G85885QD", "error": "Starting point for pathway to G85885QD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85891FA", "error": "Missing intermediate; no pathways to [G85891FA] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G85895SP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G85895SP", "source": "G61751GZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G85900AY", "error": "Starting point for pathway to G85900AY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G85953MG", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25731WL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G95113MM", "dp": 14 }, { "id": "G66961CH", "dp": 15 }, { "id": "G83992YN", "dp": 16 }, { "id": "G25731WL", "dp": 17 }, { "id": "G85953MG", "dp": 17 } ], "links": [ { "target": "G85953MG", "source": "G25731WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25731WL", "source": "G83992YN", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83992YN", "source": "G66961CH", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66961CH", "source": "G95113MM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85974HF", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G78030KJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G78030KJ", "dp": 14 }, { "id": "G85974HF", "dp": 14 } ], "links": [ { "target": "G85974HF", "source": "G78030KJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78030KJ", "source": "G53812BX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G85992CY", "error": "Missing intermediate; no pathways to [G85992CY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95695ZV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86002PC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G86002PC", "source": "G69411IG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86005HP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 }, { "id": "G91147LL", "dp": 14 }, { "id": "G25097RR", "dp": 15 } ], "links": [ { "target": "G86005HP", "source": "G25097RR", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25097RR", "source": "G91147LL", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86018QV", "error": "Missing intermediate; no pathways to [G86018QV] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G74264KM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86030CA", "error": "Missing intermediate; no pathways to [G86030CA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95989NQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86053IC", "error": "Starting point for pathway to G86053IC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G86083QZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G04185VX", "dp": 10 }, { "id": "G30569KZ", "dp": 11 } ], "links": [ { "target": "G86083QZ", "source": "G30569KZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30569KZ", "source": "G04185VX", "residue_affected": { "residue_id": "N239", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G04185VX", "source": "G36191CD", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86095OE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G75237SS", "dp": 16 } ], "links": [ { "target": "G86095OE", "source": "G75237SS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75237SS", "source": "G28957FB", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86102AA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 } ], "links": [ { "target": "G86102AA", "source": "G85542KD", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86102WJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89993FE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 }, { "id": "G86102WJ", "dp": 8 } ], "links": [ { "target": "G86102WJ", "source": "G89993FE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86118KP", "error": "Missing intermediate; no pathways to [G86118KP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G89285HT]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86157UQ", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98559XP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G98559XP", "dp": 14 }, { "id": "G86157UQ", "dp": 14 } ], "links": [ { "target": "G86157UQ", "source": "G98559XP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98559XP", "source": "G18938DW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86188FJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G02422RD", "dp": 9 } ], "links": [ { "target": "G86188FJ", "source": "G02422RD", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02422RD", "source": "G10219AA", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86191DF", "error": "Starting point for pathway to G86191DF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G86202BL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G78503JC", "dp": 12 } ], "links": [ { "target": "G86202BL", "source": "G78503JC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78503JC", "source": "G31010RQ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86221TY", "error": "Starting point for pathway to G86221TY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G86270DU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G86270DU", "source": "G11041DA", "residue_affected": { "residue_id": "N473", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86294MW", "error": "Missing intermediate; no pathways to [G86294MW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86298IX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G60215UL", "dp": 12 } ], "links": [ { "target": "G86298IX", "source": "G60215UL", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60215UL", "source": "G47175EF", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86309VR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10182XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G86309VR", "dp": 7 } ], "links": [ { "target": "G86309VR", "source": "G10182XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86321OX", "error": "Missing intermediate; no pathways to [G86321OX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86335RZ", "error": "Missing intermediate; no pathways to [G86335RZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86347EY", "error": "Missing intermediate; no pathways to [G86347EY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53962WT]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G86357DX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 } ], "links": [ { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86377KB", "error": "Missing intermediate; no pathways to [G86377KB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90542MP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86377SM", "error": "Missing intermediate; no pathways to [G86377SM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86385RC", "error": "Starting point for pathway to G86385RC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G86386QT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G69411IG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G86386QT", "dp": 7 } ], "links": [ { "target": "G86386QT", "source": "G69411IG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86414FL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G81085EP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G81085EP", "dp": 11 }, { "id": "G86414FL", "dp": 11 } ], "links": [ { "target": "G86414FL", "source": "G81085EP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81085EP", "source": "G87073UP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86445KR", "error": "Missing intermediate; no pathways to [G86445KR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G86466QK", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G31004HS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 }, { "id": "G95404EQ", "dp": 17 }, { "id": "G31004HS", "dp": 18 }, { "id": "G86466QK", "dp": 18 } ], "links": [ { "target": "G86466QK", "source": "G31004HS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31004HS", "source": "G95404EQ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86471BL", "error": "Missing intermediate; no pathways to [G86471BL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86475BX", "error": "Missing intermediate; no pathways to [G86475BX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86487TG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G62826CL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G62826CL", "dp": 9 }, { "id": "G86487TG", "dp": 9 } ], "links": [ { "target": "G86487TG", "source": "G62826CL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G62826CL", "source": "G80858MF", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86490WA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17473NR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G17473NR", "dp": 13 }, { "id": "G86490WA", "dp": 13 } ], "links": [ { "target": "G86490WA", "source": "G17473NR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17473NR", "source": "G10733HY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86495BQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56340GX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G56340GX", "dp": 10 }, { "id": "G86495BQ", "dp": 10 } ], "links": [ { "target": "G86495BQ", "source": "G56340GX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56340GX", "source": "G27919IH", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86504RY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59361OW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G59361OW", "dp": 11 }, { "id": "G86504RY", "dp": 11 } ], "links": [ { "target": "G86504RY", "source": "G59361OW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59361OW", "source": "G44946WH", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86517XT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85767HW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 }, { "id": "G86517XT", "dp": 10 } ], "links": [ { "target": "G86517XT", "source": "G85767HW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86522OD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52934AK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G86522OD", "dp": 10 } ], "links": [ { "target": "G86522OD", "source": "G52934AK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86555OF", "error": "Missing intermediate; no pathways to [G86555OF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G86563OV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40806JH]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G40806JH", "dp": 11 }, { "id": "G86563OV", "dp": 11 } ], "links": [ { "target": "G86563OV", "source": "G40806JH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40806JH", "source": "G11637WL", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86566MF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G32699RJ", "dp": 10 } ], "links": [ { "target": "G86566MF", "source": "G32699RJ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32699RJ", "source": "G63074CQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86582QF", "error": "Starting point for pathway to G86582QF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G86598ZY", "error": "Missing intermediate; no pathways to [G86598ZY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86601RH", "error": "Starting point for pathway to G86601RH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G86606NT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16523AO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G16523AO", "dp": 9 }, { "id": "G86606NT", "dp": 9 } ], "links": [ { "target": "G86606NT", "source": "G16523AO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16523AO", "source": "G10219AA", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86646KC", "error": "Missing intermediate; no pathways to [G86646KC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86680XI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84852GW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G84852GW", "dp": 9 }, { "id": "G86680XI", "dp": 9 } ], "links": [ { "target": "G86680XI", "source": "G84852GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84852GW", "source": "G12398HZ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86681BW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G13267ZY", "dp": 10 } ], "links": [ { "target": "G86681BW", "source": "G13267ZY", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13267ZY", "source": "G46638GC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86681SC", "error": "Missing intermediate; no pathways to [G86681SC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G86681UT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G23295TF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G23295TF", "dp": 10 }, { "id": "G86681UT", "dp": 10 } ], "links": [ { "target": "G86681UT", "source": "G23295TF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23295TF", "source": "G27919IH", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86682RV", "error": "Starting point for pathway to G86682RV could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G86685MK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91303GW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G91303GW", "dp": 11 }, { "id": "G86685MK", "dp": 11 } ], "links": [ { "target": "G86685MK", "source": "G91303GW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91303GW", "source": "G45560HM", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86696LV", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 } ], "links": [ { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86704VD", "error": "Missing intermediate; no pathways to [G86704VD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86718LZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71690HK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G71690HK", "dp": 10 }, { "id": "G86718LZ", "dp": 10 } ], "links": [ { "target": "G86718LZ", "source": "G71690HK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71690HK", "source": "G61207RZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86730KO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 } ], "links": [ { "target": "G86730KO", "source": "G48658PB", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86744QF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93060PS]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G93060PS", "dp": 9 }, { "id": "G86744QF", "dp": 9 } ], "links": [ { "target": "G86744QF", "source": "G93060PS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93060PS", "source": "G08520NM", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86753CK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 } ], "links": [ { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86766IO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99770NO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G15103WJ", "dp": 12 }, { "id": "G99770NO", "dp": 13 }, { "id": "G86766IO", "dp": 13 } ], "links": [ { "target": "G86766IO", "source": "G99770NO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99770NO", "source": "G15103WJ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G15103WJ", "source": "G25520XG", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86770JF", "error": "Missing intermediate; no pathways to [G86770JF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86781KH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G74928QN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G74928QN", "dp": 14 }, { "id": "G86781KH", "dp": 14 } ], "links": [ { "target": "G86781KH", "source": "G74928QN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74928QN", "source": "G29449JO", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86782KC", "error": "Missing intermediate; no pathways to [G86782KC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26935KA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86789PZ", "error": "Missing intermediate; no pathways to [G86789PZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86870NX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74928QN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G29449JO", "dp": 13 }, { "id": "G74928QN", "dp": 14 }, { "id": "G86870NX", "dp": 14 } ], "links": [ { "target": "G86870NX", "source": "G74928QN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74928QN", "source": "G29449JO", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29449JO", "source": "G45359RY", "residue_affected": { "residue_id": "N51", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86872YM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84363RQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G84363RQ", "dp": 11 }, { "id": "G86872YM", "dp": 11 } ], "links": [ { "target": "G86872YM", "source": "G84363RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84363RQ", "source": "G07995VK", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86884BW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 } ], "links": [ { "target": "G86884BW", "source": "G69812OF", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86912FM", "error": "Missing intermediate; no pathways to [G86912FM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03473UD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86912UU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50078RT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G50078RT", "dp": 12 }, { "id": "G86912UU", "dp": 12 } ], "links": [ { "target": "G86912UU", "source": "G50078RT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50078RT", "source": "G79809MM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86928SV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 } ], "links": [ { "target": "G86928SV", "source": "G62504BU", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86928UZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 } ], "links": [ { "target": "G86928UZ", "source": "G85767HW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G86938GJ", "error": "Missing intermediate; no pathways to [G86938GJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G86952JZ", "error": "Missing intermediate; no pathways to [G86952JZ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G82036CW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87018HM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G89255EP", "dp": 13 } ], "links": [ { "target": "G87018HM", "source": "G89255EP", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G89255EP", "source": "G75049FP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87049YA", "error": "Missing intermediate; no pathways to [G87049YA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87064NW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96674LJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 }, { "id": "G96674LJ", "dp": 18 }, { "id": "G87064NW", "dp": 18 } ], "links": [ { "target": "G87064NW", "source": "G96674LJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96674LJ", "source": "G50489VC", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87073UP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87106NZ", "error": "Missing intermediate; no pathways to [G87106NZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G87107PF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G87535DG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 }, { "id": "G87535DG", "dp": 12 }, { "id": "G87107PF", "dp": 12 } ], "links": [ { "target": "G87107PF", "source": "G87535DG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G87535DG", "source": "G74675FC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87124HX", "error": "Missing intermediate; no pathways to [G87124HX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G30880RA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87134ZP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G87134ZP", "source": "G39213VZ", "residue_affected": { "residue_id": "N513", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87136DV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G52645LW", "dp": 13 } ], "links": [ { "target": "G87136DV", "source": "G52645LW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52645LW", "source": "G79578JB", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87138HL", "error": "Starting point for pathway to G87138HL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G87178PF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32704TW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G32704TW", "dp": 9 }, { "id": "G87178PF", "dp": 9 } ], "links": [ { "target": "G87178PF", "source": "G32704TW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32704TW", "source": "G12398HZ", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87192TH", "error": "Missing intermediate; no pathways to [G87192TH] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87202LK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G42097JO", "dp": 14 }, { "id": "G28846QB", "dp": 15 } ], "links": [ { "target": "G87202LK", "source": "G28846QB", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28846QB", "source": "G42097JO", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42097JO", "source": "G85085MS", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87217OF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71857KQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G71857KQ", "dp": 10 }, { "id": "G87217OF", "dp": 10 } ], "links": [ { "target": "G87217OF", "source": "G71857KQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71857KQ", "source": "G29434RB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87228KQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63889NK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G87228KQ", "dp": 14 } ], "links": [ { "target": "G87228KQ", "source": "G63889NK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87244OY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08709JB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G08709JB", "dp": 13 }, { "id": "G87244OY", "dp": 13 } ], "links": [ { "target": "G87244OY", "source": "G08709JB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08709JB", "source": "G45359RY", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87260SO", "error": "Missing intermediate; no pathways to [G87260SO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87264NH", "error": "Missing intermediate; no pathways to [G87264NH] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G53854XZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87273JO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G02311IE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G87273JO", "dp": 16 } ], "links": [ { "target": "G87273JO", "source": "G02311IE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87293AR", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G59655SA", "dp": 12 } ], "links": [ { "target": "G87293AR", "source": "G59655SA", "residue_affected": { "residue_id": "N457", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G59655SA", "source": "G53752TA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87299HQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G52934AK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G87299HQ", "dp": 10 } ], "links": [ { "target": "G87299HQ", "source": "G52934AK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87308QC", "error": "Starting point for pathway to G87308QC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G87309GS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80393PG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G87309GS", "dp": 9 } ], "links": [ { "target": "G87309GS", "source": "G80393PG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87334KQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53812BX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G87334KQ", "dp": 13 } ], "links": [ { "target": "G87334KQ", "source": "G53812BX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87349YT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 } ], "links": [ { "target": "G87349YT", "source": "G75049FP", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87377GM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47108UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G47108UC", "dp": 9 }, { "id": "G87377GM", "dp": 9 } ], "links": [ { "target": "G87377GM", "source": "G47108UC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47108UC", "source": "G80858MF", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87377KZ", "error": "Missing intermediate; no pathways to [G87377KZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87407JY", "error": "Starting point for pathway to G87407JY could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G87411TE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95956WE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G42548XF", "dp": 7 }, { "id": "G95956WE", "dp": 8 }, { "id": "G87411TE", "dp": 8 } ], "links": [ { "target": "G87411TE", "source": "G95956WE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95956WE", "source": "G42548XF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42548XF", "source": "G61751GZ", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] } ] } , { "glytoucan_ac": "G87427GY", "error": "Missing intermediate; no pathways to [G87427GY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41811VQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87430GQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90698PW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G34175ZP", "dp": 10 }, { "id": "G90698PW", "dp": 11 }, { "id": "G87430GQ", "dp": 11 } ], "links": [ { "target": "G87430GQ", "source": "G90698PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90698PW", "source": "G34175ZP", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34175ZP", "source": "G01265XZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87457SB", "error": "Missing intermediate; no pathways to [G87457SB] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87470NI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G28723UT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G87073UP", "dp": 10 }, { "id": "G28723UT", "dp": 11 }, { "id": "G87470NI", "dp": 11 } ], "links": [ { "target": "G87470NI", "source": "G28723UT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28723UT", "source": "G87073UP", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87073UP", "source": "G36191CD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87503IV", "error": "Missing intermediate; no pathways to [G87503IV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G97686QU]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G87504BP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G11910RR", "dp": 15 } ], "links": [ { "target": "G87504BP", "source": "G11910RR", "residue_affected": { "residue_id": "N294", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G11910RR", "source": "G89877QI", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87535DG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G74675FC", "dp": 11 } ], "links": [ { "target": "G87535DG", "source": "G74675FC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74675FC", "source": "G78059CC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87554PU", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G15998WM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 }, { "id": "G15998WM", "dp": 17 }, { "id": "G87554PU", "dp": 17 } ], "links": [ { "target": "G87554PU", "source": "G15998WM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G15998WM", "source": "G79950YS", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87623VS", "error": "Missing intermediate; no pathways to [G87623VS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87645JA", "error": "Missing intermediate; no pathways to [G87645JA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82410AF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87656FV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10258MC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G25835MT", "dp": 10 }, { "id": "G10258MC", "dp": 11 }, { "id": "G87656FV", "dp": 11 } ], "links": [ { "target": "G87656FV", "source": "G10258MC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10258MC", "source": "G25835MT", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25835MT", "source": "G96063MG", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87656ID", "error": "Missing intermediate; no pathways to [G87656ID] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88864RV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87668ED", "error": "Starting point for pathway to G87668ED could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G87687NN", "error": "Missing intermediate; no pathways to [G87687NN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G14615WQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87690VK", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G25407RZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G25407RZ", "dp": 11 }, { "id": "G87690VK", "dp": 11 } ], "links": [ { "target": "G87690VK", "source": "G25407RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25407RZ", "source": "G65597BI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87692UE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03385XG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G03385XG", "dp": 13 }, { "id": "G87692UE", "dp": 13 } ], "links": [ { "target": "G87692UE", "source": "G03385XG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03385XG", "source": "G01669LU", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87695KR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80393PG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G87695KR", "dp": 9 } ], "links": [ { "target": "G87695KR", "source": "G80393PG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87699TW", "error": "Missing intermediate; no pathways to [G87699TW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10425AY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87706EO", "error": "Missing intermediate; no pathways to [G87706EO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87773EB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G37476QB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G87773EB", "dp": 8 } ], "links": [ { "target": "G87773EB", "source": "G37476QB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87777GG", "error": "Starting point for pathway to G87777GG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G87784HD", "error": "Starting point for pathway to G87784HD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G87807PF", "error": "Missing intermediate; no pathways to [G87807PF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87824CU", "error": "Missing intermediate; no pathways to [G87824CU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G62389NM]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G87854BA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G67942CH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G67942CH", "dp": 11 }, { "id": "G87854BA", "dp": 11 } ], "links": [ { "target": "G87854BA", "source": "G67942CH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G67942CH", "source": "G71013KY", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87888LG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41331JX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G87888LG", "dp": 12 } ], "links": [ { "target": "G87888LG", "source": "G41331JX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87908HE", "error": "Missing intermediate; no pathways to [G87908HE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G11010AN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87918MM", "error": "Starting point for pathway to G87918MM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G87921DA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86357DX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G87921DA", "dp": 12 } ], "links": [ { "target": "G87921DA", "source": "G86357DX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G87935PM", "error": "Missing intermediate; no pathways to [G87935PM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89865CB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G87937HR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21788RU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G21788RU", "dp": 12 }, { "id": "G87937HR", "dp": 12 } ], "links": [ { "target": "G87937HR", "source": "G21788RU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21788RU", "source": "G25520XG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88002CH", "error": "Missing intermediate; no pathways to [G88002CH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47279LF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88038QS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G62880PC", "dp": 9 }, { "id": "G45686NF", "dp": 10 } ], "links": [ { "target": "G88038QS", "source": "G45686NF", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45686NF", "source": "G62880PC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62880PC", "source": "G59471TH", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88069QW", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G28826SH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 }, { "id": "G88069QW", "dp": 10 } ], "links": [ { "target": "G88069QW", "source": "G28826SH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88094DN", "error": "Missing intermediate; no pathways to [G88094DN] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88122ZQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76384QV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G98852TR", "dp": 16 }, { "id": "G76384QV", "dp": 17 }, { "id": "G88122ZQ", "dp": 17 } ], "links": [ { "target": "G88122ZQ", "source": "G76384QV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76384QV", "source": "G98852TR", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98852TR", "source": "G28957FB", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88127MB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 } ], "links": [ { "target": "G88127MB", "source": "G74120DW", "residue_affected": { "residue_id": "N46", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88176UG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17473NR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G17473NR", "dp": 13 }, { "id": "G88176UG", "dp": 13 } ], "links": [ { "target": "G88176UG", "source": "G17473NR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17473NR", "source": "G10733HY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88185OE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99603GB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 }, { "id": "G99603GB", "dp": 9 }, { "id": "G88185OE", "dp": 9 } ], "links": [ { "target": "G88185OE", "source": "G99603GB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99603GB", "source": "G64669AQ", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G88219FI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G90223GH", "dp": 9 } ], "links": [ { "target": "G88219FI", "source": "G90223GH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90223GH", "source": "G29011JC", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88224HM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93582HM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G88224HM", "dp": 13 } ], "links": [ { "target": "G88224HM", "source": "G93582HM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88227HW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G60439QY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 }, { "id": "G99891PR", "dp": 16 }, { "id": "G60439QY", "dp": 17 }, { "id": "G88227HW", "dp": 17 } ], "links": [ { "target": "G88227HW", "source": "G60439QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60439QY", "source": "G99891PR", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88235TO", "error": "Starting point for pathway to G88235TO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88238LO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92466WU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G92466WU", "dp": 10 }, { "id": "G88238LO", "dp": 10 } ], "links": [ { "target": "G88238LO", "source": "G92466WU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92466WU", "source": "G46638GC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88242BL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07392QY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G07392QY", "dp": 11 }, { "id": "G88242BL", "dp": 11 } ], "links": [ { "target": "G88242BL", "source": "G07392QY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07392QY", "source": "G78059CC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88266ZO", "error": "Missing intermediate; no pathways to [G88266ZO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83738AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88289CZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51490BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G88289CZ", "dp": 8 } ], "links": [ { "target": "G88289CZ", "source": "G51490BW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88309FO", "error": "Missing intermediate; no pathways to [G88309FO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71957GO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88310CR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78956IC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G91413ZX", "dp": 15 }, { "id": "G78956IC", "dp": 16 }, { "id": "G88310CR", "dp": 16 } ], "links": [ { "target": "G88310CR", "source": "G78956IC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78956IC", "source": "G91413ZX", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88310KZ", "error": "Missing intermediate; no pathways to [G88310KZ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88315CV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78890OB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G78890OB", "dp": 10 }, { "id": "G88315CV", "dp": 10 } ], "links": [ { "target": "G88315CV", "source": "G78890OB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78890OB", "source": "G96063MG", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88321DT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 } ], "links": [ { "target": "G88321DT", "source": "G53485VW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88329BN", "error": "Missing intermediate; no pathways to [G88329BN] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G08520NM]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G88334IC", "error": "Starting point for pathway to G88334IC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88369LF", "error": "Missing intermediate; no pathways to [G88369LF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88376NU", "error": "Starting point for pathway to G88376NU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88380UG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G88380UG", "source": "G39213VZ", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88382QE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G88382QE", "source": "G18938DW", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88399MJ", "error": "Starting point for pathway to G88399MJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88417ED", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 } ], "links": [ { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88419IN", "error": "Missing intermediate; no pathways to [G88419IN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88421PE", "error": "Starting point for pathway to G88421PE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88423HG", "error": "Starting point for pathway to G88423HG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88426SE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G78155FK", "dp": 10 } ], "links": [ { "target": "G88426SE", "source": "G78155FK", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78155FK", "source": "G43299SD", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88431VL", "error": "Missing intermediate; no pathways to [G88431VL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G88435TS", "error": "Starting point for pathway to G88435TS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88461FF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 } ], "links": [ { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88468EP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G29706UC", "dp": 10 } ], "links": [ { "target": "G88468EP", "source": "G29706UC", "residue_affected": { "residue_id": "N484", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G29706UC", "source": "G58667NI", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88482YZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72536JI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 }, { "id": "G72536JI", "dp": 13 }, { "id": "G88482YZ", "dp": 13 } ], "links": [ { "target": "G88482YZ", "source": "G72536JI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72536JI", "source": "G81432SH", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88495BI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77252PU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G88495BI", "dp": 11 } ], "links": [ { "target": "G88495BI", "source": "G77252PU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88500SX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19124KK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 }, { "id": "G19124KK", "dp": 12 }, { "id": "G88500SX", "dp": 12 } ], "links": [ { "target": "G88500SX", "source": "G19124KK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19124KK", "source": "G84467IZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88537BJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 } ], "links": [ { "target": "G88537BJ", "source": "G23616ZX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88561PH", "error": "Starting point for pathway to G88561PH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88582ZD", "error": "Missing intermediate; no pathways to [G88582ZD] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88605BA", "error": "Missing intermediate; no pathways to [G88605BA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36324QX]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88617BH", "error": "Missing intermediate; no pathways to [G88617BH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72411HX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88707IJ", "error": "Starting point for pathway to G88707IJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88711NV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 }, { "id": "G42097JO", "dp": 14 }, { "id": "G28846QB", "dp": 15 } ], "links": [ { "target": "G88711NV", "source": "G28846QB", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28846QB", "source": "G42097JO", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42097JO", "source": "G85085MS", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88727SH", "error": "Starting point for pathway to G88727SH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88734GE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86753CK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G86753CK", "dp": 17 }, { "id": "G88734GE", "dp": 17 } ], "links": [ { "target": "G88734GE", "source": "G86753CK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88749TS", "error": "Missing intermediate; no pathways to [G88749TS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50023BR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88757PX", "error": "Missing intermediate; no pathways to [G88757PX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88784SV", "error": "Starting point for pathway to G88784SV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88796EH", "error": "Missing intermediate; no pathways to [G88796EH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G69960SA]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G88800UV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18938DW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G88800UV", "dp": 13 } ], "links": [ { "target": "G88800UV", "source": "G18938DW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88814KX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G61718TK", "dp": 11 } ], "links": [ { "target": "G88814KX", "source": "G61718TK", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61718TK", "source": "G43694RQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88827CD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59942FB]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 }, { "id": "G59942FB", "dp": 11 }, { "id": "G88827CD", "dp": 11 } ], "links": [ { "target": "G88827CD", "source": "G59942FB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59942FB", "source": "G56748EO", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88839FI", "error": "Starting point for pathway to G88839FI could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88864RV", "error": "Missing intermediate; no pathways to [G88864RV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88876JQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G39213VZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G88876JQ", "dp": 7 } ], "links": [ { "target": "G88876JQ", "source": "G39213VZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88878CV", "error": "Missing intermediate; no pathways to [G88878CV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G88884NJ", "error": "Starting point for pathway to G88884NJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G88913VB", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G88913VB", "source": "G16828VN", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88928GI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G88928GI", "source": "G11041DA", "residue_affected": { "residue_id": "N55", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88948CY", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 } ], "links": [ { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88963CA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26274XD]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G26274XD", "dp": 11 }, { "id": "G88963CA", "dp": 11 } ], "links": [ { "target": "G88963CA", "source": "G26274XD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26274XD", "source": "G08187GM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88966ZO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 } ], "links": [ { "target": "G88966ZO", "source": "G63889NK", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G88998CC", "error": "Starting point for pathway to G88998CC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89036WC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 } ], "links": [ { "target": "G89036WC", "source": "G02427KF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89058RF", "error": "Missing intermediate; no pathways to [G89058RF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86555OF]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G89091LQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66265KN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G33262YZ", "dp": 11 }, { "id": "G66265KN", "dp": 12 }, { "id": "G89091LQ", "dp": 12 } ], "links": [ { "target": "G89091LQ", "source": "G66265KN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66265KN", "source": "G33262YZ", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33262YZ", "source": "G52934AK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89099NM", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 } ], "links": [ { "target": "G89099NM", "source": "G20966TZ", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89109GC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71407IE]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G71407IE", "dp": 8 }, { "id": "G89109GC", "dp": 8 } ], "links": [ { "target": "G89109GC", "source": "G71407IE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71407IE", "source": "G69411IG", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89117DH", "error": "Starting point for pathway to G89117DH could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89143RS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 } ], "links": [ { "target": "G89143RS", "source": "G32065BG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89153EV", "error": "Starting point for pathway to G89153EV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89168LM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 }, { "id": "G16057DE", "dp": 14 } ], "links": [ { "target": "G89168LM", "source": "G16057DE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16057DE", "source": "G67289UM", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89181JW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 } ], "links": [ { "target": "G89181JW", "source": "G03445UI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89192XO", "error": "Missing intermediate; no pathways to [G89192XO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89206JP", "error": "Missing intermediate; no pathways to [G89206JP] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89222FP", "error": "Missing intermediate; no pathways to [G89222FP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G67410LQ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89253ZV", "error": "Starting point for pathway to G89253ZV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89255EP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 } ], "links": [ { "target": "G89255EP", "source": "G75049FP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89261EQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16774YZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G16774YZ", "dp": 18 }, { "id": "G89261EQ", "dp": 18 } ], "links": [ { "target": "G89261EQ", "source": "G16774YZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16774YZ", "source": "G86696LV", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89285HT", "error": "Missing intermediate; no pathways to [G89285HT] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89285QP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85542KD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G89285QP", "dp": 10 } ], "links": [ { "target": "G89285QP", "source": "G85542KD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89290XU", "error": "Starting point for pathway to G89290XU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89323TE", "error": "Missing intermediate; no pathways to [G89323TE] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G80943NY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89325VN", "error": "Starting point for pathway to G89325VN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89333YV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08242BT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G08242BT", "dp": 12 }, { "id": "G89333YV", "dp": 12 } ], "links": [ { "target": "G89333YV", "source": "G08242BT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08242BT", "source": "G26949IX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89345GA", "error": "Missing intermediate; no pathways to [G89345GA] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G00662IB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89353OJ", "error": "Starting point for pathway to G89353OJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89362MU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G86928SV", "dp": 11 } ], "links": [ { "target": "G89362MU", "source": "G86928SV", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86928SV", "source": "G62504BU", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89364NG", "error": "Missing intermediate; no pathways to [G89364NG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G24748QU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89366NN", "error": "Missing intermediate; no pathways to [G89366NN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89375LQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90698PW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G34175ZP", "dp": 10 }, { "id": "G90698PW", "dp": 11 }, { "id": "G89375LQ", "dp": 11 } ], "links": [ { "target": "G89375LQ", "source": "G90698PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90698PW", "source": "G34175ZP", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34175ZP", "source": "G01265XZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89378FW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13267ZY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G13267ZY", "dp": 10 }, { "id": "G89378FW", "dp": 10 } ], "links": [ { "target": "G89378FW", "source": "G13267ZY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G13267ZY", "source": "G46638GC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89414BZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 } ], "links": [ { "target": "G89414BZ", "source": "G65597BI", "residue_affected": { "residue_id": "N422", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89463XE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41278YY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G82540VC", "dp": 8 }, { "id": "G41278YY", "dp": 9 }, { "id": "G89463XE", "dp": 9 } ], "links": [ { "target": "G89463XE", "source": "G41278YY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41278YY", "source": "G82540VC", "residue_affected": { "residue_id": "N238", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G82540VC", "source": "G39213VZ", "residue_affected": { "residue_id": "N250", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89498BT", "error": "Missing intermediate; no pathways to [G89498BT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82639GQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89532GI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32201IL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G89532GI", "dp": 10 } ], "links": [ { "target": "G89532GI", "source": "G32201IL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89561DW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G89561DW", "source": "G39213VZ", "residue_affected": { "residue_id": "N422", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89584RR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G45603BW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G45603BW", "dp": 14 }, { "id": "G89584RR", "dp": 14 } ], "links": [ { "target": "G89584RR", "source": "G45603BW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45603BW", "source": "G56549DH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89602QT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G13267ZY", "dp": 10 } ], "links": [ { "target": "G89602QT", "source": "G13267ZY", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13267ZY", "source": "G46638GC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89612MM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93265QH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G57117TO", "dp": 8 }, { "id": "G93265QH", "dp": 9 }, { "id": "G89612MM", "dp": 9 } ], "links": [ { "target": "G89612MM", "source": "G93265QH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93265QH", "source": "G57117TO", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G57117TO", "source": "G69411IG", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89615SV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G08242BT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G08242BT", "dp": 12 }, { "id": "G89615SV", "dp": 12 } ], "links": [ { "target": "G89615SV", "source": "G08242BT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08242BT", "source": "G26949IX", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89615VR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84712FF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84712FF", "dp": 12 }, { "id": "G89615VR", "dp": 12 } ], "links": [ { "target": "G89615VR", "source": "G84712FF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84712FF", "source": "G29857RC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89619KY", "error": "Starting point for pathway to G89619KY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89637WE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G80858MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G89637WE", "dp": 8 } ], "links": [ { "target": "G89637WE", "source": "G80858MF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89654YT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79457WN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G79457WN", "dp": 11 }, { "id": "G89654YT", "dp": 11 } ], "links": [ { "target": "G89654YT", "source": "G79457WN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79457WN", "source": "G00176HZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89658RO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50427EN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G42028DN", "dp": 11 }, { "id": "G26264SQ", "dp": 12 }, { "id": "G50427EN", "dp": 13 }, { "id": "G89658RO", "dp": 13 } ], "links": [ { "target": "G89658RO", "source": "G50427EN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50427EN", "source": "G26264SQ", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G26264SQ", "source": "G42028DN", "residue_affected": { "residue_id": "N101", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42028DN", "source": "G09921WG", "residue_affected": { "residue_id": "N73", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89663TB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30159WR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G89663TB", "dp": 9 } ], "links": [ { "target": "G89663TB", "source": "G30159WR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89669IB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56748EO]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 }, { "id": "G89669IB", "dp": 10 } ], "links": [ { "target": "G89669IB", "source": "G56748EO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89720ZS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G52880ZN", "dp": 12 } ], "links": [ { "target": "G89720ZS", "source": "G52880ZN", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52880ZN", "source": "G82252QI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89736EE", "error": "Missing intermediate; no pathways to [G89736EE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08493GY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89808TP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05260RH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G56591LC", "dp": 10 }, { "id": "G05260RH", "dp": 11 }, { "id": "G89808TP", "dp": 11 } ], "links": [ { "target": "G89808TP", "source": "G05260RH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05260RH", "source": "G56591LC", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56591LC", "source": "G36191CD", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89838LO", "error": "Starting point for pathway to G89838LO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89845CN", "error": "Starting point for pathway to G89845CN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89864BN", "error": "Starting point for pathway to G89864BN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89865CB", "error": "Missing intermediate; no pathways to [G89865CB] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89868JS", "error": "Missing intermediate; no pathways to [G89868JS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89877QI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 } ], "links": [ { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89905SH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00536FZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G00536FZ", "dp": 12 }, { "id": "G89905SH", "dp": 12 } ], "links": [ { "target": "G89905SH", "source": "G00536FZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00536FZ", "source": "G71679MX", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89908RT", "error": "Starting point for pathway to G89908RT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89920YU", "error": "Missing intermediate; no pathways to [G89920YU] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G89923TD", "error": "Starting point for pathway to G89923TD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89941FZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 } ], "links": [ { "target": "G89941FZ", "source": "G00743WU", "residue_affected": { "residue_id": "N70", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89950AZ", "error": "Starting point for pathway to G89950AZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89970IY", "error": "Starting point for pathway to G89970IY could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89980SM", "error": "Starting point for pathway to G89980SM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G89982KK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10228OD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G89982KK", "dp": 14 } ], "links": [ { "target": "G89982KK", "source": "G10228OD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G89993FE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 } ], "links": [ { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90000WS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10614GM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G10614GM", "dp": 9 }, { "id": "G90000WS", "dp": 9 } ], "links": [ { "target": "G90000WS", "source": "G10614GM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10614GM", "source": "G10209QU", "residue_affected": { "residue_id": "N275", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90017UO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 } ], "links": [ { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90028HY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75903TQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G75903TQ", "dp": 12 }, { "id": "G90028HY", "dp": 12 } ], "links": [ { "target": "G90028HY", "source": "G75903TQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75903TQ", "source": "G82252QI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90033AN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53098FA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 }, { "id": "G53098FA", "dp": 14 }, { "id": "G90033AN", "dp": 14 } ], "links": [ { "target": "G90033AN", "source": "G53098FA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53098FA", "source": "G95898GD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90054TK", "error": "Starting point for pathway to G90054TK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90065BD", "error": "Missing intermediate; no pathways to [G90065BD] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G90081OR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23626NI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G23626NI", "dp": 11 }, { "id": "G90081OR", "dp": 11 } ], "links": [ { "target": "G90081OR", "source": "G23626NI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23626NI", "source": "G85542KD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90099GV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84467IZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G84467IZ", "dp": 11 }, { "id": "G90099GV", "dp": 11 } ], "links": [ { "target": "G90099GV", "source": "G84467IZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84467IZ", "source": "G91365ZQ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90111MD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G03895SR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G03895SR", "dp": 15 }, { "id": "G90111MD", "dp": 15 } ], "links": [ { "target": "G90111MD", "source": "G03895SR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90125QJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10733HY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G90125QJ", "dp": 12 } ], "links": [ { "target": "G90125QJ", "source": "G10733HY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90130AG", "error": "Missing intermediate; no pathways to [G90130AG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90133BE", "error": "Missing intermediate; no pathways to [G90133BE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90163GT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G69812OF", "dp": 8 }, { "id": "G05546WG", "dp": 9 } ], "links": [ { "target": "G90163GT", "source": "G05546WG", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05546WG", "source": "G69812OF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69812OF", "source": "G39213VZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90175OT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 } ], "links": [ { "target": "G90175OT", "source": "G37476QB", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90204HK", "error": "Missing intermediate; no pathways to [G90204HK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90223GH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G90223GH", "source": "G29011JC", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90238QO", "error": "Missing intermediate; no pathways to [G90238QO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06635WE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90244AZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 } ], "links": [ { "target": "G90244AZ", "source": "G29492IF", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90267TS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25407RZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G25407RZ", "dp": 11 }, { "id": "G90267TS", "dp": 11 } ], "links": [ { "target": "G90267TS", "source": "G25407RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25407RZ", "source": "G65597BI", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90284FM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 } ], "links": [ { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90305AF", "error": "Missing intermediate; no pathways to [G90305AF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90308YV", "error": "Starting point for pathway to G90308YV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90334KL", "error": "Missing intermediate; no pathways to [G90334KL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84778XH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90348RI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G90348RI", "source": "G11041DA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90363CW", "error": "Starting point for pathway to G90363CW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90509QW", "error": "Missing intermediate; no pathways to [G90509QW] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90542MP", "error": "Missing intermediate; no pathways to [G90542MP] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90564EX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G28826SH", "dp": 10 } ], "links": [ { "target": "G90564EX", "source": "G28826SH", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28826SH", "source": "G09782JM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90618SW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G57943ZV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G57943ZV", "dp": 11 }, { "id": "G90618SW", "dp": 11 } ], "links": [ { "target": "G90618SW", "source": "G57943ZV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90651NI", "error": "Missing intermediate; no pathways to [G90651NI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90670ZD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G97093EP", "dp": 12 } ], "links": [ { "target": "G90670ZD", "source": "G97093EP", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97093EP", "source": "G43433FA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90672BM", "error": "Missing intermediate; no pathways to [G90672BM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81328FA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90677OQ", "error": "Starting point for pathway to G90677OQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90686FD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G91365ZQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G90686FD", "dp": 10 } ], "links": [ { "target": "G90686FD", "source": "G91365ZQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90698PW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G34175ZP", "dp": 10 } ], "links": [ { "target": "G90698PW", "source": "G34175ZP", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34175ZP", "source": "G01265XZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90703DJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 } ], "links": [ { "target": "G90703DJ", "source": "G74120DW", "residue_affected": { "residue_id": "N295", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90712YJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G23484GM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G69086TY", "dp": 12 }, { "id": "G42400JK", "dp": 13 }, { "id": "G23484GM", "dp": 14 }, { "id": "G90712YJ", "dp": 14 } ], "links": [ { "target": "G90712YJ", "source": "G23484GM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23484GM", "source": "G42400JK", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42400JK", "source": "G69086TY", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90719DY", "error": "Missing intermediate; no pathways to [G90719DY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13322RS]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90725ZC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G89993FE", "dp": 8 } ], "links": [ { "target": "G90725ZC", "source": "G89993FE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89993FE", "source": "G39213VZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90737HD", "error": "Missing intermediate; no pathways to [G90737HD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90766ZI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G42193NQ]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G56748EO", "dp": 10 }, { "id": "G42193NQ", "dp": 11 }, { "id": "G90766ZI", "dp": 11 } ], "links": [ { "target": "G90766ZI", "source": "G42193NQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G42193NQ", "source": "G56748EO", "residue_affected": { "residue_id": "N373", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G56748EO", "source": "G20966TZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90769IN", "error": "Missing intermediate; no pathways to [G90769IN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90774IS", "error": "Starting point for pathway to G90774IS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90779DH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56499YQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G56499YQ", "dp": 16 }, { "id": "G90779DH", "dp": 16 } ], "links": [ { "target": "G90779DH", "source": "G56499YQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56499YQ", "source": "G57955DP", "residue_affected": { "residue_id": "N228", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90784AP", "error": "Missing intermediate; no pathways to [G90784AP] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90789AP", "error": "Missing intermediate; no pathways to [G90789AP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90790SM", "error": "Missing intermediate; no pathways to [G90790SM] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G19104OH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90797SN", "error": "Missing intermediate; no pathways to [G90797SN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90825UM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 } ], "links": [ { "target": "G90825UM", "source": "G01856RL", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90833YY", "error": "Starting point for pathway to G90833YY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90840KY", "error": "Missing intermediate; no pathways to [G90840KY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84390MS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90853RR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44504SC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G44504SC", "dp": 10 }, { "id": "G90853RR", "dp": 10 } ], "links": [ { "target": "G90853RR", "source": "G44504SC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44504SC", "source": "G20030CU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90858SP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G41820ZZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G41820ZZ", "dp": 11 }, { "id": "G90858SP", "dp": 11 } ], "links": [ { "target": "G90858SP", "source": "G41820ZZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41820ZZ", "source": "G45560HM", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90870DG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 } ], "links": [ { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90873EK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78097CL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 }, { "id": "G78097CL", "dp": 13 }, { "id": "G90873EK", "dp": 13 } ], "links": [ { "target": "G90873EK", "source": "G78097CL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78097CL", "source": "G09150LP", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90889KG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17689DH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 }, { "id": "G90889KG", "dp": 12 } ], "links": [ { "target": "G90889KG", "source": "G17689DH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90923YW", "error": "Starting point for pathway to G90923YW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90950UC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20030CU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G90950UC", "dp": 9 } ], "links": [ { "target": "G90950UC", "source": "G20030CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G90974OF", "error": "Starting point for pathway to G90974OF could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90983BT", "error": "Starting point for pathway to G90983BT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G90987JA", "error": "Missing intermediate; no pathways to [G90987JA] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90995MU", "error": "Missing intermediate; no pathways to [G90995MU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G90999CW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G05307LM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G05307LM", "dp": 13 }, { "id": "G90999CW", "dp": 13 } ], "links": [ { "target": "G90999CW", "source": "G05307LM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05307LM", "source": "G91023GB", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91020ZU", "error": "Missing intermediate; no pathways to [G91020ZU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91023GB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91031XA", "error": "Missing intermediate; no pathways to [G91031XA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75097MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91038CM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29797YX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G89181JW", "dp": 11 }, { "id": "G29797YX", "dp": 12 }, { "id": "G91038CM", "dp": 12 } ], "links": [ { "target": "G91038CM", "source": "G29797YX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G29797YX", "source": "G89181JW", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89181JW", "source": "G03445UI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91068DJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G91068DJ", "source": "G29011JC", "residue_affected": { "residue_id": "N359", "pubchem_name": "GlcNAc", "anomer": "a", "absolute": "D", "form_name": "GlcpNAc", "full_name": "α-D-GlcpNAc" }, "effect": "Add α-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91074JT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59277TZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G59277TZ", "dp": 10 }, { "id": "G91074JT", "dp": 10 } ], "links": [ { "target": "G91074JT", "source": "G59277TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59277TZ", "source": "G30159WR", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91089ZR", "error": "Starting point for pathway to G91089ZR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91114LN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06216UH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G09482NW", "dp": 9 }, { "id": "G06216UH", "dp": 10 }, { "id": "G91114LN", "dp": 10 } ], "links": [ { "target": "G91114LN", "source": "G06216UH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06216UH", "source": "G09482NW", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G09482NW", "source": "G67045LB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91125VM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71679MX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G91125VM", "dp": 11 } ], "links": [ { "target": "G91125VM", "source": "G71679MX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91144YH", "error": "Starting point for pathway to G91144YH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91147LL", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 } ], "links": [ { "target": "G91147LL", "source": "G92359VA", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91150PB", "error": "Starting point for pathway to G91150PB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91151XY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23901NY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G23901NY", "dp": 11 }, { "id": "G91151XY", "dp": 11 } ], "links": [ { "target": "G91151XY", "source": "G23901NY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23901NY", "source": "G52934AK", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91156HJ", "error": "Starting point for pathway to G91156HJ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91159AV", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G12643KN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G34175ZP", "dp": 10 }, { "id": "G12643KN", "dp": 11 }, { "id": "G91159AV", "dp": 11 } ], "links": [ { "target": "G91159AV", "source": "G12643KN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G12643KN", "source": "G34175ZP", "residue_affected": { "residue_id": "N302", "pubchem_name": "GlcNAc", "anomer": "a", "absolute": "D", "form_name": "GlcpNAc", "full_name": "α-D-GlcpNAc" }, "effect": "Add α-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G34175ZP", "source": "G01265XZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91164NP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16679DU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G69086TY", "dp": 12 }, { "id": "G42400JK", "dp": 13 }, { "id": "G16679DU", "dp": 14 }, { "id": "G91164NP", "dp": 14 } ], "links": [ { "target": "G91164NP", "source": "G16679DU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16679DU", "source": "G42400JK", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42400JK", "source": "G69086TY", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91180QG", "error": "Missing intermediate; no pathways to [G91180QG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91193KQ", "error": "Missing intermediate; no pathways to [G91193KQ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G10385EY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91199QX", "error": "Missing intermediate; no pathways to [G91199QX] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91208VE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G91208VE", "source": "G29011JC", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91209EK", "error": "Starting point for pathway to G91209EK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91219PM", "error": "Starting point for pathway to G91219PM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91227VL", "error": "Missing intermediate; no pathways to [G91227VL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91233DP", "error": "Starting point for pathway to G91233DP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91247WI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20030CU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G91247WI", "dp": 9 } ], "links": [ { "target": "G91247WI", "source": "G20030CU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91257NC", "error": "Missing intermediate; no pathways to [G91257NC] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91277HN", "error": "Starting point for pathway to G91277HN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91288FV", "error": "Starting point for pathway to G91288FV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91303GW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 } ], "links": [ { "target": "G91303GW", "source": "G45560HM", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91303IT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G46712PI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G46712PI", "dp": 11 }, { "id": "G91303IT", "dp": 11 } ], "links": [ { "target": "G91303IT", "source": "G46712PI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G46712PI", "source": "G00176HZ", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91312MX", "error": "Starting point for pathway to G91312MX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91337ZP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 } ], "links": [ { "target": "G91337ZP", "source": "G58667NI", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91345JE", "error": "Missing intermediate; no pathways to [G91345JE] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91345QW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82033VN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G82033VN", "dp": 14 }, { "id": "G91345QW", "dp": 14 } ], "links": [ { "target": "G91345QW", "source": "G82033VN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82033VN", "source": "G20926BB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91365ZH", "error": "Missing intermediate; no pathways to [G91365ZH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07162IJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91365ZQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 } ], "links": [ { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91386RN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G60564DP", "dp": 14 }, { "id": "G31494OZ", "dp": 15 } ], "links": [ { "target": "G91386RN", "source": "G31494OZ", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31494OZ", "source": "G60564DP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91388QD", "error": "Missing intermediate; no pathways to [G91388QD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66765ZA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91409SX", "error": "Missing intermediate; no pathways to [G91409SX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G13659RH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91413ZX", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 } ], "links": [ { "target": "G91413ZX", "source": "G10228OD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91452ZH", "error": "Missing intermediate; no pathways to [G91452ZH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91470EV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G26756VT", "dp": 11 } ], "links": [ { "target": "G91470EV", "source": "G26756VT", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G26756VT", "source": "G08863NS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91474EO", "error": "Starting point for pathway to G91474EO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91487MA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G87349YT", "dp": 13 }, { "id": "G95019KZ", "dp": 14 } ], "links": [ { "target": "G91487MA", "source": "G95019KZ", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G95019KZ", "source": "G87349YT", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87349YT", "source": "G75049FP", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91511MZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G91511MZ", "source": "G11041DA", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91513OX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39029JR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G39029JR", "dp": 10 }, { "id": "G91513OX", "dp": 10 } ], "links": [ { "target": "G91513OX", "source": "G39029JR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39029JR", "source": "G93500PH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91518OM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78276SQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G78276SQ", "dp": 12 }, { "id": "G91518OM", "dp": 12 } ], "links": [ { "target": "G91518OM", "source": "G78276SQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78276SQ", "source": "G11041DA", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91550OH", "error": "Missing intermediate; no pathways to [G91550OH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91599FN", "error": "Starting point for pathway to G91599FN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91616GP", "error": "Missing intermediate; no pathways to [G91616GP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91624NX", "error": "Missing intermediate; no pathways to [G91624NX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G95695ZV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91658LT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85180ML]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G85180ML", "dp": 10 }, { "id": "G91658LT", "dp": 10 } ], "links": [ { "target": "G91658LT", "source": "G85180ML", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85180ML", "source": "G96063MG", "residue_affected": { "residue_id": "N490", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91700SA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41656NL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G41656NL", "dp": 15 }, { "id": "G91700SA", "dp": 15 } ], "links": [ { "target": "G91700SA", "source": "G41656NL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G41656NL", "source": "G23616ZX", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91704EI", "error": "Missing intermediate; no pathways to [G91704EI] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G30437YI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91704UR", "error": "Starting point for pathway to G91704UR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91729DG", "error": "Starting point for pathway to G91729DG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G91731RP", "error": "Missing intermediate; no pathways to [G91731RP] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G14393TF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91803EA", "error": "Missing intermediate; no pathways to [G91803EA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G27273FD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91827TX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40358EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G40358EZ", "dp": 11 }, { "id": "G91827TX", "dp": 11 } ], "links": [ { "target": "G91827TX", "source": "G40358EZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40358EZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91832SW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 } ], "links": [ { "target": "G91832SW", "source": "G85085MS", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91847ME", "error": "Missing intermediate; no pathways to [G91847ME] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G91865AW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09118YK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G03895SR", "dp": 15 }, { "id": "G09118YK", "dp": 16 }, { "id": "G91865AW", "dp": 16 } ], "links": [ { "target": "G91865AW", "source": "G09118YK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09118YK", "source": "G03895SR", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91873GT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 } ], "links": [ { "target": "G91873GT", "source": "G43299SD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91877SC", "error": "Missing intermediate; no pathways to [G91877SC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95542JQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G91905FJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 } ], "links": [ { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G91979JZ", "error": "Starting point for pathway to G91979JZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92003CT", "error": "Starting point for pathway to G92003CT could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92009KQ", "error": "Missing intermediate; no pathways to [G92009KQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92024SL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G92024SL", "source": "G61751GZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92042VQ", "error": "Starting point for pathway to G92042VQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92055NH", "error": "Missing intermediate; no pathways to [G92055NH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41953RN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92057EA", "error": "Missing intermediate; no pathways to [G92057EA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96503EZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92067KW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G40289RO]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G40289RO", "dp": 10 }, { "id": "G92067KW", "dp": 10 } ], "links": [ { "target": "G92067KW", "source": "G40289RO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G40289RO", "source": "G20966TZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92083LG", "error": "Starting point for pathway to G92083LG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92090QA", "error": "Missing intermediate; no pathways to [G92090QA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92101NE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86102AA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G86102AA", "dp": 11 }, { "id": "G92101NE", "dp": 11 } ], "links": [ { "target": "G92101NE", "source": "G86102AA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86102AA", "source": "G85542KD", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92117KA", "error": "Missing intermediate; no pathways to [G92117KA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G57345HS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92129YX", "error": "Starting point for pathway to G92129YX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92133UT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76384QV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G98852TR", "dp": 16 }, { "id": "G76384QV", "dp": 17 }, { "id": "G92133UT", "dp": 17 } ], "links": [ { "target": "G92133UT", "source": "G76384QV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76384QV", "source": "G98852TR", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98852TR", "source": "G28957FB", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92140GK", "error": "Missing intermediate; no pathways to [G92140GK] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92143CS", "error": "Missing intermediate; no pathways to [G92143CS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92145EO", "error": "Missing intermediate; no pathways to [G92145EO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92165DB", "error": "Starting point for pathway to G92165DB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92177FO", "error": "Missing intermediate; no pathways to [G92177FO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92180XB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17689DH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 }, { "id": "G92180XB", "dp": 12 } ], "links": [ { "target": "G92180XB", "source": "G17689DH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92219PK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G09670SR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 }, { "id": "G92219PK", "dp": 10 } ], "links": [ { "target": "G92219PK", "source": "G09670SR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92241FG", "error": "Starting point for pathway to G92241FG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92257YN", "error": "Starting point for pathway to G92257YN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92266BO", "error": "Starting point for pathway to G92266BO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92278VP", "error": "Missing intermediate; no pathways to [G92278VP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G48753IC]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G92303LR", "error": "Starting point for pathway to G92303LR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92320FG", "error": "Starting point for pathway to G92320FG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92320PF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71679MX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G92320PF", "dp": 11 } ], "links": [ { "target": "G92320PF", "source": "G71679MX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92355BR", "error": "Starting point for pathway to G92355BR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92359VA", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 } ], "links": [ { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92383TF", "error": "Starting point for pathway to G92383TF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92386GP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G81473LO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G81473LO", "dp": 11 }, { "id": "G92386GP", "dp": 11 } ], "links": [ { "target": "G92386GP", "source": "G81473LO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G81473LO", "source": "G01856RL", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92401YL", "error": "Missing intermediate; no pathways to [G92401YL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92413DG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G37385TT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 }, { "id": "G92413DG", "dp": 11 } ], "links": [ { "target": "G92413DG", "source": "G37385TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92442AF", "error": "Missing intermediate; no pathways to [G92442AF] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92466WU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 } ], "links": [ { "target": "G92466WU", "source": "G46638GC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92477LS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89877QI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G92477LS", "dp": 14 } ], "links": [ { "target": "G92477LS", "source": "G89877QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92485DY", "error": "Missing intermediate; no pathways to [G92485DY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56516KW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92506EC", "error": "Missing intermediate; no pathways to [G92506EC] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G54300AX]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92520XS", "error": "Starting point for pathway to G92520XS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92527BY", "error": "Missing intermediate; no pathways to [G92527BY] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92574YO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 } ], "links": [ { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92575UZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G85767HW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G85767HW", "dp": 10 }, { "id": "G92575UZ", "dp": 10 } ], "links": [ { "target": "G92575UZ", "source": "G85767HW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85767HW", "source": "G30159WR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92594VG", "error": "Missing intermediate; no pathways to [G92594VG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G27844UM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92597HN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G79803HS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G74438AB", "dp": 12 }, { "id": "G79803HS", "dp": 13 }, { "id": "G92597HN", "dp": 13 } ], "links": [ { "target": "G92597HN", "source": "G79803HS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79803HS", "source": "G74438AB", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G74438AB", "source": "G34905OT", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92602UC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G35655SC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G74574VX", "dp": 11 }, { "id": "G83499UD", "dp": 12 }, { "id": "G35655SC", "dp": 13 }, { "id": "G92602UC", "dp": 13 } ], "links": [ { "target": "G92602UC", "source": "G35655SC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G35655SC", "source": "G83499UD", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G83499UD", "source": "G74574VX", "residue_affected": { "residue_id": "N245", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74574VX", "source": "G27123NH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92612ZM", "error": "Starting point for pathway to G92612ZM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92617LF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 } ], "links": [ { "target": "G92617LF", "source": "G27919IH", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92627GM", "error": "Missing intermediate; no pathways to [G92627GM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92681HQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 }, { "id": "G98852TR", "dp": 16 } ], "links": [ { "target": "G92681HQ", "source": "G98852TR", "residue_affected": { "residue_id": "N471", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G98852TR", "source": "G28957FB", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92684AL", "error": "Starting point for pathway to G92684AL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92695JQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G48658PB", "dp": 12 }, { "id": "G66572SF", "dp": 13 }, { "id": "G26877LE", "dp": 14 } ], "links": [ { "target": "G92695JQ", "source": "G26877LE", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G26877LE", "source": "G66572SF", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66572SF", "source": "G48658PB", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G48658PB", "source": "G06131VP", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92712BL", "error": "Missing intermediate; no pathways to [G92712BL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75359HS]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G92739ZU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G92739ZU", "source": "G29011JC", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92752RB", "error": "Starting point for pathway to G92752RB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92758ST", "error": "Missing intermediate; no pathways to [G92758ST] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00662IB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92777SG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 } ], "links": [ { "target": "G92777SG", "source": "G62504BU", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92782XB", "error": "Missing intermediate; no pathways to [G92782XB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92805XC", "error": "Starting point for pathway to G92805XC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92848CF", "error": "Missing intermediate; no pathways to [G92848CF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92848QA", "error": "Starting point for pathway to G92848QA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G92855TK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G84712FF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84712FF", "dp": 12 }, { "id": "G92855TK", "dp": 12 } ], "links": [ { "target": "G92855TK", "source": "G84712FF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84712FF", "source": "G29857RC", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92918FJ", "error": "Missing intermediate; no pathways to [G92918FJ] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92927TC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37597FW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 }, { "id": "G92927TC", "dp": 13 } ], "links": [ { "target": "G92927TC", "source": "G37597FW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92940AF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 } ], "links": [ { "target": "G92940AF", "source": "G67289UM", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G92962QH", "error": "Missing intermediate; no pathways to [G92962QH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G92983WW", "error": "Starting point for pathway to G92983WW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93023PL", "error": "Starting point for pathway to G93023PL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93029JO", "error": "Missing intermediate; no pathways to [G93029JO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20924UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93043WX", "error": "Missing intermediate; no pathways to [G93043WX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G36324QX]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93060PS", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 } ], "links": [ { "target": "G93060PS", "source": "G08520NM", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93075HW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G40289RO", "dp": 10 }, { "id": "G71102UV", "dp": 11 } ], "links": [ { "target": "G93075HW", "source": "G71102UV", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71102UV", "source": "G40289RO", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40289RO", "source": "G20966TZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93080GN", "error": "Missing intermediate; no pathways to [G93080GN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93086RK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01727PW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G93086RK", "dp": 13 } ], "links": [ { "target": "G93086RK", "source": "G01727PW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93088EE", "error": "Starting point for pathway to G93088EE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93088YQ", "error": "Starting point for pathway to G93088YQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93107BF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 } ], "links": [ { "target": "G93107BF", "source": "G11637WL", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93132NV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58403SV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 }, { "id": "G99270AV", "dp": 10 }, { "id": "G58403SV", "dp": 11 }, { "id": "G93132NV", "dp": 11 } ], "links": [ { "target": "G93132NV", "source": "G58403SV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G58403SV", "source": "G99270AV", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93132YJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G85895SP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G85895SP", "dp": 7 }, { "id": "G93132YJ", "dp": 7 } ], "links": [ { "target": "G93132YJ", "source": "G85895SP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G85895SP", "source": "G61751GZ", "residue_affected": { "residue_id": "N306", "pubchem_name": "Glc", "anomer": "b", "absolute": "D", "form_name": "Glcp", "full_name": "β-D-Glcp" }, "effect": "Add β-D-Glcp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G93138KJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16150CJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G93138KJ", "dp": 14 } ], "links": [ { "target": "G93138KJ", "source": "G16150CJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93148GC", "error": "Missing intermediate; no pathways to [G93148GC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94838KN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93162SU", "error": "Missing intermediate; no pathways to [G93162SU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G51050LD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93164KQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G04576KS]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G04576KS", "dp": 10 }, { "id": "G93164KQ", "dp": 10 } ], "links": [ { "target": "G93164KQ", "source": "G04576KS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04576KS", "source": "G16828VN", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93176JI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 } ], "links": [ { "target": "G93176JI", "source": "G43299SD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93193OD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G17473NR", "dp": 13 } ], "links": [ { "target": "G93193OD", "source": "G17473NR", "residue_affected": { "residue_id": "N267", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G17473NR", "source": "G10733HY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93195YO", "error": "Starting point for pathway to G93195YO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93204KY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G57943ZV", "dp": 11 } ], "links": [ { "target": "G93204KY", "source": "G57943ZV", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93211HX", "error": "Starting point for pathway to G93211HX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93218WT", "error": "Starting point for pathway to G93218WT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93237CR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 }, { "id": "G85085MS", "dp": 13 } ], "links": [ { "target": "G93237CR", "source": "G85085MS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85085MS", "source": "G74645FT", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93265QH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G57117TO", "dp": 8 } ], "links": [ { "target": "G93265QH", "source": "G57117TO", "residue_affected": { "residue_id": "N224", "pubchem_name": "Fuc", "anomer": "b", "absolute": "D", "form_name": "Fucp", "full_name": "β-D-Fucp" }, "effect": "Add β-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G57117TO", "source": "G69411IG", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93279DZ", "error": "Starting point for pathway to G93279DZ could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93279TH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G21246OH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G21246OH", "dp": 11 }, { "id": "G93279TH", "dp": 11 } ], "links": [ { "target": "G93279TH", "source": "G21246OH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G21246OH", "source": "G00176HZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93282XR", "error": "Missing intermediate; no pathways to [G93282XR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03260OU]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93285LF", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 }, { "id": "G74645FT", "dp": 12 } ], "links": [ { "target": "G93285LF", "source": "G74645FT", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74645FT", "source": "G43433FA", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93299MA", "error": "Starting point for pathway to G93299MA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93310KW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59741XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G93310KW", "dp": 7 } ], "links": [ { "target": "G93310KW", "source": "G59741XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93320VA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26949IX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G26949IX", "dp": 11 }, { "id": "G93320VA", "dp": 11 } ], "links": [ { "target": "G93320VA", "source": "G26949IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26949IX", "source": "G78059CC", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93336DT", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 } ], "links": [ { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93427DE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 } ], "links": [ { "target": "G93427DE", "source": "G29857RC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93446UA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23484GM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G71679MX", "dp": 11 }, { "id": "G69086TY", "dp": 12 }, { "id": "G42400JK", "dp": 13 }, { "id": "G23484GM", "dp": 14 }, { "id": "G93446UA", "dp": 14 } ], "links": [ { "target": "G93446UA", "source": "G23484GM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G23484GM", "source": "G42400JK", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42400JK", "source": "G69086TY", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69086TY", "source": "G71679MX", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71679MX", "source": "G00176HZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93447XI", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G60941RE", "dp": 13 }, { "id": "G29931YE", "dp": 14 } ], "links": [ { "target": "G93447XI", "source": "G29931YE", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29931YE", "source": "G60941RE", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60941RE", "source": "G75185NU", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93450TT", "error": "Missing intermediate; no pathways to [G93450TT] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93464IM", "error": "Missing intermediate; no pathways to [G93464IM] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G93500PH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 } ], "links": [ { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93516TF", "error": "Starting point for pathway to G93516TF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93527UH", "error": "Starting point for pathway to G93527UH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93553MJ", "error": "Missing intermediate; no pathways to [G93553MJ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G81328FA]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93575MM", "error": "Starting point for pathway to G93575MM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93582HM", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 } ], "links": [ { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93597JV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G39213VZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G93597JV", "dp": 7 } ], "links": [ { "target": "G93597JV", "source": "G39213VZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93602DI", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G79578JB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G93602DI", "dp": 12 } ], "links": [ { "target": "G93602DI", "source": "G79578JB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93624ZP", "error": "Starting point for pathway to G93624ZP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93638BI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G89877QI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G93638BI", "dp": 14 } ], "links": [ { "target": "G93638BI", "source": "G89877QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93638TT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G48767NV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G48767NV", "dp": 14 }, { "id": "G93638TT", "dp": 14 } ], "links": [ { "target": "G93638TT", "source": "G48767NV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48767NV", "source": "G53812BX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93646CO", "error": "Starting point for pathway to G93646CO could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93655SG", "error": "Missing intermediate; no pathways to [G93655SG] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93692VT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G36519NW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G01669LU", "dp": 12 }, { "id": "G36519NW", "dp": 13 }, { "id": "G93692VT", "dp": 13 } ], "links": [ { "target": "G93692VT", "source": "G36519NW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G36519NW", "source": "G01669LU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01669LU", "source": "G29857RC", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93696HW", "error": "Starting point for pathway to G93696HW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G93698KA", "error": "Missing intermediate; no pathways to [G93698KA] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93707PO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G55974RB", "dp": 11 } ], "links": [ { "target": "G93707PO", "source": "G55974RB", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G55974RB", "source": "G08187GM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93722FJ", "error": "Missing intermediate; no pathways to [G93722FJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93746CY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G96063MG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 }, { "id": "G96063MG", "dp": 9 }, { "id": "G93746CY", "dp": 9 } ], "links": [ { "target": "G93746CY", "source": "G96063MG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93755GW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G93755GW", "source": "G66937TJ", "residue_affected": { "residue_id": "N240", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93758YP", "error": "Missing intermediate; no pathways to [G93758YP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G50364FV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93767EH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53322JT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G53322JT", "dp": 11 }, { "id": "G93767EH", "dp": 11 } ], "links": [ { "target": "G93767EH", "source": "G53322JT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53322JT", "source": "G00176HZ", "residue_affected": { "residue_id": "N502", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93788SW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G79809MM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G93788SW", "dp": 11 } ], "links": [ { "target": "G93788SW", "source": "G79809MM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93802RY", "error": "Missing intermediate; no pathways to [G93802RY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G48109OV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93816OI", "error": "Missing intermediate; no pathways to [G93816OI] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G72112RK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93824CM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G18768EK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G18768EK", "dp": 11 }, { "id": "G93824CM", "dp": 11 } ], "links": [ { "target": "G93824CM", "source": "G18768EK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G18768EK", "source": "G78803YD", "residue_affected": { "residue_id": "N78", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93833DE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10770RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G82033VN", "dp": 14 }, { "id": "G10770RR", "dp": 15 }, { "id": "G93833DE", "dp": 15 } ], "links": [ { "target": "G93833DE", "source": "G10770RR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10770RR", "source": "G82033VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82033VN", "source": "G20926BB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93839ET", "error": "Missing intermediate; no pathways to [G93839ET] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G15859AU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93858FG", "error": "Missing intermediate; no pathways to [G93858FG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58473KL]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93906VI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G69905CP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G29434RB", "dp": 9 }, { "id": "G09670SR", "dp": 10 }, { "id": "G69905CP", "dp": 11 }, { "id": "G93906VI", "dp": 11 } ], "links": [ { "target": "G93906VI", "source": "G69905CP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G69905CP", "source": "G09670SR", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09670SR", "source": "G29434RB", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29434RB", "source": "G29011JC", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93913SP", "error": "Missing intermediate; no pathways to [G93913SP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G17650QU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93933CG", "error": "Missing intermediate; no pathways to [G93933CG] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93986UQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10182XZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G10182XZ", "dp": 7 }, { "id": "G93986UQ", "dp": 7 } ], "links": [ { "target": "G93986UQ", "source": "G10182XZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10182XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G93993PE", "error": "Missing intermediate; no pathways to [G93993PE] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G93994MR", "error": "Missing intermediate; no pathways to [G93994MR] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94013DC", "error": "Starting point for pathway to G94013DC could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94019IV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G28218GE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G53752TA", "dp": 11 }, { "id": "G17689DH", "dp": 12 }, { "id": "G28218GE", "dp": 13 }, { "id": "G94019IV", "dp": 13 } ], "links": [ { "target": "G94019IV", "source": "G28218GE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G28218GE", "source": "G17689DH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17689DH", "source": "G53752TA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53752TA", "source": "G68937TM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94027HD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72698LT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G59471TH", "dp": 8 }, { "id": "G82861UH", "dp": 9 }, { "id": "G72698LT", "dp": 10 }, { "id": "G94027HD", "dp": 10 } ], "links": [ { "target": "G94027HD", "source": "G72698LT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72698LT", "source": "G82861UH", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82861UH", "source": "G59471TH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59471TH", "source": "G39213VZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94045IP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 } ], "links": [ { "target": "G94045IP", "source": "G91023GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94047VH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 } ], "links": [ { "target": "G94047VH", "source": "G07995VK", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94053XX", "error": "Missing intermediate; no pathways to [G94053XX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40064GR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94105PL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57955DP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G94105PL", "dp": 15 } ], "links": [ { "target": "G94105PL", "source": "G57955DP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94116NC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G80147LG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G80147LG", "dp": 10 }, { "id": "G94116NC", "dp": 10 } ], "links": [ { "target": "G94116NC", "source": "G80147LG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80147LG", "source": "G27919IH", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94132EL", "error": "Starting point for pathway to G94132EL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94156YI", "error": "Starting point for pathway to G94156YI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94163JZ", "error": "Missing intermediate; no pathways to [G94163JZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94166QX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99969SS]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G99969SS", "dp": 10 }, { "id": "G94166QX", "dp": 10 } ], "links": [ { "target": "G94166QX", "source": "G99969SS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99969SS", "source": "G13151XE", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94232LU", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G16546ZZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G41331JX", "dp": 12 }, { "id": "G16546ZZ", "dp": 13 }, { "id": "G94232LU", "dp": 13 } ], "links": [ { "target": "G94232LU", "source": "G16546ZZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16546ZZ", "source": "G41331JX", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G41331JX", "source": "G25520XG", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94252JR", "error": "Starting point for pathway to G94252JR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94277TH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G09118YK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G04989WY", "dp": 13 }, { "id": "G16150CJ", "dp": 14 }, { "id": "G03895SR", "dp": 15 }, { "id": "G09118YK", "dp": 16 }, { "id": "G94277TH", "dp": 16 } ], "links": [ { "target": "G94277TH", "source": "G09118YK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09118YK", "source": "G03895SR", "residue_affected": { "residue_id": "N82", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G03895SR", "source": "G16150CJ", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G16150CJ", "source": "G04989WY", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04989WY", "source": "G86357DX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94297FY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 } ], "links": [ { "target": "G94297FY", "source": "G29492IF", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94322IZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16529MG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G16529MG", "dp": 14 }, { "id": "G94322IZ", "dp": 14 } ], "links": [ { "target": "G94322IZ", "source": "G16529MG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16529MG", "source": "G56549DH", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94363RH", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G08194HH", "dp": 14 }, { "id": "G14782PJ", "dp": 15 }, { "id": "G79950YS", "dp": 16 } ], "links": [ { "target": "G94363RH", "source": "G79950YS", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79950YS", "source": "G14782PJ", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14782PJ", "source": "G08194HH", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08194HH", "source": "G18938DW", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94394GK", "error": "Missing intermediate; no pathways to [G94394GK] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94401RA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G94401RA", "source": "G36191CD", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94423NC", "error": "Missing intermediate; no pathways to [G94423NC] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26881SV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94428FR", "error": "Starting point for pathway to G94428FR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94437IW", "error": "Missing intermediate; no pathways to [G94437IW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94450ZJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66634LZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G66634LZ", "dp": 9 }, { "id": "G94450ZJ", "dp": 9 } ], "links": [ { "target": "G94450ZJ", "source": "G66634LZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66634LZ", "source": "G29492IF", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94459TE", "error": "Starting point for pathway to G94459TE could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94481KZ", "error": "Starting point for pathway to G94481KZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94483MH", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92940AF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G67289UM", "dp": 13 }, { "id": "G92940AF", "dp": 14 }, { "id": "G94483MH", "dp": 14 } ], "links": [ { "target": "G94483MH", "source": "G92940AF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92940AF", "source": "G67289UM", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67289UM", "source": "G14959WS", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94485NP", "error": "Missing intermediate; no pathways to [G94485NP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G29857PJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94490EL", "error": "Missing intermediate; no pathways to [G94490EL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G94497JT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G31010RQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G31010RQ", "dp": 11 }, { "id": "G94497JT", "dp": 11 } ], "links": [ { "target": "G94497JT", "source": "G31010RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G31010RQ", "source": "G08863NS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94516KE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74012OU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G74012OU", "dp": 10 }, { "id": "G94516KE", "dp": 10 } ], "links": [ { "target": "G94516KE", "source": "G74012OU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G74012OU", "source": "G28550OD", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94529LL", "error": "Missing intermediate; no pathways to [G94529LL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94531EZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 } ], "links": [ { "target": "G94531EZ", "source": "G50489VC", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94541XJ", "error": "Missing intermediate; no pathways to [G94541XJ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G58473KL]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94544XK", "error": "Missing intermediate; no pathways to [G94544XK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10295MW]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94547KR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G14127XU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 }, { "id": "G14127XU", "dp": 13 }, { "id": "G94547KR", "dp": 13 } ], "links": [ { "target": "G94547KR", "source": "G14127XU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G14127XU", "source": "G91023GB", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94600JO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G94600JO", "source": "G61751GZ", "residue_affected": { "residue_id": "N256", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G94610SC", "error": "Missing intermediate; no pathways to [G94610SC] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94626AX", "error": "Missing intermediate; no pathways to [G94626AX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G09576QH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94630FK", "error": "Missing intermediate; no pathways to [G94630FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G20924UR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94667GT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G10209QU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G94667GT", "dp": 8 } ], "links": [ { "target": "G94667GT", "source": "G10209QU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94671TE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G98809PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G94671TE", "dp": 12 } ], "links": [ { "target": "G94671TE", "source": "G98809PE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94679TQ", "error": "Missing intermediate; no pathways to [G94679TQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94692TX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08340FW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G08340FW", "dp": 8 }, { "id": "G94692TX", "dp": 8 } ], "links": [ { "target": "G94692TX", "source": "G08340FW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08340FW", "source": "G39089YD", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G94718HG", "error": "Starting point for pathway to G94718HG could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94720HF", "error": "Starting point for pathway to G94720HF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94733WZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 } ], "links": [ { "target": "G94733WZ", "source": "G89877QI", "residue_affected": { "residue_id": "N203", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94734OT", "error": "Starting point for pathway to G94734OT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94736EY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G71835BN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G71835BN", "dp": 10 }, { "id": "G94736EY", "dp": 10 } ], "links": [ { "target": "G94736EY", "source": "G71835BN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94743PE", "error": "Missing intermediate; no pathways to [G94743PE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08062CY]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94748CQ", "error": "Starting point for pathway to G94748CQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G94754ZO", "error": "Missing intermediate; no pathways to [G94754ZO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94770AN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G33862NZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G90703DJ", "dp": 13 }, { "id": "G33862NZ", "dp": 14 }, { "id": "G94770AN", "dp": 14 } ], "links": [ { "target": "G94770AN", "source": "G33862NZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G33862NZ", "source": "G90703DJ", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G90703DJ", "source": "G74120DW", "residue_affected": { "residue_id": "N295", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94773HW", "error": "Missing intermediate; no pathways to [G94773HW] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94804ZC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G60660BN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G10228OD", "dp": 14 }, { "id": "G60660BN", "dp": 15 }, { "id": "G94804ZC", "dp": 15 } ], "links": [ { "target": "G94804ZC", "source": "G60660BN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60660BN", "source": "G10228OD", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10228OD", "source": "G50584UT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94806YM", "error": "Missing intermediate; no pathways to [G94806YM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G07162IJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94809SW", "error": "Missing intermediate; no pathways to [G94809SW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G62326NX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94814YD", "error": "Missing intermediate; no pathways to [G94814YD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G58827HR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94816EL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86298IX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G47175EF", "dp": 11 }, { "id": "G60215UL", "dp": 12 }, { "id": "G86298IX", "dp": 13 }, { "id": "G94816EL", "dp": 13 } ], "links": [ { "target": "G94816EL", "source": "G86298IX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86298IX", "source": "G60215UL", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60215UL", "source": "G47175EF", "residue_affected": { "residue_id": "N104", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47175EF", "source": "G78059CC", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94827FB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00951UF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G79198BK", "dp": 9 }, { "id": "G00951UF", "dp": 10 }, { "id": "G94827FB", "dp": 10 } ], "links": [ { "target": "G94827FB", "source": "G00951UF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00951UF", "source": "G79198BK", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79198BK", "source": "G10219AA", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94827SR", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G90348RI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G90348RI", "dp": 12 }, { "id": "G94827SR", "dp": 12 } ], "links": [ { "target": "G94827SR", "source": "G90348RI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90348RI", "source": "G11041DA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94838KN", "error": "Missing intermediate; no pathways to [G94838KN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94876HV", "error": "Missing intermediate; no pathways to [G94876HV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94926TV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20170YB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G34838RM", "dp": 10 }, { "id": "G63585HN", "dp": 11 }, { "id": "G20170YB", "dp": 12 }, { "id": "G94926TV", "dp": 12 } ], "links": [ { "target": "G94926TV", "source": "G20170YB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20170YB", "source": "G63585HN", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63585HN", "source": "G34838RM", "residue_affected": { "residue_id": "N74", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G34838RM", "source": "G80393PG", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94935XB", "error": "Missing intermediate; no pathways to [G94935XB] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G94941OA", "error": "Missing intermediate; no pathways to [G94941OA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94946LG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G44946WH]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G94946LG", "dp": 10 } ], "links": [ { "target": "G94946LG", "source": "G44946WH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94959AA", "error": "Missing intermediate; no pathways to [G94959AA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47279LF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G94975UV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G92574YO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G92574YO", "dp": 17 }, { "id": "G94975UV", "dp": 17 } ], "links": [ { "target": "G94975UV", "source": "G92574YO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G92574YO", "source": "G32287FD", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G94979RS", "error": "Missing intermediate; no pathways to [G94979RS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95019KZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G87349YT", "dp": 13 } ], "links": [ { "target": "G95019KZ", "source": "G87349YT", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G87349YT", "source": "G75049FP", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95021HX", "error": "Starting point for pathway to G95021HX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95081JK", "error": "Missing intermediate; no pathways to [G95081JK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G98906WL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95081VM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 } ], "links": [ { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95109CV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G34972BB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 }, { "id": "G34972BB", "dp": 15 }, { "id": "G95109CV", "dp": 15 } ], "links": [ { "target": "G95109CV", "source": "G34972BB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34972BB", "source": "G91905FJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95113MM", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G95113MM", "source": "G18938DW", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95172ZM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G57092OJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G95172ZM", "dp": 10 } ], "links": [ { "target": "G95172ZM", "source": "G57092OJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95186HE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78030KJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G78030KJ", "dp": 14 }, { "id": "G95186HE", "dp": 14 } ], "links": [ { "target": "G95186HE", "source": "G78030KJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78030KJ", "source": "G53812BX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95186RK", "error": "Missing intermediate; no pathways to [G95186RK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95201NS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G12740VA", "dp": 10 }, { "id": "G04544OS", "dp": 11 } ], "links": [ { "target": "G95201NS", "source": "G04544OS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04544OS", "source": "G12740VA", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12740VA", "source": "G09782JM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95222PD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75049FP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 }, { "id": "G95222PD", "dp": 12 } ], "links": [ { "target": "G95222PD", "source": "G75049FP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95227SJ", "error": "Starting point for pathway to G95227SJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95233RZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G38407OC", "dp": 12 } ], "links": [ { "target": "G95233RZ", "source": "G38407OC", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38407OC", "source": "G20815TK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95238UV", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G80858MF]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G95238UV", "dp": 8 } ], "links": [ { "target": "G95238UV", "source": "G80858MF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95251MI", "error": "Missing intermediate; no pathways to [G95251MI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90784AP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95260HV", "error": "Missing intermediate; no pathways to [G95260HV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95272YB", "error": "Starting point for pathway to G95272YB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95288UB", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 } ], "links": [ { "target": "G95288UB", "source": "G16828VN", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95294TJ", "error": "Missing intermediate; no pathways to [G95294TJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95298UR", "error": "Missing intermediate; no pathways to [G95298UR] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95312HT", "error": "Starting point for pathway to G95312HT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95333ZG", "error": "Missing intermediate; no pathways to [G95333ZG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G19104OH]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95335FK", "error": "Missing intermediate; no pathways to [G95335FK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95375WT", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G95617FJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G95617FJ", "dp": 12 }, { "id": "G95375WT", "dp": 12 } ], "links": [ { "target": "G95375WT", "source": "G95617FJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95617FJ", "source": "G25520XG", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95382MF", "error": "Starting point for pathway to G95382MF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95393JS", "error": "Starting point for pathway to G95393JS could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95404EQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G35310KA", "dp": 11 }, { "id": "G50774CV", "dp": 12 }, { "id": "G81663ZI", "dp": 13 }, { "id": "G11953VE", "dp": 14 }, { "id": "G40606GB", "dp": 15 }, { "id": "G90284FM", "dp": 16 } ], "links": [ { "target": "G95404EQ", "source": "G90284FM", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90284FM", "source": "G40606GB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40606GB", "source": "G11953VE", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11953VE", "source": "G81663ZI", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G81663ZI", "source": "G50774CV", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50774CV", "source": "G35310KA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G35310KA", "source": "G79609RF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95421II", "error": "Missing intermediate; no pathways to [G95421II] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53504BR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95423TN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G38395YJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G38395YJ", "dp": 14 }, { "id": "G95423TN", "dp": 14 } ], "links": [ { "target": "G95423TN", "source": "G38395YJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95440SV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59579TL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G78797VK", "dp": 15 }, { "id": "G02311IE", "dp": 16 }, { "id": "G86753CK", "dp": 17 }, { "id": "G59579TL", "dp": 18 }, { "id": "G95440SV", "dp": 18 } ], "links": [ { "target": "G95440SV", "source": "G59579TL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G59579TL", "source": "G86753CK", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86753CK", "source": "G02311IE", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02311IE", "source": "G78797VK", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78797VK", "source": "G63889NK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95462VZ", "error": "Missing intermediate; no pathways to [G95462VZ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G36223VW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95473VJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09150LP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G44946WH", "dp": 10 }, { "id": "G88948CY", "dp": 11 }, { "id": "G09150LP", "dp": 12 }, { "id": "G95473VJ", "dp": 12 } ], "links": [ { "target": "G95473VJ", "source": "G09150LP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09150LP", "source": "G88948CY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88948CY", "source": "G44946WH", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G44946WH", "source": "G61207RZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95474CQ", "error": "Missing intermediate; no pathways to [G95474CQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G74286KY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95490LA", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G95490LA", "source": "G18938DW", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95512GZ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G60564DP", "dp": 14 }, { "id": "G31494OZ", "dp": 15 }, { "id": "G91386RN", "dp": 16 } ], "links": [ { "target": "G95512GZ", "source": "G91386RN", "residue_affected": { "residue_id": "N200", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] }, { "target": "G91386RN", "source": "G31494OZ", "residue_affected": { "residue_id": "N71", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G31494OZ", "source": "G60564DP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G60564DP", "source": "G18938DW", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95515VZ", "error": "Starting point for pathway to G95515VZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95525PB", "error": "Missing intermediate; no pathways to [G95525PB] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95528TZ", "error": "Missing intermediate; no pathways to [G95528TZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G83541HL]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95528UC", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G60103QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 }, { "id": "G60103QI", "dp": 12 }, { "id": "G95528UC", "dp": 12 } ], "links": [ { "target": "G95528UC", "source": "G60103QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60103QI", "source": "G54611ZT", "residue_affected": { "residue_id": "N266", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95536UW", "error": "Missing intermediate; no pathways to [G95536UW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G12241WD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95542JQ", "error": "Missing intermediate; no pathways to [G95542JQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95593DQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G11041DA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G95593DQ", "dp": 11 } ], "links": [ { "target": "G95593DQ", "source": "G11041DA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95617FJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 } ], "links": [ { "target": "G95617FJ", "source": "G25520XG", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95619PX", "error": "Missing intermediate; no pathways to [G95619PX] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G87807PF]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95633RJ", "error": "Starting point for pathway to G95633RJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95639FY", "error": "Starting point for pathway to G95639FY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95655OA", "error": "Starting point for pathway to G95655OA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95658PH", "error": "Missing intermediate; no pathways to [G95658PH] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95677OZ", "error": "Starting point for pathway to G95677OZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95695ZV", "error": "Missing intermediate; no pathways to [G95695ZV] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95713LQ", "error": "Starting point for pathway to G95713LQ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95732UV", "error": "Starting point for pathway to G95732UV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95782RB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G37140SO]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G37140SO", "dp": 10 }, { "id": "G95782RB", "dp": 10 } ], "links": [ { "target": "G95782RB", "source": "G37140SO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37140SO", "source": "G93500PH", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95786NX", "error": "Starting point for pathway to G95786NX could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95788IL", "error": "Missing intermediate; no pathways to [G95788IL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95796NP", "error": "Starting point for pathway to G95796NP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95801CS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75412QZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G75412QZ", "dp": 14 }, { "id": "G95801CS", "dp": 14 } ], "links": [ { "target": "G95801CS", "source": "G75412QZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75412QZ", "source": "G18938DW", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95819KY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G37166HP]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G11637WL", "dp": 10 }, { "id": "G37166HP", "dp": 11 }, { "id": "G95819KY", "dp": 11 } ], "links": [ { "target": "G95819KY", "source": "G37166HP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G37166HP", "source": "G11637WL", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11637WL", "source": "G16828VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95849ZD", "error": "Starting point for pathway to G95849ZD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95861WO", "error": "Missing intermediate; no pathways to [G95861WO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95898GD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 } ], "links": [ { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95901MC", "error": "Starting point for pathway to G95901MC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95910WJ", "error": "Missing intermediate; no pathways to [G95910WJ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G36223VW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95919TI", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G30651IU", "dp": 13 } ], "links": [ { "target": "G95919TI", "source": "G30651IU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30651IU", "source": "G86357DX", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95940WS", "error": "Missing intermediate; no pathways to [G95940WS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G92918FJ]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95952ST", "error": "Missing intermediate; no pathways to [G95952ST] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G34508UC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95956WE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G42548XF", "dp": 7 } ], "links": [ { "target": "G95956WE", "source": "G42548XF", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42548XF", "source": "G61751GZ", "residue_affected": { "residue_id": "N204", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [] } ] } , { "glytoucan_ac": "G95963DM", "error": "Starting point for pathway to G95963DM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95984JN", "error": "Starting point for pathway to G95984JN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G95989NQ", "error": "Missing intermediate; no pathways to [G95989NQ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95994EE", "error": "Missing intermediate; no pathways to [G95994EE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G77475MM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G95997CK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10716SX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G37385TT", "dp": 11 }, { "id": "G10716SX", "dp": 12 }, { "id": "G95997CK", "dp": 12 } ], "links": [ { "target": "G95997CK", "source": "G10716SX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10716SX", "source": "G37385TT", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37385TT", "source": "G88417ED", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G95998QK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G09446VC", "dp": 10 }, { "id": "G49827WK", "dp": 11 } ], "links": [ { "target": "G95998QK", "source": "G49827WK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G49827WK", "source": "G09446VC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09446VC", "source": "G30159WR", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96004HC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G32065BG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G96004HC", "dp": 12 } ], "links": [ { "target": "G96004HC", "source": "G32065BG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96024GG", "error": "Starting point for pathway to G96024GG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96045AL", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G57955DP]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G96045AL", "dp": 15 } ], "links": [ { "target": "G96045AL", "source": "G57955DP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96060VZ", "error": "Missing intermediate; no pathways to [G96060VZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08076GP]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G96063MG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 } ], "links": [ { "target": "G96063MG", "source": "G67045LB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96079QX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54956ME]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G88417ED", "dp": 10 }, { "id": "G18641OW", "dp": 11 }, { "id": "G54956ME", "dp": 12 }, { "id": "G96079QX", "dp": 12 } ], "links": [ { "target": "G96079QX", "source": "G54956ME", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54956ME", "source": "G18641OW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18641OW", "source": "G88417ED", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88417ED", "source": "G88461FF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96081GH", "error": "Missing intermediate; no pathways to [G96081GH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G59752BW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96091LW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G93500PH", "dp": 9 }, { "id": "G07228BR", "dp": 10 } ], "links": [ { "target": "G96091LW", "source": "G07228BR", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07228BR", "source": "G93500PH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93500PH", "source": "G29011JC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96113SZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G82420SH", "dp": 10 } ], "links": [ { "target": "G96113SZ", "source": "G82420SH", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82420SH", "source": "G45262QY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96122UB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16759KR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G96122UB", "dp": 9 } ], "links": [ { "target": "G96122UB", "source": "G16759KR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96137SX", "error": "Missing intermediate; no pathways to [G96137SX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G42477ZH]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G96153DN", "error": "Starting point for pathway to G96153DN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96168ED", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G54611ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G54611ZT", "dp": 11 }, { "id": "G96168ED", "dp": 11 } ], "links": [ { "target": "G96168ED", "source": "G54611ZT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54611ZT", "source": "G78059CC", "residue_affected": { "residue_id": "N45", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96175KT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94047VH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G94047VH", "dp": 11 }, { "id": "G96175KT", "dp": 11 } ], "links": [ { "target": "G96175KT", "source": "G94047VH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G94047VH", "source": "G07995VK", "residue_affected": { "residue_id": "N479", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96176PI", "error": "Missing intermediate; no pathways to [G96176PI] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96192TD", "error": "Missing intermediate; no pathways to [G96192TD] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G96223WK", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 } ], "links": [ { "target": "G96223WK", "source": "G47782UT", "residue_affected": { "residue_id": "N52", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96235XM", "error": "Missing intermediate; no pathways to [G96235XM] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96251ED", "error": "Starting point for pathway to G96251ED could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96293XW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G95617FJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G95617FJ", "dp": 12 }, { "id": "G96293XW", "dp": 12 } ], "links": [ { "target": "G96293XW", "source": "G95617FJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G95617FJ", "source": "G25520XG", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96309VY", "error": "Starting point for pathway to G96309VY could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96370EB", "error": "Starting point for pathway to G96370EB could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96384IY", "error": "Missing intermediate; no pathways to [G96384IY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03948VT]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96417PJ", "error": "Starting point for pathway to G96417PJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96439CH", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G60419KX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G96963QG", "dp": 12 }, { "id": "G73759SD", "dp": 13 }, { "id": "G60419KX", "dp": 14 }, { "id": "G96439CH", "dp": 14 } ], "links": [ { "target": "G96439CH", "source": "G60419KX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G60419KX", "source": "G73759SD", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73759SD", "source": "G96963QG", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96444IW", "error": "", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G84363RQ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G07995VK", "dp": 10 }, { "id": "G84363RQ", "dp": 11 }, { "id": "G96444IW", "dp": 11 } ], "links": [ { "target": "G96444IW", "source": "G84363RQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G84363RQ", "source": "G07995VK", "residue_affected": { "residue_id": "N237", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G07995VK", "source": "G36191CD", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96445EY", "error": "Missing intermediate; no pathways to [G96445EY] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G84163ZT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96484SJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 } ], "links": [ { "target": "G96484SJ", "source": "G21755KD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96503EZ", "error": "Missing intermediate; no pathways to [G96503EZ] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96508BN", "error": "Missing intermediate; no pathways to [G96508BN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G41953RN]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96552CZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75720YC]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G75720YC", "dp": 11 }, { "id": "G96552CZ", "dp": 11 } ], "links": [ { "target": "G96552CZ", "source": "G75720YC", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75720YC", "source": "G01856RL", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96554LN", "error": "Missing intermediate; no pathways to [G96554LN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G55645TD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96570OI", "error": "Starting point for pathway to G96570OI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96578LW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09921WG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G10209QU", "dp": 8 }, { "id": "G45262QY", "dp": 9 }, { "id": "G09921WG", "dp": 10 }, { "id": "G96578LW", "dp": 10 } ], "links": [ { "target": "G96578LW", "source": "G09921WG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09921WG", "source": "G45262QY", "residue_affected": { "residue_id": "N86", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45262QY", "source": "G10209QU", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10209QU", "source": "G07483YN", "residue_affected": { "residue_id": "N44", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96644ZT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G09826WW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G09826WW", "dp": 11 }, { "id": "G96644ZT", "dp": 11 } ], "links": [ { "target": "G96644ZT", "source": "G09826WW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G09826WW", "source": "G85542KD", "residue_affected": { "residue_id": "N271", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96650VB", "error": "Starting point for pathway to G96650VB could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96671XB", "error": "Missing intermediate; no pathways to [G96671XB] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96674LJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G32287FD", "dp": 16 }, { "id": "G50489VC", "dp": 17 } ], "links": [ { "target": "G96674LJ", "source": "G50489VC", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50489VC", "source": "G32287FD", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32287FD", "source": "G76842ZR", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96677EZ", "error": "Missing intermediate; no pathways to [G96677EZ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96680QM", "error": "Missing intermediate; no pathways to [G96680QM] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08896RO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96715HA", "error": "Starting point for pathway to G96715HA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96719MC", "error": "Missing intermediate; no pathways to [G96719MC] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96727JJ", "error": "Starting point for pathway to G96727JJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96738MG", "error": "Missing intermediate; no pathways to [G96738MG] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G81738MQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96768SN", "error": "Starting point for pathway to G96768SN could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96786JM", "error": "Starting point for pathway to G96786JM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96788FR", "error": "Starting point for pathway to G96788FR could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96794ZC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53812BX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G96794ZC", "dp": 13 } ], "links": [ { "target": "G96794ZC", "source": "G53812BX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96841SQ", "error": "Missing intermediate; no pathways to [G96841SQ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G83635VI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96852FA", "error": "Missing intermediate; no pathways to [G96852FA] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G83635VI]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96852SM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75412QZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G75412QZ", "dp": 14 }, { "id": "G96852SM", "dp": 14 } ], "links": [ { "target": "G96852SM", "source": "G75412QZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75412QZ", "source": "G18938DW", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96861IW", "error": "Missing intermediate; no pathways to [G96861IW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96866DI", "error": "Starting point for pathway to G96866DI could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96891EB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75308SV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G88966ZO", "dp": 15 }, { "id": "G75308SV", "dp": 16 }, { "id": "G96891EB", "dp": 16 } ], "links": [ { "target": "G96891EB", "source": "G75308SV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75308SV", "source": "G88966ZO", "residue_affected": { "residue_id": "N37", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88966ZO", "source": "G63889NK", "residue_affected": { "residue_id": "N36", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "B3GNT8", "uniprot": "Q7Z7M8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT4", "uniprot": "Q9C0J1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GNT2", "uniprot": "Q9NY97", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3gnt4", "uniprot": "Q1RLK6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt8", "uniprot": "Q8R3I9", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3gnt2", "uniprot": "Q9Z222", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96896RL", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G63787RZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G27919IH", "dp": 9 }, { "id": "G63787RZ", "dp": 10 }, { "id": "G96896RL", "dp": 10 } ], "links": [ { "target": "G96896RL", "source": "G63787RZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63787RZ", "source": "G27919IH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27919IH", "source": "G80858MF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96906RY", "error": "Starting point for pathway to G96906RY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G96915NW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G51793MY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G51793MY", "dp": 11 }, { "id": "G96915NW", "dp": 11 } ], "links": [ { "target": "G96915NW", "source": "G51793MY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51793MY", "source": "G45560HM", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96916QO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G16529MG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G16529MG", "dp": 14 }, { "id": "G96916QO", "dp": 14 } ], "links": [ { "target": "G96916QO", "source": "G16529MG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16529MG", "source": "G56549DH", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96919WB", "error": "Missing intermediate; no pathways to [G96919WB] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96921ZU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 } ], "links": [ { "target": "G96921ZU", "source": "G11041DA", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96925LL", "error": "Missing intermediate; no pathways to [G96925LL] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96931PQ", "error": "Missing intermediate; no pathways to [G96931PQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G96931TH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 }, { "id": "G30723RE", "dp": 11 } ], "links": [ { "target": "G96931TH", "source": "G30723RE", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30723RE", "source": "G68937TM", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G96963QG", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 } ], "links": [ { "target": "G96963QG", "source": "G79809MM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97021RI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G04783EJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G05600OX", "dp": 14 }, { "id": "G04783EJ", "dp": 15 }, { "id": "G97021RI", "dp": 15 } ], "links": [ { "target": "G97021RI", "source": "G04783EJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G04783EJ", "source": "G05600OX", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G05600OX", "source": "G01727PW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97023FS", "error": "Starting point for pathway to G97023FS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97039HI", "error": "Missing intermediate; no pathways to [G97039HI] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97048SU", "error": "Starting point for pathway to G97048SU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97066VR", "error": "Starting point for pathway to G97066VR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97078FW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 } ], "links": [ { "target": "G97078FW", "source": "G56549DH", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97093EP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G27123NH", "dp": 10 }, { "id": "G43433FA", "dp": 11 } ], "links": [ { "target": "G97093EP", "source": "G43433FA", "residue_affected": { "residue_id": "N257", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G43433FA", "source": "G27123NH", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G27123NH", "source": "G46638GC", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97105ZG", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G91023GB", "dp": 12 } ], "links": [ { "target": "G97105ZG", "source": "G91023GB", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91023GB", "source": "G25520XG", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97109LT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G76478FT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G76478FT", "dp": 11 }, { "id": "G97109LT", "dp": 11 } ], "links": [ { "target": "G97109LT", "source": "G76478FT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76478FT", "source": "G78059CC", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97123TW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61575RT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G82050MN", "dp": 13 }, { "id": "G61575RT", "dp": 14 }, { "id": "G97123TW", "dp": 14 } ], "links": [ { "target": "G97123TW", "source": "G61575RT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61575RT", "source": "G82050MN", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82050MN", "source": "G84376FR", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97130PD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90870DG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G97130PD", "dp": 11 } ], "links": [ { "target": "G97130PD", "source": "G90870DG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97159KS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 } ], "links": [ { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97166FW", "error": "Starting point for pathway to G97166FW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97168QA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45187EI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G45187EI", "dp": 11 }, { "id": "G97168QA", "dp": 11 } ], "links": [ { "target": "G97168QA", "source": "G45187EI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45187EI", "source": "G08577ZR", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97179UV", "error": "Starting point for pathway to G97179UV could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97183TW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08577ZR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97183TW", "dp": 10 } ], "links": [ { "target": "G97183TW", "source": "G08577ZR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97185IQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G10770RR]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G03951JJ", "dp": 12 }, { "id": "G20926BB", "dp": 13 }, { "id": "G82033VN", "dp": 14 }, { "id": "G10770RR", "dp": 15 }, { "id": "G97185IQ", "dp": 15 } ], "links": [ { "target": "G97185IQ", "source": "G10770RR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G10770RR", "source": "G82033VN", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82033VN", "source": "G20926BB", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20926BB", "source": "G03951JJ", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03951JJ", "source": "G79809MM", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97201CX", "error": "Missing intermediate; no pathways to [G97201CX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G97267JL", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 } ], "links": [ { "target": "G97267JL", "source": "G69411IG", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97292GW", "error": "Starting point for pathway to G97292GW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97307XK", "error": "Starting point for pathway to G97307XK could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97309BN", "error": "Missing intermediate; no pathways to [G97309BN] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97347VR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53485VW]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 }, { "id": "G97347VR", "dp": 14 } ], "links": [ { "target": "G97347VR", "source": "G53485VW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97352VJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G98809PE]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G97352VJ", "dp": 12 } ], "links": [ { "target": "G97352VJ", "source": "G98809PE", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97353GO", "error": "Starting point for pathway to G97353GO could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97423PY", "error": "Starting point for pathway to G97423PY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97453GF", "error": "Missing intermediate; no pathways to [G97453GF] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97455PT", "error": "Starting point for pathway to G97455PT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97487AJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G06374YY]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G06374YY", "dp": 10 }, { "id": "G97487AJ", "dp": 10 } ], "links": [ { "target": "G97487AJ", "source": "G06374YY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06374YY", "source": "G16828VN", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97498CP", "error": "Missing intermediate; no pathways to [G97498CP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G94610SC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97511SW", "error": "Starting point for pathway to G97511SW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97523ON", "error": "Missing intermediate; no pathways to [G97523ON] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G94610SC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97545UW", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G37046CZ", "dp": 11 }, { "id": "G14959WS", "dp": 12 }, { "id": "G95898GD", "dp": 13 }, { "id": "G01923XE", "dp": 14 }, { "id": "G32808NL", "dp": 15 } ], "links": [ { "target": "G97545UW", "source": "G32808NL", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32808NL", "source": "G01923XE", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01923XE", "source": "G95898GD", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95898GD", "source": "G14959WS", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14959WS", "source": "G37046CZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37046CZ", "source": "G32305RZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97547WF", "error": "Starting point for pathway to G97547WF could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97548TA", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G99645NK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G97548TA", "dp": 11 } ], "links": [ { "target": "G97548TA", "source": "G99645NK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97553BW", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G30460NZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G30460NZ", "dp": 11 }, { "id": "G97553BW", "dp": 11 } ], "links": [ { "target": "G97553BW", "source": "G30460NZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30460NZ", "source": "G78059CC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97575FW", "error": "Missing intermediate; no pathways to [G97575FW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G53962WT]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G97616MU", "error": "Starting point for pathway to G97616MU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97628LQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G50078RT", "dp": 12 } ], "links": [ { "target": "G97628LQ", "source": "G50078RT", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G50078RT", "source": "G79809MM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97645ML", "error": "Missing intermediate; no pathways to [G97645ML] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G96719MC]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97655FR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G48954CA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G48954CA", "dp": 9 }, { "id": "G97655FR", "dp": 9 } ], "links": [ { "target": "G97655FR", "source": "G48954CA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G48954CA", "source": "G12398HZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97674NY", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 } ], "links": [ { "target": "G97674NY", "source": "G89877QI", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97682ZN", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G59915YZ", "dp": 11 } ], "links": [ { "target": "G97682ZN", "source": "G59915YZ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59915YZ", "source": "G79609RF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97686QU", "error": "Missing intermediate; no pathways to [G97686QU] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G97709WW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78030KJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G78030KJ", "dp": 14 }, { "id": "G97709WW", "dp": 14 } ], "links": [ { "target": "G97709WW", "source": "G78030KJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78030KJ", "source": "G53812BX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97720QM", "error": "Starting point for pathway to G97720QM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97765TT", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 } ], "links": [ { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97770GP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56499YQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G38022PE", "dp": 14 }, { "id": "G57955DP", "dp": 15 }, { "id": "G56499YQ", "dp": 16 }, { "id": "G97770GP", "dp": 16 } ], "links": [ { "target": "G97770GP", "source": "G56499YQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56499YQ", "source": "G57955DP", "residue_affected": { "residue_id": "N228", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G57955DP", "source": "G38022PE", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G38022PE", "source": "G19726AG", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97814YJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G25140TA]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G22795QB", "dp": 10 }, { "id": "G25140TA", "dp": 11 }, { "id": "G97814YJ", "dp": 11 } ], "links": [ { "target": "G97814YJ", "source": "G25140TA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G25140TA", "source": "G22795QB", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G22795QB", "source": "G72718TT", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97842ZO", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G78173WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G78173WX", "dp": 11 }, { "id": "G97842ZO", "dp": 11 } ], "links": [ { "target": "G97842ZO", "source": "G78173WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G78173WX", "source": "G43694RQ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97846KQ", "error": "Missing intermediate; no pathways to [G97846KQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97865QM", "error": "Missing intermediate; no pathways to [G97865QM] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97893LN", "error": "Starting point for pathway to G97893LN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97895RK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 } ], "links": [ { "target": "G97895RK", "source": "G79578JB", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97910HZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G72821WX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G72821WX", "dp": 9 }, { "id": "G97910HZ", "dp": 9 } ], "links": [ { "target": "G97910HZ", "source": "G72821WX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97915KM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G56549DH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G97915KM", "dp": 13 } ], "links": [ { "target": "G97915KM", "source": "G56549DH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97947UQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G04791QM", "dp": 9 }, { "id": "G91365ZQ", "dp": 10 }, { "id": "G14047PA", "dp": 11 } ], "links": [ { "target": "G97947UQ", "source": "G14047PA", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G14047PA", "source": "G91365ZQ", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91365ZQ", "source": "G04791QM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G04791QM", "source": "G66937TJ", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97948YW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G34905OT]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G77639OD", "dp": 10 }, { "id": "G34905OT", "dp": 11 }, { "id": "G97948YW", "dp": 11 } ], "links": [ { "target": "G97948YW", "source": "G34905OT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G34905OT", "source": "G77639OD", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G77639OD", "source": "G20030CU", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97958KV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G45365RV", "dp": 10 } ], "links": [ { "target": "G97958KV", "source": "G45365RV", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45365RV", "source": "G46638GC", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97964WC", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G07410AW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G37597FW", "dp": 13 }, { "id": "G07410AW", "dp": 14 }, { "id": "G97964WC", "dp": 14 } ], "links": [ { "target": "G97964WC", "source": "G07410AW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G07410AW", "source": "G37597FW", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37597FW", "source": "G98809PE", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G97970WP", "error": "Missing intermediate; no pathways to [G97970WP] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G97972ZM", "error": "Starting point for pathway to G97972ZM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G97996SP", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G80393PG", "dp": 9 }, { "id": "G08577ZR", "dp": 10 }, { "id": "G97159KS", "dp": 11 }, { "id": "G45359RY", "dp": 12 }, { "id": "G93582HM", "dp": 13 }, { "id": "G91905FJ", "dp": 14 } ], "links": [ { "target": "G97996SP", "source": "G91905FJ", "residue_affected": { "residue_id": "N57", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G91905FJ", "source": "G93582HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93582HM", "source": "G45359RY", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45359RY", "source": "G97159KS", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G97159KS", "source": "G08577ZR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08577ZR", "source": "G80393PG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80393PG", "source": "G10219AA", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98016TZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G01935FK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G01935FK", "dp": 10 }, { "id": "G98016TZ", "dp": 10 } ], "links": [ { "target": "G98016TZ", "source": "G01935FK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G01935FK", "source": "G36191CD", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98030BR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G51066TO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 }, { "id": "G51066TO", "dp": 13 }, { "id": "G98030BR", "dp": 13 } ], "links": [ { "target": "G98030BR", "source": "G51066TO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G51066TO", "source": "G10733HY", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98048XD", "error": "Starting point for pathway to G98048XD could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98066UT", "error": "Starting point for pathway to G98066UT could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98115AV", "error": "Missing intermediate; no pathways to [G98115AV] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98117HW", "error": "Missing intermediate; no pathways to [G98117HW] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G98136FX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G82252QI]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G98136FX", "dp": 11 } ], "links": [ { "target": "G98136FX", "source": "G82252QI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98140IX", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 } ], "links": [ { "target": "G98140IX", "source": "G61751GZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98144KB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G45664QZ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G29492IF", "dp": 8 }, { "id": "G09782JM", "dp": 9 }, { "id": "G21755KD", "dp": 10 }, { "id": "G71442FU", "dp": 11 }, { "id": "G81432SH", "dp": 12 }, { "id": "G45664QZ", "dp": 13 }, { "id": "G98144KB", "dp": 13 } ], "links": [ { "target": "G98144KB", "source": "G45664QZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G45664QZ", "source": "G81432SH", "residue_affected": { "residue_id": "N216", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G81432SH", "source": "G71442FU", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71442FU", "source": "G21755KD", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21755KD", "source": "G09782JM", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G09782JM", "source": "G29492IF", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29492IF", "source": "G69411IG", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98190RD", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 } ], "links": [ { "target": "G98190RD", "source": "G52934AK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98207CW", "error": "Missing intermediate; no pathways to [G98207CW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84777MO]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98212GQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77252PU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G45560HM", "dp": 10 }, { "id": "G77252PU", "dp": 11 }, { "id": "G98212GQ", "dp": 11 } ], "links": [ { "target": "G98212GQ", "source": "G77252PU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77252PU", "source": "G45560HM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G45560HM", "source": "G16759KR", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98215MN", "error": "Missing intermediate; no pathways to [G98215MN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G98217YG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G66265KN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G33262YZ", "dp": 11 }, { "id": "G66265KN", "dp": 12 }, { "id": "G98217YG", "dp": 12 } ], "links": [ { "target": "G98217YG", "source": "G66265KN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66265KN", "source": "G33262YZ", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G33262YZ", "source": "G52934AK", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98218PF", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G68937TM", "dp": 10 } ], "links": [ { "target": "G98218PF", "source": "G68937TM", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G68937TM", "source": "G58667NI", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98220BB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G26255AN]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G16828VN", "dp": 9 }, { "id": "G08187GM", "dp": 10 }, { "id": "G26274XD", "dp": 11 }, { "id": "G26255AN", "dp": 12 }, { "id": "G98220BB", "dp": 12 } ], "links": [ { "target": "G98220BB", "source": "G26255AN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26255AN", "source": "G26274XD", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26274XD", "source": "G08187GM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08187GM", "source": "G16828VN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G16828VN", "source": "G08520NM", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98223HN", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90825UM]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G30370YC", "dp": 9 }, { "id": "G01856RL", "dp": 10 }, { "id": "G90825UM", "dp": 11 }, { "id": "G98223HN", "dp": 11 } ], "links": [ { "target": "G98223HN", "source": "G90825UM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90825UM", "source": "G01856RL", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01856RL", "source": "G30370YC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30370YC", "source": "G66937TJ", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98256YA", "error": "Starting point for pathway to G98256YA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98277JD", "error": "Missing intermediate; no pathways to [G98277JD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98292JT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43299SD]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G29011JC", "dp": 8 }, { "id": "G43299SD", "dp": 9 }, { "id": "G98292JT", "dp": 9 } ], "links": [ { "target": "G98292JT", "source": "G43299SD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43299SD", "source": "G29011JC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29011JC", "source": "G39213VZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98296BQ", "error": "Missing intermediate; no pathways to [G98296BQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G40341NV]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98305AY", "error": "Starting point for pathway to G98305AY could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98344LB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G19726AG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G19726AG", "dp": 13 }, { "id": "G98344LB", "dp": 13 } ], "links": [ { "target": "G98344LB", "source": "G19726AG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G19726AG", "source": "G86357DX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98348DX", "error": "Missing intermediate; no pathways to [G98348DX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G99808VS]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98366ZJ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G99074EO", "dp": 13 } ], "links": [ { "target": "G98366ZJ", "source": "G99074EO", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98369DU", "error": "Missing intermediate; no pathways to [G98369DU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G24984RR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98380JU", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 }, { "id": "G59915YZ", "dp": 11 } ], "links": [ { "target": "G98380JU", "source": "G59915YZ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59915YZ", "source": "G79609RF", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98415RH", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G40358EZ", "dp": 11 }, { "id": "G07800ED", "dp": 12 } ], "links": [ { "target": "G98415RH", "source": "G07800ED", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07800ED", "source": "G40358EZ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G40358EZ", "source": "G00176HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98416UB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75903TQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G82252QI", "dp": 11 }, { "id": "G75903TQ", "dp": 12 }, { "id": "G98416UB", "dp": 12 } ], "links": [ { "target": "G98416UB", "source": "G75903TQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75903TQ", "source": "G82252QI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82252QI", "source": "G90017UO", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98419CX", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G97765TT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G18219CJ", "dp": 11 }, { "id": "G97765TT", "dp": 12 }, { "id": "G98419CX", "dp": 12 } ], "links": [ { "target": "G98419CX", "source": "G97765TT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G97765TT", "source": "G18219CJ", "residue_affected": { "residue_id": "N97", "pubchem_name": "GalNAc", "anomer": "a", "absolute": "D", "form_name": "GalpNAc", "full_name": "α-D-GalpNAc" }, "effect": "Add α-D-GalpNAc", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18219CJ", "source": "G78059CC", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98434QR", "error": "Starting point for pathway to G98434QR could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98445EF", "error": "Missing intermediate; no pathways to [G98445EF] could be generated at this time", "notes": [ "reducing end mismatch [a-D-GlcpNAc]", "homologous pathway end-point [G43873MM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98450JT", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88537BJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G75120WS", "dp": 13 }, { "id": "G23616ZX", "dp": 14 }, { "id": "G88537BJ", "dp": 15 }, { "id": "G98450JT", "dp": 15 } ], "links": [ { "target": "G98450JT", "source": "G88537BJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88537BJ", "source": "G23616ZX", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G23616ZX", "source": "G75120WS", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75120WS", "source": "G84376FR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98452OT", "error": "Missing intermediate; no pathways to [G98452OT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G22865RK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98453VS", "error": "Missing intermediate; no pathways to [G98453VS] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98485VQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G65597BI]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G98485VQ", "dp": 10 } ], "links": [ { "target": "G98485VQ", "source": "G65597BI", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98490BN", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G20815TK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G98490BN", "dp": 11 } ], "links": [ { "target": "G98490BN", "source": "G20815TK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98516BG", "error": "Starting point for pathway to G98516BG could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98537XO", "error": "Missing intermediate; no pathways to [G98537XO] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98549NZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G00743WU]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G85542KD", "dp": 10 }, { "id": "G00743WU", "dp": 11 }, { "id": "G98549NZ", "dp": 11 } ], "links": [ { "target": "G98549NZ", "source": "G00743WU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G00743WU", "source": "G85542KD", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G85542KD", "source": "G88461FF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98552UD", "error": "Missing intermediate; no pathways to [G98552UD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98559XP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 } ], "links": [ { "target": "G98559XP", "source": "G18938DW", "residue_affected": { "residue_id": "N18", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98562YD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G89099NM]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G89099NM", "dp": 10 }, { "id": "G98562YD", "dp": 10 } ], "links": [ { "target": "G98562YD", "source": "G89099NM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G89099NM", "source": "G20966TZ", "residue_affected": { "residue_id": "N23", "pubchem_name": "Man", "anomer": "a", "absolute": "D", "form_name": "Manp", "full_name": "α-D-Manp" }, "effect": "Add α-D-Manp", "enzymes": [ { "gene_name": "ALG12", "uniprot": "Q9BV10", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Alg12", "uniprot": "Q8VDB2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98565KP", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G53485VW", "dp": 14 } ], "links": [ { "target": "G98565KP", "source": "G53485VW", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53485VW", "source": "G18938DW", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98566CZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G93204KY]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G57943ZV", "dp": 11 }, { "id": "G93204KY", "dp": 12 }, { "id": "G98566CZ", "dp": 12 } ], "links": [ { "target": "G98566CZ", "source": "G93204KY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G93204KY", "source": "G57943ZV", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57943ZV", "source": "G52934AK", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98572JS", "error": "Starting point for pathway to G98572JS could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98590PE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G43677TG", "dp": 8 }, { "id": "G72718TT", "dp": 9 }, { "id": "G52934AK", "dp": 10 }, { "id": "G76528ZS", "dp": 11 }, { "id": "G68946DB", "dp": 12 } ], "links": [ { "target": "G98590PE", "source": "G68946DB", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G68946DB", "source": "G76528ZS", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76528ZS", "source": "G52934AK", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52934AK", "source": "G72718TT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72718TT", "source": "G43677TG", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43677TG", "source": "G69411IG", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98602UY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20966TZ]", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G20966TZ", "dp": 9 }, { "id": "G98602UY", "dp": 9 } ], "links": [ { "target": "G98602UY", "source": "G20966TZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20966TZ", "source": "G08520NM", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98608RK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G32699RJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G32699RJ", "dp": 10 }, { "id": "G98608RK", "dp": 10 } ], "links": [ { "target": "G98608RK", "source": "G32699RJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G32699RJ", "source": "G63074CQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98615GD", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G90703DJ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G74120DW", "dp": 12 }, { "id": "G90703DJ", "dp": 13 }, { "id": "G98615GD", "dp": 13 } ], "links": [ { "target": "G98615GD", "source": "G90703DJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90703DJ", "source": "G74120DW", "residue_affected": { "residue_id": "N295", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [] }, { "target": "G74120DW", "source": "G82779CI", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98619FZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G08340FW]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G08340FW", "dp": 8 }, { "id": "G98619FZ", "dp": 8 } ], "links": [ { "target": "G98619FZ", "source": "G08340FW", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G08340FW", "source": "G39089YD", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G98671GW", "error": "Starting point for pathway to G98671GW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98683EN", "error": "Missing intermediate; no pathways to [G98683EN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47554EG]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98687PM", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G16759KR]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G16759KR", "dp": 9 }, { "id": "G98687PM", "dp": 9 } ], "links": [ { "target": "G98687PM", "source": "G16759KR", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G16759KR", "source": "G66937TJ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98698LY", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86566MF]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G02427KF", "dp": 7 }, { "id": "G37476QB", "dp": 8 }, { "id": "G63074CQ", "dp": 9 }, { "id": "G32699RJ", "dp": 10 }, { "id": "G86566MF", "dp": 11 }, { "id": "G98698LY", "dp": 11 } ], "links": [ { "target": "G98698LY", "source": "G86566MF", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86566MF", "source": "G32699RJ", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32699RJ", "source": "G63074CQ", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63074CQ", "source": "G37476QB", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37476QB", "source": "G02427KF", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G02427KF", "source": "G61751GZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98712QJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G20815TK]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G98712QJ", "dp": 11 } ], "links": [ { "target": "G98712QJ", "source": "G20815TK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98723AA", "error": "Starting point for pathway to G98723AA could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98728LU", "error": "Starting point for pathway to G98728LU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98732ZL", "error": "Missing intermediate; no pathways to [G98732ZL] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98736SM", "error": "Starting point for pathway to G98736SM could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98766GK", "error": "", "notes": [ "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G12504XV", "dp": 9 } ], "links": [ { "target": "G98766GK", "source": "G12504XV", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12504XV", "source": "G08520NM", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] } ] } , { "glytoucan_ac": "G98780RD", "error": "Missing intermediate; no pathways to [G98780RD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G17140UR]", "glycan is core-fucosylated", "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G98790NR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G05600OX]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G32611KT", "dp": 8 }, { "id": "G06290ZS", "dp": 9 }, { "id": "G93336DT", "dp": 10 }, { "id": "G82779CI", "dp": 11 }, { "id": "G32065BG", "dp": 12 }, { "id": "G01727PW", "dp": 13 }, { "id": "G05600OX", "dp": 14 }, { "id": "G98790NR", "dp": 14 } ], "links": [ { "target": "G98790NR", "source": "G05600OX", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G05600OX", "source": "G01727PW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01727PW", "source": "G32065BG", "residue_affected": { "residue_id": "N222", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G32065BG", "source": "G82779CI", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G82779CI", "source": "G93336DT", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G93336DT", "source": "G06290ZS", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06290ZS", "source": "G32611KT", "residue_affected": { "residue_id": "N32", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32611KT", "source": "G39213VZ", "residue_affected": { "residue_id": "N31", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98795XC", "error": "Starting point for pathway to G98795XC could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98803VP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G44202NB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G72821WX", "dp": 9 }, { "id": "G44202NB", "dp": 10 }, { "id": "G98803VP", "dp": 10 } ], "links": [ { "target": "G98803VP", "source": "G44202NB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G44202NB", "source": "G72821WX", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72821WX", "source": "G12398HZ", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98809PE", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 } ], "links": [ { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98852TR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G17909DH", "dp": 14 }, { "id": "G28957FB", "dp": 15 } ], "links": [ { "target": "G98852TR", "source": "G28957FB", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28957FB", "source": "G17909DH", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17909DH", "source": "G18938DW", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98855LF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G82312JY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G80858MF", "dp": 8 }, { "id": "G82312JY", "dp": 9 }, { "id": "G98855LF", "dp": 9 } ], "links": [ { "target": "G98855LF", "source": "G82312JY", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G82312JY", "source": "G80858MF", "residue_affected": { "residue_id": "N30", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G80858MF", "source": "G07483YN", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98862GW", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75049FP", "dp": 12 } ], "links": [ { "target": "G98862GW", "source": "G75049FP", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75049FP", "source": "G99645NK", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G98894JN", "error": "Missing intermediate; no pathways to [G98894JN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G84536BM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98899DA", "error": "Starting point for pathway to G98899DA could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G98906WL", "error": "Missing intermediate; no pathways to [G98906WL] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G98950NS", "error": "Missing intermediate; no pathways to [G98950NS] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99026RX", "error": "Starting point for pathway to G99026RX could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99061KV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G54505OS]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G95081VM", "dp": 9 }, { "id": "G65597BI", "dp": 10 }, { "id": "G54505OS", "dp": 11 }, { "id": "G99061KV", "dp": 11 } ], "links": [ { "target": "G99061KV", "source": "G54505OS", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G54505OS", "source": "G65597BI", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G65597BI", "source": "G95081VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G95081VM", "source": "G66937TJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99067GT", "error": "Missing intermediate; no pathways to [G99067GT] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99074EO", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 } ], "links": [ { "target": "G99074EO", "source": "G11034PZ", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99075EP", "error": "Starting point for pathway to G99075EP could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99078IR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G26018HD]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G26018HD", "dp": 12 }, { "id": "G99078IR", "dp": 12 } ], "links": [ { "target": "G99078IR", "source": "G26018HD", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G26018HD", "source": "G90870DG", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99129GB", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G66937TJ]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G99129GB", "dp": 8 } ], "links": [ { "target": "G99129GB", "source": "G66937TJ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99141XX", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G56549DH]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G01265XZ", "dp": 9 }, { "id": "G78803YD", "dp": 10 }, { "id": "G79809MM", "dp": 11 }, { "id": "G11034PZ", "dp": 12 }, { "id": "G56549DH", "dp": 13 }, { "id": "G99141XX", "dp": 13 } ], "links": [ { "target": "G99141XX", "source": "G56549DH", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G56549DH", "source": "G11034PZ", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G11034PZ", "source": "G79809MM", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79809MM", "source": "G78803YD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78803YD", "source": "G01265XZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G01265XZ", "source": "G10219AA", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99154NV", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G76478FT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G78059CC", "dp": 10 }, { "id": "G76478FT", "dp": 11 }, { "id": "G99154NV", "dp": 11 } ], "links": [ { "target": "G99154NV", "source": "G76478FT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G76478FT", "source": "G78059CC", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G78059CC", "source": "G58667NI", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99165YY", "error": "Missing intermediate; no pathways to [G99165YY] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99182WQ", "error": "Missing intermediate; no pathways to [G99182WQ] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G64618XR]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99204QC", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G79578JB", "dp": 12 }, { "id": "G53812BX", "dp": 13 }, { "id": "G78030KJ", "dp": 14 } ], "links": [ { "target": "G99204QC", "source": "G78030KJ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G78030KJ", "source": "G53812BX", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G53812BX", "source": "G79578JB", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79578JB", "source": "G29857RC", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99225RS", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G52676LZ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G20956ZK", "dp": 8 }, { "id": "G88461FF", "dp": 9 }, { "id": "G72082VM", "dp": 10 }, { "id": "G59877NF", "dp": 11 }, { "id": "G32659RY", "dp": 12 }, { "id": "G52676LZ", "dp": 13 }, { "id": "G99225RS", "dp": 13 } ], "links": [ { "target": "G99225RS", "source": "G52676LZ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52676LZ", "source": "G32659RY", "residue_affected": { "residue_id": "N108", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [] }, { "target": "G32659RY", "source": "G59877NF", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59877NF", "source": "G72082VM", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G72082VM", "source": "G88461FF", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G88461FF", "source": "G20956ZK", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20956ZK", "source": "G07483YN", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99229VQ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G63166WT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G63166WT", "dp": 12 }, { "id": "G99229VQ", "dp": 12 } ], "links": [ { "target": "G99229VQ", "source": "G63166WT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G63166WT", "source": "G30302VM", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99242KO", "error": "", "notes": [ "reducing end mismatch [o-D-GlcNAc]", "homologous pathway end-point [G17740GV]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G29857RC", "dp": 11 }, { "id": "G84376FR", "dp": 12 }, { "id": "G66282NU", "dp": 13 }, { "id": "G89877QI", "dp": 14 }, { "id": "G17740GV", "dp": 15 }, { "id": "G99242KO", "dp": 15 } ], "links": [ { "target": "G99242KO", "source": "G17740GV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G17740GV", "source": "G89877QI", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G89877QI", "source": "G66282NU", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66282NU", "source": "G84376FR", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G84376FR", "source": "G29857RC", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G29857RC", "source": "G62504BU", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99257WS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 } ], "links": [ { "target": "G99257WS", "source": "G36191CD", "residue_affected": { "residue_id": "N49", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99258WN", "error": "Starting point for pathway to G99258WN could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99270AV", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G52663AD", "dp": 9 } ], "links": [ { "target": "G99270AV", "source": "G52663AD", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G52663AD", "source": "G10219AA", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99306JE", "error": "Missing intermediate; no pathways to [G99306JE] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G87457SB]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99307NJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G71835BN]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G36191CD", "dp": 9 }, { "id": "G71835BN", "dp": 10 }, { "id": "G99307NJ", "dp": 10 } ], "links": [ { "target": "G99307NJ", "source": "G71835BN", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G71835BN", "source": "G36191CD", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G36191CD", "source": "G66937TJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99309EE", "error": "", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G52080WL]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G66937TJ", "dp": 8 }, { "id": "G52080WL", "dp": 9 }, { "id": "G99309EE", "dp": 9 } ], "links": [ { "target": "G99309EE", "source": "G52080WL", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G52080WL", "source": "G66937TJ", "residue_affected": { "residue_id": "N53", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G66937TJ", "source": "G39213VZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99323KN", "error": "Missing intermediate; no pathways to [G99323KN] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99342HD", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 } ], "links": [ { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99356PZ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 } ], "links": [ { "target": "G99356PZ", "source": "G12398HZ", "residue_affected": { "residue_id": "N56", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99370TQ", "error": "Missing intermediate; no pathways to [G99370TQ] could be generated at this time", "notes": [ "pathway start-point [G08520NM]" ] }, { "glytoucan_ac": "G99372TR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G30302VM]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G57092OJ", "dp": 10 }, { "id": "G30302VM", "dp": 11 }, { "id": "G99372TR", "dp": 11 } ], "links": [ { "target": "G99372TR", "source": "G30302VM", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G30302VM", "source": "G57092OJ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G57092OJ", "source": "G58667NI", "residue_affected": { "residue_id": "N47", "pubchem_name": "NeuNGc", "anomer": "a", "absolute": "D", "form_name": "NeupNGc", "full_name": "α-D-NeupNGc" }, "effect": "Add α-D-NeupNGc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99376JI", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G47975JA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G58667NI", "dp": 9 }, { "id": "G43694RQ", "dp": 10 }, { "id": "G11041DA", "dp": 11 }, { "id": "G47975JA", "dp": 12 }, { "id": "G99376JI", "dp": 12 } ], "links": [ { "target": "G99376JI", "source": "G47975JA", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G47975JA", "source": "G11041DA", "residue_affected": { "residue_id": "N487", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G11041DA", "source": "G43694RQ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G43694RQ", "source": "G58667NI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G58667NI", "source": "G12398HZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99382AP", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G75143LK]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G75143LK", "dp": 11 }, { "id": "G99382AP", "dp": 11 } ], "links": [ { "target": "G99382AP", "source": "G75143LK", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G75143LK", "source": "G71013KY", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99393DF", "error": "Missing intermediate; no pathways to [G99393DF] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99403QU", "error": "Missing intermediate; no pathways to [G99403QU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G55645TD]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99411XJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G47782UT", "dp": 12 }, { "id": "G92359VA", "dp": 13 } ], "links": [ { "target": "G99411XJ", "source": "G92359VA", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G92359VA", "source": "G47782UT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G47782UT", "source": "G10691MJ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99448WD", "error": "Missing intermediate; no pathways to [G99448WD] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99452IK", "error": "Missing intermediate; no pathways to [G99452IK] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99465IE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 } ], "links": [ { "target": "G99465IE", "source": "G06131VP", "residue_affected": { "residue_id": "N54", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT1", "uniprot": "P19526", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT2", "uniprot": "Q10981", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut1", "uniprot": "O09160", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Sec1", "uniprot": "P97353", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut2", "uniprot": "Q9JL27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99501KJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G53933HU]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G59741XZ", "dp": 7 }, { "id": "G53933HU", "dp": 8 }, { "id": "G99501KJ", "dp": 8 } ], "links": [ { "target": "G99501KJ", "source": "G53933HU", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G53933HU", "source": "G59741XZ", "residue_affected": { "residue_id": "N69", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G59741XZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99502WP", "error": "Missing intermediate; no pathways to [G99502WP] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G23546LY]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99503MW", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G06131VP]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G32201IL", "dp": 10 }, { "id": "G06131VP", "dp": 11 }, { "id": "G99503MW", "dp": 11 } ], "links": [ { "target": "G99503MW", "source": "G06131VP", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G06131VP", "source": "G32201IL", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32201IL", "source": "G20030CU", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99505XE", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G79609RF", "dp": 10 } ], "links": [ { "target": "G99505XE", "source": "G79609RF", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G79609RF", "source": "G20030CU", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99511SH", "error": "Missing intermediate; no pathways to [G99511SH] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G59989VG]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99516QU", "error": "Starting point for pathway to G99516QU could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99519QZ", "error": "Starting point for pathway to G99519QZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99533GU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G10292TC", "dp": 15 }, { "id": "G99342HD", "dp": 16 }, { "id": "G28106CM", "dp": 17 } ], "links": [ { "target": "G99533GU", "source": "G28106CM", "residue_affected": { "residue_id": "N35", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28106CM", "source": "G99342HD", "residue_affected": { "residue_id": "N14", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99342HD", "source": "G10292TC", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10292TC", "source": "G63889NK", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99568AR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G86696LV]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G00176HZ", "dp": 10 }, { "id": "G90870DG", "dp": 11 }, { "id": "G98809PE", "dp": 12 }, { "id": "G73492AT", "dp": 13 }, { "id": "G63889NK", "dp": 14 }, { "id": "G76842ZR", "dp": 15 }, { "id": "G17155VX", "dp": 16 }, { "id": "G86696LV", "dp": 17 }, { "id": "G99568AR", "dp": 17 } ], "links": [ { "target": "G99568AR", "source": "G86696LV", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G86696LV", "source": "G17155VX", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G17155VX", "source": "G76842ZR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G76842ZR", "source": "G63889NK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G63889NK", "source": "G73492AT", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73492AT", "source": "G98809PE", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G98809PE", "source": "G90870DG", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G90870DG", "source": "G00176HZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00176HZ", "source": "G20030CU", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99571EV", "error": "Missing intermediate; no pathways to [G99571EV] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G13282WA]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99584SF", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G50584UT]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G42672MA", "dp": 9 }, { "id": "G32305RZ", "dp": 10 }, { "id": "G10691MJ", "dp": 11 }, { "id": "G86357DX", "dp": 12 }, { "id": "G50584UT", "dp": 13 }, { "id": "G99584SF", "dp": 13 } ], "links": [ { "target": "G99584SF", "source": "G50584UT", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G50584UT", "source": "G86357DX", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G86357DX", "source": "G10691MJ", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10691MJ", "source": "G32305RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G32305RZ", "source": "G42672MA", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G42672MA", "source": "G12398HZ", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99595YZ", "error": "Starting point for pathway to G99595YZ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99603GB", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39089YD", "dp": 7 }, { "id": "G64669AQ", "dp": 8 } ], "links": [ { "target": "G99603GB", "source": "G64669AQ", "residue_affected": { "residue_id": "N485", "pubchem_name": "Xyl", "anomer": "b", "absolute": "D", "form_name": "Xylp", "full_name": "β-D-Xylp" }, "effect": "Add β-D-Xylp", "enzymes": [] }, { "target": "G64669AQ", "source": "G39089YD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39089YD", "source": "G61751GZ", "residue_affected": { "residue_id": "N40", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [] } ] } , { "glytoucan_ac": "G99622IJ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G43664YB]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G43664YB", "dp": 9 }, { "id": "G99622IJ", "dp": 9 } ], "links": [ { "target": "G99622IJ", "source": "G43664YB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G43664YB", "source": "G24420RT", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99626QO", "error": "Missing intermediate; no pathways to [G99626QO] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G86377SM]", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99645NK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 } ], "links": [ { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99647DZ", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G03272YQ]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G21788RU", "dp": 12 }, { "id": "G03272YQ", "dp": 13 }, { "id": "G99647DZ", "dp": 13 } ], "links": [ { "target": "G99647DZ", "source": "G03272YQ", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G03272YQ", "source": "G21788RU", "residue_affected": { "residue_id": "N42", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT3", "uniprot": "P21217", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT4", "uniprot": "P22083", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT6", "uniprot": "P51993", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT5", "uniprot": "Q11128", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT9", "uniprot": "Q9Y231", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut9", "uniprot": "O88819", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut4", "uniprot": "Q11127", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G21788RU", "source": "G25520XG", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99651QK", "error": "", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [G61684ET]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G61684ET", "dp": 12 }, { "id": "G99651QK", "dp": 12 } ], "links": [ { "target": "G99651QK", "source": "G61684ET", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G61684ET", "source": "G25520XG", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99669MJ", "error": "Starting point for pathway to G99669MJ could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99691HE", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G88380UG]", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G88380UG", "dp": 8 }, { "id": "G99691HE", "dp": 8 } ], "links": [ { "target": "G99691HE", "source": "G88380UG", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G88380UG", "source": "G39213VZ", "residue_affected": { "residue_id": "N206", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99729IU", "error": "Missing intermediate; no pathways to [G99729IU] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcpNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99732NX", "error": "Missing intermediate; no pathways to [G99732NX] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [not found]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99770NO", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G15103WJ", "dp": 12 } ], "links": [ { "target": "G99770NO", "source": "G15103WJ", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G15103WJ", "source": "G25520XG", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99783ON", "error": "Starting point for pathway to G99783ON could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99796NW", "error": "Starting point for pathway to G99796NW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99801SM", "error": "Starting point for pathway to G99801SM could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99808VS", "error": "Missing intermediate; no pathways to [G99808VS] could be generated at this time", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99829YW", "error": "Starting point for pathway to G99829YW could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99846PG", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G90017UO]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G12398HZ", "dp": 8 }, { "id": "G28550OD", "dp": 9 }, { "id": "G90017UO", "dp": 10 }, { "id": "G99846PG", "dp": 10 } ], "links": [ { "target": "G99846PG", "source": "G90017UO", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G90017UO", "source": "G28550OD", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G28550OD", "source": "G12398HZ", "residue_affected": { "residue_id": "N41", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT11", "uniprot": "Q495W5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "FUT10", "uniprot": "Q6P4F1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut10", "uniprot": "Q5F2L2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Fut11", "uniprot": "Q8BHC9", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G12398HZ", "source": "G07483YN", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99853JR", "error": "", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G77537OB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G26182BM", "dp": 8 }, { "id": "G61207RZ", "dp": 9 }, { "id": "G03445UI", "dp": 10 }, { "id": "G77537OB", "dp": 11 }, { "id": "G99853JR", "dp": 11 } ], "links": [ { "target": "G99853JR", "source": "G77537OB", "residue_affected": [], "effect": "Release or transfer entire glycan", "enzymes": [] }, { "target": "G77537OB", "source": "G03445UI", "residue_affected": { "residue_id": "N50", "pubchem_name": "Gal", "anomer": "a", "absolute": "D", "form_name": "Galp", "full_name": "α-D-Galp" }, "effect": "Add α-D-Galp", "enzymes": [ { "gene_name": "ABO", "uniprot": "P16442", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Abo", "uniprot": "P38649", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G03445UI", "source": "G61207RZ", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G61207RZ", "source": "G26182BM", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G26182BM", "source": "G07483YN", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99858XP", "error": "Starting point for pathway to G99858XP could not be determined; no pathways were generated", "notes": [ "glycan is core-fucosylated", "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99866WK", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G69411IG", "dp": 7 }, { "id": "G24420RT", "dp": 8 }, { "id": "G46638GC", "dp": 9 }, { "id": "G62504BU", "dp": 10 }, { "id": "G20815TK", "dp": 11 }, { "id": "G10874QT", "dp": 12 }, { "id": "G00909PI", "dp": 13 }, { "id": "G38395YJ", "dp": 14 } ], "links": [ { "target": "G99866WK", "source": "G38395YJ", "residue_affected": { "residue_id": "N241", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [] }, { "target": "G38395YJ", "source": "G00909PI", "residue_affected": { "residue_id": "N12", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G00909PI", "source": "G10874QT", "residue_affected": { "residue_id": "N33", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10874QT", "source": "G20815TK", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20815TK", "source": "G62504BU", "residue_affected": { "residue_id": "N28", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B3GALT2", "uniprot": "O43825", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3GALT5", "uniprot": "Q9Y2C3", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B3galt2", "uniprot": "O54905", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B3galt5", "uniprot": "Q9JI67", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G62504BU", "source": "G46638GC", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G46638GC", "source": "G24420RT", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G24420RT", "source": "G69411IG", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G69411IG", "source": "G61751GZ", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99876AH", "error": "Starting point for pathway to G99876AH could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99891PR", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G10219AA", "dp": 8 }, { "id": "G20030CU", "dp": 9 }, { "id": "G08863NS", "dp": 10 }, { "id": "G99645NK", "dp": 11 }, { "id": "G75185NU", "dp": 12 }, { "id": "G18938DW", "dp": 13 }, { "id": "G73775WR", "dp": 14 }, { "id": "G37990ZT", "dp": 15 } ], "links": [ { "target": "G99891PR", "source": "G37990ZT", "residue_affected": { "residue_id": "N38", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G37990ZT", "source": "G73775WR", "residue_affected": { "residue_id": "N34", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G73775WR", "source": "G18938DW", "residue_affected": { "residue_id": "N16", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G18938DW", "source": "G75185NU", "residue_affected": { "residue_id": "N10", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G75185NU", "source": "G99645NK", "residue_affected": { "residue_id": "N8", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G99645NK", "source": "G08863NS", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G08863NS", "source": "G20030CU", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G20030CU", "source": "G10219AA", "residue_affected": { "residue_id": "N7", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT4C", "uniprot": "Q9UBM8", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4A", "uniprot": "Q9UM21", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT4B", "uniprot": "Q9UQ53", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat4b", "uniprot": "Q812F8", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4a", "uniprot": "Q812G0", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat4c", "uniprot": "Q9D306", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10219AA", "source": "G39213VZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99896CG", "error": "Missing intermediate; no pathways to [G99896CG] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G78885XB]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99897FQ", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G39213VZ", "dp": 7 }, { "id": "G67045LB", "dp": 8 } ], "links": [ { "target": "G99897FQ", "source": "G67045LB", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G67045LB", "source": "G39213VZ", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G39213VZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99927HL", "error": "Starting point for pathway to G99927HL could not be determined; no pathways were generated", "notes": [ "pathway start-point [not determined]" ] }, { "glytoucan_ac": "G99935CU", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 }, { "id": "G99969SS", "dp": 10 } ], "links": [ { "target": "G99935CU", "source": "G99969SS", "residue_affected": { "residue_id": "N469", "pubchem_name": "sulfate", "anomer": "n", "absolute": "n", "form_name": "sulfate", "full_name": "-n-sulfate" }, "effect": "Add -n-sulfate", "enzymes": [] }, { "target": "G99969SS", "source": "G13151XE", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99943EE", "error": "Missing intermediate; no pathways to [G99943EE] could be generated at this time", "notes": [ "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99954GW", "error": "Missing intermediate; no pathways to [G99954GW] could be generated at this time", "notes": [ "reducing end mismatch [x-D-GlcNAc]", "homologous pathway end-point [G75853FN]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99954ZJ", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G07483YN", "dp": 7 }, { "id": "G51490BW", "dp": 8 }, { "id": "G30159WR", "dp": 9 }, { "id": "G71013KY", "dp": 10 }, { "id": "G25520XG", "dp": 11 }, { "id": "G10733HY", "dp": 12 } ], "links": [ { "target": "G99954ZJ", "source": "G10733HY", "residue_affected": { "residue_id": "N13", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST6GAL1", "uniprot": "P15907", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST6GAL2", "uniprot": "Q96JF0", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St6gal1", "uniprot": "Q64685", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St6gal2", "uniprot": "Q76K27", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G10733HY", "source": "G25520XG", "residue_affected": { "residue_id": "N17", "pubchem_name": "NeuNAc", "anomer": "a", "absolute": "D", "form_name": "NeupNAc", "full_name": "α-D-NeupNAc" }, "effect": "Add α-D-NeupNAc", "enzymes": [ { "gene_name": "ST3GAL3", "uniprot": "Q11203", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL4", "uniprot": "Q11206", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "ST3GAL6", "uniprot": "Q9Y274", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "St3gal3", "uniprot": "P97325", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal6", "uniprot": "Q8VIB3", "type": "GT", "species": "Mus musculus" }, { "gene_name": "St3gal4", "uniprot": "Q91Y74", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G25520XG", "source": "G71013KY", "residue_affected": { "residue_id": "N6", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G71013KY", "source": "G30159WR", "residue_affected": { "residue_id": "N3", "pubchem_name": "Gal", "anomer": "b", "absolute": "D", "form_name": "Galp", "full_name": "β-D-Galp" }, "effect": "Add β-D-Galp", "enzymes": [ { "gene_name": "B4GALT3", "uniprot": "O60512", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT2", "uniprot": "O60909", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALT1", "uniprot": "P15291", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galt1", "uniprot": "P15535", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt3", "uniprot": "Q91YY2", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galt2", "uniprot": "Q9Z2Y2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G30159WR", "source": "G51490BW", "residue_affected": { "residue_id": "N5", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT2", "uniprot": "Q10469", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat2", "uniprot": "Q921V5", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G51490BW", "source": "G07483YN", "residue_affected": { "residue_id": "N11", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT3", "uniprot": "Q09327", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat3", "uniprot": "Q10470", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G07483YN", "source": "G61751GZ", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99956MJ", "error": "Missing intermediate; no pathways to [G99956MJ] could be generated at this time", "notes": [ "reducing end mismatch [o-D-GlcolNAc]", "homologous pathway end-point [G46767VX]", "glycan is core-fucosylated", "pathway start-point [G61751GZ]" ] }, { "glytoucan_ac": "G99969SS", "error": "", "notes": [ "glycan is core-fucosylated", "pathway start-point [G08520NM]" ], "nodes": [ { "id": "G08520NM", "dp": 8 }, { "id": "G13151XE", "dp": 9 } ], "links": [ { "target": "G99969SS", "source": "G13151XE", "residue_affected": { "residue_id": "N15", "pubchem_name": "Fuc", "anomer": "a", "absolute": "L", "form_name": "Fucp", "full_name": "α-L-Fucp" }, "effect": "Add α-L-Fucp", "enzymes": [ { "gene_name": "FUT8", "uniprot": "Q9BYC5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Fut8", "uniprot": "Q9WTS2", "type": "GT", "species": "Mus musculus" } ] }, { "target": "G13151XE", "source": "G08520NM", "residue_affected": { "residue_id": "N29", "pubchem_name": "GalNAc", "anomer": "b", "absolute": "D", "form_name": "GalpNAc", "full_name": "β-D-GalpNAc" }, "effect": "Add β-D-GalpNAc", "enzymes": [ { "gene_name": "B4GALNT3", "uniprot": "Q6L9W6", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4GALNT4", "uniprot": "Q76KP1", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "B4galnt3", "uniprot": "A0A1D5RMF7", "type": "GT", "species": "Mus musculus" }, { "gene_name": "B4galnt4", "uniprot": "Q766D5", "type": "GT", "species": "Mus musculus" } ] } ] } , { "glytoucan_ac": "G99997WS", "error": "", "notes": [ "pathway start-point [G61751GZ]" ], "nodes": [ { "id": "G61751GZ", "dp": 6 }, { "id": "G74090KZ", "dp": 7 } ], "links": [ { "target": "G99997WS", "source": "G74090KZ", "residue_affected": { "residue_id": "N201", "pubchem_name": "Fuc", "anomer": "a", "absolute": "D", "form_name": "Fucp", "full_name": "α-D-Fucp" }, "effect": "Add α-D-Fucp", "enzymes": [ { "gene_name": "abiotic", "uniprot": "abiotic", "type": "", "species": "no known organism" } ] }, { "target": "G74090KZ", "source": "G61751GZ", "residue_affected": { "residue_id": "N9", "pubchem_name": "GlcNAc", "anomer": "b", "absolute": "D", "form_name": "GlcpNAc", "full_name": "β-D-GlcpNAc" }, "effect": "Add β-D-GlcpNAc", "enzymes": [ { "gene_name": "MGAT5", "uniprot": "Q09328", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "MGAT5B", "uniprot": "Q3V5L5", "type": "GT", "species": "Homo sapiens" }, { "gene_name": "Mgat5b", "uniprot": "Q765H6", "type": "GT", "species": "Mus musculus" }, { "gene_name": "Mgat5", "uniprot": "Q8R4G6", "type": "GT", "species": "Mus musculus" } ] } ] } ] }